Author results

2RJP
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CRYSTAL STRUCTURE OF ADAMTS4 WITH INHIBITOR BOUND
Descriptor:ADAMTS-4, ZINC ION, CALCIUM ION, ...
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-15
Release date:2007-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
2RJQ
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CRYSTAL STRUCTURE OF ADAMTS5 WITH INHIBITOR BOUND
Descriptor:ADAMTS-5, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-15
Release date:2007-12-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
3B2Z
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CRYSTAL STRUCTURE OF ADAMTS4 (APO FORM)
Descriptor:ADAMTS-4, ZINC ION, CALCIUM ION
Authors:Mosyak, L., Stahl, M., Somers, W.
Deposit date:2007-10-19
Release date:2007-12-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
1F46
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THE BACTERIAL CELL-DIVISION PROTEIN ZIPA AND ITS INTERACTION WITH AN FTSZ FRAGMENT REVEALED BY X-RAY CRYSTALLOGRAPHY
Descriptor:CELL DIVISION PROTEIN ZIPA
Authors:Mosyak, L., Zhang, Y., Glasfeld, E., Stahl, M., Somers, W.S.
Deposit date:2000-06-07
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.
EMBO J., 19, 2000
1F47
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THE BACTERIAL CELL-DIVISION PROTEIN ZIPA AND ITS INTERACTION WITH AN FTSZ FRAGMENT REVEALED BY X-RAY CRYSTALLOGRAPHY
Descriptor:CELL DIVISION PROTEIN ZIPA, CELL DIVISION PROTEIN FTSZ
Authors:Mosyak, L., Zhang, Y., Glasfeld, E., Stahl, M., Somers, W.S.
Deposit date:2000-06-07
Release date:2001-06-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.
EMBO J., 19, 2000
2ID5
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CRYSTAL STRUCTURE OF THE LINGO-1 ECTODOMAIN
Descriptor:Leucine rich repeat neuronal 6A, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Mosyak, L., Wood, A., Dwyer, B., Johnson, M., Stahl, M.L., Somers, W.S.
Deposit date:2006-09-14
Release date:2006-09-26
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.
J.Biol.Chem., 281, 2006
5FCS
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DIABODY
Descriptor:Diabody, SULFATE ION
Authors:Mosyak, L., Root, A.
Deposit date:2015-12-15
Release date:2016-12-14
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer
Antibodies, 2016
1PYS
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PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS
Descriptor:PHENYLALANYL-TRNA SYNTHETASE, MAGNESIUM ION
Authors:Safro, M., Mosyak, L., Goldgur, Y., Reshetnikova, L., Delarue, M.
Deposit date:1996-11-14
Release date:1997-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus.
Nat.Struct.Biol., 2, 1995
1HDM
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HISTOCOMPATIBILITY ANTIGEN HLA-DM
Descriptor:PROTEIN (CLASS II HISTOCOMPATIBILITY ANTIGEN, M ALPHA CHAIN), M BETA CHAIN)
Authors:Wiley, D.C., Mosyak, L.
Deposit date:1998-09-09
Release date:1999-09-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.
Immunity, 9, 1998
1Y2F
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CRYSTAL STRUCTURE OF ZIPA WITH AN INHIBITOR
Descriptor:Cell division protein zipA, 4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE
Authors:Mosyak, L., Rush, T.S.
Deposit date:2004-11-22
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction
J.Med.Chem., 48, 2005
1Y2G
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CRYSTAL STRUCTURE OF ZIPA IN COMPLEX WITH AN INHIBITOR
Descriptor:Cell division protein zipA, N-METHYL-N-[3-(6-PHENYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-3-YL)PHENYL]ACETAMIDE
Authors:Mosyak, L., Rush, T.S.
Deposit date:2004-11-22
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction
J.Med.Chem., 48, 2005
1SQ0
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CRYSTAL STRUCTURE OF THE COMPLEX OF THE WILD-TYPE VON WILLEBRAND FACTOR A1 DOMAIN AND GLYCOPROTEIN IB ALPHA AT 2.6 ANGSTROM RESOLUTION
Descriptor:Von Willebrand factor (vWF) [Contains: Von Willebrand antigen II], Platelet glycoprotein Ib alpha chain (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (CD42B-alpha) (CD42B) [Contains: Glycocalicin]
Authors:Dumas, J.J., Kumar, R., McDonagh, T., Sullivan, F., Stahl, M.L., Somers, W.S., Mosyak, L.
Deposit date:2004-03-17
Release date:2004-04-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations
J.Biol.Chem., 279, 2004
1EIY
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THE CRYSTAL STRUCTURE OF PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH COGNATE TRNAPHE
Descriptor:TRNA(PHE), PHENYLALANYL-TRNA SYNTHETASE
Authors:Goldgur, Y., Mosyak, L., Reshetnikova, L., Ankilova, V., Safro, M.
Deposit date:2000-02-29
Release date:2000-03-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe.
