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1TMN
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BINDING OF N-CARBOXYMETHYL DIPEPTIDE INHIBITORS TO THERMOLYSIN DETERMINED BY X-RAY CRYSTALLOGRAPHY. A NOVEL CLASS OF TRANSITION-STATE ANALOGUES FOR ZINC PEPTIDASES
分子名称:THERMOLYSIN, N-[(1R)-1-carboxy-3-phenylpropyl]-L-leucyl-L-tryptophan, CALCIUM ION, ...
著者Monzingo, A.F., Matthews, B.W.
登録日1987-06-29
公開日1989-01-09
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Binding of N-carboxymethyl dipeptide inhibitors to thermolysin determined by X-ray crystallography: a novel class of transition-state analogues for zinc peptidases
Biochemistry, 23, 1984
1EDZ
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STRUCTURE OF THE NAD-DEPENDENT 5,10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE FROM SACCHAROMYCES CEREVISIAE
分子名称:5,10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE
著者Monzingo, A.F., Breksa, A., Ernst, S., Appling, D.R., Robertus, J.D.
登録日2000-01-28
公開日2000-12-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The X-ray structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae.
Protein Sci., 9, 2000
1EE9
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CRYSTAL STRUCTURE OF THE NAD-DEPENDENT 5,10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH NAD
分子名称:5,10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Monzingo, A.F., Breksa, A., Ernst, S., Appling, D.R., Robertus, J.D.
登録日2000-01-31
公開日2000-12-06
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The X-ray structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae.
Protein Sci., 9, 2000
1PAF
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THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN
分子名称:POKEWEED ANTIVIRAL PROTEIN
著者Monzingo, A.F., Collins, E.J., Ernst, S.R., Irvin, J.D., Robertus, J.D.
登録日1992-10-19
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The 2.5 A structure of pokeweed antiviral protein.
J.Mol.Biol., 233, 1993
1PAG
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THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN
分子名称:POKEWEED ANTIVIRAL PROTEIN, FORMYCIN-5'-MONOPHOSPHATE
著者Monzingo, A.F., Collins, E.J., Ernst, S.R., Irvin, J.D., Robertus, J.D.
登録日1992-10-19
公開日1994-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The 2.5 A structure of pokeweed antiviral protein.
J.Mol.Biol., 233, 1993
1Q5X
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STRUCTURE OF OF RRAA (MENG), A PROTEIN INHIBITOR OF RNA PROCESSING
分子名称:REGULATOR OF RNASE E ACTIVITY A
著者Monzingo, A.F., Gao, J., Qiu, J., Georgiou, G., Robertus, J.D.
登録日2003-08-11
公開日2003-09-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The X-ray Structure of Escherichia coli RraA (MenG), A Protein Inhibitor of RNA Processing.
J.Mol.Biol., 332, 2003
2IDR
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CRYSTAL STRUCTURE OF TRANSLATION INITIATION FACTOR EIF4E FROM WHEAT
分子名称:Eukaryotic translation initiation factor 4E-1
著者Monzingo, A.F., Sadow, J., Dhaliwal, S., Lyon, A., Hoffman, D.W., Robertus, J.D., Browning, K.S.
登録日2006-09-15
公開日2007-06-12
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond.
Plant Physiol., 143, 2007
2IDV
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CRYSTAL STRUCTURE OF WHEAT C113S MUTANT EIF4E BOUND TO 7-METHYL-GDP
分子名称:Eukaryotic translation initiation factor 4E-1, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
著者Monzingo, A.F., Dutt-Chaudhuri, A., Sadow, J., Dhaliwal, S., Hoffman, D.W., Robertus, J.D., Browning, K.S.
登録日2006-09-15
公開日2007-06-12
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond.
Plant Physiol., 143, 2007
2NS6
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CRYSTAL STRUCTURE OF THE MINIMAL RELAXASE DOMAIN OF MOBA FROM PLASMID R1162
分子名称:Mobilization protein A, MANGANESE (II) ION
著者Monzingo, A.F., Ozburn, A., Xia, S., Meyer, R.J., Robertus, J.D.
登録日2006-11-03
公開日2007-02-06
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Structure of the Minimal Relaxase Domain of MobA at 2.1 A Resolution.
