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6ILI
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BU of 6ili by Molmil
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 6.5
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2018-10-18
Release date:2018-11-07
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
5WS7
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BU of 5ws7 by Molmil
Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 2-oxo-dATP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-12-05
Release date:2017-01-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
1IRY
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BU of 1iry by Molmil
Solution structure of the hMTH1, a nucleotide pool sanitization enzyme
Descriptor: hMTH1
Authors:Mishima, M, Itoh, N, Sakai, Y, Kamiya, H, Nakabeppu, Y, Shirakawa, M.
Deposit date:2001-10-25
Release date:2003-12-23
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates
J.Biol.Chem., 279, 2004
5GHM
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BU of 5ghm by Molmil
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 7.0
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-06-20
Release date:2017-01-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
5GHI
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BU of 5ghi by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGTP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-06-20
Release date:2017-01-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.211 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
5GHO
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BU of 5gho by Molmil
Crystal structure of human MTH1(G2K/D120A mutant) in complex with 8-oxo-dGTP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-06-20
Release date:2017-01-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.191 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
5GHN
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BU of 5ghn by Molmil
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-06-20
Release date:2017-01-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.391 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
5GHQ
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BU of 5ghq by Molmil
Crystal structure of human MTH1(G2K/D120A mutant) in complex with 2-oxo-dATP under high concentrations of 2-oxo-dATP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-06-20
Release date:2017-01-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.181 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
5GHJ
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BU of 5ghj by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-06-20
Release date:2017-01-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
5GHP
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BU of 5ghp by Molmil
Crystal structure of human MTH1(G2K/D120A mutant) in complex with 2-oxo-dATP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION
Authors:Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y.
Deposit date:2016-06-20
Release date:2017-01-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.192 Å)
Cite:Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292, 2017
7EF8
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BU of 7ef8 by Molmil
Crystal structure of mouse MUTYH in complex with DNA containing AP site analogue:8-oxoG (Form I)
Descriptor: Adenine DNA glycosylase, DNA (5'-D(*TP*AP*GP*TP*CP*CP*CP*(3DR)P*GP*TP*CP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*GP*AP*CP*(8OG)P*GP*GP*GP*AP*CP*T)-3'), ...
Authors:Nakamura, T, Nakabeppu, Y, Yamagata, Y.
Deposit date:2021-03-21
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.
Nucleic Acids Res., 49, 2021
7EFA
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BU of 7efa by Molmil
Crystal structure of the complex between the C-terminal domain of mouse MUTYH and human PCNA
Descriptor: Adenine DNA glycosylase, Proliferating cell nuclear antigen
Authors:Nakamura, T, Nakabeppu, Y, Yamagata, Y.
Deposit date:2021-03-21
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.
Nucleic Acids Res., 49, 2021
7EF9
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BU of 7ef9 by Molmil
Crystal structure of mouse MUTYH in complex with DNA containing AP site analogue:8-oxoG (Form II)
Descriptor: Adenine DNA glycosylase, DNA (5'-D(*AP*TP*GP*AP*GP*AP*CP*(8OG)P*GP*GP*GP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*CP*CP*CP*(3DR)P*GP*TP*CP*TP*C)-3'), ...
Authors:Nakamura, T, Nakabeppu, Y, Yamagata, Y.
Deposit date:2021-03-21
Release date:2021-06-23
Last modified:2021-07-21
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.
Nucleic Acids Res., 49, 2021
6IJY
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BU of 6ijy by Molmil
Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 8-oxo-dGTP determined using a crystal obtained under microgravity
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2018-10-12
Release date:2019-02-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity.
Int. J. Microgravity Sci. Appl., 36, 2019
1MPG
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BU of 1mpg by Molmil
3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI
Descriptor: 3-METHYLADENINE DNA GLYCOSYLASE II, GLYCEROL
Authors:Labahn, J, Schaerer, O.D, Long, A, Ezaz-Nikpay, K, Verdine, G.L, Ellenberger, T.E.
Deposit date:1997-10-28
Release date:1998-01-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the excision repair of alkylation-damaged DNA.
Cell(Cambridge,Mass.), 86, 1996
8I1G
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BU of 8i1g by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 9.1
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, SODIUM ION, ...
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I18
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BU of 8i18 by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGTP at pH 7.7
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I19
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BU of 8i19 by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGTP at pH 8.0
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I8T
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BU of 8i8t by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dAMP and Mn2+
Descriptor: 2'-DEOXYISOGUANINE-5'-MONOPHOSPHATE, 7,8-dihydro-8-oxoguanine triphosphatase, MANGANESE (II) ION
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-02-05
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I1H
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BU of 8i1h by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 9.7
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, GLYCEROL, SODIUM ION
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I1E
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BU of 8i1e by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 8.0
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I1J
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BU of 8i1j by Molmil
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP at pH 9.7
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I1A
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BU of 8i1a by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGTP at pH 8.6
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I1I
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BU of 8i1i by Molmil
Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP at pH 7.7
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023
8I1D
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BU of 8i1d by Molmil
Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP at pH 7.7
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
Authors:Nakamura, T, Yamagata, Y.
Deposit date:2023-01-13
Release date:2023-03-22
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Protonation states of Asp residues in the human Nudix hydrolase MTH1 contribute to its broad substrate recognition.
Febs Lett., 597, 2023

 

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