6ZM3
 
 | | The structure of an E2 ubiquitin-conjugating complex (UBC2-UEV1) essential for Leishmania amastigote differentiation | | Descriptor: | Putative ubiquitin-conjugating enzyme e2, Ubiquitin-conjugating enzyme-like protein | | Authors: | Burge, R.J, Dodson, E.J, Wilkinson, A.J, Mottram, J.C. | | Deposit date: | 2020-07-01 | | Release date: | 2020-07-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex.
Plos Pathog., 16, 2020
|
|
2C34
 | | Leishmania mexicana ICP | | Descriptor: | INHIBITOR OF CYSTEINE PEPTIDASES | | Authors: | Smith, B.O, Picken, N.C, Bromek, K, Westrop, G.D, Mottram, J.C, Coombs, G.H. | | Deposit date: | 2005-10-04 | | Release date: | 2005-12-21 | | Last modified: | 2021-06-23 | | Method: | SOLUTION NMR | | Cite: | The Structure of Leishmania Mexicana Icp Provides Evidence for Convergent Evolution of Cysteine Peptidase Inhibitors.
J.Biol.Chem., 281, 2006
|
|
2XE4
 | | Structure of Oligopeptidase B from Leishmania major | | Descriptor: | ANTIPAIN, CHLORIDE ION, GLYCEROL, ... | | Authors: | McLuskey, K, Paterson, N.G, Bland, N.D, Mottram, J.C, Isaacs, N.W. | | Deposit date: | 2010-05-11 | | Release date: | 2010-10-06 | | Last modified: | 2019-05-15 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal Structure of Leishmania Major Oligopeptidase B Gives Insight Into the Enzymatic Properties of a Trypanosomatid Virulence Factor.
J.Biol.Chem., 285, 2010
|
|
1E5E
 | | METHIONINE GAMMA-LYASE (MGL) FROM TRICHOMONAS VAGINALIS IN COMPLEX WITH PROPARGYLGLYCINE | | Descriptor: | GLYCEROL, METHIONINE GAMMA-LYASE, N-(HYDROXY{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)NORVALINE, ... | | Authors: | Goodall, G, Mottram, J.C, Coombs, G.H, Lapthorn, A.J. | | Deposit date: | 2000-07-25 | | Release date: | 2001-07-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | The Structure and Proposed Catalytic Mechanism of Methionine Gamma-Lyase
To be Published
|
|
1E5F
 | | METHIONINE GAMMA-LYASE (MGL) FROM TRICHOMONAS VAGINALIS | | Descriptor: | GLYCEROL, METHIONINE GAMMA-LYASE, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Goodall, G, Mottram, J.C, Coombs, G.H, Lapthorn, A.J. | | Deposit date: | 2000-07-25 | | Release date: | 2001-07-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | The Structure and Proposed Catalytic Mechanism of Methionine Gamma-Lyase
To be Published
|
|
4AF8
 | | The structural basis for metacaspase substrate specificity and activation | | Descriptor: | CHLORIDE ION, METACASPASE MCA2, SODIUM ION | | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | | Deposit date: | 2012-01-18 | | Release date: | 2012-05-02 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4AFR
 | | THE STRUCTURE OF METACASPASE 2 (C213A MUTANT) FROM T. BRUCEI | | Descriptor: | METACASPASE | | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | | Deposit date: | 2012-01-23 | | Release date: | 2012-05-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4AFV
 | | THE STRUCTURE OF METACASPASE 2 FROM T. BRUCEI DETERMINED IN THE PRESENCE OF CALCIUM CHLORIDE | | Descriptor: | METACASPASE MCA2 | | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | | Deposit date: | 2012-01-23 | | Release date: | 2012-05-02 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4AFP
 | | The structure of metacaspase 2 from T. brucei determined in the presence of Samarium | | Descriptor: | METACASPASE MCA2, SAMARIUM (III) ION | | Authors: | McLuskey, K, Rudolf, J, Isaacs, N.W, Coombs, G.H, Moss, C.X, Mottram, J.C. | | Deposit date: | 2012-01-23 | | Release date: | 2012-05-02 | | Last modified: | 2017-07-05 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of a Trypanosoma Brucei Metacaspase.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
8BPT
 | |
8GCC
 | | T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1 | | Descriptor: | 2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one, DNA (28-MER), DNA topoisomerase 2 | | Authors: | Schenk, A, Deniston, C, Noeske, J. | | Deposit date: | 2023-03-01 | | Release date: | 2023-07-12 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Science, 380, 2023
|
|
6Q2A
 | |
1OKG
 | | 3-mercaptopyruvate sulfurtransferase from Leishmania major | | Descriptor: | CALCIUM ION, POSSIBLE 3-MERCAPTOPYRUVATE SULFURTRANSFERASE, SULFITE ION | | Authors: | Alphey, M.S, Hunter, W.N. | | Deposit date: | 2003-07-24 | | Release date: | 2003-09-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Crystal Structure of Leishmania Major 3-Mercaptopyruvate Sulfurtransferase: A Three-Domain Architecture with a Serine Protease-Like Triad at the Active Site
J.Biol.Chem., 278, 2003
|
|
3UWS
 | |
3FWU
 | | Crystal structure of Leishmania major MIF1 | | Descriptor: | Macrophage migration inhibitory factor-like protein | | Authors: | RIchardson, J.M, Walkinshaw, M.D. | | Deposit date: | 2009-01-19 | | Release date: | 2009-03-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of Leishmania major orthologues of macrophage migration inhibitory factor
Biochem.Biophys.Res.Commun., 380, 2009
|
|
3FWT
 | | Crystal structure of Leishmania major MIF2 | | Descriptor: | Macrophage migration inhibitory factor-like protein | | Authors: | Walkinshaw, M.D, Richardson, J.M. | | Deposit date: | 2009-01-19 | | Release date: | 2009-03-17 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of Leishmania major orthologues of macrophage migration inhibitory factor
Biochem.Biophys.Res.Commun., 380, 2009
|
|
6QU5
 | | Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb12 | | Descriptor: | 1-[(3,4-dichlorophenyl)methyl]imidazole, ATP-dependent 6-phosphofructokinase, CITRIC ACID, ... | | Authors: | McNae, I.W, Dornan, J, Walkinshaw, M.D. | | Deposit date: | 2019-02-26 | | Release date: | 2020-03-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.
Nat Commun, 12, 2021
|
|
6QU3
 | | Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb360 | | Descriptor: | 1-[(3,4-dichlorophenyl)methyl]-7~{H}-pyrrolo[3,2-c]pyridin-4-one, ATP-dependent 6-phosphofructokinase, CITRIC ACID, ... | | Authors: | McNae, I.W, Dornan, J, Walkinshaw, M.D. | | Deposit date: | 2019-02-26 | | Release date: | 2020-03-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.
Nat Commun, 12, 2021
|
|
6QU4
 | | Crystal Structure of Phosphofructokinase from Trypanosoma brucei in complex with an allosteric inhibitor ctcb405 | | Descriptor: | 1-[(3,4-dichlorophenyl)methyl]-5-[2-(dimethylamino)ethyl]pyrrolo[3,2-c]pyridin-4-one, ATP-dependent 6-phosphofructokinase, CITRIC ACID, ... | | Authors: | McNae, I.W, Dornan, J, Walkinshaw, M.D. | | Deposit date: | 2019-02-26 | | Release date: | 2020-03-18 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice.
Nat Commun, 12, 2021
|
|
4DH4
 | |
