5DU1
| Crystal structure of Dendroaspis polylepis mambalgin-1 wild-type in P21 space group. | Descriptor: | Mambalgin-1 | Authors: | Stura, E.A, Tepshi, L, Mourier, G, Kessler, P, Servent, D. | Deposit date: | 2015-09-18 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J.Biol.Chem., 291, 2016
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5DZ5
| Crystal structure of Dendroaspis polylepis mambalgin-1 wild-type in P41212 space group | Descriptor: | Mambalgin-1 | Authors: | Stura, E.A, Tepshi, L, Mourier, G, Kessler, P, Servent, D. | Deposit date: | 2015-09-25 | Release date: | 2015-12-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J.Biol.Chem., 291, 2016
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2VLW
| Crystal structure of the muscarinic toxin MT7 diiodoTYR51 derivative. | Descriptor: | ACETATE ION, MUSCARINIC M1-TOXIN1, SULFATE ION | Authors: | Menez, R, Granata, V, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D, Stura, E.A. | Deposit date: | 2008-01-17 | Release date: | 2008-10-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.39 Å) | Cite: | Different Interactions between Mt7 Toxin and the Human Muscarinic M1 Receptor in its Free and N-Methylscopolamine-Occupied States. Mol.Pharmacol., 74, 2008
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3FEV
| Crystal structure of the chimeric muscarinic toxin MT7 with loop 1 from MT1. | Descriptor: | Fusion of Muscarinic toxin 1, Muscarinic m1-toxin1, SULFATE ION | Authors: | Stura, E.A, Menez, R, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D. | Deposit date: | 2008-12-01 | Release date: | 2009-12-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors. Plos One, 7, 2012
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5MG9
| Putative Ancestral Mamba toxin 1 (AncTx1-W28R/I38S) | Descriptor: | 1,2-ETHANEDIOL, AncTx1-W28R/I38S, S-1,2-PROPANEDIOL, ... | Authors: | Stura, E.A, Tepshi, L, Blanchet, G, Mourier, G, Servent, D. | Deposit date: | 2016-11-21 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep, 7, 2017
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5M4V
| X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor | Descriptor: | CHLORIDE ION, Mambaquaretin-1, S-1,2-PROPANEDIOL | Authors: | Stura, E.A, Vera, L, Ciolek, J, Mourier, G, Gilles, N. | Deposit date: | 2016-10-19 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5DO6
| Crystal structure of Dendroaspis polylepis venom mambalgin-1 T23A mutant | Descriptor: | 1,2-ETHANEDIOL, IODIDE ION, Mambalgin-1, ... | Authors: | Stura, E.A, Tepshi, L, Kessler, P, Gilles, M, Servent, D. | Deposit date: | 2015-09-10 | Release date: | 2015-12-30 | Last modified: | 2017-01-25 | Method: | X-RAY DIFFRACTION (1.697 Å) | Cite: | Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J.Biol.Chem., 291, 2016
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2LDE
| Solution structure of the long sarafotoxin srtx-i3 | Descriptor: | Sarafotoxin-i3 | Authors: | Cordier, F, Zorba, A, Hajj, M, Ducancel, F, Servent, D, Delepierre, M. | Deposit date: | 2011-05-24 | Release date: | 2011-09-21 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension. Biochimie, 94, 2012
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2LDF
| Solution structure of the long sarafotoxin srtx-m | Descriptor: | Sarafotoxin-m | Authors: | Cordier, F, Zorba, A, Hajj, M, Ducancel, F, Servent, D, Delepierre, M. | Deposit date: | 2011-05-24 | Release date: | 2011-09-21 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension. Biochimie, 94, 2012
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6R5M
| Crystal structure of toxin MT9 from mamba venom | Descriptor: | ACETYL GROUP, Dendroaspis polylepis MT9, GLYCEROL, ... | Authors: | Stura, E.A, Tepshi, L, Ciolek, J, Triquigneaux, M, Zoukimian, C, De Waard, M, Beroud, R, Servent, D, Gilles, N, Legrand, P, Ciccone, L. | Deposit date: | 2019-03-25 | Release date: | 2020-02-12 | Last modified: | 2022-05-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries Biomed Pharmacother, 150, 2022
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3NEQ
| Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1 | Descriptor: | SULFATE ION, Three-finger muscarinic toxin 7 | Authors: | Stura, E.A, Servent, D, Menez, R, Mournier, G, Menez, A, Fruchart-Gaillard, C. | Deposit date: | 2010-06-09 | Release date: | 2011-08-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors. Plos One, 7, 2012
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4DO8
