Author results

1UGH
  • Download 1ugh
  • View 1ugh
Molmil generated image of 1ugh
CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE IN COMPLEX WITH A PROTEIN INHIBITOR: PROTEIN MIMICRY OF DNA
Descriptor:PROTEIN (URACIL-DNA GLYCOSYLASE), PROTEIN (URACIL-DNA GLYCOSYLASE INHIBITOR)
Authors:Mol, C.D., Arvai, A.S., Sanderson, R.J., Slupphaug, G., Kavli, B., Krokan, H.E., Mosbaugh, D.W., Tainer, J.A.
Deposit date:1999-02-05
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA.
Cell(Cambridge,Mass.), 82, 1995
1KEA
  • Download 1kea
  • View 1kea
Molmil generated image of 1kea
STRUCTURE OF A THERMOSTABLE THYMINE-DNA GLYCOSYLASE
Descriptor:Possible G-T mismatches repair enzyme, ZINC ION, ACETATE ION, ...
Authors:Mol, C.D., Arvai, A.S., Begley, T.J., Cunningham, R.P., Tainer, J.A.
Deposit date:2001-11-14
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases.
J.Mol.Biol., 315, 2002
1AKO
  • Download 1ako
  • View 1ako
Molmil generated image of 1ako
EXONUCLEASE III FROM ESCHERICHIA COLI
Descriptor:EXONUCLEASE III
Authors:Mol, C.D., Kuo, C.-F., Thayer, M.M., Cunningham, R.P., Tainer, J.A.
Deposit date:1997-05-26
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and function of the multifunctional DNA-repair enzyme exonuclease III.
Nature, 374, 1995
1DE8
  • Download 1de8
  • View 1de8
Molmil generated image of 1de8
HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE-1 (APE1) BOUND TO ABASIC DNA
Descriptor:DNA (5'-D(*GP*CP*TP*AP*CP*(3DR)P*GP*AP*TP*CP*G)-3'), DNA (5'-D(*CP*GP*AP*TP*CP*GP*GP*TP*AP*GP*C)-3'), MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE
Authors:Mol, C.D., Izumi, T., Mitra, S., Tainer, J.A.
Deposit date:1999-11-13
Release date:2000-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected
Nature, 403, 2000
1DE9
  • Download 1de9
  • View 1de9
Molmil generated image of 1de9
HUMAN APE1 ENDONUCLEASE WITH BOUND ABASIC DNA AND MN2+ ION
Descriptor:5'-d(*CP*TP*AP*C)-3', 5'-d(P*(3DR)P*GP*AP*TP*C)-3', 5'-d(*GP*AP*TP*CP*GP*GP*TP*AP*G)-3', ...
Authors:Mol, C.D., Izumi, T., Mitra, S., Tainer, J.A.
Deposit date:1999-11-13
Release date:2000-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
Nature, 403, 2000
1DEW
  • Download 1dew
  • View 1dew
Molmil generated image of 1dew
CRYSTAL STRUCTURE OF HUMAN APE1 BOUND TO ABASIC DNA
Descriptor:5'-D(*GP*CP*GP*TP*CP*CP*(3DR)P*CP*GP*AP*CP*GP*AP*CP*G)-3', 5'-D(*GP*TP*CP*GP*TP*CP*GP*GP*GP*GP*AP*CP*GP*C)-3', MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE, ...
Authors:Mol, C.D., Izumi, T., Mitra, S., Tainer, J.A.
Deposit date:1999-11-15
Release date:2000-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination
Nature, 403, 2000
1P31
  • Download 1p31
  • View 1p31
Molmil generated image of 1p31
CRYSTAL STRUCTURE OF UDP-N-ACETYLMURAMIC ACID:L-ALANINE LIGASE (MURC) FROM HAEMOPHILUS INFLUENZAE
Descriptor:UDP-N-acetylmuramate--alanine ligase, MAGNESIUM ION, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID
Authors:Mol, C.D., Brooun, A., Dougan, D.R., Hilgers, M.T., Tari, L.W., Wijnands, R.A., Knuth, M.W., McRee, D.E., Swanson, R.V.
Deposit date:2003-04-16
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae.
