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6APL
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BU of 6apl by Molmil
Crystal Structure of human ST6GALNAC2 in complex with CMP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2, CYTIDINE-5'-MONOPHOSPHATE
Authors:Forouhar, F, Moremen, K.W, Northeast Structural Genomics Consortium (NESG), Tong, L.
Deposit date:2017-08-17
Release date:2017-12-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Expression system for structural and functional studies of human glycosylation enzymes.
Nat. Chem. Biol., 14, 2018
6APJ
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BU of 6apj by Molmil
Crystal Structure of human ST6GALNAC2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Authors:Forouhar, F, Moremen, K.W, Northeast Structural Genomics Consortium (NESG), Tong, L.
Deposit date:2017-08-17
Release date:2017-12-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Expression system for structural and functional studies of human glycosylation enzymes.
Nat. Chem. Biol., 14, 2018
1NXC
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BU of 1nxc by Molmil
Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases)
Descriptor: CALCIUM ION, Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Tempel, W, Liu, Z.-J, Karaveg, K, Rose, J, Moremen, K.W, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2003-02-10
Release date:2004-05-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases
J.Biol.Chem., 279, 2004
7MU8
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BU of 7mu8 by Molmil
Structure of the minimally glycosylated human CEACAM1 N-terminal domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 1, GLYCEROL, ...
Authors:Belcher Dufrisne, M, Swope, N, Kieber, M, Yang, J.Y, Han, J, Li, J, Moremen, K.W, Prestegard, J.H, Columbus, L.
Deposit date:2021-05-14
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human CEACAM1 N-domain dimerization is independent from glycan modifications.
Structure, 30, 2022
1FMI
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BU of 1fmi by Molmil
CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE
Descriptor: CALCIUM ION, ENDOPLASMIC RETICULUM ALPHA-MANNOSIDASE I, SULFATE ION
Authors:Vallee, F, Karaveg, K, Herscovics, A, Moremen, K.W, Howell, P.L.
Deposit date:2000-08-17
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.
J.Biol.Chem., 275, 2000
1FO3
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BU of 1fo3 by Molmil
CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH KIFUNENSINE
Descriptor: ALPHA1,2-MANNOSIDASE, CALCIUM ION, KIFUNENSINE, ...
Authors:Vallee, F, Karaveg, K, Moremen, K.W, Herscovics, A, Howell, P.L.
Deposit date:2000-08-24
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.
J.Biol.Chem., 275, 2000
1FO2
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BU of 1fo2 by Molmil
CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH 1-DEOXYMANNOJIRIMYCIN
Descriptor: 1-DEOXYMANNOJIRIMYCIN, ALPHA1,2-MANNOSIDASE, CALCIUM ION, ...
Authors:Vallee, F, Karaveg, K, Moremen, K.W, Herscovics, A, Howell, P.L.
Deposit date:2000-08-24
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.
J.Biol.Chem., 275, 2000
4MPS
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BU of 4mps by Molmil
Crystal structure of rat Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1), Northeast Structural Genomics Consortium Target RnR367A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-galactoside alpha-2,6-sialyltransferase 1
Authors:Forouhar, F, Meng, L, Milaninia, S, Seetharaman, J, Su, M, Kornhaber, G, Montelione, G.T, Hunt, J.F, Moremen, K.W, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-09-13
Release date:2013-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Enzymatic Basis for N-Glycan Sialylation: STRUCTURE OF RAT alpha 2,6-SIALYLTRANSFERASE (ST6GAL1) REVEALS CONSERVED AND UNIQUE FEATURES FOR GLYCAN SIALYLATION.
J.Biol.Chem., 288, 2013
1X9D
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BU of 1x9d by Molmil
Crystal Structure Of Human Class I alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue
Descriptor: 1,4-BUTANEDIOL, CALCIUM ION, Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, ...
Authors:Karaveg, K, Tempel, W, Liu, Z.J, Siriwardena, A, Moremen, K.W, Wang, B.C.
Deposit date:2004-08-20
Release date:2005-02-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Mechanism of class 1 (glycosylhydrolase family 47) {alpha}-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control.
J.Biol.Chem., 280, 2005
2WZS
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BU of 2wzs by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482 in complex with Mannoimidazole
Descriptor: (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, CALCIUM ION, GLYCEROL, ...
Authors:Zhu, Y, Suits, M.D.L, Thompson, A, Chavan, S, Dinev, Z, Dumon, C, Smith, N, Moremen, K.W, Xiang, Y, Siriwardena, A, Williams, S.J, Gilbert, H.J, Davies, G.J.
Deposit date:2009-12-02
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
5FBH
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BU of 5fbh by Molmil
Crystal structure of the extracellular domain of human calcium sensing receptor with bound Gd3+
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ...
Authors:Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J.
Deposit date:2015-12-14
Release date:2016-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Sci Adv, 2, 2016
5FBK
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BU of 5fbk by Molmil
Crystal structure of the extracellular domain of human calcium sensing receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ...
