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5DU1
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BU of 5du1 by Molmil
Crystal structure of Dendroaspis polylepis mambalgin-1 wild-type in P21 space group.
Descriptor: Mambalgin-1
Authors:Stura, E.A, Tepshi, L, Mourier, G, Kessler, P, Servent, D.
Deposit date:2015-09-18
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.
J.Biol.Chem., 291, 2016
5DZ5
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BU of 5dz5 by Molmil
Crystal structure of Dendroaspis polylepis mambalgin-1 wild-type in P41212 space group
Descriptor: Mambalgin-1
Authors:Stura, E.A, Tepshi, L, Mourier, G, Kessler, P, Servent, D.
Deposit date:2015-09-25
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.
J.Biol.Chem., 291, 2016
2VLW
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BU of 2vlw by Molmil
Crystal structure of the muscarinic toxin MT7 diiodoTYR51 derivative.
Descriptor: ACETATE ION, MUSCARINIC M1-TOXIN1, SULFATE ION
Authors:Menez, R, Granata, V, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D, Stura, E.A.
Deposit date:2008-01-17
Release date:2008-10-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Different Interactions between Mt7 Toxin and the Human Muscarinic M1 Receptor in its Free and N-Methylscopolamine-Occupied States.
Mol.Pharmacol., 74, 2008
3FEV
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BU of 3fev by Molmil
Crystal structure of the chimeric muscarinic toxin MT7 with loop 1 from MT1.
Descriptor: Fusion of Muscarinic toxin 1, Muscarinic m1-toxin1, SULFATE ION
Authors:Stura, E.A, Menez, R, Mourier, G, Fruchart-Gaillard, C, Menez, A, Servant, D.
Deposit date:2008-12-01
Release date:2009-12-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
Plos One, 7, 2012
5MG9
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BU of 5mg9 by Molmil
Putative Ancestral Mamba toxin 1 (AncTx1-W28R/I38S)
Descriptor: 1,2-ETHANEDIOL, AncTx1-W28R/I38S, S-1,2-PROPANEDIOL, ...
Authors:Stura, E.A, Tepshi, L, Blanchet, G, Mourier, G, Servent, D.
Deposit date:2016-11-21
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins.
Sci Rep, 7, 2017
5M4V
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BU of 5m4v by Molmil
X-ray structure of the mambaquaretin-1, a selective antagonist of the vasopressin type 2 receptor
Descriptor: CHLORIDE ION, Mambaquaretin-1, S-1,2-PROPANEDIOL
Authors:Stura, E.A, Vera, L, Ciolek, J, Mourier, G, Gilles, N.
Deposit date:2016-10-19
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5DO6
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BU of 5do6 by Molmil
Crystal structure of Dendroaspis polylepis venom mambalgin-1 T23A mutant
Descriptor: 1,2-ETHANEDIOL, IODIDE ION, Mambalgin-1, ...
Authors:Stura, E.A, Tepshi, L, Kessler, P, Gilles, M, Servent, D.
Deposit date:2015-09-10
Release date:2015-12-30
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition.
J.Biol.Chem., 291, 2016
2LDE
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BU of 2lde by Molmil
Solution structure of the long sarafotoxin srtx-i3
Descriptor: Sarafotoxin-i3
Authors:Cordier, F, Zorba, A, Hajj, M, Ducancel, F, Servent, D, Delepierre, M.
Deposit date:2011-05-24
Release date:2011-09-21
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension.
Biochimie, 94, 2012
2LDF
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BU of 2ldf by Molmil
Solution structure of the long sarafotoxin srtx-m
Descriptor: Sarafotoxin-m
Authors:Cordier, F, Zorba, A, Hajj, M, Ducancel, F, Servent, D, Delepierre, M.
Deposit date:2011-05-24
Release date:2011-09-21
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension.
Biochimie, 94, 2012
6R5M
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BU of 6r5m by Molmil
Crystal structure of toxin MT9 from mamba venom
Descriptor: ACETYL GROUP, Dendroaspis polylepis MT9, GLYCEROL, ...
Authors:Stura, E.A, Tepshi, L, Ciolek, J, Triquigneaux, M, Zoukimian, C, De Waard, M, Beroud, R, Servent, D, Gilles, N, Legrand, P, Ciccone, L.
Deposit date:2019-03-25
Release date:2020-02-12
Last modified:2022-05-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries
Biomed Pharmacother, 150, 2022
3NEQ
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BU of 3neq by Molmil
Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1
Descriptor: SULFATE ION, Three-finger muscarinic toxin 7
Authors:Stura, E.A, Servent, D, Menez, R, Mournier, G, Menez, A, Fruchart-Gaillard, C.
