Author results

2E4U
  • Download 2e4u
  • View 2e4u
Molmil generated image of 2e4u
CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH L-GLUTAMATE
分子名称:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, GLUTAMIC ACID
著者Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
登録日2006-12-17
公開日2007-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4V
  • Download 2e4v
  • View 2e4v
Molmil generated image of 2e4v
CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH DCG-IV
分子名称:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (1R,2R)-3-[(S)-amino(carboxy)methyl]cyclopropane-1,2-dicarboxylic acid
著者Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
登録日2006-12-17
公開日2007-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4W
  • Download 2e4w
  • View 2e4w
Molmil generated image of 2e4w
CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH 1S,3S-ACPD
分子名称:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid
著者Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
登録日2006-12-17
公開日2007-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4X
  • Download 2e4x
  • View 2e4x
Molmil generated image of 2e4x
CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH 1S,3R-ACPD
分子名称:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID
著者Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
登録日2006-12-17
公開日2007-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4Y
  • Download 2e4y
  • View 2e4y
Molmil generated image of 2e4y
CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE GROUP II METABOTROPIC GLUTAMATE RECEPTOR COMPLEXED WITH 2R,4R-APDC
分子名称:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid
著者Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
登録日2006-12-17
公開日2007-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E4Z
  • Download 2e4z
  • View 2e4z
Molmil generated image of 2e4z
CRYSTAL STRUCTURE OF THE LIGAND-BINDING REGION OF THE GROUP III METABOTROPIC GLUTAMATE RECEPTOR
分子名称:Metabotropic glutamate receptor 7, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者Muto, T., Tsuchiya, D., Morikawa, K., Jingami, H.
登録日2006-12-17
公開日2007-02-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104, 2007
3WG8
  • Download 3wg8
  • View 3wg8
Molmil generated image of 3wg8
CRYSTAL STRUCTURE OF THE ABSCISIC ACID RECEPTOR PYR1 IN COMPLEX WITH AN ANTAGONIST AS6
分子名称:Abscisic acid receptor PYR1, (2Z,4E)-5-[(1S)-3-(hexylsulfanyl)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid
著者Akiyama, T., Sue, M., Takeuchi, J., Okamoto, M., Muto, T., Endo, A., Nambara, E., Hirai, N., Ohnishi, T., Cutler, S.R., Todoroki, Y., Yajima, S.
登録日2013-07-31
公開日2014-05-07
最終更新日2014-06-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions
Nat.Chem.Biol., 10, 2014
1OM2
  • Download 1om2
  • View 1om2
Molmil generated image of 1om2
SOLUTION NMR STRUCTURE OF THE MITOCHONDRIAL PROTEIN IMPORT RECEPTOR TOM20 FROM RAT IN A COMPLEX WITH A PRESEQUENCE PEPTIDE DERIVED FROM RAT ALDEHYDE DEHYDROGENASE (ALDH)
分子名称:PROTEIN (MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20), PROTEIN (MITOCHONDRIAL ALDEHYDE DEHYDROGENASE)
著者Abe, Y., Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S., Endo, T., Kohda, D.
登録日1999-04-23
公開日2000-02-02
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20.
Cell(Cambridge,Mass.), 100, 2000
2EGK
  • Download 2egk
  • View 2egk
Molmil generated image of 2egk
CRYSTAL STRUCTURE OF TAMALIN PDZ-INTRINSIC LIGAND FUSION PROTEIN
分子名称:General receptor for phosphoinositides 1-associated scaffold protein, PHOSPHATE ION
著者Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K., Jingami, H.
登録日2007-03-01
公開日2007-05-08
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
2EGN
  • Download 2egn
  • View 2egn
Molmil generated image of 2egn
CRYSTAL STRUCTURE OF TAMALIN PDZ DOMAIN IN COMPLEX WITH MGLUR5 C-TERMINAL PEPTIDE
分子名称:General receptor for phosphoinositides 1-associated scaffold protein, mGluR5 C-terminal peptide
著者Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K., Jingami, H.
登録日2007-03-01
公開日2007-05-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
2EGO
  • Download 2ego
  • View 2ego
Molmil generated image of 2ego
CRYSTAL STRUCTURE OF TAMALIN PDZ DOMAIN
分子名称:General receptor for phosphoinositides 1-associated scaffold protein
著者Sugi, T., Oyama, T., Muto, T., Nakanishi, S., Morikawa, K., Jingami, H.
登録日2007-03-01
公開日2007-05-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation
Embo J., 26, 2007
1VSR
  • Download 1vsr
  • View 1vsr
Molmil generated image of 1vsr
VERY SHORT PATCH REPAIR (VSR) ENDONUCLEASE FROM ESCHERICHIA COLI
分子名称:PROTEIN (VSR ENDONUCLEASE), ZINC ION
著者Tsutakawa, S.E., Muto, T., Jingami, H., Kunishima, N., Ariyoshi, M., Kohda, D., Nakagawa, M., Morikawa, K.
登録日1999-02-13
公開日1999-10-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystallographic and functional studies of very short patch repair endonuclease.
Mol.Cell, 3, 1999
6AHS
  • Download 6ahs
  • View 6ahs
Molmil generated image of 6ahs
MOUSE KALLIKREIN 7 IN COMPLEX WITH IMIDAZOLINYLINDOLE DERIVATIVE
分子名称:Kallikrein-7, 1-[(2-chlorophenyl)sulfonyl]-5-methyl-3-[(4R)-2-methyl-4,5-dihydro-1H-imidazol-4-yl]-1H-indole, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
著者Sugawara, H.
