Author results

5IT7
  • Download 5it7
  • View 5it7
Molmil generated image of 5it7
STRUCTURE OF THE KLUYVEROMYCES LACTIS 80S RIBOSOME IN COMPLEX WITH THE CRICKET PARALYSIS VIRUS IRES AND EEF2
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Murray, J., Savva, C.G., Shin, B.S., Dever, T.E., Ramakrishnan, V., Fernandez, I.S.
Deposit date:2016-03-16
Release date:2016-05-18
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural characterization of ribosome recruitment and translocation by type IV IRES.
Elife, 5, 2016
5IT9
  • Download 5it9
  • View 5it9
Molmil generated image of 5it9
STRUCTURE OF THE YEAST KLUYVEROMYCES LACTIS SMALL RIBOSOMAL SUBUNIT IN COMPLEX WITH THE CRICKET PARALYSIS VIRUS IRES.
Descriptor:Ribosomal protein uS2, Ribosomal protein eS1, Ribosomal protein uS5, ...
Authors:Murray, J., Savva, C.G., Shin, B.S., Dever, T.E., Ramakrishnan, V., Fernandez, I.S.
Deposit date:2016-03-16
Release date:2016-05-18
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural characterization of ribosome recruitment and translocation by type IV IRES.
Elife, 5, 2016
5LZS
  • Download 5lzs
  • View 5lzs
Molmil generated image of 5lzs
STRUCTURE OF THE MAMMALIAN RIBOSOMAL ELONGATION COMPLEX WITH AMINOACYL-TRNA, EEF1A, AND DIDEMNIN B
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZT
  • Download 5lzt
  • View 5lzt
Molmil generated image of 5lzt
STRUCTURE OF THE MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ERF1 AND ERF3.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-10
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZU
  • Download 5lzu
  • View 5lzu
Molmil generated image of 5lzu
STRUCTURE OF THE MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ACCOMMODATED ERF1
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
4GVJ
  • Download 4gvj
  • View 4gvj
Molmil generated image of 4gvj
TYK2 (JH1) IN COMPLEX WITH ADENOSINE DI-PHOSPHATE
Descriptor:Non-receptor tyrosine-protein kinase TYK2, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Liang, J., Abbema, A.V., Bao, L., Barrett, K., Beresini, M., Berezhkovskiy, L., Blair, W., Chang, C., Driscoll, J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Halladay, J., Johnson, A., Kohli, P.B., Lai, Y., Liimatta, M., Mantik, P., Menghrajani, K., Murray, J., Sambrone, A., Shao, Y., Shia, S., Shin, Y., Smith, J., Sohn, S., Stanley, M., Tsui, V., Ultsch, M., Wu, L., Zhang, B., Magnuson, S.
Deposit date:2012-08-30
Release date:2013-08-14
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Lead identification of novel and selective TYK2 inhibitors.
Eur.J.Med.Chem., 67, 2013
4FCP
  • Download 4fcp
  • View 4fcp
Molmil generated image of 4fcp
TARGETTING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5-CYANOPYRROLO [2,3-D] PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION
Descriptor:Heat shock protein HSP 90-alpha, N,N-dimethyl-7H-purin-6-amine
Authors:Davies, N.G.M., Browne, H., Davies, B., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Drysdale, M., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Roughley, S.D., Jensen, M.R., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wright, L., Brough, P.
Deposit date:2012-05-25
Release date:2012-10-24
Last modified:2012-11-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg.Med.Chem., 20, 2012
4FCQ
  • Download 4fcq
  • View 4fcq
Molmil generated image of 4fcq
TARGETING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5-CYANOPYRROLO[2,3-D]PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION
Descriptor:Heat shock protein HSP 90-alpha, 4-(2,4-dimethylphenyl)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Authors:Davies, N.G., Browne, H., Davis, B., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Drysdale, M.J., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Roughley, S.D., Jensen, M.R., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wright, L., Brough, P.
Deposit date:2012-05-25
Release date:2012-10-24
Last modified:2012-11-07
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg.Med.Chem., 20, 2012
4FCR
  • Download 4fcr
  • View 4fcr
Molmil generated image of 4fcr
TARGETING CONSERVED WATER MOLECULES: DESIGN OF 4-ARYL-5-CYANOPYRROLO[2,3-D]PYRIMIDINE HSP90 INHIBITORS USING FRAGMENT-BASED SCREENING AND STRUCTURE-BASED OPTIMIZATION
Descriptor:Heat shock protein HSP 90-alpha, 2-{[4-(2-chloro-4,5-dimethoxyphenyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-yl]sulfanyl}-N,N-dimethylacetamide
Authors:Davies, N.G., Browne, H., Davis, B., Foloppe, N., Geoffrey, S., Gibbons, B., Hart, T., Drysdale, M.J., Mansell, H., Massey, A., Matassova, N., Moore, J.D., Murray, J., Pratt, R., Ray, S., Roughley, S.D., Jensen, M.R., Schoepfer, J., Scriven, K., Simmonite, H., Stokes, S., Surgenor, A., Webb, P., Wright, L., Brough, P.
