Author results

1HKO
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NMR STRUCTURE OF BOVINE CYTOCHROME B5
Descriptor:CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE
Authors:Muskett, F.W., Whitford, D.
Deposit date:2003-03-10
Release date:2003-03-18
Method:SOLUTION NMR
Cite:The Solution Structure of Bovine Ferricytochrome B5 Determined Using Heteronuclear NMR Methods.
J.Mol.Biol., 258, 1996
1PE3
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SOLUTION STRUCTURE OF THE DISULPHIDE-LINKED DIMER OF HUMAN INTESTINAL TREFOIL FACTOR (TFF3)
Descriptor:Trefoil factor 3
Authors:Muskett, F.W., May, F.E., Westley, B.R., Feeney, J.
Deposit date:2003-05-21
Release date:2004-03-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins.
Biochemistry, 42, 2003
2L1M
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SOLUTION STRUCTURE OF THE EAG DOMAIN OF THE HERG (KV11.1) K+ CHANNEL
Descriptor:Potassium voltage-gated channel subfamily H member 2
Authors:Muskett, F.W., Mitcheson, J.S.
Deposit date:2010-07-29
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mechanistic insight into human ether-a-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.
J.Biol.Chem., 286, 2011
2TMP
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N-TERMINAL DOMAIN OF TISSUE INHIBITOR OF METALLOPROTEINASE-2 (N-TIMP-2), NMR, 49 STRUCTURES
Descriptor:TISSUE INHIBITOR OF METALLOPROTEINASES-2
Authors:Muskett, F.W., Frenkiel, T.A., Feeney, J., Freedman, R.B., Carr, M.D., Williamson, R.A.
Deposit date:1998-05-26
Release date:1998-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High resolution structure of the N-terminal domain of tissue inhibitor of metalloproteinases-2 and characterization of its interaction site with matrix metalloproteinase-3.
J.Biol.Chem., 273, 1998
2G0K
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SOLUTION STRUCTURE OF NEOCARZINOSTATIN APO-PROTEIN
Descriptor:Neocarzinostatin
Authors:Muskett, F.W., Stoneman, R.G., Caddick, S., Woolfson, D.N.
Deposit date:2006-02-13
Release date:2006-03-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Synthetic Ligands for Apo-Neocarzinostatin
J.Am.Chem.Soc., 128, 2006
2G0L
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SOLUTION STRUCTURE OF NEOCARZINOSTATIN APO-PROTEIN WITH BOUND FLAVONE
Descriptor:NEOCARZINOSTATIN, 2-PHENYL-4H-CHROMEN-4-ONE
Authors:Muskett, F.W., Stoneman, R.G., Caddick, S., Woolfson, D.N.
Deposit date:2006-02-13
Release date:2006-03-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Synthetic Ligands for Apo-Neocarzinostatin
J.Am.Chem.Soc., 128, 2006
1H8B
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EF-HANDS 3,4 FROM ALPHA-ACTININ / Z-REPEAT 7 FROM TITIN
Descriptor:ALPHA-ACTININ 2, SKELETAL MUSCLE ISOFORM, TITIN
Authors:Atkinson, R.A., Joseph, C., Kelly, G., Muskett, F.W., Frenkiel, T.A., Nietlispach, D., Pastore, A.
Deposit date:2001-02-01
Release date:2001-08-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Ca2+-Independent Binding of an EF-Hand Domain to a Novel Motif in the Alpha-Actinin-Titin Complex
Nat.Struct.Biol., 8, 2001
1J5H
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SOLUTION STRUCTURE OF APO-NEOCARZINOSTATIN
Descriptor:Apo-Neocarzinostatin
Authors:Urbaniak, M.D., Muskett, F.W., Finucane, M.D., Caddick, S., Woolfson, D.N.
Deposit date:2002-05-02
Release date:2002-09-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore
Biochemistry, 41, 2002
1J5I
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SOLUTION STRUCTURE OF A NOVEL CHROMOPROTEIN DERIVED FROM APO-NEOCARZINOSTATIN AND A SYNTHETIC CHROMOPHORE
Descriptor:PROTEIN (Apo-Neocarzinostatin), 2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC ACID MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL ESTER
Authors:Urbaniak, M.D., Muskett, F.W., Finucane, M.D., Caddick, S., Woolfson, D.N.
