Author results

1GES
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ANATOMY OF AN ENGINEERED NAD-BINDING SITE
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mittl, P.R.E., Schulz, G.E.
Deposit date:1994-01-18
Release date:1994-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Anatomy of an engineered NAD-binding site.
Protein Sci., 3, 1994
1GET
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ANATOMY OF AN ENGINEERED NAD-BINDING SITE
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Mittl, P.R.E., Schulz, G.E.
Deposit date:1994-01-18
Release date:1994-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Anatomy of an engineered NAD-binding site.
Protein Sci., 3, 1994
1GEU
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ANATOMY OF AN ENGINEERED NAD-BINDING SITE
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Mittl, P.R.E., Schulz, G.E.
Deposit date:1994-01-18
Release date:1994-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anatomy of an engineered NAD-binding site.
Protein Sci., 3, 1994
2DKO
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EXTENDED SUBSTRATE RECOGNITION IN CASPASE-3 REVEALED BY HIGH RESOLUTION X-RAY STRUCTURE ANALYSIS
Descriptor:Caspase-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:Mittl, P.R.E., Ganesan, R., Jelakovic, S., Grutter, M.G.
Deposit date:2006-04-12
Release date:2006-07-04
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-ray Structure Analysis
J.Mol.Biol., 359, 2006
1AIE
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P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE
Descriptor:P53
Authors:Mittl, P.R.E., Chene, P., Gruetter, M.G.
Deposit date:1997-04-17
Release date:1997-06-16
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template.
Acta Crystallogr.,Sect.D, 54, 1998
2CJX
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EXTENDED SUBSTRATE RECOGNITION IN CASPASE-3 REVEALED BY HIGH RESOLUTION X-RAY STRUCTURE ANALYSIS
Descriptor:CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:Ganesan, R., Mittl, P.R.E., Jelakovic, S., Grutter, M.G.
Deposit date:2006-04-09
Release date:2006-06-27
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
J.Mol.Biol., 359, 2006
2CJY
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EXTENDED SUBSTRATE RECOGNITION IN CASPASE-3 REVEALED BY HIGH RESOLUTION X-RAY STRUCTURE ANALYSIS
Descriptor:CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:Ganesan, R., Mittl, P.R.E., Jelakovic, S., Grutter, M.G.
Deposit date:2006-04-09
Release date:2006-06-27
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
J.Mol.Biol., 359, 2006
4BS0
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CRYSTAL STRUCTURE OF KEMP ELIMINASE HG3.17 E47N,N300D COMPLEXED WITH TRANSITION STATE ANALOG 6-NITROBENZOTRIAZOLE
Descriptor:KEMP ELIMINASE HG3.17, SULFATE ION, 6-NITROBENZOTRIAZOLE
Authors:Blomberg, R., Kries, H., Pinkas, D.M., Mittl, P.R.E., Gruetter, M.G., Privett, H.K., Mayo, S., Hilvert, D.
Deposit date:2013-06-06
Release date:2013-10-16
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Precision is Essential for Efficient Catalysis in an Evolved Kemp Eliminase
Nature, 503, 2013
4CG4
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CRYSTAL STRUCTURE OF THE CHS-B30.2 DOMAINS OF TRIM20
Descriptor:PYRIN, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Weinert, C., Morger, D., Djekic, A., Mittl, P.R.E., Gruetter, M.G.
Deposit date:2013-11-20
Release date:2015-04-29
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Trim20 C-Terminal Coiled-Coil/B30.2 Fragment: Implications for the Recognition of Higher Order Oligomers
Sci.Rep., 5, 2015
4D49
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CRYSTAL STRUCTURE OF COMPUTATIONALLY DESIGNED ARMADILLO REPEAT PROTEINS FOR MODULAR PEPTIDE RECOGNITION.
Descriptor:ARMADILLO REPEAT PROTEIN ARM00027, POLY ARG DECAPEPTIDE, ARGININE
Authors:Reichen, C., Forzani, C., Zhou, T., Parmeggiani, F., Fleishman, S.J., Mittl, P.R.E., Madhurantakam, C., Honegger, A., Ewald, C., Zerbe, O., Baker, D., Caflisch, A., Pluckthun, A.
Deposit date:2014-10-27
Release date:2016-01-13
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
4D4E
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CRYSTAL STRUCTURE OF COMPUTATIONALLY DESIGNED ARMADILLO REPEAT PROTEINS FOR MODULAR PEPTIDE RECOGNITION.
Descriptor:ARMADILLO REPEAT PROTEIN ARM00016, GLYCEROL
Authors:Reichen, C., Forzani, C., Zhou, T., Parmeggiani, F., Fleishman, S.J., Mittl, P.R.E., Madhurantakam, C., Honegger, A., Ewald, C., Zerbe, O., Baker, D., Caflisch, A., Pluckthun, A.
Deposit date:2014-10-28
Release date:2016-01-13
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
5OD9
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STRUCTURE OF THE ENGINEERED METALLOESTERASE MID1SC9
Descriptor:MID1sc9, ZINC ION, CHLORIDE ION, ...
Authors:Studer, S., Mittl, P.R.E., Hilvert, D.
Deposit date:2017-07-05
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Structure of the engineered metalloesterase MID1sc9
To be Published
1C94
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REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.
Descriptor:RETRO-GCN4 LEUCINE ZIPPER
Authors:Mittl, P.R.E., Deillon, C.A., Sargent, D., Liu, N., Klauser, S., Thomas, R.M., Gutte, B., Gruetter, M.G.
Deposit date:1999-07-30
Release date:2000-03-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure.