| Crystal structure of the muscarinic toxin MT1 | Descriptor: | ACETATE ION, Muscarinic toxin 1, THIOCYANATE ION | Authors: | Fruchart-Gaillard, C, Mournier, G, Vera, L, Servent, D, Stura, E.A. | Deposit date: | 2012-02-09 | Release date: | 2012-06-27 | Last modified: | 2012-07-04 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors. Plos One, 7, 2012
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6SAB
| M-BUTX-Ptr1a (Parabuthus transvaalicus) | Descriptor: | M-BUTX-Ptr1a | Authors: | Meudal, H, Landon, C, Delmas, A.F. | Deposit date: | 2019-07-16 | Release date: | 2020-07-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J.Med.Chem., 63, 2020
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6SAA
| M-TRTX-Preg1a (Poecilotheria regalis) | Descriptor: | U1-theraphotoxin-Pf3 | Authors: | Meudal, H, Landon, C, Delmas, A.F. | Deposit date: | 2019-07-16 | Release date: | 2020-07-22 | Last modified: | 2020-08-26 | Method: | SOLUTION NMR | Cite: | A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J.Med.Chem., 63, 2020
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8AJ7
| Kunitz domain of Amblyomin-X | Descriptor: | 1,2-ETHANEDIOL, Kunitz domain of Amblyomin-X | Authors: | Ciccone, L, Servent, D, Stura, E.A. | Deposit date: | 2022-07-27 | Release date: | 2023-02-15 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity. Front Mol Biosci, 10, 2023
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4IYE
| Crystal structure of AdTx1 (rho-Da1a) from eastern green mamba (Dendroaspis angusticeps) | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Toxin AdTx1 | Authors: | Stura, E.A, Vera, L, Maiga, A.A, Marchetti, C, Lorphelin, A, Bellanger, L, Servant, D, Gilles, N. | Deposit date: | 2013-01-28 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.951 Å) | Cite: | Crystallization of recombinant green mamba rho-Da1a toxin during a lyophilization procedure and its structure determination. Acta Crystallogr.,Sect.F, 69, 2013
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5N5Q
| Human TTR altered conformation from soaking in iron chloride. | Descriptor: | ACETATE ION, FE (III) ION, Transthyretin, ... | Authors: | Ciccone, L, Savko, M, Shepard, W, Stura, E.A. | Deposit date: | 2017-02-14 | Release date: | 2018-03-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Copper mediated amyloid-beta binding to Transthyretin. Sci Rep, 8, 2018
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5N7C
| Human TTR altered conformation from soaking in CuCl2. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, COPPER (II) ION, ... | Authors: | Ciccone, L, Savko, M, Shepard, W, Stura, E.A. | Deposit date: | 2017-02-20 | Release date: | 2018-03-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Copper mediated amyloid-beta binding to Transthyretin. Sci Rep, 8, 2018
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5N62
| Human TTR crystals soaked in manganese chloride. | Descriptor: | MANGANESE (II) ION, Transthyretin | Authors: | Ciccone, L, Savko, M, Shepard, W, Stura, E.A. | Deposit date: | 2017-02-14 | Release date: | 2018-03-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Copper mediated amyloid-beta binding to Transthyretin. Sci Rep, 8, 2018
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2H5F
| Denmotoxin: A the three-finger toxin from colubrid snake Boiga dendrophila with bird-specific activity | Descriptor: | PHOSPHATE ION, POTASSIUM ION, SODIUM ION, ... | Authors: | Pawlak, J, Kini, R.M, Stura, E.A. | Deposit date: | 2006-05-26 | Release date: | 2006-08-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity. J.Biol.Chem., 281, 2006
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2HEO
| General Structure-Based Approach to the Design of Protein Ligands: Application to the Design of Kv1.2 Potassium Channel Blockers. | Descriptor: | 5'-D(*TP*CP*GP*CP*GP*CP*G)-3', Z-DNA binding protein 1 | Authors: | Magis, C, Gasparini, S, Charbonnier, J.B, Stura, E, Le Du, M.H, Menez, A, Cuniasse, P. | Deposit date: | 2006-06-21 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-based secondary structure-independent approach to design protein ligands: Application to the design of Kv1.2 potassium channel blockers. J.Am.Chem.Soc., 128, 2006
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2H7Z
| Crystal structure of irditoxin | Descriptor: | Irditoxin subunit A, Irditoxin subunit B | Authors: | Pawlak, J, Kini, R.M, Stura, E.A, Le Du, M.H. | Deposit date: | 2006-06-06 | Release date: | 2006-08-29 | Last modified: | 2011-10-05 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity. Faseb J., 23, 2009
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