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3TK5
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BU of 3tk5 by Molmil
Factor Xa in complex with D102-4380
Descriptor: 4-{3-[(4-chlorophenyl)amino]-3-oxopropyl}-3-({[5-(propan-2-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]carbonyl}amino)benzoic acid, CALCIUM ION, Factor X heavy chain, ...
Authors:Suzuki, M, Mochizuki, A, Nagata, T, Takano, H, Kanno, H, Kishida, M, Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
3TK6
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BU of 3tk6 by Molmil
factor Xa in complex with D46-5241
Descriptor: CALCIUM ION, Factor X heavy chain, Factor X light chain, ...
Authors:Suzuki, M, Mochizuki, A, Nagata, T, Takano, H, Kanno, H, Kishida, M, Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
2D1J
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BU of 2d1j by Molmil
Factor Xa in complex with the inhibitor 2-[[4-[(5-chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide
Descriptor: 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE, CALCIUM ION, Coagulation factor X, ...
Authors:Suzuki, M.
Deposit date:2005-08-24
Release date:2006-08-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.
Bioorg.Med.Chem., 13, 2005
3Q3K
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BU of 3q3k by Molmil
Factor Xa in complex with a phenylenediamine derivative
Descriptor: Activated factor Xa heavy chain, CALCIUM ION, Factor X light chain, ...
Authors:Suzuki, M, Imai, E.
Deposit date:2010-12-22
Release date:2011-12-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3IIT
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BU of 3iit by Molmil
Factor XA in complex with a cis-1,2-diaminocyclohexane derivative
Descriptor: 7-chloro-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazol-2-yl)carbonyl]amino}cyclohexyl]isoquinoline-3-carboxamide, Activated factor Xa heavy chain, CALCIUM ION, ...
Authors:Suzuki, M.
Deposit date:2009-08-03
Release date:2010-08-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg.Med.Chem., 17, 2009
1WU1
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BU of 1wu1 by Molmil
Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine
Descriptor: 5-CHLORO-2-({3-ISOBUTYL-4-[(5-PYRIDIN-4-YLPYRIMIDIN-2-YL)CARBONYL]PIPERAZIN-1-YL}SULFONYL)-1H-INDOLE, CALCIUM ION, Coagulation factor X, ...
Authors:Suzuki, M.
Deposit date:2004-11-29
Release date:2005-11-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites
Bioorg.Med.Chem., 13, 2005
3VYF
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BU of 3vyf by Molmil
Human renin in complex with inhibitor 9
Descriptor: (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(2,6-dimethylheptan-4-yl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin
Authors:Takahashi, M, Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VYE
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BU of 3vye by Molmil
Human renin in complex with inhibitor 7
Descriptor: (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(3-methylbutyl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin
Authors:Takahashi, M, Matsui, Y, Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012
3VYD
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BU of 3vyd by Molmil
Human renin in complex with inhibitor 6
Descriptor: (3S,5R)-5-{[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]methyl}-N-(3-methylbutyl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin
Authors:Takahashi, M, Hanzawa, H.
Deposit date:2012-09-24
Release date:2012-12-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22, 2012

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