J.Bacteriol., 185, 2003
1P3D
  • Download 1p3d
  • View 1p3d
Molmil generated image of 1p3d
CRYSTAL STRUCTURE OF UDP-N-ACETYLMURAMIC ACID:L-ALANINE LIGASE (MURC) IN COMPLEX WITH UMA AND ANP.
Descriptor:UDP-N-acetylmuramate--alanine ligase, MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE, ...
Authors:Mol, C.D., Brooun, A., Dougan, D.R., Hilgers, M.T., Tari, L.W., Wijnands, R.A., Knuth, M.W., McRee, D.E., Swanson, R.V.
Deposit date:2003-04-17
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae.
J.Bacteriol., 185, 2003
1PKG
  • Download 1pkg
  • View 1pkg
Molmil generated image of 1pkg
STRUCTURE OF A C-KIT KINASE PRODUCT COMPLEX
Descriptor:c-kit protein, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Mol, C.D., Lim, K.B., Sridhar, V., Zou, H., Chien, E.Y.T., Sang, B.-C., Nowakowski, J., Kassel, D.B., Cronin, C.N., McRee, D.E.
Deposit date:2003-06-05
Release date:2003-08-12
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation.
J.Biol.Chem., 278, 2003
1Q5H
  • Download 1q5h
  • View 1q5h
Molmil generated image of 1q5h
HUMAN DUTP PYROPHOSPHATASE COMPLEX WITH DUDP
Descriptor:dUTP pyrophosphatase, MAGNESIUM ION, DEOXYURIDINE-5'-DIPHOSPHATE
Authors:Mol, C.D., Harris, J.M., McIntosh, E.M., Tainer, J.A.
Deposit date:2003-08-07
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human dUTP pyrophosphatase: uracil recognition by a Beta hairpin and active sites formed by three separate subunits
Structure, 4, 1996
1Q5U
  • Download 1q5u
  • View 1q5u
Molmil generated image of 1q5u
HUMAN DUTP PYROPHOSPHATASE
Descriptor:dUTP pyrophosphatase
Authors:Mol, C.D., Harris, J.M., Mcintosh, E.M., Tainer, J.A.
Deposit date:2003-08-11
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Human dUTP Pyrophosphatase: Uracil Recognition by a Beta Hairpin and Active Sites Formed by Three Separate Subunits
Structure, 4, 1996
1T45
  • Download 1t45
  • View 1t45
Molmil generated image of 1t45
STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Descriptor:Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Authors:Mol, C.D., Dougan, D.R., Schneider, T.R., Skene, R.J., Kraus, M.L., Scheibe, D.N., Snell, G.P., Zou, H., Sang, B.C., Wilson, K.P.
Deposit date:2004-04-28
Release date:2004-06-15
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.
J.Biol.Chem., 279, 2004
1T46
  • Download 1t46
  • View 1t46
Molmil generated image of 1t46
STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Descriptor:Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PHOSPHATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
Authors:Mol, C.D., Dougan, D.R., Schneider, T.R., Skene, R.J., Kraus, M.L., Scheibe, D.N., Snell, G.P., Zou, H., Sang, B.C., Wilson, K.P.
Deposit date:2004-04-28
Release date:2004-06-15
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.
J.Biol.Chem., 279, 2004
1UUG
  • Download 1uug
  • View 1uug
Molmil generated image of 1uug
ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH WILD-TYPE UDG AND WILD-TYPE UGI
Descriptor:URACIL-DNA GLYCOSYLASE, URACIL-DNA GLYCOSYLASE INHIBITOR
Authors:Mol, C.D., Arvai, A.S., Putnam, C.D., Tainer, J.A.
Deposit date:1998-10-31
Release date:1999-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase
J.Mol.Biol., 287, 1999
3F7Z
  • Download 3f7z
  • View 3f7z
Molmil generated image of 3f7z
X-RAY CO-CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3BETA IN COMPLEX WITH AN INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
Authors:Mol, C.D., Dougan, D.R.
Deposit date:2008-11-10
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.
Bioorg.Med.Chem., 17, 2009
3F88
  • Download 3f88
  • View 3f88
Molmil generated image of 3f88
GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR COMPLEX
Descriptor:Glycogen synthase kinase-3 beta, 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione, 3-methylbenzonitrile
Authors:Mol, C.D., Dougan, D.R.
Deposit date:2008-11-11
Release date:2009-03-10
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta.