Deposit date:2002-05-02
Release date:2002-09-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore
Biochemistry, 41, 2002
1RGW
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SOLUTION STRUCTURE OF ZASP'S PDZ DOMAIN
Descriptor:ZASP protein
Authors:Au, Y., Atkinson, R.A., Pallavicini, A., Joseph, C., Martin, S.R., Muskett, F.W., Guerrini, R., Faulkner, G., Pastore, A.
Deposit date:2003-11-13
Release date:2004-04-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of ZASP PDZ Domain; Implications for Sarcomere Ultrastructure and Enigma Family Redundancy.
Structure, 12, 2004
1WA8
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SOLUTION STRUCTURE OF THE CFP-10.ESAT-6 COMPLEX. MAJOR VIRULENCE DETERMINANTS OF PATHOGENIC MYCOBACTERIA
Descriptor:ESAT-6 LIKE PROTEIN ESXB, 6 KDA EARLY SECRETORY ANTIGENIC TARGET (ESAT-6)
Authors:Renshaw, P.S., Lightbody, K.L., Veverka, V., Muskett, F.W., Kelly, G., Frenkiel, T.A., Gordon, S.V., Hewinson, R.G., Burke, B., Norman, J., Williamson, R.A., Carr, M.D., TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-10-25
Release date:2005-06-27
Last modified:2019-08-21
Method:SOLUTION NMR
Cite:Structure and Function of the Complex Formed by the Tuberculosis Virulence Factors Cfp-10 and Esat-6
Embo J., 24, 2005
2BQZ
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF THE HUMAN HISTONE METHYLTRANSFERASE PR-SET7 (ALSO KNOWN AS SET8)
Descriptor:SET8 PROTEIN, HISTONE H4, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Xiao, B., Jing, C., Kelly, G., Walker, P.A., Muskett, F.W., Frenkiel, T.A., Martin, S.R., Sarma, K., Reinberg, D., Gamblin, S.J., Wilson, J.R.
Deposit date:2005-04-28
Release date:2005-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
Genes Dev., 19, 2005
2HM8
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SOLUTION STRUCTURE OF THE C-TERMINAL MA-3 DOMAIN OF PDCD4
Descriptor:Pdcd4 C-terminal MA-3 domain
Authors:Waters, L.C., Veverka, V., Bohm, M., Muskett, F.W., Choong, P.T., Klempnauer, K.H., Carr, M.D.
Deposit date:2006-07-11
Release date:2007-02-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A
Oncogene, 26, 2007
2K8P
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CHARACTERISATION OF THE STRUCTURAL FEATURES AND INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTO A KEY REGULATOR OF WNT-MEDIATED BONE FORMATION
Descriptor:Sclerostin
Authors:Veverka, V., Henry, A.J., Slocombe, P.M., Ventom, A., Mulloy, B., Muskett, F.W., Muzylak, M., Greenslade, K., Moore, A., Zhang, L., Gong, J., Qian, X., Paszty, C., Taylor, R.J., Robinson, M.K., Carr, M.D.
Deposit date:2008-09-18
Release date:2009-02-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
J.Biol.Chem., 284, 2009
2KH2
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SOLUTION STRUCTURE OF A SCFV-IL-1B COMPLEX
Descriptor:Interleukin-1 beta, scFv
Authors:Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2009-03-23
Release date:2009-09-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284, 2009
2KZT
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STRUCTURE OF THE TANDEM MA-3 REGION OF PDCD4
Descriptor:Programmed cell death protein 4
Authors:Waters, L.C., Strong, S.L., Oka, O., Muskett, F.W., Veverka, V., Banerjee, S., Schmedt, T., Henry, A.J., Klempnauer, K.H., Carr, M.D.
Deposit date:2010-06-24
Release date:2011-03-16
Last modified:2011-11-23
Method:SOLUTION NMR
Cite:Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor
J.Biol.Chem., 286, 2011
2L3Y
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SOLUTION STRUCTURE OF MOUSE IL-6
Descriptor:Interleukin-6
Authors:Veverka, V., Redpath, N.T., Carrington, B., Muskett, F.W., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Last modified:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
2M2D
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HUMAN PROGRAMMED CELL DEATH 1 RECEPTOR
Descriptor:Programmed cell death protein 1
Authors:Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.
