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1HK6
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BU of 1hk6 by Molmil
Ral binding domain from Sec5
Descriptor: EXOCYST COMPLEX COMPONENT SEC5
Authors:Mott, H.R, Nietlispach, D, Hopkins, L.J, Mirey, G, Camonis, J.H, Owen, D.
Deposit date:2003-03-05
Release date:2003-03-13
Last modified:2018-03-28
Method:SOLUTION NMR
Cite:Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site.
J. Biol. Chem., 278, 2003
1ZSG
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BU of 1zsg by Molmil
beta PIX-SH3 complexed with an atypical peptide from alpha-PAK
Descriptor: Rho guanine nucleotide exchange factor 7, Serine/threonine-protein kinase PAK 1
Authors:Mott, H.R, Nietlispach, D, Evetts, K.A, Owen, D.
Deposit date:2005-05-24
Release date:2005-08-30
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural Analysis of the SH3 Domain of beta-PIX and Its Interaction with alpha-p21 Activated Kinase (PAK)
Biochemistry, 44, 2005
1IRL
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BU of 1irl by Molmil
THE SOLUTION STRUCTURE OF THE F42A MUTANT OF HUMAN INTERLEUKIN 2
Descriptor: INTERLEUKIN-2
Authors:Mott, H.R, Baines, B.S, Hall, R.M, Cooke, R.M, Driscoll, P.C, Weir, M.P, Campbell, I.D.
Deposit date:1995-08-25
Release date:1995-12-07
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:The solution structure of the F42A mutant of human interleukin 2.
J.Mol.Biol., 247, 1995
1CF4
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BU of 1cf4 by Molmil
CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN (ACTIVATED P21CDC42HS KINASE), ...
Authors:Mott, H.R, Owen, D, Nietlispach, D, Lowe, P.N, Lim, L, Laue, E.D.
Deposit date:1999-03-23
Release date:1999-06-18
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.
Nature, 399, 1999
1FAR
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BU of 1far by Molmil
RAF-1 CYSTEINE RICH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: RAF-1, ZINC ION
Authors:Mott, H.R, Campbell, S.L.
Deposit date:1996-09-05
Release date:1997-01-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.
Proc.Natl.Acad.Sci.USA, 93, 1996
1FAQ
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BU of 1faq by Molmil
RAF-1 CYSTEINE RICH DOMAIN, NMR, 27 STRUCTURES
Descriptor: RAF-1, ZINC ION
Authors:Mott, H.R, Campbell, S.L.
Deposit date:1996-09-05
Release date:1997-01-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.
Proc.Natl.Acad.Sci.USA, 93, 1996
3ZPK
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BU of 3zpk by Molmil
Atomic-resolution structure of a quadruplet cross-beta amyloid fibril.
Descriptor: TRANSTHYRETIN
Authors:Fitzpatrick, A.W.P, Debelouchina, G.T, Bayro, M.J, Clare, D.K, Caporini, M.A, Bajaj, V.S, Jaroniec, C.P, Wang, L, Ladizhansky, V, Muller, S.A, MacPhee, C.E, Waudby, C.A, Mott, H.R, de Simone, A, Knowles, T.P.J, Saibil, H.R, Vendruscolo, M, Orlova, E.V, Griffin, R.G, Dobson, C.M.
Deposit date:2013-02-28
Release date:2013-12-04
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY, SOLID-STATE NMR
Cite:Atomic Structure and Hierarchical Assembly of a Cross-Beta Amyloid Fibril.
Proc.Natl.Acad.Sci.USA, 110, 2013
5M4T
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BU of 5m4t by Molmil
C-terminal domain structure of VSG M1.1
Descriptor: Variant surface glycoprotein MITAT 1.1
Authors:Jones, N.G, Mott, H.R, Carrington, M.
Deposit date:2016-10-19
Release date:2017-09-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.
Nat Microbiol, 2, 2017
7NQC
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BU of 7nqc by Molmil
Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane targeting motifs
Descriptor: CALCIUM ION, Calmodulin-1, PRO-ASN-GLY-LYS-LYS-LYS-ARG-LYS-SER-LEU-ALA-LYS-ARG-ILE-ARG-GLU-ARG-CMF, ...
Authors:Chamberlain, S.G, Owen, D, Mott, H.R.
Deposit date:2021-03-01
Release date:2021-09-22
Method:SOLUTION NMR
Cite:Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs.
