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5WAH
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BU of 5wah by Molmil
SOLUTION NMR STRUCTURE OF SIGLEC-5 BINDING DOMAIN FROM STREPTOCOCCAL BETA PROTEIN
Descriptor: IgA FC receptor
Authors:ELETSKY, A, CHEN, C, FONG, J.J, NIZET, V, VARKI, A, PRESTEGARD, J.H.
Deposit date:2017-06-26
Release date:2018-06-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:SOLUTION NMR STRUCTURE OF SIGLEC-5 BINDING DOMAIN FROM STREPTOCOCCAL BETA PROTEIN
To Be Published
2XNX
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BU of 2xnx by Molmil
BC1 fragment of streptococcal M1 protein in complex with human fibrinogen
Descriptor: FIBRINOGEN ALPHA CHAIN, FIBRINOGEN BETA CHAIN, FIBRINOGEN GAMMA CHAIN, ...
Authors:Macheboeuf, P, Y Fu, C, Zinkernagel, A.S, Johnson, J.E, Nizet, V, Ghosh, P.
Deposit date:2010-08-06
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Streptococcal M1 Protein Constructs a Pathological Host Fibrinogen Network
Nature, 472, 2011
2XNY
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BU of 2xny by Molmil
A fragment of streptococcal M1 protein in complex with human fibrinogen
Descriptor: FIBRINOGEN ALPHA CHAIN, FIBRINOGEN BETA CHAIN, FIBRINOGEN GAMMA CHAIN, ...
Authors:Macheboeuf, P, Y Fu, C, Zinkernagel, A.S, Johnson, J.E, Nizet, V, Ghosh, P.
Deposit date:2010-08-06
Release date:2011-04-13
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (7.5 Å)
Cite:Streptococcal M1 Protein Constructs a Pathological Host Fibrinogen Network
Nature, 472, 2011
7SAF
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BU of 7saf by Molmil
Fragment of streptococcal M87 protein fused to GCN4 adaptor
Descriptor: General control transcription factor GCN4/M protein chimera, PHOSPHATE ION
Authors:Kolesinski, P, Ghosh, P.
Deposit date:2021-09-22
Release date:2022-07-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37
Elife, 11, 2022
7SAY
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BU of 7say by Molmil
Fragment of streptococcal M87 protein fused to GCN4 adaptor in complex with human cathelicidin
Descriptor: 1,2-ETHANEDIOL, Antibacterial peptide LL-37, General control transcription factor GCN4/M protein chimera
Authors:Kolesinski, P, Ghosh, P.
Deposit date:2021-09-23
Release date:2022-07-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37
Elife, 11, 2022
8C5N
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BU of 8c5n by Molmil
Sub-atomic resolution structure of the chitin-binding protein D (CbpD) from Pseudomonas aeruginosa
Descriptor: CHLORIDE ION, Chitin-binding protein CbpD
Authors:Cordara, G, Krengel, U, Golten, O, Vaaje-Kolstad, G, Vinther Soerensen, H.
Deposit date:2023-01-09
Release date:2023-06-28
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (0.75 Å)
Cite:Immunization with lytic polysaccharide monooxygenase CbpD induces protective immunity against Pseudomonas aeruginosa pneumonia.
Proc.Natl.Acad.Sci.USA, 120, 2023
6UKD
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BU of 6ukd by Molmil
Co-complex of S. pyogenes 10782 streptopain bound with a nitrile-based specific covalent inhibitor
Descriptor: NITRATE ION, Streptopain, benzyl [(2S)-1-(3-nitrophenyl)-3-oxobutan-2-yl]carbamate
Authors:Wolan, D.W, Woehl, J.L, Kitamura, S.
Deposit date:2019-10-04
Release date:2020-09-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.589 Å)
Cite:An Irreversible Inhibitor to Probe the Role ofStreptococcus pyogenesCysteine Protease SpeB in Evasion of Host Complement Defenses.
Acs Chem.Biol., 15, 2020
6UQD
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BU of 6uqd by Molmil
Co-complex of S. pyogenes 10782 streptopain bound with a SuFEx-based optimized small molecule inhibitor
Descriptor: Streptopain, benzyl [(1S)-2-(3-{[(4-carbamoylpiperidin-1-yl)(fluoro)oxo-lambda~6~-sulfanylidene]amino}phenyl)-1-cyanoethyl]carbamate
Authors:Wolan, D.W, Woehl, J.L, Kitamura, S.
Deposit date:2019-10-18
Release date:2020-08-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry.
J.Am.Chem.Soc., 142, 2020
2OTO
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BU of 2oto by Molmil
N-terminal fragment of Streptococcus pyogenes M1 protein
Descriptor: M protein
Authors:McNamara, C.W, Ghosh, P.
Deposit date:2007-02-08
Release date:2008-03-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence.
Science, 319, 2008
1S6W
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BU of 1s6w by Molmil
Solution Structure of hybrid white striped bass hepcidin
Descriptor: Hepcidin
Authors:Babon, J.J, Singh, S, Pennington, M.W, Norton, R.S, Westerman, M.E.
Deposit date:2004-01-28
Release date:2004-12-14
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections.