Deposit date:2012-12-18
Release date:2013-02-27
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
2M4V
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MYCOBACTERIUM TUBERCULOSIS RNA POLYMERASE BINDING PROTEIN A (RBPA) AND ITS INTERACTIONS WITH SIGMA FACTORS
Descriptor:Putative uncharacterized protein
Authors:Bortoluzzi, A., Muskett, F.W., Waters, L.C., Addis, P.W., Rieck, B., Munder, T., Schleier, S., Forti, F., Ghisotti, D., Carr, M.D., O'Hare, H.M.
Deposit date:2013-02-11
Release date:2013-04-17
Last modified:2013-08-07
Method:SOLUTION NMR
Cite:Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.
J.Biol.Chem., 288, 2013
2MWI
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THE STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF DNTTIP1
Descriptor:Deoxynucleotidyltransferase terminal-interacting protein 1
Authors:Schwabe, J.W.R., Muskett, F.W., Itoh, T.
Deposit date:2014-11-11
Release date:2015-02-18
Last modified:2015-03-18
Method:SOLUTION NMR
Cite:Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting.
Nucleic Acids Res., 43, 2015
2NPU
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THE SOLUTION STRUCTURE OF THE RAPAMYCIN-BINDING DOMAIN OF MTOR (FRB)
Descriptor:FKBP12-rapamycin complex-associated protein
Authors:Veverka, V., Crabbe, T., Bird, I., Lennie, G., Muskett, F.W., Taylor, R.J., Carr, M.D.
Deposit date:2006-10-30
Release date:2007-09-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
4F8A
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CYCLIC NUCLEOTIDE BINDING-HOMOLOGY DOMAIN FROM MOUSE EAG1 POTASSIUM CHANNEL
Descriptor:Potassium voltage-gated channel subfamily H member 1
Authors:Marques-Carvalho, M.J., Sahoo, N., Muskett, F.W., Vieira-Pires, R.S., Gabant, G., Cadene, M., Schonherr, R., Morais-Cabral, J.H.
Deposit date:2012-05-17
Release date:2012-07-11
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural, Biochemical, and Functional Characterization of the Cyclic Nucleotide Binding Homology Domain from the Mouse EAG1 Potassium Channel.
J.Mol.Biol., 423, 2012
5O57
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SOLUTION STRUCTURE OF THE N-TERMINAL REGION OF DKK4
Descriptor:Dickkopf-related protein 4
Authors:Waters, L.C., Patel, S., Barkell, A.M., Muskett, F.W., Robinson, M.K., Holdsworth, G., Carr, M.D.
Deposit date:2017-06-01
Release date:2018-06-13
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293, 2018
1E9T
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HIGH RESOLUTION SOLUTION STRUCTURE OF HUMAN INTESTINAL TREFOIL FACTOR
Descriptor:INTESTINAL TREFOIL FACTOR
Authors:Lemercinier, X., Muskett, F., Cheeseman, B., McIntosh, P., Carr, M.
Deposit date:2000-10-26
Release date:2000-12-08
Last modified:2017-04-19
Method:SOLUTION NMR
Cite:High-Resolution Solution Structure of Human Intestinal Trefoil Factor and Functional Insights from Detailed Structural Comparisons with the Other Members of the Trefoil Family of Mammalian Cell Motility Factors
Biochemistry, 40, 2001
2C52
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STRUCTURAL DIVERSITY IN CBP P160 COMPLEXES
Descriptor:CREB-BINDING PROTEIN, NUCLEAR RECEPTOR COACTIVATOR 1
Authors:Waters, L.C., Yue, B., Veverka, V., Renshaw, P.S., Bramham, J., Matsuda, S., Frenkiel, T., Kelly, G., Muskett, F.W., Carr, M.D., Heery, D.M.
Deposit date:2005-10-25
Release date:2006-03-15
Last modified:2018-05-02
Method:SOLUTION NMR
Cite:Structural diversity in p160/CREB-binding protein coactivator complexes.
J. Biol. Chem., 281, 2006
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