Proc.Natl.Acad.Sci.USA, 97, 2000
1CP3
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CRYSTAL STRUCTURE OF THE COMPLEX OF APOPAIN WITH THE TETRAPEPTIDE INHIBITOR ACE-DVAD-FMC
Descriptor:APOPAIN, ACETYL-ASP-VAL-ALA-ASP-FLUOROMETHYLKETONE
Authors:Mittl, P.R.E., Dimarco, S., Gruetter, M.G.
Deposit date:1996-12-12
Release date:1997-12-24
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone.
J.Biol.Chem., 272, 1997
1GER
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THE STRUCTURE OF GLUTATHIONE REDUCTASE FROM ESCHERICHIA COLI AT 1.86 ANGSTROMS RESOLUTION: COMPARISON WITH THE ENZYME FROM HUMAN ERYTHROCYTES
Descriptor:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mittl, P.R.E., Schulz, G.E.
Deposit date:1994-01-18
Release date:1994-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of glutathione reductase from Escherichia coli at 1.86 A resolution: comparison with the enzyme from human erythrocytes.
Protein Sci., 3, 1994
1TGJ
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HUMAN TRANSFORMING GROWTH FACTOR-BETA 3, CRYSTALLIZED FROM DIOXANE
Descriptor:TRANSFORMING GROWTH FACTOR-BETA 3, 1,4-DIETHYLENE DIOXIDE
Authors:Mittl, P.R.E., Priestle, J.P., Gruetter, M.G.
Deposit date:1996-07-09
Release date:1997-01-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Protein Sci., 5, 1996
1TGK
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HUMAN TRANSFORMING GROWTH FACTOR BETA 3, CRYSTALLIZED FROM PEG 4000
Descriptor:TRANSFORMING GROWTH FACTOR BETA 3
Authors:Mittl, P.R.E., Priestle, J.P., Gruetter, M.G.
Deposit date:1996-07-10
Release date:1997-03-12
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding.
Protein Sci., 5, 1996
2AXI
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HDM2 IN COMPLEX WITH A BETA-HAIRPIN
Descriptor:Ubiquitin-protein ligase E3 Mdm2, cyclic 8-mer peptide, SULFATE ION, ...
Authors:Mittl, P.R.E., Fasan, R., Robinson, J., Gruetter, M.G.
Deposit date:2005-09-05
Release date:2006-03-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
Chembiochem, 7, 2006
4ATZ
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AD5 KNOB IN COMPLEX WITH A DESIGNED ANKYRIN REPEAT PROTEIN
Descriptor:Fiber protein, DESIGNED ANKYRIN REPEAT PROTEIN
Authors:Mittl, P.R.E., Hess, C., Dreier, B.
Deposit date:2012-05-11
Release date:2013-02-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
5OD1
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STRUCTURE OF THE ENGINEERED METALLOESTERASE MID1SC10 COMPLEXED WITH A PHOSPHONATE TRANSITION STATE ANALOGUE
Descriptor:MID1sc10, ZINC ION, [2-oxidanylidene-7-[oxidanyl-[(1~{S})-1-phenylethyl]phosphoryl]oxy-chromen-4-yl]methanesulfonic acid, ...
Authors:Mittl, P.R.E., Studer, S., Hansen, D.A., Hilvert, D.
Deposit date:2017-07-04
Release date:2018-12-12
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:engineered metalloenzyme
To Be Published
1BX7
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HIRUSTASIN FROM HIRUDO MEDICINALIS AT 1.2 ANGSTROMS
Descriptor:HIRUSTASIN, SULFATE ION
Authors:Uson, I., Sheldrick, G.M., De La Fortelle, E., Bricogne, G., Di Marco, S., Priestle, J.P., Gruetter, M.G., Mittl, P.R.E.
Deposit date:1998-10-14
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The 1.2 A crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors.
Structure Fold.Des., 7, 1999
1BX8
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HIRUSTASIN FROM HIRUDO MEDICINALIS AT 1.4 ANGSTROMS
Descriptor:HIRUSTASIN, SULFATE ION
Authors:Uson, I., Sheldrick, G.M., De La Fortelle, E., Bricogne, G., Di Marco, S., Priestle, J.P., Gruetter, M.G., Mittl, P.R.E.
Deposit date:1998-10-14
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The 1.2 A crystal structure of hirustasin reveals the intrinsic flexibility of a family of highly disulphide-bridged inhibitors.
Structure Fold.Des., 7, 1999
1FG2
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CRYSTAL STRUCTURE OF THE LCMV PEPTIDIC EPITOPE GP33 IN COMPLEX WITH THE MURINE CLASS I MHC MOLECULE H-2DB
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2 MICROGLOBULIN, ...
Authors:Tissot, A.C., Ciatto, C., Mittl, P.R.E., Gruetter, M.G., Plueckthun, A.
Deposit date:2000-07-27
Release date:2000-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.754 Å)
Cite:Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex.
J.Mol.Biol., 302, 2000
1KKC
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CRYSTAL STRUCTURE OF ASPERGILLUS FUMIGATUS MNSOD
Descriptor:Manganese Superoxide Dismutase, MANGANESE (II) ION
Authors:Fluckiger, S., Mittl, P.R.E., Scapozza, L., Fijten, H., Folkers, G., Grutter, M.G., Blaser, K., Crameri, R.
Deposit date:2001-12-07
Release date:2001-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-A resolution.
J.Immunol., 168, 2002
1KLX
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HELICOBACTER PYLORI CYSTEINE RICH PROTEIN B (HCPB)
Descriptor:Cysteine Rich Protein B
Authors:Luethy, L., Gruetter, M.G., Mittl, P.R.E.
Deposit date:2001-12-13
Release date:2002-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of Helicobacter pylori cysteine-rich protein B reveals a novel fold for a penicillin-binding protein.
J.Biol.Chem., 277, 2002
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