Author results

1FF3
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STRUCTURE OF THE PEPTIDE METHIONINE SULFOXIDE REDUCTASE FROM ESCHERICHIA COLI
Descriptor:PEPTIDE METHIONINE SULFOXIDE REDUCTASE, SULFATE ION
Authors:Tete-Favier, F., Cobessi, D., Boschi-Muller, S., Azza, S., Branlant, G., Aubry, A.
Deposit date:2000-07-25
Release date:2000-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the Escherichia coli peptide methionine sulphoxide reductase at 1.9 A resolution.
Structure Fold.Des., 8, 2000
2FY6
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STRUCTURE OF THE N-TERMINAL DOMAIN OF NEISSERIA MENINGITIDIS PILB
Descriptor:Peptide methionine sulfoxide reductase msrA/msrB, CHLORIDE ION, SULFATE ION
Authors:Ranaivoson, F.M., Kauffmann, B., Neiers, F., Boschi-Muller, S., Branlant, G., Favier, F.
Deposit date:2006-02-07
Release date:2006-04-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The X-ray Structure of the N-terminal Domain of PILB from Neisseria meningitidis Reveals a Thioredoxin-fold
J.Mol.Biol., 358, 2006
2IEM
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SOLUTION STRUCTURE OF AN OXIDIZED FORM (CYS51-CYS198) OF E. COLI METHIONINE SULFOXIDE REDUCTASE A (MSRA)
Descriptor:Peptide methionine sulfoxide reductase msrA
Authors:Coudevylle, N., Antoine, M., Bouguet-Bonnet, S., Mutzenhardt, P., Boschi-Muller, S., Branlant, G., Cung, M.T.
Deposit date:2006-09-19
Release date:2007-02-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure and Backbone Dynamics of the Reduced Form and an Oxidized Form of E. coli Methionine Sulfoxide Reductase A (MsrA): Structural Insight of the MsrA Catalytic Cycle.
J.Mol.Biol., 366, 2007
2X5J
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CRYSTAL STRUCTURE OF THE APOFORM OF THE D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE FROM E. COLI
Descriptor:D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE, PHOSPHATE ION
Authors:Moniot, S., Didierjean, C., Boschi-Muller, S., Branlant, G., Corbier, C.
Deposit date:2010-02-09
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Characterization of Erythrose-4- Phosphate Dehydrogenase from Escherichia Coli: Peculiar Features When Compared to Phosphorylating Gapdhs
To be Published
2X5K
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STRUCTURE OF AN ACTIVE SITE MUTANT OF THE D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE FROM E. COLI
Descriptor:D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE, GLYCEROL, 1,2-ETHANEDIOL, ...
Authors:Moniot, S., Didierjean, C., Boschi-Muller, S., Branlant, G., Corbier, C.
Deposit date:2010-02-10
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural Characterization of Erythrose-4- Phosphate Dehydrogenase from Escherichia Coli: Peculiar Features When Compared to Phosphorylating Gapdhs
To be Published
2XF8
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STRUCTURE OF THE D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE FROM E. COLI IN COMPLEX WITH A NAD COFACTOR ANALOG (3-CHLOROACETYL ADENINE PYRIDINE DINUCLEOTIDE) AND SULFATE ANION
Descriptor:D-ERYTHROSE-4-PHOSPHATE DEHYDROGENASE, SULFATE ION, 3-(CHLOROACETYL) PYRIDINE ADENINE DINUCLEOTIDE
Authors:Moniot, S., Didierjean, C., Boschi-Muller, S., Branlant, G., Corbier, C.
Deposit date:2010-05-20
Release date:2011-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural Characterization of Erythrose-4- Phosphate Dehydrogenase from Escherichia Coli: Peculiar Features When Compared to Phosphorylating Gapdhs
To be Published
5DKC
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRM (SMARCA2) IN COMPLEX WITH PFI-3 CHEMICAL PROBE
Descriptor:Probable global transcription activator SNF2L2, ZINC ION, (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Fedorov, O., Savitsky, P., Nunez-Alonso, G., Fonseca, M., Krojer, T., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
Deposit date:2015-09-03
Release date:2015-10-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe
To Be Published
5DKD
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRG1 (SMARCA4) IN COMPLEX WITH PFI-3 CHEMICAL PROBE
Descriptor:Transcription activator BRG1, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Fedorov, O., Savitsky, P., Nunez-Alonso, G., Newman, J.A., Filippakopoulos, P., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
Deposit date:2015-09-03
Release date:2015-10-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe
To Be Published
5FBX
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH PNZ5 ISOXAZOLE INHIBITOR
Descriptor:Bromodomain-containing protein 4, (3~{S})-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methyl-3-phenyl-3~{H}-isoindol-1-one
Authors:Tallant, C., Clark, P.G.K., Siejka, P., Fedorov, O., Nowak, R., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Brennan, P.E., Dixon, D., Knapp, S.