Deposit date:2012-05-25
Release date:2012-10-24
Last modified:2012-11-07
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg.Med.Chem., 20, 2012
4V25
  • Download 4v25
  • View 4v25
Molmil generated image of 4v25
VER-246608, A NOVEL PAN-ISOFORM ATP COMPETITIVE INHIBITOR OF PYRUVATE DEHYDROGENASE KINASE, DISRUPTS WARBURG METABOLISM AND INDUCES CONTEXT- DEPENDENT CYTOSTASIS IN CANCER CELLS
Descriptor:[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 2, MITOCHONDRIAL, N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE, ...
Authors:Moore, J.D., Staniszewska, A., Shaw, T., D'Alessandro, J., Davis, B., Surgenor, A., Baker, L., Matassova, N., Murray, J., Macias, A., Brough, P., Wood, M., Mahon, P.C.
Deposit date:2014-10-06
Release date:2014-12-03
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ver-246608, a Novel Pan-Isoform ATP Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells.
Oncotarget, 5, 2014
4V26
  • Download 4v26
  • View 4v26
Molmil generated image of 4v26
VER-246608, A NOVEL PAN-ISOFORM ATP COMPETITIVE INHIBITOR OF PYRUVATE DEHYDROGENASE KINASE, DISRUPTS WARBURG METABOLISM AND INDUCES CONTEXT- DEPENDENT CYTOSTASIS IN CANCER CELLS
Descriptor:[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 2, MITOCHONDRIAL, N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE, ...
Authors:Moore, J.D., Staniszewska, A., Shaw, T., D'Alessandro, J., Davis, B., Surgenor, A., Baker, L., Matassova, N., Murray, J., Macias, A., Brough, P., Wood, M., Mahon, P.C.
Deposit date:2014-10-06
Release date:2014-12-03
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Ver-246608, a Novel Pan-Isoform ATP Competitive Inhibitor of Pyruvate Dehydrogenase Kinase, Disrupts Warburg Metabolism and Induces Context-Dependent Cytostasis in Cancer Cells.
Oncotarget, 5, 2014
5LOF
  • Download 5lof
  • View 5lof
Molmil generated image of 5lof
CRYSTAL STRUCTURE OF THE MBP-MCL1 COMPLEX WITH HIGHLY SELECTIVE AND POTENT INHIBITOR OF MCL1
Descriptor:Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid, MALTOSE
Authors:Dokurno, P., Kotschy, A., Szlavik, Z., Murray, J., Davidson, J., Csekei, M., Paczal, A., Szabo, Z., Sipos, S., Radics, G., Proszenyak, A., Balint, B., Ondi, L., Blasko, G., Robertson, A., Surgenor, A., Chen, I., Matassova, N., Smith, J., Pedder, C., Graham, C., Geneste, O.
Deposit date:2016-08-09
Release date:2016-10-26
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Nature, 538, 2016
5LZV
  • Download 5lzv
  • View 5lzv
Molmil generated image of 5lzv
STRUCTURE OF THE MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ACCOMMODATED ERF1(AAQ) AND ABCE1.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZW
  • Download 5lzw
  • View 5lzw
Molmil generated image of 5lzw
STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A TRUNCATED MRNA.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZX
  • Download 5lzx
  • View 5lzx
Molmil generated image of 5lzx
STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A UGA STOP CODON.