登録日2018-08-20
公開日2019-01-02
最終更新日2019-01-23
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors.
Bioorg. Med. Chem. Lett., 29, 2019
5ZFH
  • Download 5zfh
  • View 5zfh
Molmil generated image of 5zfh
MOUSE KALLIKREIN 7
分子名称:Kallikrein-7
著者Sugawara, H.
登録日2018-03-06
公開日2018-06-27
最終更新日2018-07-04
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.
Bioorg. Med. Chem., 26, 2018
5ZFI
  • Download 5zfi
  • View 5zfi
Molmil generated image of 5zfi
MOUSE KALLIKREIN 7 IN COMPLEX WITH 6-BENZYL-1,4-DIAZEPAN-7-ONE DERIVATIVE
分子名称:Kallikrein-7, 2-[(3Z,6R)-6-[(2,6-dichlorophenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxo-1,4-diazepan-1-yl]-N-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]acetamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Sugawara, H.
登録日2018-03-06
公開日2018-06-27
最終更新日2018-07-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-based drug design to overcome species differences in kallikrein 7 inhibition of 1,3,6-trisubstituted 1,4-diazepan-7-ones.
Bioorg. Med. Chem., 26, 2018
1V7M
  • Download 1v7m
  • View 1v7m
Molmil generated image of 1v7m
HUMAN THROMBOPOIETIN FUNCTIONAL DOMAIN COMPLEXED TO NEUTRALIZING ANTIBODY TN1 FAB
分子名称:Monoclonal TN1 Fab Light Chain, Monoclonal TN1 Fab Heavy Chain, Thrombopoietin
著者Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R.
登録日2003-12-18
公開日2004-03-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Proc.Natl.Acad.Sci.USA, 101, 2004
1V7N
  • Download 1v7n
  • View 1v7n
Molmil generated image of 1v7n
HUMAN THROMBOPOIETIN FUNCTIONAL DOMAIN COMPLEXED TO NEUTRALIZING ANTIBODY TN1 FAB
分子名称:Monoclonal TN1 Fab Light Chain, Monoclonal TN1 Fab Heavy Chain, Thrombopoietin
著者Feese, M.D., Tamada, T., Kato, Y., Maeda, Y., Hirose, M., Matsukura, Y., Shigematsu, H., Kato, T., Miyazaki, H., Kuroki, R.
登録日2003-12-18
公開日2004-03-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
Proc.Natl.Acad.Sci.USA, 101, 2004
1GIF
  • Download 1gif
  • View 1gif
Molmil generated image of 1gif
HUMAN GLYCOSYLATION-INHIBITING FACTOR
分子名称:GLYCOSYLATION-INHIBITING FACTOR
著者Kato, Y., Kuroki, R.
登録日1996-02-27
公開日1997-03-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets.
Proc.Natl.Acad.Sci.USA, 93, 1996
3ARN
  • Download 3arn
  • View 3arn
Molmil generated image of 3arn
HUMAN DUTPASE IN COMPLEX WITH NOVEL URACIL DERIVATIVE
分子名称:Deoxyuridine 5'-triphosphate nucleotidohydrolase, N-{5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl}benzenesulfonamide, MAGNESIUM ION
著者Chong, K.T., Miyahara, S., Miyakoshi, H., Fukuoka, M.
登録日2010-12-03
公開日2010-12-15
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors
J.Med.Chem., 55, 2012
5YJM
  • Download 5yjm
  • View 5yjm
Molmil generated image of 5yjm
HUMAN CHYMASE IN COMPLEX WITH 7-OXO-3-(PHENOXYIMINO)-1,4-DIAZEPANE DERIVATIVE
分子名称:human chymase, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
著者Sugawara, H.
登録日2017-10-11
公開日2017-12-27
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
Bioorg. Med. Chem. Lett., 28, 2018
5YJP
  • Download 5yjp
  • View 5yjp
Molmil generated image of 5yjp
HUMAN CHYMASE IN COMPLEX WITH 3-(ETHOXYIMINO)-7-OXO-1,4-DIAZEPANE DERIVATIVE
分子名称:human chymase, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
著者Sugawara, H.
登録日2017-10-11
公開日2017-12-27
最終更新日2018-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
Bioorg. Med. Chem. Lett., 28, 2018
5Y9L
  • Download 5y9l
  • View 5y9l
Molmil generated image of 5y9l
HUMAN KALLIKREIN 7 IN COMPLEX WITH 1,3,6-TRISUBSTITUTED 1,4-DIAZEPANE-7-ONE
分子名称:Kallikrein-7, 3-[2-[(3Z,6R)-6-[(5-chloranyl-2-methoxy-phenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxidanylidene-1,4-diazepan-1-yl]ethanoylamino]benzoic acid, CHLORIDE ION
著者Sugawara, H.
登録日2017-08-25
公開日2017-11-29
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors
Bioorg. Med. Chem. Lett., 27, 2017
5YJK
  • Download 5yjk
  • View 5yjk
Molmil generated image of 5yjk
HUMAN KALLIKREIN 7 IN COMPLEX WITH 1,4-DIAZEPANE-7-ONE 1-ACETAMIDE DERIVATIVE
分子名称:Kallikrein-7, (R)-2-(6-(5-chloro-2-methoxybenzyl)-3-(2,2-dimethylhydrazono)-7-oxo-1,4-diazepan-1-yl)-N-(3-(methylsulfonyl)phenyl)acetamide, CHLORIDE ION
著者Sugawara, H.
登録日2017-10-11
公開日2017-12-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors
Bioorg. Med. Chem. Lett., 27, 2017