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5T44
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BU of 5t44 by Molmil
Crystal structure of Frizzled 7 CRD
Descriptor: Frizzled-7
Authors:Mukund, S, Nile, A.H, Stanger, K, Hannous, R.H, Wang, W.
Deposit date:2016-08-29
Release date:2017-04-05
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.9944 Å)
Cite:Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5URV
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BU of 5urv by Molmil
Crystal structure of Frizzled 7 CRD in complex with C24 fatty acid
Descriptor: (15E)-TETRACOS-15-ENOIC ACID, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mukund, S, Nile, A.H, Stanger, K, Hannoush, R.N, Wang, W.
Deposit date:2017-02-13
Release date:2017-05-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5URZ
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BU of 5urz by Molmil
Crystal structure of Frizzled 5 CRD in complex with BOG
Descriptor: Frizzled-5, alpha-L-fucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, octyl beta-D-glucopyranoside
Authors:Mukund, S, Nile, A.H, Stanger, K, Hannoush, R.N, Wang, W.
Deposit date:2017-02-13
Release date:2017-05-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5URY
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BU of 5ury by Molmil
Crystal structure of Frizzled 5 CRD in complex with PAM
Descriptor: Frizzled-5, PALMITOLEIC ACID, alpha-L-fucopyranose-(1-3)-[alpha-L-fucopyranose-(1-4)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Mukund, S, Nile, A.H, Stanger, K, Hannoush, R.N, Wang, W.
Deposit date:2017-02-13
Release date:2017-05-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4LEX
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BU of 4lex by Molmil
Unliganded crystal structure of mAb7
Descriptor: FAB HEAVY CHAIN, FAB LIGHT CHAIN
Authors:Murray, J.M, Mukund, S.
Deposit date:2013-06-26
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
4LF3
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BU of 4lf3 by Molmil
Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor
Descriptor: Fab heavy chain, Fab light chain, Glucagon receptor
Authors:Murray, J.M, Mukund, S.
Deposit date:2013-06-26
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.735 Å)
Cite:Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
J.Biol.Chem., 288, 2013
1AOR
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BU of 1aor by Molmil
STRUCTURE OF A HYPERTHERMOPHILIC TUNGSTOPTERIN ENZYME, ALDEHYDE FERREDOXIN OXIDOREDUCTASE
Descriptor: ALDEHYDE FERREDOXIN OXIDOREDUCTASE, FE (III) ION, IRON/SULFUR CLUSTER, ...
Authors:Chan, M.K, Mukund, S, Kletzin, A, Adams, M.W.W, Rees, D.C.
Deposit date:1995-02-13
Release date:1995-04-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase.
Science, 267, 1995
5EK0
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BU of 5ek0 by Molmil
Human Nav1.7-VSD4-NavAb in complex with GX-936.
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-cyano-4-[2-[2-(1-ethylazetidin-3-yl)pyrazol-3-yl]-4-(trifluoromethyl)phenoxy]-~{N}-(1,2,4-thiadiazol-5-yl)benzenesulfonamide, Chimera of bacterial Ion transport protein and human Sodium channel protein type 9 subunit alpha
Authors:Ahuja, S, Mukund, S, Starovasnik, M.A, Koth, C.M, Payandeh, J.
Deposit date:2015-11-03
Release date:2015-12-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.
Science, 350, 2015
5W96
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BU of 5w96 by Molmil
Solution structure of phage derived peptide inhibitor of frizzled 7 receptor
Descriptor: Fz7 binding peptide
Authors:Nile, A.H, de Sousa e Melo, F, Mukund, S, Piskol, R, Hansen, S, Zhou, L, Zhang, Y, Fu, Y, Gogol, E.B, Komuves, L.G, Modrusan, Z, Angers, S, Franke, Y, Koth, C, Fairbrother, W.J, Wang, W, de Sauvage, F.J, Hannoush, R.N.
Deposit date:2017-06-22
Release date:2018-04-18
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat. Chem. Biol., 14, 2018
4ERS
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BU of 4ers by Molmil
A Molecular Basis for Negative Regulation of the Glucagon Receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ...
Authors:Murray, J.M, Koth, C.M, Mukund, S.
Deposit date:2012-04-20
Release date:2012-08-29
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.637 Å)
Cite:Molecular basis for negative regulation of the glucagon receptor.
Proc.Natl.Acad.Sci.USA, 109, 2012
5WBS
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BU of 5wbs by Molmil
Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21
Descriptor: Frizzled-7,inhibitor peptide Fz7-21
Authors:Nile, A.H, Mukund, S, Hannoush, R.N, Wang, W.
Deposit date:2017-06-29
Release date:2018-04-18
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.
Nat. Chem. Biol., 14, 2018
1YZ0
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BU of 1yz0 by Molmil
R-State AMP Complex Reveals Initial Steps of the Quaternary Transition of Fructose-1,6-bisphosphatase
Descriptor: 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase, ...
Authors:Iancu, C.V, Mukund, S, Fromm, H.J, Honzatko, R.B.
Deposit date:2005-02-25
Release date:2005-03-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase.
J.Biol.Chem., 280, 2005
1YXI
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BU of 1yxi by Molmil
R-State AMP Complex Reveals Initial Steps of the Quaternary Transition of Fructose-1,6-bisphosphatase
Descriptor: 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase, MAGNESIUM ION, ...
Authors:Iancu, C.V, Mukund, S, Fromm, H.J, Honzatko, R.B.