Descriptor:uL2, Ul3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZY
  • Download 5lzy
  • View 5lzy
Molmil generated image of 5lzy
STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A POLYADENYLATED MRNA.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.99 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZZ
  • Download 5lzz
  • View 5lzz
Molmil generated image of 5lzz
STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L (COMBINED)
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
6GL8
  • Download 6gl8
  • View 6gl8
Molmil generated image of 6gl8
CRYSTAL STRUCTURE OF BCL-2 IN COMPLEX WITH THE NOVEL ORALLY ACTIVE INHIBITOR S55746
Descriptor:Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
Authors:Casara, P., Davidson, J., Claperon, A., Le Toumelin-Braizat, G., Vogler, M., Bruno, A., Chanrion, M., Lysiak-Auvity, G., Le Diguarher, T., Starck, J.B., Chen, I., Whitehead, N., Graham, C., Matassova, N., Dokurno, P., Pedder, C., Wang, Y., Qiu, S., Girard, A.M., Schneider, E., Grave, F., Studeny, A., Guasconi, G., Rocchetti, F., Maiga, S., Henlin, J.M., Colland, F., Kraus-Berthier, L., Le Gouill, S., Dyer, M.J.S., Hubbard, R., Wood, M., Amiot, M., Cohen, G.M., Hickman, J.A., Morris, E., Murray, J., Geneste, O.
Deposit date:2018-05-23
Release date:2018-11-07
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.
Oncotarget, 9, 2018
6B8U
  • Download 6b8u
  • View 6b8u
Molmil generated image of 6b8u
CRYSTALS STRUCTURE OF B-RAF KINASE DOMAIN IN COMPLEX WITH AN IMIDAZOPYRIDINYL BENZAMIDE INHIBITOR
Descriptor:Serine/threonine-protein kinase B-raf, ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide
Authors:Appleton, B.A., Murray, J., Shafer, C.M.
Deposit date:2017-10-09
Release date:2017-11-22
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
1L3W
  • Download 1l3w
  • View 1l3w
Molmil generated image of 1l3w
C-CADHERIN ECTODOMAIN
Descriptor:EP-cadherin, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Boggon, T.J., Murray, J., Chappuis-Flament, S., Wong, E., Gumbiner, B.M., Shapiro, L.
Deposit date:2002-03-01
Release date:2002-04-26
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:C-cadherin ectodomain structure and implications for cell adhesion mechanisms
Science, 296, 2002
2VRE
  • Download 2vre
  • View 2vre
Molmil generated image of 2vre
CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3,5,DELTA2,4-DIENOYL COA ISOMERASE
Descriptor:DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, CHLORIDE ION
Authors:Yue, W., Guo, K., von Delft, F., Pilka, E., Murray, J., Roos, A., Kochan, G., Bountra, C., Arrowsmith, C., Wikstrom, M., Edwards, A., Oppermann, U.
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Human Peroxisomal Delta3,5, Delta2,4-Dienoyl Coa Isomerase (Ech1)
To be Published
2VRF
  • Download 2vrf
  • View 2vrf
Molmil generated image of 2vrf
CRYSTAL STRUCTURE OF THE HUMAN BETA-2-SYNTROPHIN PDZ DOMAIN
Descriptor:BETA-2-SYNTROPHIN, 1,2-ETHANEDIOL
Authors:Sun, Z., Roos, A.K., Pike, A.C.W., Pilka, E.S., Cooper, C., Elkins, J.M., Murray, J., Arrowsmith, C.H., Doyle, D., Edwards, A., von Delft, F., Bountra, C., Oppermann, U.
Deposit date:2008-03-31
Release date:2008-04-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Human Beta-2-Syntrophin Pdz Domain
To be Published
3COS
  • Download 3cos
  • View 3cos
Molmil generated image of 3cos
CRYSTAL STRUCTURE OF HUMAN CLASS II ALCOHOL DEHYDROGENASE (ADH4) IN COMPLEX WITH NAD AND ZN
Descriptor:Alcohol dehydrogenase 4, ZINC ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Kavanagh, K.L., Shafqat, N., Yue, W., von Delft, F., Bishop, S., Roos, A., Murray, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2008-03-29
Release date:2008-04-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn.
To be Published
3JAG
  • Download 3jag
  • View 3jag
Molmil generated image of 3jag
STRUCTURE OF A MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ABCE1, ERF1(AAQ), AND THE UAA STOP CODON
Descriptor:uL2, uL3, uL4, ...
Authors:Brown, A., Shao, S., Murray, J., Hegde, R.S., Ramakrishnan, V.
Deposit date:2015-06-10
Release date:2015-08-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Structural basis for stop codon recognition in eukaryotes.
Nature, 524, 2015
3JAH
  • Download 3jah
  • View 3jah
Molmil generated image of 3jah
STRUCTURE OF A MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ABCE1, ERF1(AAQ), AND THE UAG STOP CODON
Descriptor:uL2, uL3, uL4, ...
Authors:Brown, A., Shao, S., Murray, J., Hegde, R.S., Ramakrishnan, V.
Deposit date:2015-06-10
Release date:2015-08-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structural basis for stop codon recognition in eukaryotes.
Nature, 524, 2015
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan