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3HQN
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APO CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA(LMPYK)PYRUVATE KINASE
Descriptor:Pyruvate kinase, GLYCEROL, SULFATE ION, ...
Authors:Morgan, H.P., Walkinshaw, M.D.
Deposit date:2009-06-08
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
J.Biol.Chem., 285, 2010
3HQO
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CRYSTAL STRUCTURES OF LEISHMANIA MEXICANA PYRUVATE KINASE (LMPYK) IN COMPLEX WITH ATP AND OXALATE
Descriptor:Pyruvate kinase, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Morgan, H.P., Walkinshaw, M.D.
Deposit date:2009-06-08
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
J.Biol.Chem., 285, 2010
3HQP
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE (LMPYK) IN COMPLEX WITH ATP, OXALATE AND FRUCTOSE 2,6 BISPHOSPHATE
Descriptor:Pyruvate kinase, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Morgan, H.P., Walkinshaw, M.D.
Deposit date:2009-06-08
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
J.Biol.Chem., 285, 2010
3HQQ
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE (LMPYK) IN COMPLEX WITH FRUCTOSE 2,6 BISPHOSPHATE
Descriptor:Pyruvate kinase, FRUCTOSE-2,6-DIPHOSPHATE
Authors:Morgan, H.P., Walkinshaw, M.D.
Deposit date:2009-06-08
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (5.07 Å)
Cite:The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model
J.Biol.Chem., 285, 2010
3I2Z
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STRUCTURE OF COLD SHOCK PROTEIN E FROM SALMONELLA TYPHIMURIUM
Descriptor:RNA chaperone, negative regulator of cspA transcription
Authors:Morgan, H.P., McNae, I., Wear, M.A., Gallagher, M., Walkinshaw, M.D.
Deposit date:2009-06-30
Release date:2009-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium
Acta Crystallogr.,Sect.F, 65, 2009
3KTX
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE (LMPYK)IN COMPLEX WITH 1,3,6,8-PYRENETETRASULFONIC ACID
Descriptor:Pyruvate kinase, GLYCEROL, pyrene-1,3,6,8-tetrasulfonic acid
Authors:Morgan, H.P., Walkinshaw, M.D.
Deposit date:2009-11-26
Release date:2010-02-09
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase.
Acta Crystallogr.,Sect.F, 66, 2010
3OXU
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COMPLEMENT COMPONENTS FACTOR H CCP19-20 AND C3D IN COMPLEX
Descriptor:Complement C3, HF protein, GLYCEROL
Authors:Morgan, H.P., Schmidt, C.Q., Guariento, M., Gillespie, D., Herbert, A.P., Mertens, H., Blaum, B.S., Svergun, D., Johansson, C.M., Uhrin, D., Barlow, P.N., Hannan, J.P.
Deposit date:2010-09-22
Release date:2011-02-16
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for engagement by complement factor H of C3b on a self surface.
Nat.Struct.Mol.Biol., 18, 2011
3PP7
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE IN COMPLEX WITH THE DRUG SURAMIN, AN INHIBITOR OF GLYCOLYSIS.
Descriptor:Pyruvate kinase, pyrene-1,3,6,8-tetrasulfonic acid, GLYCEROL, ...
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2010-11-24
Release date:2010-12-15
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV6
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE(LMPYK)IN COMPLEX WITH ACID BLUE 80.
Descriptor:Pyruvate kinase, 3-({4-[(2,4-dimethyl-5-sulfophenyl)amino]-9,10-dioxo-9,10-dihydroanthracen-1-yl}amino)-2,4,6-trimethylbenzenesulfonic acid, POTASSIUM ION, ...
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV7
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE(LMPYK)IN COMPLEX WITH PONCEAU S AND ACID BLUE 25.
Descriptor:Pyruvate kinase, SULFATE ION, POTASSIUM ION, ...
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV8
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE(LMPYK)IN COMPLEX WITH BENZOTHIAZOLE-2,5-DISULFONIC ACID.
Descriptor:Pyruvate kinase, 1,3-benzothiazole-2,5-disulfonic acid, PHOSPHATE ION
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-06-29
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3QV9
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CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI PYRUVATE KINASE(TCPYK)IN COMPLEX WITH PONCEAU S.
Descriptor:Pyruvate kinase 2, POTASSIUM ION, PHOSPHATE ION, ...
Authors:Morgan, H.P., Auld, D.S., McNae, I.W., Nowicki, M.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-02-25
Release date:2011-07-06
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286, 2011
3R62
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STRUCTURE OF COMPLEMENT REGULATOR FACTOR H MUTANT, T1184R.
Descriptor:Complement factor H, GLYCEROL
Authors:Morgan, H.P., Jiang, J., Herbert, A.P., Kavanagh, D., Uhran, D., Barlow, P.N., Hannan, J.P.
Deposit date:2011-03-21
Release date:2011-06-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystallographic determination of the disease-associated T1184R variant of the complement Factor H.
Acta Crystallogr.,Sect.D, 67, 2011
3SRD
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HUMAN M2 PYRUVATE KINASE IN COMPLEX WITH FRUCTOSE 1-6 BISPHOSPHATE AND OXALATE.