J.Mol.Biol., 366, 2007
3RTI
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CRYSTAL STRUCTURE OF RICIN BOUND WITH FORMYCIN MONOPHOSPHATE
分子名称:Ricin, FORMYCIN-5'-MONOPHOSPHATE, BETA-D-GALACTOSE, ...
著者Monzingo, A.F., Robertus, J.D.
登録日2011-05-03
公開日2011-08-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献X-ray analysis of substrate analogs in the ricin A-chain active site.
J.Mol.Biol., 227, 1992
3RTJ
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CRYSTAL STRUCTURE OF RICIN BOUND WITH DINUCLEOTIDE APG
分子名称:RNA (5'-R(*AP*G)-3'), Ricin A chain, Ricin B chain, ...
著者Monzingo, A.F., Robertus, J.D.
登録日2011-05-03
公開日2011-08-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray analysis of substrate analogs in the ricin A-chain active site.
J.Mol.Biol., 227, 1992
3BPB
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CRYSTAL STRUCTURE OF THE DIMETHYLARGININE DIMETHYLAMINOHYDROLASE H162G ADDUCT WITH S-METHYL-L-THIOCITRULLINE
分子名称:dimethylarginine dimethylaminohydrolase, N~5~-[(E)-imino(methylsulfanyl)methyl]-L-ornithine
著者Monzingo, A.F., Linsky, T.W., Stone, E.M., Fast, W., Robertus, J.D.
登録日2007-12-18
公開日2008-06-17
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Promiscuous partitioning of a covalent intermediate common in the pentein superfamily.
Chem.Biol., 15, 2008
3ESU
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CRYSTAL STRUCTURE OF ANTHRAX-NEUTRALIZING SINGLE-CHAIN ANTIBODY 14B7
分子名称:Antibody 14b7* light chain and antibody 14b7* heavy chain linked with a synthetic (GGGGS)4 linker
著者Monzingo, A.F., Maynard, J.A., Iverson, B.L., Georgiou, G., Robertus, J.D.
登録日2008-10-06
公開日2009-04-28
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structure of the engineered neutralizing antibody m18 complexed to domain 4 of the anthrax protective antigen.
J.Mol.Biol., 387, 2009
3ESV
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CRYSTAL STRUCTURE OF THE ENGINEERED NEUTRALIZING ANTIBODY M18
分子名称:Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker
著者Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D.
登録日2008-10-06
公開日2009-04-28
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the engineered neutralizing antibody m18 complexed to domain 4 of the anthrax protective antigen.
J.Mol.Biol., 387, 2009
3ETB
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CRYSTAL STRUCTURE OF THE ENGINEERED NEUTRALIZING ANTIBODY M18 COMPLEXED WITH ANTHRAX PROTECTIVE ANTIGEN DOMAIN 4
分子名称:Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker, Anthrax Protective Antigen
著者Monzingo, A.F., Leysath, C.E., Barnett, J., Iverson, B.L., Georgiou, G., Robertus, J.D.
登録日2008-10-07
公開日2009-04-28
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen.
J.Mol.Biol., 387, 2009
3I2E
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CRYSTAL STRUCTURE OF HUMAN DIMETHYLARGININE DYMETHYLAMINOHYDROLASE-1 (DDAH-1)
分子名称:N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
著者Monzingo, A.F., Wang, Y., Hu, S., Schaller, T.H., Robertus, J.D., Fast, W.
登録日2009-06-29
公開日2009-08-25
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
Biochemistry, 48, 2009
3I4A
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CRYSTAL STRUCTURE OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) IN COMPLEX WITH N5-(1-IMINOPROPYL)-L-ORNITHINE
分子名称:N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N5-(1-iminopropyl)-L-ornithine
著者Monzingo, A.F., Wang, Y., Hu, S., Schaller, T.H., Fast, W., Robertus, J.D.
登録日2009-07-01
公開日2009-08-25
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.898 Å)
主引用文献Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
Biochemistry, 48, 2009
3P8P
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CRYSTAL STRUCTURE OF HUMAN DIMETHYLARGININE DIMETHYLAMINOHYDROLASE-1 (DDAH-1) VARIANT C274S BOUND WITH N5-(1-IMINOPENTYL)-L-ORNITHINE
分子名称:N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N~5~-[(1E)-pentanimidoyl]-L-ornithine
著者Monzingo, A.F., Lluis, M., Wang, Y., Fast, W., Robertus, J.D.
登録日2010-10-14
公開日2010-11-10
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Characterization of C-Alkyl Amidines as Bioavailable Covalent Reversible Inhibitors of Human DDAH-1.
