Author results

1ITC
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BETA-AMYLASE FROM BACILLUS CEREUS VAR. MYCOIDES COMPLEXED WITH MALTOPENTAOSE
Descriptor:Beta-Amylase, ALPHA-D-GLUCOSE, CALCIUM ION, ...
Authors:Miyake, H., Kurisu, G., Kusunoki, M., Nishimura, S., Kitamura, S., Nitta, Y.
Deposit date:2002-01-17
Release date:2003-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of a Catalytic Site Mutant of beta-Amylase from Bacillus cereus var. mycoides Cocrystallized with Maltopentaose
BIOCHEMISTRY, 42, 2003
1J18
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CRYSTAL STRUCTURE OF A BETA-AMYLASE FROM BACILLUS CEREUS VAR. MYCOIDES COCRYSTALLIZED WITH MALTOSE
Descriptor:Beta-amylase, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE, ...
Authors:Miyake, H., Kurisu, G., Kusunoki, M., Nishimura, S., Kitamura, S., Nitta, Y.
Deposit date:2002-12-02
Release date:2003-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a Catalytic Site Mutant of beta-Amylase from Bacillus cereus var. mycoides Cocrystallized with Maltopentaose
BIOCHEMISTRY, 42, 2003
5GHL
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CRYSTAL STRUCTURE ANALYSIS OF THE STARCH-BINDING DOMAIN OF GLUCOAMYLASE FROM ASPERGILLUS NIGER
Descriptor:Glucoamylase, GLYCEROL, SULFATE ION
Authors:Miyake, H., Suyama, Y., Muraki, N., Kusunoki, M., Tanaka, A.
Deposit date:2016-06-20
Release date:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the starch-binding domain of glucoamylase from Aspergillus niger
Acta Crystallogr.,Sect.F, 73, 2017
1OMY
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CRYSTAL STRUCTURE OF A RECOMBINANT ALPHA-INSECT TOXIN BMKAIT1 FROM THE SCORPION BUTHUS MARTENSII KARSCH
Descriptor:Alpha-neurotoxin TX12, CHLORIDE ION, ACETIC ACID
Authors:Huang, Y., Huang, Q., Chen, H., Tang, Y., Miyake, H., Kusunoki, M.
Deposit date:2003-02-26
Release date:2003-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallization and preliminary crystallographic study of rBmKalphaIT1, a recombinant alpha-insect toxin from the scorpion Buthus martensii Karsch.
Acta Crystallogr.,Sect.D, 59, 2003
1WOK
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CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH A QUINOXALINE-TYPE INHIBITOR
Descriptor:Poly [ADP-ribose] polymerase-1, 3-(4-CHLOROPHENYL)QUINOXALINE-5-CARBOXAMIDE
Authors:Iwashita, A., Hattori, K., Yamamoto, H., Ishida, J., Kido, Y., Kamijo, K., Murano, K., Miyake, H., Kinoshita, T., Warizaya, M., Ohkubo, M., Matsuoka, N., Mutoh, S.
Deposit date:2004-08-20
Release date:2005-03-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors.
Febs Lett., 579, 2005
1IEI
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CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE INHIBITOR ZENARESTAT.
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [3-(4-BROMO-2-FLUORO-BENZYL)-7-CHLORO-2,4-DIOXO-3,4-DIHYDRO-2H-QUINAZOLIN-1-YL]-ACETIC ACID
Authors:Kinoshita, T., Miyake, H., Fujii, T., Takakura, S., Goto, T.
Deposit date:2001-04-09
Release date:2002-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat.
Acta Crystallogr.,Sect.D, 58, 2002
1J0Y
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BETA-AMYLASE FROM BACILLUS CEREUS VAR. MYCOIDES IN COMPLEX WITH GLUCOSE
Descriptor:Beta-amylase, BETA-D-GLUCOSE, CALCIUM ION
Authors:Oyama, T., Miyake, H., Kusunoki, M., Nitta, Y.
Deposit date:2002-11-25
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of beta-Amylase from Bacillus cereus var. mycoides in Complexes with Substrate Analogs and Affinity-Labeling Reagents
J.BIOCHEM.(TOKYO), 133, 2003
1J0Z
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BETA-AMYLASE FROM BACILLUS CEREUS VAR. MYCOIDES IN COMPLEX WITH MALTOSE
Descriptor:Beta-amylase, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE, ...
Authors:Oyama, T., Miyake, H., Kusunoki, M., Nitta, Y.
Deposit date:2002-11-25
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of beta-Amylase from Bacillus cereus var. mycoides in Complexes with Substrate Analogs and Affinity-Labeling Reagents
J.BIOCHEM.(TOKYO), 133, 2003
1J10
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BETA-AMYLASE FROM BACILLUS CEREUS VAR. MYCOIDES IN COMPLEX WITH GGX
Descriptor:Beta-amylase, ALPHA-D-GLUCOSE, BETA-D-XYLOPYRANOSE, ...
Authors:Oyama, T., Miyake, H., Kusunoki, M., Nitta, Y.
Deposit date:2002-11-25
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of beta-Amylase from Bacillus cereus var. mycoides in Complexes with Substrate Analogs and Affinity-Labeling Reagents
J.BIOCHEM.(TOKYO), 133, 2003
1J11
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BETA-AMYLASE FROM BACILLUS CEREUS VAR. MYCOIDES IN COMPLEX WITH ALPHA-EPG
Descriptor:Beta-amylase, 2-HYDROXYMETHYL-6-OXIRANYLMETHOXY-TETRAHYDRO-PYRAN-3,4,5-TRIOL, CALCIUM ION
Authors:Oyama, T., Miyake, H., Kusunoki, M., Nitta, Y.