Deposit date:2015-12-14
Release date:2015-12-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
To Be Published
5FG4
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH OF-1 CHEMICAL PROBE
Descriptor:Peregrin, 4-bromanyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)-2-methyl-benzenesulfonamide
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
Deposit date:2015-12-20
Release date:2016-01-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe
To Be Published
5FG5
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH PFI-4 CHEMICAL PROBE
Descriptor:Peregrin, ~{N}-(1,3-dimethyl-2-oxidanylidene-6-pyrrolidin-1-yl-benzimidazol-5-yl)-2-methoxy-benzamide, NITRATE ION
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Brennan, P.E., Knapp, S.
Deposit date:2015-12-20
Release date:2015-12-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the bromodomain of human BRPF1 in complex with PFI-4 chemical probe
To Be Published
5FG6
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRD1 (BRPF2) IN COMPLEX WITH OF-1 CHEMICAL PROBE
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, 4-bromanyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)-2-methyl-benzenesulfonamide, ...
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
Deposit date:2015-12-20
Release date:2016-02-03
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure of the bromodomain of human BRD1 (BRPF2) in complex with OF-1 chemical probe
To Be Published
5MG2
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF HUMAN TAF1 IN COMPLEX WITH BAY-299 CHEMICAL PROBE
Descriptor:Transcription initiation factor TFIID subunit 1, 1,2-ETHANEDIOL, 6-(3-oxidanylpropyl)-2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione
Authors:Tallant, C., Bouche, L., Holton, S.J., Fedorov, O., Siejka, P., Picaud, S., Krojer, T., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Hartung, I.V., Haendler, B., Muller, S., Huber, K.V.M., Structural Genomics Consortium (SGC)
Deposit date:2016-11-20
Release date:2017-05-03
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
J. Med. Chem., 60, 2017
5MR8
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CRYSTAL STRUCTURE OF TRIM33 PHD-BROMODOMAIN ISOFORM B IN COMPLEX WITH H3K9AC HISTONE PEPTIDE
Descriptor:E3 ubiquitin-protein ligase TRIM33, Histone H3, ZINC ION
Authors:Tallant, C., Savitsky, P., Fedorov, O., Nunez-Alonso, G., Siejka, P., Krojer, T., Williams, E., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-12-21
Release date:2018-01-17
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of TRIM33 PHD-Bromodomain isoform B in complex with H3K9ac histone peptide
To Be Published
5MYG
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH NI-57 CHEMICAL PROBE
Descriptor:Peregrin, 4-cyano-~{N}-(1,3-dimethyl-2-oxidanylidene-quinolin-6-yl)-2-methoxy-benzenesulfonamide
Authors:Tallant, C., Igoe, N., Bayle, E.D., Krojer, T., Nunez-Alonso, G., Kopec, J., Fitzpatrick, F., Savitsky, P., Fedorov, O., Brennan, P.E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Fish, P., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2017-01-26
Release date:2017-08-09
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.
J. Med. Chem., 60, 2017
5T4U
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH A QUINOLINONE LIGAND
Descriptor:Peregrin, NITRATE ION, 1-METHYLQUINOLIN-2(1H)-ONE
Authors:Tallant, C., Igoe, N., Bayle, E.D., Nunez-Alonso, G., Newman, J.A., Mathea, S., Savitsky, P., Fedorov, O., Brennan, P.E., Muller, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fish, P., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-08-30
Release date:2017-02-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
J. Med. Chem., 60, 2017
5T4V
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH NI-48 LIGAND
Descriptor:Peregrin, 4-cyano-N-(7-methoxy-1,4-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzene-1-sulfonamide, 1,2-ETHANEDIOL, ...
