7TCD
 
 | | LOV2-DARPIN fusion: D13 | | Descriptor: | CHLORIDE ION, D13 LOV2-DARPin fusion, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Mittl, P. | | Deposit date: | 2021-12-23 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | LOV2-DARPIN fusion: D13
To Be Published
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2XEN
 | | Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins With a Redesigned C-capping Module. | | Descriptor: | 1,2-ETHANEDIOL, METHANOL, NI1C MUT4, ... | | Authors: | Kramer, M, Wetzel, S.K, Pluckthun, A, Mittl, P, Grutter, M. | | Deposit date: | 2010-05-17 | | Release date: | 2010-08-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
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2XEH
 | | Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins With a Redesigned C-capping Module. | | Descriptor: | NI3C MUT6, SULFATE ION | | Authors: | Kramer, M, Wetzel, S.K, Pluckthun, A, Mittl, P, Grutter, M. | | Deposit date: | 2010-05-14 | | Release date: | 2010-08-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
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2XZD
 | | Caspase-3 in Complex with an Inhibitory DARPin-3.4 | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ... | | Authors: | Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G. | | Deposit date: | 2010-11-24 | | Release date: | 2011-12-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21, 2013
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2Y0B
 | | Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R | | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CASPASE-3, ... | | Authors: | Barandun, J, Schroeder, T, Mittl, P, Grutter, M.G. | | Deposit date: | 2010-12-01 | | Release date: | 2011-12-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21, 2013
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2XEE
 | | Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins With a Redesigned C-capping Module. | | Descriptor: | NI3C DARPIN MUTANT5 | | Authors: | Kramer, M, Wetzel, S.K, Pluckthun, A, Mittl, P, Grutter, M. | | Deposit date: | 2010-05-14 | | Release date: | 2010-08-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
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5MDI
 | | Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution | | Descriptor: | ACETATE ION, TAR DNA-binding protein 43 | | Authors: | Afroz, T, Hock, E.-M, Ernst, P, Foglieni, C, Jambeau, M, Gilhespy, L, Laferriere, F, Maniecka, Z, Plueckthun, A, Mittl, P, Paganetti, P, Allain, F.H.T, Polymenidou, M. | | Deposit date: | 2016-11-11 | | Release date: | 2017-07-05 | | Last modified: | 2017-07-12 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.
Nat Commun, 8, 2017
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8AED
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6HV2
 | | MMP-13 in complex with the peptide IMISF | | Descriptor: | CALCIUM ION, Collagenase 3, GLYCEROL, ... | | Authors: | Mittl, P, Riedl, R, Hohl, D. | | Deposit date: | 2018-10-10 | | Release date: | 2019-01-30 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.709 Å) | | Cite: | Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template.
Angew.Chem.Int.Ed.Engl., 58, 2019
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8AH9
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7QNL
 | | LOV2-DARPIN FUSION - D4_DeltaLOV | | Descriptor: | DARPIN, SULFATE ION | | Authors: | Mittl, P. | | Deposit date: | 2021-12-21 | | Release date: | 2023-07-05 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | LOV2-DARPIN FUSION - D4_DeltaLOV
To Be Published
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7TBN
 | | LOV2-DARPIN fusion : D11 | | Descriptor: | CARBONATE ION, D11 LOV2-DARPin fusion, GLYCEROL | | Authors: | Mittl, P. | | Deposit date: | 2021-12-22 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | LOV2-DARPIN fusion : D11
To Be Published
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7TBO
 | | LOV2-DARPIN fusion : D12 | | Descriptor: | D12 LOV2-DARPin fusion, GLYCEROL | | Authors: | Mittl, P. | | Deposit date: | 2021-12-22 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | LOV2-DARPIN fusion : D12
To Be Published
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7TBQ
 | | LOV2-DARPIN fusion : D7 | | Descriptor: | CHLORIDE ION, D7 LOV2-DARPin fusion, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Mittl, P. | | Deposit date: | 2021-12-22 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.678 Å) | | Cite: | LOV2-DARPIN fusion : D7
To Be Published
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7TAL
 | | LOV2-DARPIN fusion : D4_deltaDARP | | Descriptor: | D4_deltaDARP LOV2-DARPin fusion, FLAVIN MONONUCLEOTIDE, MAGNESIUM ION | | Authors: | Mittl, P. | | Deposit date: | 2021-12-21 | | Release date: | 2023-07-05 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | LOV2-DARPIN fusion : D4_deltaDARP
To Be Published
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1HIA
 | | KALLIKREIN COMPLEXED WITH HIRUSTASIN | | Descriptor: | HIRUSTASIN, KALLIKREIN | | Authors: | Mittl, P, Di Marco, S, Gruetter, M. | | Deposit date: | 1996-12-12 | | Release date: | 1997-12-24 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | A new structural class of serine protease inhibitors revealed by the structure of the hirustasin-kallikrein complex.