Proc.Natl.Acad.Sci.USA, 118, 2021
5FRG
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BU of 5frg by Molmil
The NMR Structure of the Cdc42-interacting region of TOCA1
Descriptor: FORMIN-BINDING PROTEIN 1-LIKE
Authors:Watson, J.R, Nietlispach, D, Owen, D, Mott, H.R.
Deposit date:2015-12-17
Release date:2016-05-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Investigation of the Interaction between Cdc42 and its Effector Toca1: Handover of Cdc42 to the Actin Regulator N-Wasp is Facilitated by Differential Binding Affinities.
J.Biol.Chem., 291, 2016
1S4Z
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BU of 1s4z by Molmil
HP1 chromo shadow domain in complex with PXVXL motif of CAF-1
Descriptor: Chromatin assembly factor 1 subunit A, Chromobox protein homolog 1
Authors:Thiru, A, Nietlispach, D, Mott, H.R, Okuwaki, M, Lyon, D, Nielsen, P.R, Hirshberg, M, Verreault, A, Murzina, N.V, Laue, E.D.
Deposit date:2004-01-19
Release date:2004-03-23
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin.
Embo J., 23, 2004
2M5K
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BU of 2m5k by Molmil
Atomic-resolution structure of a doublet cross-beta amyloid fibril
Descriptor: Transthyretin
Authors:Fitzpatrick, A.W.P, Debelouchina, G.T, Bayro, M.J, Clare, D.K, Caporini, M.A, Bajaj, V.S, Jaroniec, C.P, Wang, L, Ladizhansky, V, Muller, S, MacPhee, C.E, Waudby, C.A, Mott, H.R, de Simone, A, Knowles, T.P.J, Saibil, H.R, Vendruscolo, M, Orlova, E.V, Griffin, R.G, Dobson, C.M.
Deposit date:2013-02-27
Release date:2013-12-04
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (12.7 Å), SOLID-STATE NMR
Cite:Atomic structure and hierarchical assembly of a cross-beta amyloid fibril.
Proc.Natl.Acad.Sci.USA, 110, 2013
2M5N
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BU of 2m5n by Molmil
Atomic-resolution structure of a cross-beta protofilament
Descriptor: Transthyretin
Authors:Fitzpatrick, A.W.P, Debelouchina, G.T, Bayro, M.J, Clare, D.K, Caporini, M.A, Bajaj, V.S, Jaroniec, C.P, Wang, L, Ladizhansky, V, Muller, S, MacPhee, C.E, Waudby, C.A, Mott, H.R, de Simone, A, Knowles, T.P.J, Saibil, H.R, Vendruscolo, M, Orlova, E.V, Griffin, R.G, Dobson, C.M.
Deposit date:2013-02-27
Release date:2013-07-17
Last modified:2023-06-14
Method:SOLID-STATE NMR
Cite:Atomic structure and hierarchical assembly of a cross-{beta} amyloid fibril.
Proc.Natl.Acad.Sci.USA, 110, 2013
2M5M
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BU of 2m5m by Molmil
Atomic-resolution structure of a triplet cross-beta amyloid fibril
Descriptor: Transthyretin
Authors:Fitzpatrick, A.W.P, Debelouchina, G.T, Bayro, M.J, Clare, D.K, Caporini, M.A, Bajaj, V.S, Jaroniec, C.P, Wang, L, Ladizhansky, V, Muller, S, MacPhee, C.E, Waudby, C.A, Mott, H.R, de Simone, A, Knowles, T.P.J, Saibil, H.R, Vendruscolo, M, Orlova, E.V, Griffin, R.G, Dobson, C.M.
Deposit date:2013-02-27
Release date:2013-12-04
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (12.2 Å), SOLID-STATE NMR
Cite:Atomic structure and hierarchical assembly of a cross-beta amyloid fibril.
Proc.Natl.Acad.Sci.USA, 110, 2013
2RMK
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BU of 2rmk by Molmil
Rac1/PRK1 Complex
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1, ...
Authors:Modha, R, Campbell, L.J, Nietlispach, D, Buhecha, H.R, Owen, D, Mott, H.R.
Deposit date:2007-10-25
Release date:2007-11-13
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:The Rac1 Polybasic Region Is Required for Interaction with Its Effector PRK1
J.Biol.Chem., 283, 2008
1URF
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BU of 1urf by Molmil
HR1b domain from PRK1
Descriptor: PROTEIN KINASE C-LIKE 1
Authors:Owen, D, Lowe, P.N, Nietlispach, D, Brosnan, C.E, Chirgadze, D.Y, Parker, P.J, Blundell, T.L, Mott, H.R.
