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5FG3
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BU of 5fg3 by Molmil
Crystal structure of GDP-bound aIF5B from Aeropyrum pernix
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Probable translation initiation factor IF-2
Authors:Murakami, R, Miyoshi, T, Uchiumi, T, Ito, K.
Deposit date:2015-12-20
Release date:2016-05-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of translation initiation factor 5B from the crenarchaeon Aeropyrum pernix.
Proteins, 84, 2016
5YT0
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BU of 5yt0 by Molmil
Crystal structure of the complex of archaeal ribosomal stalk protein aP1 and archaeal translation initiation factor aIF5B
Descriptor: Archaeal ribosomal stalk protein aP1, GUANOSINE-5'-DIPHOSPHATE, Probable translation initiation factor IF-2
Authors:Murakami, R, Singh, C.R, Morris, J, Tang, L, Harmon, I, Miyoshi, T, Ito, K, Asano, K, Uchiumi, T.
Deposit date:2017-11-16
Release date:2018-06-27
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation
Mol. Cell. Biol., 38, 2018
7CSL
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BU of 7csl by Molmil
Crystal structure of the archaeal EF1A-EF1B complex
Descriptor: Elongation factor 1-alpha, Elongation factor 1-beta
Authors:Suzuki, T, Ito, K, Miyoshi, T, Murakami, R, Uchiumi, T.
Deposit date:2020-08-15
Release date:2021-06-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the Switching Off of the Interaction between the Archaeal Ribosomal Stalk and aEF1A by Nucleotide Exchange Factor aEF1B.
J.Mol.Biol., 433, 2021
5AWH
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BU of 5awh by Molmil
Rhodobacter sphaeroides Argonaute in complex with guide RNA/target DNA heteroduplex
Descriptor: DNA (5'-D(*CP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*A)-3'), MAGNESIUM ION, RNA (5'-D(P*UP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3'), ...
Authors:Miyoshi, T, Ito, K, Murakami, R, Uchiumi, T.
Deposit date:2015-07-03
Release date:2016-07-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute.
Nat Commun, 7, 2016
3VJR
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BU of 3vjr by Molmil
Crystal structure of Peptidyl-tRNA hydrolase from Escherichia coli in complex with the CCA-acceptor-T[PSI]C domain of tRNA
Descriptor: Peptidyl-tRNA hydrolase, tRNA CCA-acceptor
Authors:Ito, K, Murakami, R, Mochizuki, M, Qi, H, Shimizu, Y, Miura, K.I, Ueda, T, Uchiumi, T.
Deposit date:2011-10-28
Release date:2012-09-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase.
Nucleic Acids Res., 40, 2012
3WY9
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BU of 3wy9 by Molmil
Crystal structure of a complex of the archaeal ribosomal stalk protein aP1 and the GDP-bound archaeal elongation factor aEF1alpha
Descriptor: 50S ribosomal protein L12, Elongation factor 1-alpha, GUANOSINE-5'-DIPHOSPHATE
Authors:Ito, K, Honda, T, Suzuki, T, Miyoshi, T, Murakami, R, Yao, M, Uchiumi, T.
Deposit date:2014-08-22
Release date:2014-12-24
Last modified:2022-08-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1 alpha.
Nucleic Acids Res., 42, 2014
3WYA
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BU of 3wya by Molmil
Crystal structure of GDP-bound EF1alpha from Pyrococcus horikoshii
Descriptor: Elongation factor 1-alpha, GUANOSINE-5'-DIPHOSPHATE
Authors:Ito, K, Honda, T, Suzuki, T, Miyoshi, T, Murakami, R, Yao, M, Uchiumi, T.
Deposit date:2014-08-22
Release date:2014-12-24
Last modified:2022-08-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1 alpha.
Nucleic Acids Res., 42, 2014
2ZFW
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BU of 2zfw by Molmil
Crystal structure of Pex from Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2)
Descriptor: Pex, SULFATE ION
Authors:Kouyama, T.
Deposit date:2008-01-14
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Functionally important structural elements of the cyanobacterial clock-related protein Pex.
Genes Cells, 14, 2009
2DQL
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BU of 2dql by Molmil
Crystal structure of the circadian clock associated protein Pex from anabaena
Descriptor: PHOSPHATE ION, Pex protein
Authors:Kurosawa, S, Kouyama, T.
Deposit date:2006-05-29
Release date:2007-05-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functionally important structural elements of the cyanobacterial clock-related protein Pex.
Genes Cells, 14, 2009
8HVA
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BU of 8hva by Molmil
Crystal structure of EGFR_TMX in complex with covalently bound compound 14
Descriptor: Epidermal growth factor receptor, ~{N}-[6-(1-methylindol-3-yl)pyrimidin-4-yl]prop-2-enamide
Authors:Takahashi, M, Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV2
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BU of 8hv2 by Molmil
Crystal structure of EGFR_wt in complex with covalently bound fragment 4
Descriptor: Epidermal growth factor receptor, ~{N}-pyridin-2-ylprop-2-enamide
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV9
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BU of 8hv9 by Molmil
Crystal structure of EGFR_TMX in complex with covalently bound fragment 12
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DIMETHYL SULFOXIDE, Epidermal growth factor receptor, ...
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV1
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BU of 8hv1 by Molmil
Crystal structure of EGFR_DMX in complex with covalently bound fragment 1
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 3-(3-bromophenyl)-1,4-dihydro-1,2,4-triazole-5-thione, Epidermal growth factor receptor, ...
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV6
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BU of 8hv6 by Molmil
Crystal structure of EGFR_TMX in complex with covalently bound fragment 8
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DIMETHYL SULFOXIDE, Epidermal growth factor receptor, ...
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV5
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BU of 8hv5 by Molmil
Crystal structure of EGFR_DMX in complex with compound 7
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Epidermal growth factor receptor, ~{N}-(1-methylbenzimidazol-4-yl)prop-2-enamide
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV4
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BU of 8hv4 by Molmil
Crystal structure of EGFR_TMX in complex with covalently bound fragment 4
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV7
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BU of 8hv7 by Molmil
Crystal structure of EGFR_TMX in complex with covalently bound fragment 9
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DIMETHYL SULFOXIDE, Epidermal growth factor receptor, ...
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV3
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BU of 8hv3 by Molmil
Crystal structure of EGFR_DMX in complex with covalently bound fragment 4
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, DIMETHYL SULFOXIDE, Epidermal growth factor receptor, ...
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
8HV8
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BU of 8hv8 by Molmil
Crystal structure of EGFR_TMX in complex with covalently bound fragment 10
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Epidermal growth factor receptor, ~{N}-pyrazolo[1,5-a]pyridin-2-ylprop-2-enamide
Authors:Dokurno, P.
Deposit date:2022-12-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Rsc Med Chem, 2023
7XNC
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BU of 7xnc by Molmil
MEK1 bound to DS94070624
Descriptor: CALCIUM ION, DIMETHYL SULFOXIDE, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Kishikawa, S, Takano, K, Ubukata, O, Hanzawa, H.
Deposit date:2022-04-28
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma.
Mol.Cancer Ther., 22, 2023
7XLP
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BU of 7xlp by Molmil
MEK1 bound to DS03090629
Descriptor: (1~{R},3~{S})-3-[[6-[2-chloranyl-4-(4-methylpyrimidin-2-yl)oxy-phenyl]-3-methyl-1~{H}-indazol-4-yl]oxy]cyclohexan-1-amine, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Kishikawa, S, Takano, K, Ubukata, O, Hanzawa, H.
Deposit date:2022-04-22
Release date:2023-03-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma.
Mol.Cancer Ther., 22, 2023

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