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2E4Z
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BU of 2e4z by Molmil
Crystal structure of the ligand-binding region of the group III metabotropic glutamate receptor
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Metabotropic glutamate receptor 7
Authors:Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4X
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BU of 2e4x by Molmil
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with 1S,3R-ACPD
Descriptor: (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3
Authors:Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4U
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BU of 2e4u by Molmil
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with L-glutamate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Metabotropic glutamate receptor 3
Authors:Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4Y
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BU of 2e4y by Molmil
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with 2R,4R-APDC
Descriptor: (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3
Authors:Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4W
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BU of 2e4w by Molmil
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with 1S,3S-ACPD
Descriptor: (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3
Authors:Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4V
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BU of 2e4v by Molmil
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with DCG-IV
Descriptor: (1R,2R)-3-[(S)-amino(carboxy)methyl]cyclopropane-1,2-dicarboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Metabotropic glutamate receptor 3
Authors:Muto, T, Tsuchiya, D, Morikawa, K, Jingami, H.
Deposit date:2006-12-17
Release date:2007-02-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
1OM2
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BU of 1om2 by Molmil
SOLUTION NMR STRUCTURE OF THE MITOCHONDRIAL PROTEIN IMPORT RECEPTOR TOM20 FROM RAT IN A COMPLEX WITH A PRESEQUENCE PEPTIDE DERIVED FROM RAT ALDEHYDE DEHYDROGENASE (ALDH)
Descriptor: PROTEIN (MITOCHONDRIAL ALDEHYDE DEHYDROGENASE), PROTEIN (MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20)
Authors:Abe, Y, Shodai, T, Muto, T, Mihara, K, Torii, H, Nishikawa, S, Endo, T, Kohda, D.
Deposit date:1999-04-23
Release date:2000-02-02
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20.
Cell(Cambridge,Mass.), 100, 2000
3WG8
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BU of 3wg8 by Molmil
Crystal structure of the abscisic acid receptor PYR1 in complex with an antagonist AS6
Descriptor: (2Z,4E)-5-[(1S)-3-(hexylsulfanyl)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYR1
Authors:Akiyama, T, Sue, M, Takeuchi, J, Okamoto, M, Muto, T, Endo, A, Nambara, E, Hirai, N, Ohnishi, T, Cutler, S.R, Todoroki, Y, Yajima, S.
Deposit date:2013-07-31
Release date:2014-05-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions
Nat.Chem.Biol., 10, 2014
1VSR
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BU of 1vsr by Molmil
VERY SHORT PATCH REPAIR (VSR) ENDONUCLEASE FROM ESCHERICHIA COLI
Descriptor: PROTEIN (VSR ENDONUCLEASE), ZINC ION
Authors:Tsutakawa, S.E, Muto, T, Jingami, H, Kunishima, N, Ariyoshi, M, Kohda, D, Nakagawa, M, Morikawa, K.
Deposit date:1999-02-13
Release date:1999-10-27
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic and functional studies of very short patch repair endonuclease.
Mol.Cell, 3, 1999
2EGN
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BU of 2egn by Molmil
Crystal Structure of Tamalin PDZ Domain in Complex with mGluR5 C-terminal Peptide
Descriptor: General receptor for phosphoinositides 1-associated scaffold protein, mGluR5 C-terminal peptide
Authors:Sugi, T, Oyama, T, Muto, T, Nakanishi, S, Morikawa, K, Jingami, H.
Deposit date:2007-03-01
Release date:2007-05-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
2EGK
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BU of 2egk by Molmil
Crystal Structure of Tamalin PDZ-Intrinsic Ligand Fusion Protein
Descriptor: General receptor for phosphoinositides 1-associated scaffold protein, PHOSPHATE ION
Authors:Sugi, T, Oyama, T, Muto, T, Nakanishi, S, Morikawa, K, Jingami, H.
Deposit date:2007-03-01
Release date:2007-05-08
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
2EGO
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BU of 2ego by Molmil
Crystal Structure of Tamalin PDZ Domain
Descriptor: General receptor for phosphoinositides 1-associated scaffold protein
Authors:Sugi, T, Oyama, T, Muto, T, Nakanishi, S, Morikawa, K, Jingami, H.
Deposit date:2007-03-01
Release date:2007-05-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
6AHS
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BU of 6ahs by Molmil
Mouse Kallikrein 7 in complex with imidazolinylindole derivative
Descriptor: 1-[(2-chlorophenyl)sulfonyl]-5-methyl-3-[(4R)-2-methyl-4,5-dihydro-1H-imidazol-4-yl]-1H-indole, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Sugawara, H.
Deposit date:2018-08-20
Release date:2019-01-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors.
Bioorg. Med. Chem. Lett., 29, 2019
1GIF
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BU of 1gif by Molmil
HUMAN GLYCOSYLATION-INHIBITING FACTOR
Descriptor: GLYCOSYLATION-INHIBITING FACTOR
Authors:Kato, Y, Kuroki, R.
Deposit date:1996-02-27
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets.
Proc.Natl.Acad.Sci.USA, 93, 1996
3ARN
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BU of 3arn by Molmil
Human dUTPase in complex with novel uracil derivative
Descriptor: Deoxyuridine 5'-triphosphate nucleotidohydrolase, MAGNESIUM ION, N-{5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl}benzenesulfonamide
Authors:Chong, K.T, Miyahara, S, Miyakoshi, H, Fukuoka, M.
Deposit date:2010-12-03
Release date:2010-12-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors
J.Med.Chem., 55, 2012
5ZFI
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BU of 5zfi by Molmil
Mouse kallikrein 7 in complex with 6-benzyl-1,4-diazepan-7-one derivative
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[(3Z,6R)-6-[(2,6-dichlorophenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxo-1,4-diazepan-1-yl]-N-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]acetamide, Kallikrein-7
Authors:Sugawara, H.
Deposit date:2018-03-06
Release date:2018-06-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.
Bioorg. Med. Chem., 26, 2018
5ZFH
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BU of 5zfh by Molmil
Mouse Kallikrein 7
Descriptor: Kallikrein-7
Authors:Sugawara, H.
Deposit date:2018-03-06
Release date:2018-06-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.
Bioorg. Med. Chem., 26, 2018
7DCF
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BU of 7dcf by Molmil
Crystal structure of EHMT2 SET domain in complex with compound 10
Descriptor: 5'-methoxy-6'-(1-methyl-2,3,4,7-tetrahydroazepin-5-yl)spiro[cyclobutane-1,3'-indole]-2'-amine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ...
Authors:Suzuki, M, Katayama, K.
Deposit date:2020-10-26
Release date:2021-02-10
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of DS79932728: A Potent, Orally Available G9a/GLP Inhibitor for Treating beta-Thalassemia and Sickle Cell Disease.
Acs Med.Chem.Lett., 12, 2021
5YJP
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BU of 5yjp by Molmil
Human chymase in complex with 3-(ethoxyimino)-7-oxo-1,4-diazepane derivative
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-((R)-1-((R,Z)-6-(5-chloro-2-methoxybenzyl)-3-(ethoxyimino)-7-oxo-1,4-diazepane-1-carboxamido)propyl)benzoic acid, ZINC ION, ...
Authors:Sugawara, H.
Deposit date:2017-10-11
Release date:2017-12-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
Bioorg. Med. Chem. Lett., 28, 2018
5YJM
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BU of 5yjm by Molmil
Human chymase in complex with 7-oxo-3-(phenoxyimino)-1,4-diazepane derivative
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-4-((R)-1-((R,Z)-6-(5-chloro-2-methoxybenzyl)-7-oxo-3-(phenoxyimino)-1,4-diazepane-1-carboxamido)propyl)benzoic acid, ZINC ION, ...
Authors:Sugawara, H.
Deposit date:2017-10-11
Release date:2017-12-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
Bioorg. Med. Chem. Lett., 28, 2018
5Y9L
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BU of 5y9l by Molmil
Human kallikrein 7 in complex with 1,3,6-trisubstituted 1,4-diazepane-7-one
Descriptor: 3-[2-[(3Z,6R)-6-[(5-chloranyl-2-methoxy-phenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxidanylidene-1,4-diazepan-1-yl]ethanoylamino]benzoic acid, CHLORIDE ION, Kallikrein-7
Authors:Sugawara, H.
Deposit date:2017-08-25
Release date:2017-11-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors
Bioorg. Med. Chem. Lett., 27, 2017
5YJK
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BU of 5yjk by Molmil
Human kallikrein 7 in complex with 1,4-diazepane-7-one 1-acetamide derivative
Descriptor: (R)-2-(6-(5-chloro-2-methoxybenzyl)-3-(2,2-dimethylhydrazono)-7-oxo-1,4-diazepan-1-yl)-N-(3-(methylsulfonyl)phenyl)acetamide, CHLORIDE ION, Kallikrein-7
Authors:Sugawara, H.
Deposit date:2017-10-11
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors
Bioorg. Med. Chem. Lett., 27, 2017
1V7M
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BU of 1v7m by Molmil
Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab
Descriptor: Monoclonal TN1 Fab Heavy Chain, Monoclonal TN1 Fab Light Chain, Thrombopoietin
Authors:Feese, M.D, Tamada, T, Kato, Y, Maeda, Y, Hirose, M, Matsukura, Y, Shigematsu, H, Kato, T, Miyazaki, H, Kuroki, R.
Deposit date:2003-12-18
Release date:2004-03-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Proc.Natl.Acad.Sci.USA, 101, 2004
1V7N
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BU of 1v7n by Molmil
Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab
Descriptor: Monoclonal TN1 Fab Heavy Chain, Monoclonal TN1 Fab Light Chain, Thrombopoietin
Authors:Feese, M.D, Tamada, T, Kato, Y, Maeda, Y, Hirose, M, Matsukura, Y, Shigematsu, H, Kato, T, Miyazaki, H, Kuroki, R.
Deposit date:2003-12-18
Release date:2004-03-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Proc.Natl.Acad.Sci.USA, 101, 2004

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