Author results

1NYF
  • Download 1nyf
  • View 1nyf
Molmil generated image of 1nyf
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE
Descriptor:FYN
Authors:Morton, C.J., Pugh, D.J.R., Campbell, I.D.
Deposit date:1996-04-22
Release date:1996-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and peptide binding of the SH3 domain from human Fyn.
Structure, 4, 1996
1NYG
  • Download 1nyg
  • View 1nyg
Molmil generated image of 1nyg
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, FAMILY OF 20 STRUCTURES
Descriptor:FYN
Authors:Morton, C.J., Pugh, D.J.R., Campbell, I.D.
Deposit date:1996-04-22
Release date:1996-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and peptide binding of the SH3 domain from human Fyn.
Structure, 4, 1996
3CWL
  • Download 3cwl
  • View 3cwl
Molmil generated image of 3cwl
CRYSTAL STRUCTURE OF ALPHA-1-ANTITRYPSIN, CRYSTAL FORM B
Descriptor:Alpha-1-antitrypsin, CHLORIDE ION
Authors:Morton, C.J., Hansen, G., Feil, S.C., Adams, J.J., Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
3CWM
  • Download 3cwm
  • View 3cwm
Molmil generated image of 3cwm
CRYSTAL STRUCTURE OF ALPHA-1-ANTITRYPSIN COMPLEXED WITH CITRATE
Descriptor:Alpha-1-antitrypsin, CITRIC ACID
Authors:Morton, C.J., Hansen, G., Feil, S.C., Adams, J.J., Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
3VDD
  • Download 3vdd
  • View 3vdd
Molmil generated image of 3vdd
STRUCTURE OF HRV2 CAPSID COMPLEXED WITH ANTIVIRAL COMPOUND BTA798
Descriptor:Protein VP1, Protein VP2, Protein VP3, ...
Authors:Morton, C.J., Feil, S.C., Parker, M.W.
Deposit date:2012-01-05
Release date:2012-09-12
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.
ACS Med Chem Lett, 3, 2012
5IMT
  • Download 5imt
  • View 5imt
Molmil generated image of 5imt
TOXIN RECEPTOR COMPLEX
Descriptor:Intermedilysin, CD59 glycoprotein, TRIETHYLENE GLYCOL, ...
Authors:Morton, C.J., Lawrence, S.L., Feil, S.C., Parker, M.W.
Deposit date:2016-03-06
Release date:2016-08-24
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.7001 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
1A0N
  • Download 1a0n
  • View 1a0n
Molmil generated image of 1a0n
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES
Descriptor:PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR, FYN
Authors:Renzoni, D.A., Pugh, D.J.R., Siligardi, G., Das, P., Morton, C.J., Rossi, C., Waterfield, M.D., Campbell, I.D., Ladbury, J.E.
Deposit date:1997-12-05
Release date:1998-02-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry, 35, 1996
1AZG
  • Download 1azg
  • View 1azg
Molmil generated image of 1azg
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE
Descriptor:PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR, FYN
Authors:Renzoni, D.A., Pugh, D.J.R., Siligardi, G., Das, P., Morton, C.J., Rossi, C., Waterfield, M.D., Campbell, I.D., Ladbury, J.E.
Deposit date:1997-11-18
Release date:1998-02-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry, 35, 1996
1AOT
  • Download 1aot
  • View 1aot
Molmil generated image of 1aot
NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE
Descriptor:FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE
Authors:Mulhern, T.D., Shaw, G.L., Morton, C.J., Day, A.J., Campbell, I.D.
Deposit date:1997-07-10
Release date:1998-01-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997
1AOU
  • Download 1aou
  • View 1aou
Molmil generated image of 1aou
NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES
Descriptor:FYN PROTEIN-TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE
Authors:Mulhern, T.D., Shaw, G.L., Morton, C.J., Day, A.J., Campbell, I.D.
Deposit date:1997-07-10
Release date:1998-01-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Structure, 5, 1997
1OWT
  • Download 1owt
  • View 1owt
Molmil generated image of 1owt
STRUCTURE OF THE ALZHEIMER'S DISEASE AMYLOID PRECURSOR PROTEIN COPPER BINDING DOMAIN
Descriptor:Amyloid beta A4 protein
Authors:Barnham, K.J., McKinstry, W.J., Multhaup, G., Galatis, D., Morton, C.J., Curtain, C.C., Williamson, N.A., White, A.R., Hinds, M.G., Norton, R.S., Beyreuther, K., Masters, C.L., Parker, M.W., Cappai, R.
Deposit date:2003-03-30
Release date:2003-05-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain. A REGULATOR OF NEURONAL COPPER HOMEOSTASIS.
J.Biol.Chem., 278, 2003
2A2R
  • Download 2a2r
  • View 2a2r
Molmil generated image of 2a2r
CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE PI IN COMPLEX WITH S-NITROSOGLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, ...
Authors:Parker, L.J., Morton, C.J., Adams, J.J., Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
2A2S
  • Download 2a2s
  • View 2a2s
Molmil generated image of 2a2s
CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE IN COMPLEX WITH S-NITROSOGLUTATHIONE IN THE ABSENCE OF REDUCING AGENT
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, ...
Authors:Parker, L.J., Morton, C.J., Adams, J.J., Parker, M.W.
Deposit date:2005-06-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1
Protein Sci., 15, 2006
2QUG
  • Download 2qug
  • View 2qug
Molmil generated image of 2qug
CRYSTAL STRUCTURE OF ALPHA-1-ANTITRYPSIN, CRYSTAL FORM A
Descriptor:Alpha-1-antitrypsin
Authors:Hansen, G., Morton, C.J., Pearce, M.C., Feil, S.C., Adams, J.J., Parker, M.W., Bottomley, S.P.