Deposit date:2003-10-29
Release date:2003-11-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Molecular Dissection of the Interaction between the Small G Proteins Rac1 and Rhoa and Protein Kinase C-Related Kinase 1 (Prk1)
J.Biol.Chem., 278, 2003
1UQV
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BU of 1uqv by Molmil
SAM domain from Ste50p
Descriptor: STE50 PROTEIN
Authors:Grimshaw, S.J, Mott, H.R, Stott, K.M, Nielsen, P.R, Evetts, K.A, Hopkins, L.J, Nietlispach, D, Owen, D.
Deposit date:2003-10-20
Release date:2003-10-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Sterile {Alpha} Motif (Sam) Domain of the Saccharomyces Cerevisiae Mitogen-Activated Protein Kinase Pathway-Modulating Protein Ste50 and Analysis of its Interaction with the Ste11 Sam
J.Biol.Chem., 279, 2004
1XU6
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BU of 1xu6 by Molmil
Structure of the C-terminal domain from Trypanosoma brucei Variant Surface Glycoprotein MITat1.2
Descriptor: Variant surface glycoprotein MITAT 1.2
Authors:Chattopadhyay, A, Jones, N.G, Nietlispach, D, Nielsen, P.R, Voorheis, H.P, Mott, H.R, Carrington, M.
Deposit date:2004-10-25
Release date:2004-11-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2
J.Biol.Chem., 280, 2004
6R28
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BU of 6r28 by Molmil
Structure of peptide P7, which binds Cdc42 and inhibits effector interactions.
Descriptor: peptide P7
Authors:Murphy, N.P, Mott, H.R, Owen, D.
Deposit date:2019-03-15
Release date:2020-01-29
Last modified:2024-03-06
Method:SOLUTION NMR
Cite:The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling.
J.Biol.Chem., 295, 2020
2MBG
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BU of 2mbg by Molmil
Rlip76 (gap-gbd)
Descriptor: RalA-binding protein 1
Authors:Rajasekar, K.V, Campbell, L.J, Nietlispach, D, Owen, D, Mott, H.R.
Deposit date:2013-07-30
Release date:2013-12-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane.
Structure, 21, 2013
2JWH
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BU of 2jwh by Molmil
Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein
Descriptor: Variant surface glycoprotein ILTAT 1.24
Authors:Jones, N.G, Nietlispach, D, Sharma, R, Burke, D.F, Eyres, I, Mues, M, Mott, H.R, Carrington, M.
Deposit date:2007-10-12
Release date:2007-11-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein
J.Biol.Chem., 283, 2008
2JWG
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BU of 2jwg by Molmil
Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein
Descriptor: Variant surface glycoprotein ILTAT 1.24
Authors:Jones, N.G, Nietlispach, D, Sharma, R, Burke, D.F, Eyres, I, Mues, M, Mott, H.R, Carrington, M.
Deposit date:2007-10-12
Release date:2007-11-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein
J.Biol.Chem., 283, 2008
2K9A
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BU of 2k9a by Molmil
The Solution Structure of the Arl2 Effector, BART
Descriptor: ADP-ribosylation factor-like protein 2-binding protein
Authors:Bailey, L.K, Campbell, L.J, Evetts, K.A, Littlefield, K, Rajendra, E, Nietlispach, D, Owen, D, Mott, H.R.
Deposit date:2008-10-06
Release date:2008-11-11
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:The Structure of Binder of Arl2 (BART) Reveals a Novel G Protein Binding Domain: IMPLICATIONS FOR FUNCTION.
J.Biol.Chem., 284, 2009
2KE5
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BU of 2ke5 by Molmil
Solution structure and dynamics of the small GTPase Ralb in its active conformation: significance for effector protein binding
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Ral-B
Authors:Fenwick, R, Prasannan, S, Campbell, L.J, Nietlispach, D, Evetts, K.A, Camonis, J, Mott, H.R, Owen, D.
Deposit date:2009-01-23
Release date:2009-02-17
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding
Biochemistry, 48, 2009
2KWH
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BU of 2kwh by Molmil
Ral binding domain of RLIP76 (RalBP1)
Descriptor: RalA-binding protein 1
Authors:Fenwick, R.B, Campbell, L.J, Rajasekar, K, Prasannan, S, Nietlispach, D, Camonis, J, Owen, D, Mott, H.R.
Deposit date:2010-04-12
Release date:2010-09-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction
Structure, 18, 2010

 

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