Author results

1FTZ
  • Download 1ftz
  • View 1ftz
Molmil generated image of 1ftz
NUCLEAR MAGNETIC RESONANCE SOLUTION STRUCTURE OF THE FUSHI TARAZU HOMEODOMAIN FROM DROSOPHILA AND COMPARISON WITH THE ANTENNAPEDIA HOMEODOMAIN
Descriptor:FUSHI TARAZU PROTEIN
Authors:Qian, Y.Q., Furukubo-Tokunaga, K., Resendez-Perez, D., Muller, M., Gehring, W.J., Wuthrich, K.
Deposit date:1994-01-07
Release date:1994-05-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain.
J.Mol.Biol., 238, 1994
1AHD
  • Download 1ahd
  • View 1ahd
Molmil generated image of 1ahd
DETERMINATION OF THE NMR SOLUTION STRUCTURE OF AN ANTENNAPEDIA HOMEODOMAIN-DNA COMPLEX
Descriptor:DNA (5'-D(*GP*AP*AP*AP*GP*CP*CP*AP*TP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*CP*TP*CP*TP*AP*AP*TP*GP*GP*CP*TP*TP*TP*C)-3'), Homeotic protein antennapedia
Authors:Billeter, M., Qian, Y.Q., Otting, G., Muller, M., Gehring, W.J., Wuthrich, K.
Deposit date:1993-04-02
Release date:1993-10-31
Last modified:2016-03-30
Method:SOLUTION NMR
Cite:Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex.
J.Mol.Biol., 234, 1993
1HOM
  • Download 1hom
  • View 1hom
Molmil generated image of 1hom
DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Descriptor:ANTENNAPEDIA PROTEIN
Authors:Qian, Y.-Q., Billeter, M., Otting, G., Muller, M., Gehring, W.J., Wuthrich, K.
Deposit date:1991-10-08
Release date:1993-10-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy.
J.Mol.Biol., 214, 1990
2HOA
  • Download 2hoa
  • View 2hoa
Molmil generated image of 2hoa
STRUCTURE DETERMINATION OF THE ANTP(C39->S) HOMEODOMAIN FROM NUCLEAR MAGNETIC RESONANCE DATA IN SOLUTION USING A NOVEL STRATEGY FOR THE STRUCTURE CALCULATION WITH THE PROGRAMS DIANA, CALIBA, HABAS AND GLOMSA
Descriptor:ANTENNAPEDIA PROTEIN
Authors:Guntert, P., Qian, Y.-Q., Otting, G., Muller, M., Gehring, W.J., Wuthrich, K.
Deposit date:1992-04-04
Release date:1993-10-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure determination of the Antp (C39----S) homeodomain from nuclear magnetic resonance data in solution using a novel strategy for the structure calculation with the programs DIANA, CALIBA, HABAS and GLOMSA.
J.Mol.Biol., 217, 1991
1ZS5
  • Download 1zs5
  • View 1zs5
Molmil generated image of 1zs5
STRUCTURE-BASED EVALUATION OF SELECTIVE AND NON-SELECTIVE SMALL MOLECULES THAT BLOCK HIV-1 TAT AND PCAF ASSOCIATION
Descriptor:Histone acetyltransferase PCAF, (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
Authors:Zeng, L., Godbole, S., Muller, M., Yan, S., Sanchez, R., Zhou, M.
Deposit date:2005-05-23
Release date:2006-05-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-based evaluation of selective nad non-selective small molecules that block hiv-1 tat and pcaf association
TO BE PUBLISHED
2L84
  • Download 2l84
  • View 2l84
Molmil generated image of 2l84
SOLUTION NMR STRUCTURES OF CBP BROMODOMAIN WITH SMALL MOLECULE J28
Descriptor:CREB-binding protein, 5-[(E)-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid
Authors:Borah, J.C., Mujtaba, S., Karakikes, I., Zeng, L., Muller, M., Patel, J., Moshkina, N., Morohashi, K., Zhang, W., Gerona-Navarro, G., Hajjar, R.J., Zhou, M.
Deposit date:2011-01-03
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes.
Chem.Biol., 18, 2011
2L85
  • Download 2l85
  • View 2l85
Molmil generated image of 2l85
SOLUTION NMR STRUCTURES OF CBP BROMODOMAIN WITH SMALL MOLECULE OF HBS
Descriptor:CREB-binding protein, 4-[(E)-(4-hydroxyphenyl)diazenyl]benzenesulfonic acid
Authors:Borah, J.C., Mujtaba, S., Karakikes, I., Zeng, L., Muller, M., Patel, J., Moshkina, N., Morohashi, K., Zhang, W., Gerona-Navarro, G., Hajjar, R.J., Zhou, M.
Deposit date:2011-01-04
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes.
