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6Q8J
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BU of 6q8j by Molmil
Nterminal domain of human SMU1 in complex with LSP641
Descriptor: 1-~{tert}-butyl-3-[6-(3,5-dimethoxyphenyl)-2-[[1-[1-(phenylmethyl)piperidin-4-yl]-1,2,3-triazol-4-yl]methylamino]pyrido[2,3-d]pyrimidin-7-yl]urea, WD40 repeat-containing protein SMU1
Authors:Tengo, L, Le Corre, L, Fournier, G, Ashraf, U, Busca, P, Rameix-Welti, M.-A, Gravier-Pelletier, C, Ruigrok, R.W.H, Jacob, Y, Vidalain, P.-O, Pietrancosta, N, Naffakh, N, McCarthy, A.A, Crepin, T.
Deposit date:2018-12-14
Release date:2019-05-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Proc.Natl.Acad.Sci.USA, 116, 2019
6Q8I
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BU of 6q8i by Molmil
Nterminal domain of human SMU1 in complex with human REDmid
Descriptor: Protein Red, WD40 repeat-containing protein SMU1
Authors:Tengo, L, Le Corre, L, Fournier, G, Ashraf, U, Busca, P, Rameix-Welti, M.-A, Gravier-Pelletier, C, Ruigrok, R.W.H, Jacob, Y, Vidalain, P.-O, Pietrancosta, N, Naffakh, N, McCarthy, A.A, Crepin, T.
Deposit date:2018-12-14
Release date:2019-05-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Proc.Natl.Acad.Sci.USA, 116, 2019
6Q8F
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BU of 6q8f by Molmil
Nterminal domain of human SMU1
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, WD40 repeat-containing protein SMU1
Authors:Tengo, L, Le Corre, L, Fournier, G, Ashraf, U, Busca, P, Rameix-Welti, M.-A, Gravier-Pelletier, C, Ruigrok, R.W.H, Jacob, Y, Vidalain, P.-O, Pietrancosta, N, Naffakh, N, McCarthy, A.A, Crepin, T.
Deposit date:2018-12-14
Release date:2019-05-22
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Proc.Natl.Acad.Sci.USA, 116, 2019
4GB1
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BU of 4gb1 by Molmil
Synthesis and Evaluation of Novel 3-C-alkylated-Neu5Ac2en Derivatives as Probes of Influenza Virus Sialidase 150-loop flexibility
Descriptor: 5-acetamido-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-phenylprop-2-en-1-yl]-D-glycero-L-altro-non-2-enonic acid, CALCIUM ION, Neuraminidase
Authors:Kerry, P.S, Rudrawar, S, Rameix-Welti, M.-A, Maggioni, A, Dyason, J.C, Rose, F.J, van der Werf, S, Thomson, R.J, Naffakh, N, Russell, R.J.M, von Itzstein, M.
Deposit date:2012-07-26
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.
Org.Biomol.Chem., 10, 2012
6H9G
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BU of 6h9g by Molmil
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 1.
Descriptor: Nucleoprotein, Polypeptide loop
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Munier, S, Carlero, D, Naffakh, N, Ortin, J, Martin-Benito, J.
Deposit date:2018-08-03
Release date:2020-02-12
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020
5M3J
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BU of 5m3j by Molmil
Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD
Descriptor: DNA-directed RNA polymerase subunit, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Lukarska, M, Pflug, A, Cusack, S.
Deposit date:2016-10-14
Release date:2016-12-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Nature, 541, 2017
5M3H
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BU of 5m3h by Molmil
Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD
Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Lukarska, M, Pflug, A, Cusack, S.
Deposit date:2016-10-14
Release date:2016-12-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Nature, 541, 2017
8R3K
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BU of 8r3k by Molmil
Influenza A/H7N9 polymerase in self-stalled pre-termination state, with Pol II pS5 CTD peptide mimic bound in site 1A/2A.
Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, PYROPHOSPHATE 2-, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-11-09
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Nat Commun, 15, 2024
8R3L
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BU of 8r3l by Molmil
Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A
Descriptor: 3' vRNA end (51-mer vRNA loop), Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-11-09
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Nat Commun, 15, 2024
8POH
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BU of 8poh by Molmil
Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R)
Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-07-04
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Nat Commun, 15, 2024
8PNP
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BU of 8pnp by Molmil
Influenza A/H7N9 polymerase in pre-initiation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A
Descriptor: 51-mer vRNA loop (v51_mut_S), Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-06-30
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.49 Å)
Cite:The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Nat Commun, 15, 2024
8PNQ
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BU of 8pnq by Molmil
Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A
Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-06-30
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Nat Commun, 15, 2024
8PM0
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BU of 8pm0 by Molmil
Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A
Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2023-06-27
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Nat Commun, 15, 2024
7Z43
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BU of 7z43 by Molmil
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B
Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2022-03-03
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.123 Å)
Cite:Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
7Z4O
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BU of 7z4o by Molmil
Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A
Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Cusack, S, Pflug, A.
Deposit date:2022-03-04
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.412 Å)
Cite:Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
7Z42
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BU of 7z42 by Molmil
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B
Descriptor: DNA-directed RNA polymerase II subunit RPB1, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Cusack, S, Drncova, P.
Deposit date:2022-03-03
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.418 Å)
Cite:Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
6I54
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BU of 6i54 by Molmil
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 2.
Descriptor: Influenza virus nucleoprotein, Nucleoprotein
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J.
Deposit date:2018-11-12
Release date:2019-11-13
Last modified:2020-05-27
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020
6I85
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BU of 6i85 by Molmil
Influenza A nucleoprotein docked into the 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 5.
Descriptor: Influenza A nucleoprotein, Nucleoprotein
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J.
Deposit date:2018-11-19
Release date:2020-01-29
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (24 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020
6I7M
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BU of 6i7m by Molmil
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 4.
Descriptor: Nucleoprotein
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J.
Deposit date:2018-11-16
Release date:2020-02-12
Last modified:2020-08-26
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020
6I7B
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BU of 6i7b by Molmil
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 3.
Descriptor: Nucleoprotein
Authors:Coloma, R, Arranz, R, de la Rosa-Trevin, J.M, Sorzano, C.O.S, Carlero, D, Ortin, J, Martin-Benito, J.
Deposit date:2018-11-16
Release date:2020-02-19
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
Nat Microbiol, 5, 2020
3O9K
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BU of 3o9k by Molmil
Influenza NA in complex with compound 6
Descriptor: 5-acetamido-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-(4-methylphenyl)prop-2-en-1-yl]-D-glycero-D-galacto-non-2-enonic acid, Neuraminidase
Authors:Russell, R.J, Kerry, P.S.
Deposit date:2010-08-04
Release date:2010-12-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4945 Å)
Cite:Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
Nat Commun, 1, 2010
3O9J
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BU of 3o9j by Molmil
Influenza NA in complex with compound 5
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 5-acetamido-2,6-anhydro-3,5-dideoxy-3-prop-2-en-1-yl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, ...
Authors:Russell, R.J, Kerry, P.S.
Deposit date:2010-08-04
Release date:2010-12-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.0002 Å)
Cite:Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
Nat Commun, 1, 2010

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