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6GL8
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CRYSTAL STRUCTURE OF BCL-2 IN COMPLEX WITH THE NOVEL ORALLY ACTIVE INHIBITOR S55746
Descriptor:Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
Authors:Casara, P., Davidson, J., Claperon, A., Le Toumelin-Braizat, G., Vogler, M., Bruno, A., Chanrion, M., Lysiak-Auvity, G., Le Diguarher, T., Starck, J.B., Chen, I., Whitehead, N., Graham, C., Matassova, N., Dokurno, P., Pedder, C., Wang, Y., Qiu, S., Girard, A.M., Schneider, E., Grave, F., Studeny, A., Guasconi, G., Rocchetti, F., Maiga, S., Henlin, J.M., Colland, F., Kraus-Berthier, L., Le Gouill, S., Dyer, M.J.S., Hubbard, R., Wood, M., Amiot, M., Cohen, G.M., Hickman, J.A., Morris, E., Murray, J., Geneste, O.
Deposit date:2018-05-23
Release date:2018-11-07
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.
Oncotarget, 9, 2018
6EU0
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RNA POLYMERASE III OPEN PRE-INITIATION COMPLEX (OC-PIC)
Descriptor:DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC2, DNA-directed RNA polymerases I and III subunit RPAC1, ...
Authors:Abascal-Palacios, G., Ramsay, E.P., Beuron, F., Morris, E., Vannini, A.
Deposit date:2017-10-27
Release date:2018-01-17
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of RNA polymerase III transcription initiation.
Nature, 553, 2018
6EU1
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RNA POLYMERASE III - OPEN DNA COMPLEX (OC-POL3)
Descriptor:DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC2, DNA-directed RNA polymerases I and III subunit RPAC1, ...
Authors:Abascal-Palacios, G., Ramsay, E.P., Beuron, F., Morris, E., Vannini, A.
Deposit date:2017-10-27
Release date:2018-01-17
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of RNA polymerase III transcription initiation.
Nature, 553, 2018
6EU2
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APO RNA POLYMERASE III - OPEN CONFORMATION (OPOL3)
Descriptor:DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC2, DNA-directed RNA polymerases I and III subunit RPAC1, ...
Authors:Abascal-Palacios, G., Ramsay, E.P., Beuron, F., Morris, E., Vannini, A.
Deposit date:2017-10-27
Release date:2018-01-17
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of RNA polymerase III transcription initiation.
Nature, 553, 2018
6EU3
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APO RNA POLYMERASE III - CLOSED CONFORMATION (CPOL3)
Descriptor:DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC2, DNA-directed RNA polymerases I and III subunit RPAC1, ...
Authors:Abascal-Palacios, G., Ramsay, E.P., Beuron, F., Morris, E., Vannini, A.
Deposit date:2017-10-27
Release date:2018-01-17
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of RNA polymerase III transcription initiation.
Nature, 553, 2018
2Y23
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CRYSTAL STRUCTURE OF THE MYOMESIN DOMAINS MY9-MY11
Descriptor:MYOMESIN, BETA-MERCAPTOETHANOL, 2-(2-METHOXYETHOXY)ETHANOL
Authors:Pinotsis, N., Chatziefthimiou, S.D., Wilmanns, M.
Deposit date:2010-12-13
Release date:2011-12-21
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Superhelical Architecture of the Myosin Filament-Linking Protein Myomesin with Unusual Elastic Properties.
Plos Biol., 10, 2012
2Y25
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CRYSTAL STRUCTURE OF THE MYOMESIN DOMAINS MY11-MY13
Descriptor:MYOMESIN
Authors:Pinotsis, N., Chatziefthimiou, S.D., Wilmanns, M.
Deposit date:2010-12-13
Release date:2011-12-21
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Superhelical Architecture of the Myosin Filament-Linking Protein Myomesin with Unusual Elastic Properties.
Plos Biol., 10, 2012
3RBS
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CRYSTAL STRUCTURE OF THE MYOMESIN DOMAINS 10 AND 11
Descriptor:Myomesin-1, BETA-MERCAPTOETHANOL, NITRATE ION
Authors:Chatziefthimiou, S.D., Pinotsis, N., Wilmanns, M.
Deposit date:2011-03-29
Release date:2012-03-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Superhelical architecture of the Myosin filament-linking protein myomesin with unusual elastic properties.
Plos Biol., 10, 2012
5JRT
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CRYSTAL STRUCTURE OF THE HUMAN TANKYRASE 2 (TNKS2) SAM DOMAIN (DH902/924RE)
Descriptor:Tankyrase-2
Authors:Guettler, S., Mariotti, L., Cronin, N.
Deposit date:2016-05-06
Release date:2016-08-03
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.
Mol.Cell, 63, 2016
5JTI
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CRYSTAL STRUCTURE OF THE HUMAN TANKYRASE 1 (TNKS) SAM DOMAIN (D1055R), CRYSTAL FORM 2
Descriptor:Tankyrase-1
Authors:Guetter, S., Mariotti, L., Cronin, N.
Deposit date:2016-05-09
Release date:2016-08-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.
Mol.Cell, 63, 2016
5JU5
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CRYSTAL STRUCTURE OF THE HUMAN TANKYRASE 1 (TNKS) SAM DOMAIN (D1055R), CRYSTAL FORM 1
Descriptor:Tankyrase-1
Authors:Guetter, S., Mariotti, L., Cronin, N.
Deposit date:2016-05-10
Release date:2016-08-03
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-beta-Catenin Signaling.
Mol.Cell, 63, 2016