Chemmedchem, 6, 2011
3RHY
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CRYSTAL STRUCTURE OF THE DIMETHYLARGININE DIMETHYLAMINOHYDROLASE ADDUCT WITH 4-CHLORO-2-HYDROXYMETHYLPYRIDINE
分子名称:N(G),N(G)-dimethylarginine dimethylaminohydrolase, (4-chloropyridin-2-yl)methanol
著者Monzingo, A.F., Johnson, C.M., Ke, Z., Yoon, D.-W., Linsky, T.W., Guo, H., Fast, W., Robertus, J.D.
登録日2011-04-12
公開日2011-06-15
最終更新日2011-07-27
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines.
J.Am.Chem.Soc., 133, 2011
6DGE
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CRYSTAL STRUCTURE OF THE DIMETHYLARGININE DIMETHYLAMINOHYDROLASE ADDUCT WITH N5-(1-IMINO-2-CHLOROETHYL)-L-LYSINE
分子名称:N(G),N(G)-dimethylarginine dimethylaminohydrolase 1, N~6~-[(1E)-2-chloroethanimidoyl]-L-lysine
著者Monzingo, A.F., Burstein-Teitelbaum, G., Er, J.A.V., Tuley, A., Fast, W.
登録日2018-05-17
公開日2018-07-25
最終更新日2018-08-08
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Dissection, Optimization, and Structural Analysis of a Covalent Irreversible DDAH1 Inhibitor.
Biochemistry, 57, 2018
4TMN
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SLOW-AND FAST-BINDING INHIBITORS OF THERMOLYSIN DISPLAY DIFFERENT MODES OF BINDING. CRYSTALLOGRAPHIC ANALYSIS OF EXTENDED PHOSPHONAMIDATE TRANSITION-STATE ANALOGUES
分子名称:THERMOLYSIN, N-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-L-leucyl-L-alanine, CALCIUM ION, ...
著者Holden, H.M., Tronrud, D.E., Monzingo, A.F., Weaver, L.H., Matthews, B.W.
登録日1987-06-29
公開日1989-01-09
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.
Biochemistry, 26, 1987
5TMN
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SLOW-AND FAST-BINDING INHIBITORS OF THERMOLYSIN DISPLAY DIFFERENT MODES OF BINDING. CRYSTALLOGRAPHIC ANALYSIS OF EXTENDED PHOSPHONAMIDATE TRANSITION-STATE ANALOGUES
分子名称:THERMOLYSIN, N-[(S)-({[(benzyloxy)carbonyl]amino}methyl)(hydroxy)phosphoryl]-L-leucyl-L-leucine, CALCIUM ION, ...
著者Holden, H.M., Tronrud, D.E., Monzingo, A.F., Weaver, L.H., Matthews, B.W.
登録日1987-06-29
公開日1989-01-09
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues.
Biochemistry, 26, 1987
1TLP
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CRYSTALLOGRAPHIC STRUCTURAL ANALYSIS OF PHOSPHORAMIDATES AS INHIBITORS AND TRANSITION-STATE ANALOGS OF THERMOLYSIN
分子名称:THERMOLYSIN, N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN, CALCIUM ION, ...
著者Tronrud, D.E., Monzingo, A.F., Matthews, B.W.
登録日1987-06-29
公開日1989-01-09
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin.
Eur.J.Biochem., 157, 1986
2TMN
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CRYSTALLOGRAPHIC STRUCTURAL ANALYSIS OF PHOSPHORAMIDATES AS INHIBITORS AND TRANSITION-STATE ANALOGS OF THERMOLYSIN
分子名称:Thermolysin, CALCIUM ION, ZINC ION, ...
著者Tronrud, D.E., Monzingo, A.F., Matthews, B.W.
登録日1987-06-29
公開日1989-01-09
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin.
Eur.J.Biochem., 157, 1986
1BR5
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RICIN A CHAIN (RECOMBINANT) COMPLEX WITH NEOPTERIN
分子名称:PROTEIN (RICIN), NEOPTERIN
著者Day, P., Yan, X., Hollis, T., Svinth, M., Monzingo, A.F., Milne, G.W.A., Robertus, J.D.
登録日1998-08-26
公開日1998-09-02
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-based identification of a ricin inhibitor.
J.Mol.Biol., 266, 1997