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7TCD
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BU of 7tcd by Molmil
LOV2-DARPIN fusion: D13
Descriptor: CHLORIDE ION, D13 LOV2-DARPin fusion, FLAVIN MONONUCLEOTIDE, ...
Authors:Mittl, P.
Deposit date:2021-12-23
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:LOV2-DARPIN fusion: D13
To Be Published
5MDI
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BU of 5mdi by Molmil
Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution
Descriptor: ACETATE ION, TAR DNA-binding protein 43
Authors:Afroz, T, Hock, E.-M, Ernst, P, Foglieni, C, Jambeau, M, Gilhespy, L, Laferriere, F, Maniecka, Z, Plueckthun, A, Mittl, P, Paganetti, P, Allain, F.H.T, Polymenidou, M.
Deposit date:2016-11-11
Release date:2017-07-05
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.
Nat Commun, 8, 2017
2XEH
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BU of 2xeh by Molmil
Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins With a Redesigned C-capping Module.
Descriptor: NI3C MUT6, SULFATE ION
Authors:Kramer, M, Wetzel, S.K, Pluckthun, A, Mittl, P, Grutter, M.
Deposit date:2010-05-14
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
2XEN
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BU of 2xen by Molmil
Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins With a Redesigned C-capping Module.
Descriptor: 1,2-ETHANEDIOL, METHANOL, NI1C MUT4, ...
Authors:Kramer, M, Wetzel, S.K, Pluckthun, A, Mittl, P, Grutter, M.
Deposit date:2010-05-17
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
2XEE
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BU of 2xee by Molmil
Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins With a Redesigned C-capping Module.
Descriptor: NI3C DARPIN MUTANT5
Authors:Kramer, M, Wetzel, S.K, Pluckthun, A, Mittl, P, Grutter, M.
Deposit date:2010-05-14
Release date:2010-08-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
2Y0B
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BU of 2y0b by Molmil
Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ...
Authors:Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G.
Deposit date:2010-12-01
Release date:2011-12-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21, 2013
2XZD
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BU of 2xzd by Molmil
Caspase-3 in Complex with an Inhibitory DARPin-3.4
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ...
Authors:Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G.
Deposit date:2010-11-24
Release date:2011-12-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21, 2013
8AED
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BU of 8aed by Molmil
Broadly neutralizing DARPin bnD.9 in complex with the HIV-1 envelope variable loop 3 peptide V3 (BG505)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Broadly neutralizing DARPin bnD.9, ...
Authors:Mittl, P, Gloegl, M.
Deposit date:2022-07-13
Release date:2023-08-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
Nat.Struct.Mol.Biol., 30, 2023
6HV2
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BU of 6hv2 by Molmil
MMP-13 in complex with the peptide IMISF
Descriptor: CALCIUM ION, Collagenase 3, GLYCEROL, ...
Authors:Mittl, P, Riedl, R, Hohl, D.
Deposit date:2018-10-10
Release date:2019-01-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.709 Å)
Cite:Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template.
Angew.Chem.Int.Ed.Engl., 58, 2019
7QNL
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BU of 7qnl by Molmil
LOV2-DARPIN FUSION - D4_DeltaLOV
Descriptor: DARPIN, SULFATE ION
Authors:Mittl, P.
Deposit date:2021-12-21
Release date:2023-07-05
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:LOV2-DARPIN FUSION - D4_DeltaLOV
To Be Published
1HIA
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BU of 1hia by Molmil
KALLIKREIN COMPLEXED WITH HIRUSTASIN
Descriptor: HIRUSTASIN, KALLIKREIN
Authors:Mittl, P, Di Marco, S, Gruetter, M.
Deposit date:1996-12-12
Release date:1997-12-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A new structural class of serine protease inhibitors revealed by the structure of the hirustasin-kallikrein complex.
Structure, 5, 1997
8AH9
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BU of 8ah9 by Molmil
De novo retro-aldolase RAbetaB-16.1
Descriptor: BENZOIC ACID, RAbetaB-16.1
Authors:Mittl, P, Oualb Chaib, A, Hilvert, D.
Deposit date:2022-07-21
Release date:2023-08-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.747 Å)
Cite:Design and optimization of enzymatic activity in a de novo beta-barrel scaffold.
Protein Sci., 31, 2022
7YWJ
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BU of 7ywj by Molmil
Crystal structure of an engineered TycA variant, TycA pPLA (L313P)
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, SULFATE ION, ...
Authors:Mittl, P, Camus, A, Truong, G, Markert, G, Hilvert, D.
Deposit date:2022-02-14
Release date:2022-09-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Reprogramming Nonribosomal Peptide Synthetases for Site-Specific Insertion of alpha-Hydroxy Acids.
