Author results

3VZV
  • Download 3vzv
  • View 3vzv
Molmil generated image of 3vzv
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH A DIHYDROIMIDAZOTHIAZOLE INHIBITOR
分子名称:E3 ubiquitin-protein ligase Mdm2, 1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-6-methyl-3-(propan-2-yl)-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N,N-dimethyl-L-prolinamide
著者Shimizu, H., Katakura, S., Miyazaki, M., Naito, H., Sugimoto, Y., Kawato, H., Okayama, T., Soga, T.
登録日2012-10-16
公開日2013-02-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold
Bioorg.Med.Chem.Lett., 23, 2013
3W69
  • Download 3w69
  • View 3w69
Molmil generated image of 3w69
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH A DIHYDROIMIDAZOTHIAZOLE INHIBITOR
分子名称:E3 ubiquitin-protein ligase Mdm2, (5R,6S)-2-[((2S,5R)-2-{[(3R)-4-acetyl-3-methylpiperazin-1-yl]carbonyl}-5-ethylpyrrolidin-1-yl)carbonyl]-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole, SULFATE ION
著者Shimizu, H., Katakura, S., Miyazaki, M., Naito, H., Sugimoto, Y., Kawato, H., Okayama, T., Soga, T.
登録日2013-02-12
公開日2013-06-05
最終更新日2014-04-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors
Bioorg.Med.Chem., 21, 2013
1IRS
  • Download 1irs
  • View 1irs
Molmil generated image of 1irs
IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:IRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE
著者Zhou, M.-M., Huang, B., Olejniczak, E.T., Meadows, R.P., Shuker, S.B., Miyazaki, M., Trub, T., Shoelson, S.E., Feisk, S.W.
登録日1996-03-22
公開日1997-05-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1SHC
  • Download 1shc
  • View 1shc
Molmil generated image of 1shc
SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:SHC, TRKA RECEPTOR PHOSPHOPEPTIDE
著者Zhou, M.-M., Ravichandran, K.S., Olejniczak, E.T., Petros, A.M., Meadows, R.P., Sattler, M., Harlan, J.E., Wade, W.S., Burakoff, S.J., Fesik, S.W.
登録日1996-03-27
公開日1997-05-15
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378, 1995