Chem.Biol., 18, 2011
1WUG
  • Download 1wug
  • View 1wug
Molmil generated image of 1wug
COMPLEX STRUCTURE OF PCAF BROMODOMAIN WITH SMALL CHEMICAL LIGAND NP1
Descriptor:Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE
Authors:Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M.
Deposit date:2004-12-07
Release date:2005-08-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
1WUM
  • Download 1wum
  • View 1wum
Molmil generated image of 1wum
COMPLEX STRUCTURE OF PCAF BROMODOMAIN WITH SMALL CHEMICAL LIGAND NP2
Descriptor:Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
Authors:Zeng, L., Li, J., Muller, M., Yan, S., Mujtaba, S., Pan, C., Wang, Z., Zhou, M.M.
Deposit date:2004-12-08
Release date:2005-08-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
J.Am.Chem.Soc., 127, 2005
4OQY
  • Download 4oqy
  • View 4oqy
Molmil generated image of 4oqy
STREPTOMYCES SP. GF3546 IMINE REDUCTASE
Descriptor:(S)-imine reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Schneider, L.K., Huber, T., Gerhardt, S., Muller, M., Einsle, O.
Deposit date:2014-02-10
Release date:2014-10-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Direct Reductive Amination of Ketones: Structure and Activity of S-Selective Imine Reductases from Streptomyces.
CHEMCATCHEM, 2014
4OQZ
  • Download 4oqz
  • View 4oqz
Molmil generated image of 4oqz
STREPTOMYCES AURANTIACUS IMINE REDUCTASE
Descriptor:Putative oxidoreductase YfjR
Authors:Schneider, L.K., Huber, T., Gerhardt, S., Muller, M., Einsle, O.
Deposit date:2014-02-10
Release date:2014-10-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Direct Reductive Amination of Ketones: Structure and Activity of S-Selective Imine Reductases from Streptomyces.
CHEMCATCHEM, 2014
4WK1
  • Download 4wk1
  • View 4wk1
Molmil generated image of 4wk1
CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS PSTA IN COMPLEX WITH C-DI-AMP
Descriptor:PstA, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, CALCIUM ION
Authors:Mueller, M., Hopfner, K.-P., Witte, G.
Deposit date:2014-10-01
Release date:2014-11-26
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:c-di-AMP recognition by Staphylococcus aureus PstA.
Febs Lett., 589, 2015
4WK3
  • Download 4wk3
  • View 4wk3
Molmil generated image of 4wk3
STRUCTURE OF STAPHYLOCCUS AUREUS PSTA
Descriptor:PstA, CHLORIDE ION
Authors:Mueller, M., Hopfner, K.-P., Witte, G.
Deposit date:2014-10-01
Release date:2014-11-26
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:c-di-AMP recognition by Staphylococcus aureus PstA.
Febs Lett., 589, 2015
4YVZ
  • Download 4yvz
  • View 4yvz
Molmil generated image of 4yvz
STRUCTURE OF THERMOTOGA MARITIMA DISA IN COMPLEX WITH 3'-DATP/MN2+
Descriptor:DNA integrity scanning protein DisA, MANGANESE (II) ION, 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE
Authors:Mueller, M., Deimling, T., Hopfner, K.-P., Witte, G.
Deposit date:2015-03-20
Release date:2015-06-03
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Biochem.J., 469, 2015
4YXJ
  • Download 4yxj
  • View 4yxj
Molmil generated image of 4yxj
STRUCTURE OF THERMOTOGA MARITIMA DISA IN COMPLEX WITH APCPP
Descriptor:DNA integrity scanning protein DisA, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
Authors:Mueller, M., Deimling, T., Hopfner, K.-P., Witte, G.
Deposit date:2015-03-23
Release date:2015-06-03
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Biochem.J., 469, 2015
4YXM
  • Download 4yxm
  • View 4yxm
Molmil generated image of 4yxm
STRUCTURE OF THERMOTOGA MARITIMA DISA D75N MUTANT WITH REACTION PRODUCT C-DI-AMP
Descriptor:DNA integrity scanning protein DisA, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Mueller, M., Deimling, T., Hopfner, K.-P., Witte, G.
Deposit date:2015-03-23
Release date:2015-06-03
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.
Biochem.J., 469, 2015
1SAN
  • Download 1san
  • View 1san
Molmil generated image of 1san
THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN
Descriptor:ANTENNAPEDIA PROTEIN
Authors:Qian, Y.Q., Resendez-Perez, D., Gehring, W.J., Wuthrich, K.
Deposit date:1994-01-07
Release date:1994-04-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain.