Authors:Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J.
Deposit date:2015-12-14
Release date:2016-06-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.
Sci Adv, 2, 2016
5KIJ
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BU of 5kij by Molmil
Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase and Man9GlcNAc2-PA complex
Descriptor: 1,4-BUTANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, ...
Authors:Karaveg, K, Xiang, Y, Moremen, K.W.
Deposit date:2016-06-16
Release date:2017-05-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5KKB
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BU of 5kkb by Molmil
Structure of mouse Golgi alpha-1,2-mannosidase IA and Man9GlcNAc2-PA complex
Descriptor: 1,4-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ...
Authors:Xiang, Y, Moremen, K.W.
Deposit date:2016-06-21
Release date:2016-12-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.774 Å)
Cite:Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5KK7
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BU of 5kk7 by Molmil
Crystal structure of the class I human endoplasmic reticulum 1,2-alpha-mannosidase T688A mutant and Thio-disaccharide substrate analog complex
Descriptor: 1,4-BUTANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ACETATE ION, ...
Authors:Karaveg, K, Xiang, Y, Moremen, K.W.
Deposit date:2016-06-21
Release date:2017-05-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.7324 Å)
Cite:Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
6XFI
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BU of 6xfi by Molmil
Crystal Structures of beta-1,4-N-Acetylglucosaminyltransferase 2 (POMGNT2): Structural Basis for Inherited Muscular Dystrophies
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2, ...
Authors:Halmo, S.M, Yeh, J, Wells, L, Moremen, K.W, Lanzilotta, W.N.
Deposit date:2020-06-15
Release date:2021-04-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of beta-1,4-N-acetylglucosaminyltransferase 2: structural basis for inherited muscular dystrophies.
Acta Crystallogr D Struct Biol, 77, 2021
6XI2
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BU of 6xi2 by Molmil
Apo form of POMGNT2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA-ALA, ALA-GLY-ALA-GLY-ALA-ALA-ALA-ALA-ALA-ALA, ...
Authors:Halmo, S.M, Yeh, J, Wells, L, Moremen, K.W, Lanzilotta, W.N.
Deposit date:2020-06-19
Release date:2021-04-21
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal structures of beta-1,4-N-acetylglucosaminyltransferase 2: structural basis for inherited muscular dystrophies.
Acta Crystallogr D Struct Biol, 77, 2021
6CCI
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BU of 6cci by Molmil
The Crystal Structure of XOAT1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Alahuhta, P.M, Lunin, V.V.
Deposit date:2018-02-07
Release date:2019-02-20
Last modified:2020-09-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular Mechanism of Polysaccharide Acetylation by the Arabidopsis XylanO-acetyltransferase XOAT1.
Plant Cell, 32, 2020
7UQY
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BU of 7uqy by Molmil
Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with UDP-GlcA
Descriptor: Exostosin-1, Exostosin-2, URIDINE-5'-DIPHOSPHATE, ...
Authors:Li, H, Li, H.
Deposit date:2022-04-20
Release date:2022-09-28
Last modified:2023-05-17
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex.
Nat.Chem.Biol., 19, 2023
7UQX
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BU of 7uqx by Molmil
Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with UDP-GlcNAc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-1, Exostosin-2, ...
Authors:Li, H, Li, H.
Deposit date:2022-04-20
Release date:2022-09-28
Last modified:2023-05-17
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex.
Nat.Chem.Biol., 19, 2023
2WW3
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BU of 2ww3 by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482 in complex with thiomannobioside
Descriptor: CALCIUM ION, GLYCEROL, PUTATIVE ALPHA-1,2-MANNOSIDASE, ...
Authors:Suits, M.D.L, Zhu, Y, Thompson, A.J, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2010-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanistic Insights Into a Ca(2+)-Dependent Family of Alpha-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
2WW1
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BU of 2ww1 by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482 in complex with Thiomannobioside
Descriptor: PUTATIVE ALPHA-1,2-MANNOSIDASE, alpha-D-mannopyranose-(1-2)-methyl 2-thio-alpha-D-mannopyranoside
Authors:Suits, M.D.L, Zhu, Y, Thompson, A, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-12-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
2WVX
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BU of 2wvx by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482
Descriptor: CALCIUM ION, GLYCEROL, PUTATIVE ALPHA-1,2-MANNOSIDASE
Authors:Suits, M.D.L, Zhu, Y, Thompson, A, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
2WW0
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BU of 2ww0 by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482
Descriptor: 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, CALCIUM ION, GLYCEROL, ...
Authors:Suits, M.D.L, Thompson, A, Zhu, Y, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-12-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
2WVY
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BU of 2wvy by Molmil
STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT2199 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482
Descriptor: ALPHA-1,2-MANNOSIDASE
Authors:Suits, M.D.L, Zhu, Y, Thompson, A, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010

 

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