Authors:Tallant, C., Igoe, N., Bayle, E.D., Nunez-Alonso, G., Newman, J.A., Mathea, S., Savitsky, P., Fedorov, O., Brennan, P.E., Muller, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fish, P., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-08-30
Release date:2017-02-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
J. Med. Chem., 60, 2017
1BCV
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SYNTHETIC PEPTIDE CORRESPONDING TO THE MAJOR IMMUNOGEN SITE OF FMD VIRUS, NMR, 10 STRUCTURES
Descriptor:PEPTIDE CORRESPONDING TO THE MAJOR IMMUNOGEN SITE OF FMD VIRUS
Authors:Petit, M.C., Benkirane, N., Guichard, G., Phan Chan Du, A., Cung, M.T., Briand, J.P., Muller, S.
Deposit date:1998-05-03
Release date:1998-11-25
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigenic site. Structural basis for its antigenic cross-reactivity with the parent peptide.
J.Biol.Chem., 274, 1999
1BFW
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RETRO-INVERSO ANALOGUE OF THE G-H LOOP OF VP1 IN FOOT-AND-MOUTH-DISEASE (FMD) VIRUS, NMR, 10 STRUCTURES
Descriptor:VP1 PROTEIN
Authors:Petit, M.C., Benkirane, N., Guichard, G., Phan Chan Du, A., Cung, M.T., Briand, J.P., Muller, S.
Deposit date:1998-05-22
Release date:1999-01-13
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of a retro-inverso peptide analogue mimicking the foot-and-mouth disease virus major antigenic site. Structural basis for its antigenic cross-reactivity with the parent peptide.
J.Biol.Chem., 274, 1999
1CS9
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SOLUTION STRUCTURE OF CGGIRGERA IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 7 STRUCTURES
Descriptor:HISTONE H3 PEPTIDE
Authors:Phan Chan Du, A., Petit, M.C., Guichard, G., Briand, J.P., Muller, S., Cung, M.T.
Deposit date:1999-08-18
Release date:1999-09-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach.
Biochemistry, 40, 2001
1CT6
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SOLUTION STRUCTURE OF CGGIRGERG IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 11 STRUCTURES
Descriptor:HISTONE H3 PEPTIDE
Authors:Phan Chan Du, A., Petit, M.C., Guichard, G., Briand, J.P., Muller, S., Cung, M.T.
Deposit date:1999-08-19
Release date:1999-09-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach.
Biochemistry, 40, 2001
1CVQ
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SOLUTION STRUCTURE OF THE ANALOGUE RETRO-INVERSO MGREGRIGGC IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 7 STRUCTURES
Descriptor:HISTONE H3
Authors:Phan Chan Du, A., Petit, M.C., Guichard, G., Briand, J.P., Muller, S., Cung, M.T.
Deposit date:1999-08-24
Release date:1999-09-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach.
Biochemistry, 40, 2001
1CW8
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SOLUTION STRUCTURE OF THE ANALOGUE RETRO-INVERSO (MA-R)REGRIGGC IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 6 STRUCTURES
Descriptor:HISTONE H3, METHYLMALONIC ACID
Authors:Phan Chan Du, A., Petit, M.C., Guichard, G., Briand, J.P., Muller, S., Cung, T.
Deposit date:1999-08-26
Release date:1999-09-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach.
Biochemistry, 40, 2001
1CWZ
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SOLUTION STRUCTURE OF THE ANALOGUE RETRO-INVERSO (MA-S)REGRIGGC IN CONTACT WITH THE MONOCLONAL ANTIBODY MAB 4X11, NMR, 7 STRUCTURES
Descriptor:HISTONE H3, METHYLMALONIC ACID
Authors:Phan Chan Du, A., Petit, M.C., Guichard, G., Briand, J.P., Muller, S., Cung, M.T.
Deposit date:1999-08-27
Release date:1999-09-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach.
Biochemistry, 40, 2001
1IM7
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SOLUTION STRUCTURE OF SYNTHETIC CYCLIC PEPTIDE MIMICKING THE LOOP OF HIV-1 GP41 GLYCOPROTEIN ENVELOPE
Descriptor:GP41-PARENT PEPTIDE ACE-ILE-TRP-GLY-CYS-SER-GLY-LYS-LEU-ILE-CYS-THR-THR-ALA
Authors:Phan Chan Du, A., Limal, D., Semetey, V., Dali, H., Jolivet, M., Desgranges, C., Cung, M.T., Briand, J.P., Petit, M.C., Muller, S.
Deposit date:2001-05-10
Release date:2002-10-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural and immunological characterisation of heteroclitic peptide analogues corresponding to the 600-612 region of the HIV envelope gp41 glycoprotein.
J.Mol.Biol., 323, 2002