Proc.Natl.Acad.Sci.USA, 91, 1994
2V3W
  • Download 2v3w
  • View 2v3w
Molmil generated image of 2v3w
CRYSTAL STRUCTURE OF THE BENZOYLFORMATE DECARBOXYLASE VARIANT L461A FROM PSEUDOMONAS PUTIDA
Descriptor:BENZOYLFORMATE DECARBOXYLASE, MAGNESIUM ION, SULFATE ION, ...
Authors:Gocke, D., Walter, L., Gauchenova, K., Kolter, G., Knoll, M., Berthold, C.L., Schneider, G., Pleiss, J., Mueller, M., Pohl, M.
Deposit date:2007-06-25
Release date:2008-01-22
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational Protein Design of Thdp-Dependent Enzymes-Engineering Stereoselectivity.
Chembiochem, 9, 2008
4MY6
  • Download 4my6
  • View 4my6
Molmil generated image of 4my6
ENAH-EVH1 IN COMPLEX WITH PEPTIDOMIMETIC LOW-MOLECULAR WEIGHT INHIBITOR AC-[2-CL-F]-[PROM-2]-[PROM-1]-OH
Descriptor:Protein enabled homolog, (3aR,5aS,8S,10aS)-1-[(3S,6R,8aS)-1'-[(2S)-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8a-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-10-oxidanylidene-2,3,3a,5a,8,10a-hexahydrodipyrrolo[3,2-b:3',1'-f]azepine-8-carboxylic acid, BROMIDE ION
Authors:Barone, M., Roske, Y., Kuehne, R.
Deposit date:2013-09-27
Release date:2014-10-15
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Proc.Natl.Acad.Sci.USA, 112, 2015
4UQG
  • Download 4uqg
  • View 4uqg
Molmil generated image of 4uqg
A NEW BIO-ISOSTERIC BASE PAIR BASED ON REVERSIBLE BONDING
Descriptor:DNA POLYMERASE, 5'-D(*GP*AP*CP*C T0TP*TP*CP*CP*CP*TP)-3', 5'-D(*AP*GP*GP*GP*A SAYP*GP*GP*TP*CP)-3', ...
Authors:Tomas-Gamasa, M., Serdjukov, S., Su, M., Mueller, M., Carell, T.
Deposit date:2014-06-23
Release date:2014-12-03
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:"Post-it" type connected DNA created with a reversible covalent cross-link.
Angew. Chem. Int. Ed. Engl., 54, 2015
5NBX
  • Download 5nbx
  • View 5nbx
Molmil generated image of 5nbx
ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PP-[PROM-9]-OH
Descriptor:Protein enabled homolog, BROMIDE ION, 2-chloro-L-phenylalanine, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-02
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
5NC2
  • Download 5nc2
  • View 5nc2
Molmil generated image of 5nc2
ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-PPPPTEDEL-NH2
Descriptor:Protein enabled homolog, Ac-[2-Cl-F]PPPPTEDEL-NH2, SULFATE ION, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-03
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
5NC7
  • Download 5nc7
  • View 5nc7
Molmil generated image of 5nc7
ENAH EVH1 IN COMPLEX WITH AC-WPPPPTEDEL-NH2
Descriptor:Protein enabled homolog, ActA-derived 10-mer Ac-FPPPPTEDEL-NH2 with acetylated (Ac) and amidated (NH2) termini. Phe is substitued by Trp to increase affinity for crystallization
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-03
Release date:2018-03-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
5NCF
  • Download 5ncf
  • View 5ncf
Molmil generated image of 5ncf
ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-4]-OH
Descriptor:Protein enabled homolog, (1~{S},4~{S},7~{R},10~{R})-14-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-2-oxidanylidene-3,14-diazatricyclo[8.4.0.0^{3,7}]tetradec-8-ene-4-carboxylic acid, SULFATE ION, ...
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-04
Release date:2017-06-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.
Proc. Natl. Acad. Sci. U.S.A., 112, 2015
5NCG
  • Download 5ncg
  • View 5ncg
Molmil generated image of 5ncg
ENAH EVH1 IN COMPLEX WITH AC-[2-CL-F]-[PROM-2]-[PROM-9]-OH
Descriptor:Protein enabled homolog, (3~{S},7~{R},10~{R},11~{R},13~{S})-4-[(3~{S},6~{R},8~{a}~{S})-1'-[(2~{S})-2-acetamido-3-(2-chlorophenyl)propanoyl]-5-oxidanylidene-spiro[1,2,3,8~{a}-tetrahydroindolizine-6,2'-pyrrolidine]-3-yl]carbonyl-11-methyl-2-oxidanylidene-1,4-diazatricyclo[8.3.0.0^{3,7}]tridec-8-ene-13-carboxylic acid, NITRATE ION
Authors:Barone, M., Roske, Y.
Deposit date:2017-03-04
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Ena/VASP as possible antimetastatic target addressed by structure-optimized ProM scaffolds
To be published
<123>