Deposit date:2005-02-21
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase.
J.Biol.Chem., 280, 2005
1YYZ
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BU of 1yyz by Molmil
R-State AMP Complex Reveals Initial Steps of the Quaternary Transition of Fructose-1,6-bisphosphatase
Descriptor: 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase, ...
Authors:Iancu, C.V, Mukund, S, Fromm, H.J, Honzatko, R.B.
Deposit date:2005-02-25
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase.
J.Biol.Chem., 280, 2005
1B25
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BU of 1b25 by Molmil
FORMALDEHYDE FERREDOXIN OXIDOREDUCTASE FROM PYROCOCCUS FURIOSUS
Descriptor: IRON/SULFUR CLUSTER, PROTEIN (FORMALDEHYDE FERREDOXIN OXIDOREDUCTASE), TUNGSTOPTERIN
Authors:Hu, Y.L, Faham, S, Roy, R, Adams, M.W.W, Rees, D.C.
Deposit date:1998-12-04
Release date:1999-03-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus: the 1.85 A resolution crystal structure and its mechanistic implications.
J.Mol.Biol., 286, 1999
1B4N
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BU of 1b4n by Molmil
FORMALDEHYDE FERREDOXIN OXIDOREDUCTASE FROM PYROCOCCUS FURIOSUS, COMPLEXED WITH GLUTARATE
Descriptor: CALCIUM ION, FORMALDEHYDE FERREDOXIN OXIDOREDUCTASE, GLUTARIC ACID, ...
Authors:Hu, Y.L, Faham, S, Roy, R, Adams, M.W.W, Rees, D.C.
Deposit date:1998-12-24
Release date:1999-05-18
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus: the 1.85 A resolution crystal structure and its mechanistic implications.
J.Mol.Biol., 286, 1999
3MEE
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BU of 3mee by Molmil
HIV-1 Reverse Transcriptase in Complex with TMC278
Descriptor: 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, SULFATE ION, p51 Reverse transcriptase, ...
Authors:Lansdon, E.B.
Deposit date:2010-03-31
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design.
J.Med.Chem., 53, 2010
3MEG
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BU of 3meg by Molmil
HIV-1 K103N Reverse Transcriptase in Complex with TMC278
Descriptor: 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, SULFATE ION, p51 Reverse transcriptase, ...
Authors:Lansdon, E.B.
Deposit date:2010-03-31
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design.
J.Med.Chem., 53, 2010
3MEC
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BU of 3mec by Molmil
HIV-1 Reverse Transcriptase in Complex with TMC125
Descriptor: 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, SULFATE ION, p51 Reverse transcriptase, ...
Authors:Lansdon, E.B.
Deposit date:2010-03-31
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design.
J.Med.Chem., 53, 2010
3MED
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BU of 3med by Molmil
HIV-1 K103N Reverse Transcriptase in Complex with TMC125
Descriptor: 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE, CHLORIDE ION, SULFATE ION, ...
Authors:Lansdon, E.B.
Deposit date:2010-03-31
Release date:2010-05-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of HIV-1 Reverse Transcriptase with Etravirine (TMC125) and Rilpivirine (TMC278): Implications for Drug Design.
J.Med.Chem., 53, 2010
2F3B
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BU of 2f3b by Molmil
Mechanism of displacement of a catalytically essential loop from the active site of fructose-1,6-bisphosphatase
Descriptor: 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase 1, PHOSPHATE ION, ...
Authors:Iancu, C.V, Mukund, S, Choe, J.-Y, Fromm, H.J, Honzatko, R.B.
Deposit date:2005-11-20
Release date:2006-04-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of displacement of a catalytically essential loop from the active site of mammalian fructose-1,6-bisphosphatase.
Biochemistry, 52, 2013
2F3D
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BU of 2f3d by Molmil
Mechanism of displacement of a catalytically essential loop from the active site of fructose-1,6-bisphosphatase
Descriptor: 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ...
Authors:Iancu, C.V, Mukund, S, Choe, J.-Y, Fromm, H.J, Honzatko, R.B.
Deposit date:2005-11-21
Release date:2006-04-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Mechanism of displacement of a catalytically essential loop from the active site of mammalian fructose-1,6-bisphosphatase.
Biochemistry, 52, 2013
4LY1
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BU of 4ly1 by Molmil
Structure of Human HDAC2 in complex with inhibitor 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-(acetylamino)-N-[2-amino-5-(thiophen-2-yl)phenyl]benzamide, CALCIUM ION, ...
Authors:Fong, R, Lupardus, P.J.
Deposit date:2013-07-30
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
J.Biol.Chem., 288, 2013
4LXZ
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BU of 4lxz by Molmil
Structure of Human HDAC2 in complex with SAHA (vorinostat)
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, Histone deacetylase 2, ...
Authors:Fong, R, Lupardus, P.J.
Deposit date:2013-07-30
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability.
J.Biol.Chem., 288, 2013
4KXP
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BU of 4kxp by Molmil
Crystal Structure of AMP complexes of Porcine Liver Fructose-1,6-bisphosphatase Mutant I10D in T-state
Descriptor: 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ...
Authors:Iancu, C.V, Mukund, S, Choe, J.-Y, Fromm, H.J, Honzatko, R.B.
Deposit date:2013-05-27
Release date:2013-07-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of Displacement of a Catalytically Essential Loop from the Active Site of Mammalian Fructose-1,6-bisphosphatase.
Biochemistry, 52, 2013

217705

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