J.Am.Chem.Soc., 144, 2022
7YWK
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BU of 7ywk by Molmil
Crystal structure of an engineered TycA variant, TycApPLA, in complex with AMP
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ...
Authors:Mittl, P, Camus, A, Truong, G, Markert, G, Hilvert, D.
Deposit date:2022-02-14
Release date:2022-09-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Reprogramming Nonribosomal Peptide Synthetases for Site-Specific Insertion of alpha-Hydroxy Acids.
J.Am.Chem.Soc., 144, 2022
7TAL
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BU of 7tal by Molmil
LOV2-DARPIN fusion : D4_deltaDARP
Descriptor: D4_deltaDARP LOV2-DARPin fusion, FLAVIN MONONUCLEOTIDE, MAGNESIUM ION
Authors:Mittl, P.
Deposit date:2021-12-21
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:LOV2-DARPIN fusion : D4_deltaDARP
To Be Published
7TBN
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BU of 7tbn by Molmil
LOV2-DARPIN fusion : D11
Descriptor: CARBONATE ION, D11 LOV2-DARPin fusion, GLYCEROL
Authors:Mittl, P.
Deposit date:2021-12-22
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:LOV2-DARPIN fusion : D11
To Be Published
7TBO
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BU of 7tbo by Molmil
LOV2-DARPIN fusion : D12
Descriptor: D12 LOV2-DARPin fusion, GLYCEROL
Authors:Mittl, P.
Deposit date:2021-12-22
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:LOV2-DARPIN fusion : D12
To Be Published
7TBQ
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BU of 7tbq by Molmil
LOV2-DARPIN fusion : D7
Descriptor: CHLORIDE ION, D7 LOV2-DARPin fusion, FLAVIN MONONUCLEOTIDE, ...
Authors:Mittl, P.
Deposit date:2021-12-22
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.678 Å)
Cite:LOV2-DARPIN fusion : D7
To Be Published
6YE3
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BU of 6ye3 by Molmil
IL-2 in complex with a Fab fragment from UFKA-20
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chains: A,D,G, Chains: B,E,H, ...
Authors:Karakus, U, Mittl, P, Boyman, O.
Deposit date:2020-03-23
Release date:2020-12-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species.
Sci Transl Med, 12, 2020
6NW4
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BU of 6nw4 by Molmil
Evolution of a computationally designed Kemp eliminase
Descriptor: 6-NITROBENZOTRIAZOLE, Indole-3-glycerol phosphate synthase, SULFATE ION
Authors:Bunzel, A, Mittl, P, Hilvert, D.
Deposit date:2019-02-06
Release date:2019-07-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Emergence of a Negative Activation Heat Capacity during Evolution of a Designed Enzyme.
J.Am.Chem.Soc., 141, 2019
4V3Q
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BU of 4v3q by Molmil
Designed armadillo repeat protein with 4 internal repeats, 2nd generation C-cap and 3rd generation N-cap.
Descriptor: CALCIUM ION, GLYCEROL, YIII_M4_AII
Authors:Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P.
Deposit date:2014-10-20
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects.
Acta Crystallogr D Struct Biol, 72, 2016
4V3O
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BU of 4v3o by Molmil
Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap.
Descriptor: ACETATE ION, CALCIUM ION, YIII_M5_AII
Authors:Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P.
Deposit date:2014-10-20
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects
Acta Crystallogr.,Sect.D, 72, 2016
4V3R
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BU of 4v3r by Molmil
Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap.
Descriptor: MAGNESIUM ION, YIII_M5_AII
Authors:Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P.
Deposit date:2014-10-20
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects
Acta Crystallogr.,Sect.D, 72, 2016
5AAO
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BU of 5aao by Molmil
Crystal structure of fluorogen-activating designed ankyrin repeat protein (DARPin) dimer in complex with malachite green
Descriptor: 4-[[4-(dimethylamino)cyclohexa-2,5-dien-1-ylidene]-(4-methoxyphenyl)methyl]-N,N-dimethyl-aniline, FAD3210
Authors:Batyuk, A, Schuetz, M, Kummer, L, Wu, Y, Mittl, P, Plueckthun, A.
Deposit date:2015-07-27
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools.
J. Mol. Biol., 428, 2016
5AEI
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BU of 5aei by Molmil
Designed Armadillo repeat protein YIIIM5AII in complex with peptide (KR)5
Descriptor: ACETATE ION, CALCIUM ION, DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII, ...
Authors:Hansen, S, Tremmel, D, Madhurantakam, C, Reichen, C, Mittl, P, Plueckthun, A.
Deposit date:2015-08-31
Release date:2016-03-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity.
J.Am.Chem.Soc., 138, 2016

 

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