Deposit date:2002-11-25
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of beta-Amylase from Bacillus cereus var. mycoides in Complexes with Substrate Analogs and Affinity-Labeling Reagents
J.BIOCHEM.(TOKYO), 133, 2003
1J12
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BETA-AMYLASE FROM BACILLUS CEREUS VAR. MYCOIDES IN COMPLEX WITH ALPHA-EBG
Descriptor:Beta-amylase, 2-HYDROXYMETHYL-6-(2-OXIRANYL-ETHOXY)-TETRAHYDRO-PYRAN-3,4,5-TRIOL, CALCIUM ION
Authors:Oyama, T., Miyake, H., Kusunoki, M., Nitta, Y.
Deposit date:2002-11-25
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of beta-Amylase from Bacillus cereus var. mycoides in Complexes with Substrate Analogs and Affinity-Labeling Reagents
J.BIOCHEM.(TOKYO), 133, 2003
1OX1
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CRYSTAL STRUCTURE OF THE BOVINE TRYPSIN COMPLEX WITH A SYNTHETIC 11 PEPTIDE INHIBITOR
Descriptor:Trypsinogen, cationic, 11-mer peptide, ...
Authors:Wu, G., Huang, Y., Zhu, G., Huang, Q., Tang, Y., Miyake, H., Kusunoki, M.
Deposit date:2003-03-31
Release date:2004-05-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:crystal structure of the bovine trypsin complex with a synthetic 11 peptide inhibitor
To be published
3A47
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CRYSTAL STRUCTURE OF ISOMALTASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:Oligo-1,6-glucosidase, CALCIUM ION
Authors:Yamamoto, K., Miyake, H., Kusunoki, M., Osaki, S.
Deposit date:2009-07-01
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Crystal structure of isomaltase from Saccharomyces cerevisiae
To be Published
3A4A
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CRYSTAL STRUCTURE OF ISOMALTASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:Oligo-1,6-glucosidase, ALPHA-D-GLUCOSE, CALCIUM ION
Authors:Yamamoto, K., Miyake, H., Kusunoki, M., Osaki, S.
Deposit date:2009-07-01
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose
Febs J., 277, 2010
3AJ7
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CRYSTAL STRUCTURE OF ISOMALTASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:Oligo-1,6-glucosidase, CALCIUM ION
Authors:Yamamoto, K., Miyake, H., Kusunoki, M., Osaki, S.
Deposit date:2010-05-26
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose
Febs J., 277, 2010
3AXH
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CRYSTAL STRUCTURE OF ISOMALTASE IN COMPLEX WITH ISOMALTOSE
Descriptor:Oligo-1,6-glucosidase IMA1, ALPHA-D-GLUCOSE, CALCIUM ION
Authors:Yamamoto, K., Miyake, H., Kusunoki, M., Osaki, S.
Deposit date:2011-04-06
Release date:2011-10-05
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Steric hindrance by 2 amino acid residues determines the substrate specificity of isomaltase from Saccharomyces cerevisiae
J.Biosci.Bioeng., 112, 2011
3AXI
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CRYSTAL STRUCTURE OF ISOMALTASE IN COMPLEX WITH MALTOSE
Descriptor:Oligo-1,6-glucosidase IMA1, ALPHA-D-GLUCOSE, CALCIUM ION
Authors:Yamamoto, K., Miyake, H., Kusunoki, M., Osaki, S.
Deposit date:2011-04-06
Release date:2011-10-05
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Steric hindrance by 2 amino acid residues determines the substrate specificity of isomaltase from Saccharomyces cerevisiae
J.Biosci.Bioeng., 112, 2011
1TVO
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THE STRUCTURE OF ERK2 IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:Mitogen-activated protein kinase 1, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
Authors:Kinoshita, T.
Deposit date:2004-06-30
Release date:2005-09-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex
Biochem.Biophys.Res.Commun., 336, 2005
1UK1
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CRYSTAL STRUCTURE OF HUMAN POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH A POTENT INHIBITOR
Descriptor:Poly [ADP-ribose] polymerase-1, 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Authors:Kinoshita, T.
Deposit date:2003-08-14
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase
J.Med.Chem., 47, 2004
3W55
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THE STRUCTURE OF ERK2 IN COMPLEX WITH FR148083
Descriptor:Mitogen-activated protein kinase 1, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
Authors:Ohori, M., Kinoshita, T.
Deposit date:2013-01-21
Release date:2013-02-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Role of a cysteine residue in the active site of ERK and the MAPKK family
Biochem.Biophys.Res.Commun., 353, 2007
5TR6
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DISCOVERY OF TAK-659, AN ORALLY AVAILABLE INVESTIGATIONAL INHIBITOR OF SPLEEN TYROSINE KINASE (SYK)
Descriptor:Tyrosine-protein kinase SYK, 6-{[(1R,2S)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one, 1,2-ETHANEDIOL
Authors:Yano, J., Jennings, A., Lam, B., Hoffman, I.D.
Deposit date:2016-10-25
Release date:2016-11-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Bioorg. Med. Chem. Lett., 26, 2016
5TT7
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DISCOVERY OF TAK-659, AN ORALLY AVAILABLE INVESTIGATIONAL INHIBITOR OF SPLEEN TYROSINE KINASE (SYK)
Descriptor:Tyrosine-protein kinase SYK, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-5-one
Authors:Yano, J., Jennings, A., Lam, B., Hoffman, I.D.
Deposit date:2016-11-01
Release date:2016-11-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Bioorg. Med. Chem. Lett., 26, 2016