J.Biol.Chem., 280, 2005
3SGT
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BU of 3sgt by Molmil
Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1299
Descriptor: 2-{[4-(3,4-dimethylphenoxy)phenyl]carbamoyl}benzoic acid, Undecaprenyl pyrophosphate synthase
Authors:Cao, R, Liu, Y.-L, Oldfield, E.
Deposit date:2011-06-15
Release date:2012-12-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
3SGV
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BU of 3sgv by Molmil
Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1290
Descriptor: 2-{[3-(3,4-dimethylphenoxy)phenyl]carbamoyl}-4-nitrobenzoic acid, Undecaprenyl pyrophosphate synthase
Authors:Cao, R, Liu, Y.-L, Oldfield, E.
Deposit date:2011-06-15
Release date:2012-12-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
3SGX
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BU of 3sgx by Molmil
Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1100
Descriptor: 4-{3-[(biphenyl-4-ylcarbonyl)amino]phenoxy}benzene-1,2-dicarboxylic acid, Undecaprenyl pyrophosphate synthase
Authors:Cao, R, Liu, Y.-L, Oldfield, E.
Deposit date:2011-06-15
Release date:2012-12-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
2ZY1
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BU of 2zy1 by Molmil
Crystal structure of the C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-830
Descriptor: Dehydrosqualene synthase, dipotassium (2-oxo-2-{[3-(3-phenoxyphenyl)propyl]amino}ethyl)phosphonate
Authors:Liu, C.I, Jeng, W.Y, Wang, A.H.J, Oldfield, E.
Deposit date:2009-01-10
Release date:2009-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
J.Med.Chem., 52, 2009
5HZP
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BU of 5hzp by Molmil
Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M49 protein.
Descriptor: C4b-binding protein alpha chain, M protein, serotype 49, ...
Authors:Buffalo, C.Z, Bahn-Suh, A.J, Ghosh, P.
Deposit date:2016-02-02
Release date:2016-07-20
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5HYP
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BU of 5hyp by Molmil
Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein
Descriptor: C4b-binding protein alpha chain, M28 protein
Authors:Buffalo, C.Z, Bahn-Suh, A.J, Ghosh, P.
Deposit date:2016-02-01
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.024 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5HYT
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BU of 5hyt by Molmil
Structure of human C4b-binidng protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M22 protein
Descriptor: C4b-binding protein alpha chain, Precursor to Protein Sir22
Authors:Buffalo, C.Z, Bahn-Suh, A.J, Ghosh, P.
Deposit date:2016-02-01
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5HYU
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BU of 5hyu by Molmil
Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M2 protein
Descriptor: C4b-binding protein alpha chain, M protein, serotype 2.1
Authors:Buffalo, C.Z, Bahn-Suh, A.J, Ghosh, P.
Deposit date:2016-02-01
Release date:2016-07-20
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.561 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
5I0Q
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BU of 5i0q by Molmil
Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein
Descriptor: C4b-binding protein alpha chain, M protein, serotype 2.1
Authors:Buffalo, C.Z, Bahn-Suh, A.J, Ghosh, P.
Deposit date:2016-02-04
Release date:2016-07-20
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (2.293 Å)
Cite:Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.
Nat Microbiol, 1, 2016
4H2M
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BU of 4h2m by Molmil
Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1408
Descriptor: 2,2'-{benzene-1,3-diylbis[ethyne-2,1-diyl(5-bromobenzene-3,1-diyl)]}diethanamine, Undecaprenyl pyrophosphate synthase
Authors:Zhu, W, Oldfield, E.
Deposit date:2012-09-12
Release date:2012-12-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4H3A
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BU of 4h3a by Molmil
Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1330
Descriptor: (2Z)-2-hydroxy-4-[4-(octyloxy)phenyl]-4-oxobut-2-enoic acid, Undecaprenyl pyrophosphate synthase
Authors:Zhu, W, Oldfield, E.
Deposit date:2012-09-13
Release date:2012-12-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4H2O
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BU of 4h2o by Molmil
Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1248
Descriptor: 2-{[3-(decyloxy)benzoyl]amino}-5-nitrobenzoic acid, Undecaprenyl pyrophosphate synthase
Authors:Zhu, W, Oldfield, E.
Deposit date:2012-09-13
Release date:2012-12-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4H2J
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BU of 4h2j by Molmil
Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1354
Descriptor: N~4~-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-N~1~-[4-(1H-imidazol-2-yl)phenyl]-2-nitrobenzene-1,4-dicarboxamide, Undecaprenyl pyrophosphate synthase
Authors:Zhu, W, Oldfield, E.
Deposit date:2012-09-12
Release date:2012-12-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4H8E
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BU of 4h8e by Molmil
Structure of S. aureus undecaprenyl diphosphate synthase in complex with FPP and sulfate
Descriptor: FARNESYL DIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ...
Authors:Zhu, W, Oldfield, E.
Deposit date:2012-09-22
Release date:2012-12-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013
4H38
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BU of 4h38 by Molmil
Structure of E. coli undecaprenyl diphosphate synthase in complex with BPH-1297
Descriptor: (5-bromo-2-{[3-(octyloxy)benzyl]oxy}phenyl)phosphonic acid, Undecaprenyl pyrophosphate synthase
Authors:Zhu, W, Oldfield, E.
Deposit date:2012-09-13
Release date:2012-12-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Antibacterial drug leads targeting isoprenoid biosynthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013

 

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