Structure, 5, 1997
1S1E
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CRYSTAL STRUCTURE OF KV CHANNEL-INTERACTING PROTEIN 1 (KCHIP-1)
Descriptor:Kv channel interacting protein 1, CALCIUM ION
Authors:Scannevin, R.H., Wang, K.-W., Jow, F., Megules, J., Kopsco, D.C., Edris, W., Carroll, K.C., Lu, Q., Xu, W.-X., Xu, Z.-B., Katz, A.H., Olland, S., Lin, L., Taylor, M., Stahl, M., Malakian, K., Somers, W., Mosyak, L., Bowlby, M.R., Chanda, P., Rhodes, K.J.
Deposit date:2004-01-06
Release date:2005-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron, 41, 2004
1S1G
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CRYSTAL STRUCTURE OF KV4.3 T1 DOMAIN
Descriptor:Potassium voltage-gated channel subfamily D member 3, ZINC ION
Authors:Scannevin, R.H., Wang, K.W., Jow, F., Megules, J., Kopsco, D.C., Edris, W., Carroll, K.C., Lu, Q., Xu, W.X., Xu, Z.B., Katz, A.H., Olland, S., Lin, L., Taylor, M., Stahl, M., Malakian, K., Somers, W., Mosyak, L., Bowlby, M.R., Chanda, P., Rhodes, K.J.
Deposit date:2004-01-06
Release date:2004-03-23
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Neuron, 41, 2004
4J12
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MONOMERIC FC
Descriptor:human Fc fragment, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Ishino, T., Wang, M., Mosyak, L., Tam, A., Duan, W., Svenson, K., Joyce, A., O'Hara, D., Lin, L., Somers, W., Kriz, R.
Deposit date:2013-01-31
Release date:2013-05-01
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics.
J.Biol.Chem., 288, 2013
4GLR
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STRUCTURE OF THE ANTI-PTAU FAB (PT231/PS235_1) IN COMPLEX WITH PHOSPHOEPITOPE PT231/PS235
Descriptor:phospho-peptide, anti-ptau heavy chain, anti-ptau light chain, ...
Authors:Tu, C., Mosyak, L., Bard, J.
Deposit date:2012-08-14
Release date:2012-11-21
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition.
J.Biol.Chem., 287, 2012
4K3V
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STRUCTURE OF STAPHYLOCOCCUS AUREUS MNTC
Descriptor:ABC superfamily ATP binding cassette transporter, binding protein, MANGANESE (II) ION
Authors:Parris, K.D., Mosyak, L.
Deposit date:2013-04-11
Release date:2013-07-17
Last modified:2013-09-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-Dimensional Structure and Biophysical Characterization of Staphylococcus aureus Cell Surface Antigen-Manganese Transporter MntC.
J.Mol.Biol., 425, 2013
5C2B
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ANTI-CXCL13 PARENTAL SCFV - 3B4
Descriptor:scFv 3B4 heavy chain, 3B4 light chain, CHLORIDE ION
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-15
Release date:2015-11-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.4049 Å)
Cite:Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair
To Be Published
5C6W
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ANTI-CXCL13 SCFV - E10
Descriptor:Protein IGHV1-69-2,Ig lambda chain V-II region NIG-84, CHLORIDE ION, SULFATE ION, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-23
Release date:2015-11-04
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Optimization of a scFv-based biotherapeutic by CDR side-chain clash repair
To Be Published
5CBA
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3B4 IN COMPLEX WITH CXCL13 - 3B4-CXCL13
Descriptor:3b4 heavy chain, 3b4 light chain, C-X-C motif chemokine 13, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J. Biol. Chem., 291, 2016
5CBE
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E10 IN COMPLEX WITH CXCL13
Descriptor:E10 heavy chain, E10 light chain, C-X-C motif chemokine 13, ...
Authors:Tu, C., Bard, J., Mosyak, L.
Deposit date:2015-06-30
Release date:2015-11-04
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J. Biol. Chem., 291, 2016
5HDQ
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MNTC CO-STRUCTURE WITH MAB 305-78-7
Descriptor:ABC transporter substrate-binding protein, Fab Heavy Chain, Fab Light Chain, ...
Authors:Parris, K., Mosyak, L.
Deposit date:2016-01-05
Release date:2016-09-21
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:High Resolution Mapping of Bactericidal Monoclonal Antibody Binding Epitopes on Staphylococcus aureus Antigen MntC.
Plos Pathog., 12, 2016
1F7W
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SOLUTION STRUCTURE OF C-TERMINAL DOMAIN ZIPA
Descriptor:CELL DIVISION PROTEIN ZIPA
Authors:Moy, F.J., Glasfeld, E., Mosyak, L., Powers, R.
Deposit date:2000-06-28
Release date:2001-06-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of ZipA, a crucial component of Escherichia coli cell division.
Biochemistry, 39, 2000
1F7X
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SOLUTION STRUCTURE OF C-TERMINAL DOMAIN ZIPA
Descriptor:CELL DIVISION PROTEIN ZIPA
Authors:Moy, F.J., Glasfeld, E., Mosyak, L., Powers, R.
Deposit date:2000-06-28
Release date:2001-06-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of ZipA, a crucial component of Escherichia coli cell division.
Biochemistry, 39, 2000
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