Author results

4LXJ
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SACCHAROMYCES CEREVISIAE LANOSTEROL 14-ALPHA DEMETHYLASE WITH LANOSTEROL BOUND
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, LANOSTEROL, ...
Authors:Monk, B.C., Tomasiak, T.M., Keniya, M.V., Huschmann, F.U., Tyndall, J.D.A., O'Connell III, J.D., Cannon, R.D., McDonald, J., Rodriguez, A., Finer-Moore, J., Stroud, R.M.
Deposit date:2013-07-29
Release date:2014-01-29
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
Proc.Natl.Acad.Sci.USA, 111, 2014
5EQB
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CRYSTAL STRUCTURE OF LANOSTEROL 14-ALPHA DEMETHYLASE WITH INTACT TRANSMEMBRANE DOMAIN BOUND TO ITRACONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Authors:Monk, B.C., Tomasiak, T.M., Keniya, M.V., Huschmann, F.U., Tyndall, J.D.A., O'Connell III, J.D., Cannon, R.D., Finer-Morre, J., Stroud, R.M., Center for Structures of Membrane Proteins (CSMP)
Deposit date:2015-11-12
Release date:2016-01-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.
Proc.Natl.Acad.Sci.USA, 111, 2014
5UL0
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S. CEREVISIAE CYP51 COMPLEXED WITH VT-1161
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol, ...
Authors:Tyndall, J.D., Keniya, M.V., Sabherwal, M., Monk, B.C.
Deposit date:2017-01-23
Release date:2017-02-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of pre-clinical drug VT-1161 with Saccharomyces Cerevisiae Lanosterol 14alpha demthylase
To Be Published
6E8Q
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S. CEREVISIAE CYP51 COMPLEXED WITH POSACONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE, ...
Authors:Tyndall, J.D., Keniya, M.V., Sabherwal, M., Monk, B.C.
Deposit date:2018-07-30
Release date:2018-09-05
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.
Antimicrob. Agents Chemother., 63, 2019
4ZE1
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SACCHAROMYCES CEREVISIAE CYP51 Y140F MUTANT COMPLEXED WITH POSACONAZOLE IN THE ACTIVE SITE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, POSACONAZOLE
Authors:Sagatova, A., Keniya, M.V., Wilson, R., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-04-20
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
Sci Rep, 6, 2016
5ESE
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) G73R MUTANT COMPLEXED WITH FLUCONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESF
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) G73E MUTANT COMPLEXED WITH FLUCONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESG
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) G73E MUTANT COMPLEXED WITH ITRACONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.981 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESH
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) G73W MUTANT IN COMPLEX WITH ITRACONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESI
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) G73W MUTANT
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sagatova, A., Keniya, M.V., Wilson, R., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESJ
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) G464S MUTANT COMPLEXED WITH FLUCONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESK
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) G464S MUTANT COMPLEXED WITH ITRACONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESL
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) T322I MUTANT COMPLEXED WITH ITRACONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESM
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) T322I MUTANT COMPLEXED WITH FLUCONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5ESN
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) T322I MUTANT STRUCTURE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-11-16
Release date:2016-11-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of lanosterol 14-alpha demethylase mutants.
To Be Published
5JLC
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STRUCTURE OF CYP51 FROM THE PATHOGEN CANDIDA GLABRATA
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ...
Authors:Keniya, M.V., Sabherwal, M., Wilson, R.K., Sagatova, A.A., Tyndall, J.D.A., Monk, B.C.
Deposit date:2016-04-26
Release date:2016-05-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of CYP51 from the pathogens Candida glabrata and Candida albicans
To Be Published
5V5Z
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STRUCTURE OF CYP51 FROM THE PATHOGEN CANDIDA ALBICANS
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Authors:Keniya, M.V., Sabherwal, M., Wilson, R.K., Sagatova, A.A., Tyndall, J.D.A., Monk, B.C.
Deposit date:2017-03-15
Release date:2017-03-29
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of CYP51 from the pathogens Candida glabrata and Candida albicans
To Be Published
4WMZ
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S. CEREVISIAE CYP51 COMPLEXED WITH FLUCONAZOLE IN THE ACTIVE SITE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
Authors:Sagatova, A., Keniya, M.V., Wilson, R., Wilbanks, S.M., Monk, B.C., Tyndall, J.D.A.
Deposit date:2014-10-09
Release date:2015-07-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase.
Antimicrob.Agents Chemother., 59, 2015
4ZDY
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) Y140F MUTANT COMPLEXED WITH ITRACONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-04-20
Release date:2016-03-30
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
Sci Rep, 6, 2016
4ZDZ
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) Y140F MUTANT COMPLEXED WITH FLUCONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
Authors:Sagatova, A., Keniya, M.V., Wilson, R.K., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-04-20
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
Sci Rep, 6, 2016
4ZE0
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) Y140F MUTANT COMPLEXED WITH VORICONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole
Authors:Sagatova, A., Keniya, M.V., Wilson, R., Tyndall, J.D.A., Monk, B.C.
Deposit date:2015-04-20
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
Sci Rep, 6, 2016
4ZE2
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) Y140H MUTANT COMPLEXED WITH ITRACONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Authors:Sagatova, A., Keniya, M.V., Wilson, R., Monk, B.C., Tyndall, J.D.A.
Deposit date:2015-04-20
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
Sci Rep, 6, 2016
4ZE3
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SACCHAROMYCES CEREVISIAE CYP51 (LANOSTEROL 14-ALPHA DEMETHYLASE) Y140H MUTANT COMPLEXED WITH FLUCONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL
Authors:Sagatova, A., Keniya, M.V., Wilson, R., Monk, B.C., Tyndall, J.D.A.
Deposit date:2015-04-20
Release date:2016-03-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase.
Sci Rep, 6, 2016
5EAB
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SACCHAROMYCES CEREVISIAE CYP51 COMPLEXED WITH THE PLANT PATHOGEN INHIBITOR S-TEBUCONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (3~{S})-1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol
Authors:Tyndall, J.D.A., Sabherwal, M., Sagatova, A.A., Keniya, M.V., Wilson, R.K., Woods, M.V., Monk, B.C.
Deposit date:2015-10-16
Release date:2016-02-10
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Functional Elucidation of Yeast Lanosterol 14 alpha-Demethylase in Complex with Agrochemical Antifungals.
PLoS ONE, 11, 2016
5EAC
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SACCHAROMYCES CEREVISIAE CYP51 COMPLEXED WITH THE PLANT PATHOGEN INHIBITOR R-TEBUCONAZOLE
Descriptor:Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (3~{R})-1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol
Authors:Tyndall, J.D.A., Sabherwal, M., Sagatova, A.A., Keniya, M.V., Wilson, R.K., Woods, M.V., Monk, B.C.
Deposit date:2015-10-16
Release date:2016-02-10
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural and Functional Elucidation of Yeast Lanosterol 14 alpha-Demethylase in Complex with Agrochemical Antifungals.
PLoS ONE, 11, 2016
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