Deposit date:2007-08-05
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
4P8Q
  • Download 4p8q
  • View 4p8q
Molmil generated image of 4p8q
CRYSTAL STRUCTURE OF HUMAN INSULIN REGULATED AMINOPEPTIDASE WITH ALANINE IN ACTIVE SITE
Descriptor:Leucyl-cystinyl aminopeptidase, ZINC ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hermans, S.J., Ascher, D.B., Hancock, N.C., Holien, J.K., Michell, B., Morton, C.J., Parker, M.W.
Deposit date:2014-03-31
Release date:2014-12-03
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Protein Sci., 24, 2015
4PJ6
  • Download 4pj6
  • View 4pj6
Molmil generated image of 4pj6
CRYSTAL STRUCTURE OF HUMAN INSULIN REGULATED AMINOPEPTIDASE WITH LYSINE IN ACTIVE SITE
Descriptor:Leucyl-cystinyl aminopeptidase, ZINC ION, LYSINE, ...
Authors:Hermans, S.J., Ascher, D.B., Hancock, N.C., Holien, J.K., Michell, B., Morton, C.J., Parker, M.W.
Deposit date:2014-05-12
Release date:2014-12-03
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Protein Sci., 24, 2015
5DAK
  • Download 5dak
  • View 5dak
Molmil generated image of 5dak
CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE PI COMPLEXED WITH A METALLOID IN THE ABSENCE OF GLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ARSENIC
Authors:Parker, L.J., Parker, M.W., Morton, C.J.
Deposit date:2015-08-20
Release date:2016-12-07
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
5DAL
  • Download 5dal
  • View 5dal
Molmil generated image of 5dal
CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE TRANSFERASE PI COMPLEXED WITH A METALLOID IN THE PRESENCE OF GLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Di-glutathione-PhenylArsine, ...
Authors:Parker, L.J., Parker, M.W., Morton, C.J.
Deposit date:2015-08-20
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
5DCG
  • Download 5dcg
  • View 5dcg
Molmil generated image of 5dcg
CRYSTAL STRUCTURE OF WT APO HUMAN GLUTATHIONE TRANSFERASE PI
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHOSPHATE ION, ...
Authors:Parker, L.J., Parker, M.W., Morton, C.J.
Deposit date:2015-08-24
Release date:2016-12-07
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
5DDL
  • Download 5ddl
  • View 5ddl
Molmil generated image of 5ddl
CRYSTAL STRUCTURE OF WT HUMAN GLUTATHIONE TRANSFERASE PI SOAKED WITH A METALLOID THEN BACK-SOAKED WITH GLUTATHIONE
Descriptor:Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Di-glutathione-PhenylArsine, ...
Authors:Parker, L.J., Parker, M.W., Morton, C.J.
Deposit date:2015-08-25
Release date:2016-10-26
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Visualisation of Organoarsenic Human Glutathione Transferase P1-1 Complexes: Metabolism of Arsenic-based Therapeutics
To Be Published
5IMW
  • Download 5imw
  • View 5imw
Molmil generated image of 5imw
TRAPPED TOXIN
Descriptor:Intermedilysin
Authors:Lawrence, S.L., Feil, S.C., Morton, C.J., Parker, M.W.
Deposit date:2016-03-07
Release date:2016-08-24
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
5IMY
  • Download 5imy
  • View 5imy
Molmil generated image of 5imy
TRAPPED TOXIN
Descriptor:Vaginolysin, CD59 glycoprotein
Authors:Lawrence, S.L., Morton, C.J., Parker, M.W.
Deposit date:2016-03-07
Release date:2016-08-24
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
5TLQ
  • Download 5tlq
  • View 5tlq
Molmil generated image of 5tlq
MODEL STRUCTURE OF THE OXIDIZED PADSBA1 AND 3-[(2-METHYLBENZYL)SULFANYL]-4H-1,2,4-TRIAZOL-4-AMINE COMPLEX
Descriptor:Thiol:disulfide interchange protein DsbA, 3-[(2-methylbenzyl)sulfanyl]-4H-1,2,4-triazol-4-amine
Authors:Mohanty, B., Rimmer, K.A., McMahon, R.M., Headey, S.J., Vazirani, M., Shouldice, S.R., Coincon, M., Tay, S., Morton, C.J., Simpson, J.S., Martin, J.L., Scanlon, M.S.
Deposit date:2016-10-11
Release date:2017-04-12
Method:SOLUTION NMR
Cite:Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1.
PLoS ONE, 12, 2017
4ZGH
  • Download 4zgh
  • View 4zgh
Molmil generated image of 4zgh
STRUCTURE OF SUGAR BINDING PROTEIN PNEUMOLYSIN
Descriptor:Pneumolysin, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Parker, M.W., Feil, S.C., Morton, C.
Deposit date:2015-04-23
Release date:2016-03-09
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Sci Rep, 5, 2015
1NXJ
  • Download 1nxj
  • View 1nxj
Molmil generated image of 1nxj
STRUCTURE OF RV3853 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable S-adenosylmethionine:2-demethylmenaquinone methyltransferase, GLYOXYLIC ACID, L(+)-TARTARIC ACID
Authors:Johnston, J.M., Arcus, V.L., Baker, E.N., TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-02-10
Release date:2003-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural Analysis
J.Bacteriol., 185, 2003
<123>