Deposit date:2010-06-09
Release date:2011-08-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
Plos One, 7, 2012
4DO8
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BU of 4do8 by Molmil
Crystal structure of the muscarinic toxin MT1
Descriptor: ACETATE ION, Muscarinic toxin 1, THIOCYANATE ION
Authors:Fruchart-Gaillard, C, Mournier, G, Vera, L, Servent, D, Stura, E.A.
Deposit date:2012-02-09
Release date:2012-06-27
Last modified:2012-07-04
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Engineering of three-finger fold toxins creates ligands with original pharmacological profiles for muscarinic and adrenergic receptors.
Plos One, 7, 2012
6SAB
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BU of 6sab by Molmil
M-BUTX-Ptr1a (Parabuthus transvaalicus)
Descriptor: M-BUTX-Ptr1a
Authors:Meudal, H, Landon, C, Delmas, A.F.
Deposit date:2019-07-16
Release date:2020-07-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
J.Med.Chem., 63, 2020
6SAA
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BU of 6saa by Molmil
M-TRTX-Preg1a (Poecilotheria regalis)
Descriptor: U1-theraphotoxin-Pf3
Authors:Meudal, H, Landon, C, Delmas, A.F.
Deposit date:2019-07-16
Release date:2020-07-22
Last modified:2020-08-26
Method:SOLUTION NMR
Cite:A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
J.Med.Chem., 63, 2020
8AJ7
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BU of 8aj7 by Molmil
Kunitz domain of Amblyomin-X
Descriptor: 1,2-ETHANEDIOL, Kunitz domain of Amblyomin-X
Authors:Ciccone, L, Servent, D, Stura, E.A.
Deposit date:2022-07-27
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity.
Front Mol Biosci, 10, 2023
4IYE
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BU of 4iye by Molmil
Crystal structure of AdTx1 (rho-Da1a) from eastern green mamba (Dendroaspis angusticeps)
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Toxin AdTx1
Authors:Stura, E.A, Vera, L, Maiga, A.A, Marchetti, C, Lorphelin, A, Bellanger, L, Servant, D, Gilles, N.
Deposit date:2013-01-28
Release date:2013-05-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Crystallization of recombinant green mamba rho-Da1a toxin during a lyophilization procedure and its structure determination.
Acta Crystallogr.,Sect.F, 69, 2013
5N5Q
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BU of 5n5q by Molmil
Human TTR altered conformation from soaking in iron chloride.
Descriptor: ACETATE ION, FE (III) ION, Transthyretin, ...
Authors:Ciccone, L, Savko, M, Shepard, W, Stura, E.A.
Deposit date:2017-02-14
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Copper mediated amyloid-beta binding to Transthyretin.
Sci Rep, 8, 2018
5N7C
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BU of 5n7c by Molmil
Human TTR altered conformation from soaking in CuCl2.
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, COPPER (II) ION, ...
Authors:Ciccone, L, Savko, M, Shepard, W, Stura, E.A.
Deposit date:2017-02-20
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Copper mediated amyloid-beta binding to Transthyretin.
Sci Rep, 8, 2018
5N62
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BU of 5n62 by Molmil
Human TTR crystals soaked in manganese chloride.
Descriptor: MANGANESE (II) ION, Transthyretin
Authors:Ciccone, L, Savko, M, Shepard, W, Stura, E.A.
Deposit date:2017-02-14
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Copper mediated amyloid-beta binding to Transthyretin.
Sci Rep, 8, 2018
2H5F
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BU of 2h5f by Molmil
Denmotoxin: A the three-finger toxin from colubrid snake Boiga dendrophila with bird-specific activity
Descriptor: PHOSPHATE ION, POTASSIUM ION, SODIUM ION, ...
Authors:Pawlak, J, Kini, R.M, Stura, E.A.
Deposit date:2006-05-26
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity.
J.Biol.Chem., 281, 2006
2HEO
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BU of 2heo by Molmil
General Structure-Based Approach to the Design of Protein Ligands: Application to the Design of Kv1.2 Potassium Channel Blockers.
Descriptor: 5'-D(*TP*CP*GP*CP*GP*CP*G)-3', Z-DNA binding protein 1
Authors:Magis, C, Gasparini, S, Charbonnier, J.B, Stura, E, Le Du, M.H, Menez, A, Cuniasse, P.
Deposit date:2006-06-21
Release date:2006-11-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-based secondary structure-independent approach to design protein ligands: Application to the design of Kv1.2 potassium channel blockers.
J.Am.Chem.Soc., 128, 2006
2H7Z
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BU of 2h7z by Molmil
Crystal structure of irditoxin
Descriptor: Irditoxin subunit A, Irditoxin subunit B
Authors:Pawlak, J, Kini, R.M, Stura, E.A, Le Du, M.H.
Deposit date:2006-06-06
Release date:2006-08-29
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity.
Faseb J., 23, 2009

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