Descriptor:Pyruvate kinase isozymes M1/M2, OXALATE ION, BETA-FRUCTOSE-1,6-DIPHOSPHATE, ...
Authors:Morgan, H.P., O'Reilly, F., Palmer, R., McNae, I.W., Nowicki, M.W., Wear, M.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Method:X-RAY DIFFRACTION (2.902 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRF
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HUMAN M1 PYRUVATE KINASE
Descriptor:Pyruvate kinase isozymes M1/M2, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Morgan, H.P., O'Reilly, F., Palmer, R., McNae, I.W., Nowicki, M.W., Wear, M.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRH
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HUMAN M2 PYRUVATE KINASE
Descriptor:Pyruvate kinase isozymes M1/M2, PHOSPHATE ION
Authors:Morgan, H.P., O'Reilly, F., Palmer, R., McNae, I.W., Nowicki, M.W., Wear, M.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-08-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosetric regulation of M2 pyruvate kinase.
To be Published
3SRK
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A NEW CLASS OF SUICIDE INHIBITOR BLOCKS NUCLEOTIDE BINDING TO PYRUVATE KINASE
Descriptor:Pyruvate kinase, 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, POTASSIUM ION, ...
Authors:Morgan, H.P., Walsh, M., Blackburn, E.A., Wear, M.A., Boxer, M., Shen, M., McNae, I.W., Michels, P.A.M., Auld, D.S., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2011-07-07
Release date:2012-07-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
To be Published
3SW0
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STRUCTURE OF THE C-TERMINAL REGION (MODULES 18-20) OF COMPLEMENT REGULATOR FACTOR H
Descriptor:Complement factor H, GLYCEROL, PHOSPHATE ION
Authors:Morgan, H.P., Guariento, M., Schmidt, C.Q., Barlow, P.N., Hannan, J.P.
Deposit date:2011-07-13
Release date:2012-03-14
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Analysis of the C-Terminal Region (Modules 18-20) of Complement Regulator Factor H (FH).
Plos One, 7, 2012
4KS0
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PYRUVATE KINASE (PYK) FROM TRYPANOSOMA CRUZI IN THE PRESENCE OF MAGNESIUM, OXALATE AND F26BP
Descriptor:Pyruvate kinase, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Morgan, H.P., Zhong, W., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-05-17
Release date:2014-11-19
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of pyruvate kinases display evolutionarily divergent allosteric strategies.
R Soc Open Sci, 1, 2014
3IS4
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA PYRUVATE KINASE (LMPYK)IN COMPLEX WITH 1,3,6,8-PYRENETETRASULFONIC ACID
Descriptor:Pyruvate kinase, GLYCEROL, pyrene-1,3,6,8-tetrasulfonic acid
Authors:Walkinshaw, M.D., Morgan, H.P.
Deposit date:2009-08-25
Release date:2010-03-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase
Acta Crystallogr.,Sect.F, 66, 2010
3RJ3
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COMPLEMENT COMPONENTS FACTOR H CCP19-20 (S1191L MUTANT) AND C3D IN COMPLEX
Descriptor:Complement C3d fragment, Complement Factor H-related protein 1, GLYCEROL
Authors:Morgan, H.P., Hannan, J.P.
Deposit date:2011-04-15
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and functional characterization of the product of disease-related factor h gene conversion.
Biochemistry, 51, 2012
4FXF
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STRUCTURE OF M2 PYRUVATE KINASE IN COMPLEX WITH PHENYLALANINE
Descriptor:Pyruvate kinase isozymes M1/M2, OXALATE ION, POTASSIUM ION, ...
Authors:Walkinshaw, M.D., Morgan, H.P.
Deposit date:2012-07-03
Release date:2013-03-27
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4FXJ
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STRUCTURE OF M2 PYRUVATE KINASE IN COMPLEX WITH PHENYLALANINE
Descriptor:Pyruvate kinase isozymes M1/M2, PHOSPHATE ION, PHENYLALANINE
Authors:Walkinshaw, M.D., Morgan, H.P.
Deposit date:2012-07-03
Release date:2013-03-27
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KRZ
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APO CRYSTAL STRUCTURE OF PYRUVATE KINASE (PYK) FROM TRYPANOSOMA CRUZI
Descriptor:Pyruvate kinase, POTASSIUM ION, GLYCEROL
Authors:Zhong, W., Morgan, H.P., McNae, I.W., Michels, P.A.M., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2013-05-17
Release date:2014-11-19
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of pyruvate kinases display evolutionarily divergent allosteric strategies.
R Soc Open Sci, 1, 2014
3IGY
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CRYSTAL STRUCTURES OF LEISHMANIA MEXICANA PHOSPHOGLYCERATE MUTASE AT HIGH COBALT CONCENTRATIONS
Descriptor:Cofactor-independent phosphoglycerate mutase, COBALT (II) ION, SODIUM ION, ...
Authors:Nowicki, M.W., Kuaprasert, B., McNae, I.W., Morgan, H.P., Harding, M.M., Michels, P.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Deposit date:2009-07-29
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
J.Mol.Biol., 394, 2009
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