Bioorg.Med.Chem., 17, 2009
3GB2
  • Download 3gb2
  • View 3gb2
Molmil generated image of 3gb2
GSK3BETA INHIBITOR COMPLEX
Descriptor:Glycogen synthase kinase-3 beta, 2-methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole
Authors:Mol, C.D.
Deposit date:2009-02-18
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.
J.Med.Chem., 52, 2009
1UGI
  • Download 1ugi
  • View 1ugi
Molmil generated image of 1ugi
URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
Descriptor:URACIL-DNA GLYCOSYLASE INHIBITOR, SULFATE ION, IMIDAZOLE
Authors:Putnam, C.D., Arvai, A.S., Mol, C.D., Tainer, J.A.
Deposit date:1998-11-04
Release date:1999-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase
J.Mol.Biol., 287, 1999
2UGI
  • Download 2ugi
  • View 2ugi
Molmil generated image of 2ugi
PROTEIN MIMICRY OF DNA FROM CRYSTAL STRUCTURES OF THE URACIL GLYCOSYLASE INHIBITOR PROTEIN AND ITS COMPLEX WITH ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE
Descriptor:URACIL-DNA GLYCOSYLASE INHIBITOR, IMIDAZOLE
Authors:Putnam, C.D., Arvai, A.S., Mol, C.D., Tainer, J.A.
Deposit date:1998-11-06
Release date:1999-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase
J.Mol.Biol., 287, 1999
2UUG
  • Download 2uug
  • View 2uug
Molmil generated image of 2uug
ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE:INHIBITOR COMPLEX WITH H187D MUTANT UDG AND WILD-TYPE UGI
Descriptor:URACIL-DNA GLYCOSYLASE, URACIL-DNA GLYCOSYLASE INHIBITOR
Authors:Putnam, C.D., Arvai, A.S., Mol, C.D., Tainer, J.A.
Deposit date:1998-10-31
Release date:1999-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase
J.Mol.Biol., 287, 1999
1SSP
  • Download 1ssp
  • View 1ssp
Molmil generated image of 1ssp
WILD-TYPE URACIL-DNA GLYCOSYLASE BOUND TO URACIL-CONTAINING DNA
Descriptor:5'-D(*CP*TP*GP*TP*(D1P)P*AP*TP*CP*TP*T)-3', 5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*AP*G)-3', URACIL-DNA GLYCOSYLASE, ...
Authors:Parikh, S.S., Mol, C.D., Slupphaug, G., Bharati, S., Krokan, H.E., Tainer, J.A.
Deposit date:1999-04-28
Release date:1999-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
EMBO J., 17, 1998
2SSP
  • Download 2ssp
  • View 2ssp
Molmil generated image of 2ssp
LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA
Descriptor:DNA (5'-D(*CP*TP*GP*TP*(AAB)P*AP*TP*CP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*GP*AP*TP*AP*AP*CP*AP*G)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE)
Authors:Parikh, S.S., Mol, C.D., Slupphaug, G., Bharati, S., Krokan, H.E., Tainer, J.A.
Deposit date:1999-04-28
Release date:1999-05-06
Last modified:2014-07-09
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
EMBO J., 17, 1998
1AKZ
  • Download 1akz
  • View 1akz
Molmil generated image of 1akz
HUMAN URACIL-DNA GLYCOSYLASE
Descriptor:URACIL-DNA GLYCOSYLASE
Authors:Tainer, J.A., Mol, C.D.
Deposit date:1997-05-27
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
Embo J., 17, 1998
1B43
  • Download 1b43
  • View 1b43
Molmil generated image of 1b43
FEN-1 FROM P. FURIOSUS
Descriptor:PROTEIN (FEN-1)
Authors:Hosfield, D.J., Mol, C.D., Shen, B., Tainer, J.A.
Deposit date:1999-01-05
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell(Cambridge,Mass.), 95, 1998
1BIX
  • Download 1bix
  • View 1bix
Molmil generated image of 1bix
THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES
Descriptor:AP ENDONUCLEASE 1, SAMARIUM (III) ION, PLATINUM (II) ION
Authors:Gorman, M.A., Morera, S., Rothwell, D.G., De La Fortelle, E., Mol, C.D., Tainer, J.A., Hickson, I.D., Freemont, P.S.
Deposit date:1998-06-19
Release date:1999-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
EMBO J., 16, 1997
<123>