Structure, 5, 1997
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7YWK
 | | Crystal structure of an engineered TycA variant, TycApPLA, in complex with AMP | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, CHLORIDE ION, ... | | Authors: | Mittl, P, Camus, A, Truong, G, Markert, G, Hilvert, D. | | Deposit date: | 2022-02-14 | | Release date: | 2022-09-21 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Reprogramming Nonribosomal Peptide Synthetases for Site-Specific Insertion of alpha-Hydroxy Acids.
J.Am.Chem.Soc., 144, 2022
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7YWJ
 | | Crystal structure of an engineered TycA variant, TycA pPLA (L313P) | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, SULFATE ION, ... | | Authors: | Mittl, P, Camus, A, Truong, G, Markert, G, Hilvert, D. | | Deposit date: | 2022-02-14 | | Release date: | 2022-09-21 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.749 Å) | | Cite: | Reprogramming Nonribosomal Peptide Synthetases for Site-Specific Insertion of alpha-Hydroxy Acids.
J.Am.Chem.Soc., 144, 2022
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4V3Q
 | | Designed armadillo repeat protein with 4 internal repeats, 2nd generation C-cap and 3rd generation N-cap. | | Descriptor: | CALCIUM ION, GLYCEROL, YIII_M4_AII | | Authors: | Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P. | | Deposit date: | 2014-10-20 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects.
Acta Crystallogr D Struct Biol, 72, 2016
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5L86
 | | engineered ascorbate peroxidise | | Descriptor: | Ascorbate peroxidase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | | Authors: | Hayashi, T, Mittl, P, Hilvert, D. | | Deposit date: | 2016-06-07 | | Release date: | 2017-03-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme.
J. Am. Chem. Soc., 138, 2016
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4V3R
 | | Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap. | | Descriptor: | MAGNESIUM ION, YIII_M5_AII | | Authors: | Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P. | | Deposit date: | 2014-10-20 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects
Acta Crystallogr.,Sect.D, 72, 2016
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4V3O
 | | Designed armadillo repeat protein with 5 internal repeats, 2nd generation C-cap and 3rd generation N-cap. | | Descriptor: | ACETATE ION, CALCIUM ION, YIII_M5_AII | | Authors: | Reichen, C, Madhurantakam, C, Pluckthun, A, Mittl, P. | | Deposit date: | 2014-10-20 | | Release date: | 2016-01-13 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects
Acta Crystallogr.,Sect.D, 72, 2016
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6NW4
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8AGQ
 | | Crystal structure of anthocyanin-related GSTF8 from Populus trichocarpa in complex with (-)-catechin and glutathione | | Descriptor: | (2~{S},3~{R})-2-[3,4-bis(oxidanyl)phenyl]-3,4-dihydro-2~{H}-chromene-3,5,7-triol, GLUTATHIONE, Glutathione transferase, ... | | Authors: | Eichenberger, M, Hueppi, S, Schwander, T, Mittl, P, Buller, M.R. | | Deposit date: | 2022-07-20 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.093 Å) | | Cite: | The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis.
Nat Catal, 6, 2023
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4PLR
 | | Crystal Structures of Designed Armadillo Repeat Proteins: Implications of Construct Design and Crystallization Conditions on Overall Structure. | | Descriptor: | Arm00008, CALCIUM ION | | Authors: | Reichen, C, Madhurantakam, C, Plueckthun, A, Mittl, P. | | Deposit date: | 2014-05-19 | | Release date: | 2014-08-27 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of designed armadillo repeat proteins: Implications of construct design and crystallization conditions on overall structure.
Protein Sci., 23, 2014
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