Author results

5MDI
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CRYSTAL STRUCTURE OF TDP-43 N-TERMINAL DOMAIN AT 2.1 A RESOLUTION
Descriptor:TAR DNA-binding protein 43, ACETATE ION
Authors:Afroz, T., Hock, E.-M., Ernst, P., Foglieni, C., Jambeau, M., Gilhespy, L., Laferriere, F., Maniecka, Z., Plueckthun, A., Mittl, P., Paganetti, P., Allain, F.H.T., Polymenidou, M.
Deposit date:2016-11-11
Release date:2017-07-05
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.
Nat Commun, 8, 2017
2XEE
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STRUCTURAL DETERMINANTS FOR IMPROVED THERMAL STABILITY OF DESIGNED ANKYRIN REPEAT PROTEINS WITH A REDESIGNED C-CAPPING MODULE.
Descriptor:NI3C DARPIN MUTANT5
Authors:Kramer, M., Wetzel, S.K., Pluckthun, A., Mittl, P., Grutter, M.
Deposit date:2010-05-14
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
2XEH
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STRUCTURAL DETERMINANTS FOR IMPROVED THERMAL STABILITY OF DESIGNED ANKYRIN REPEAT PROTEINS WITH A REDESIGNED C-CAPPING MODULE.
Descriptor:NI3C MUT6, SULFATE ION
Authors:Kramer, M., Wetzel, S.K., Pluckthun, A., Mittl, P., Grutter, M.
Deposit date:2010-05-14
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
2XEN
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STRUCTURAL DETERMINANTS FOR IMPROVED THERMAL STABILITY OF DESIGNED ANKYRIN REPEAT PROTEINS WITH A REDESIGNED C-CAPPING MODULE.
Descriptor:NI1C MUT4, 1,2-ETHANEDIOL, METHANOL, ...
Authors:Kramer, M., Wetzel, S.K., Pluckthun, A., Mittl, P., Grutter, M.
Deposit date:2010-05-17
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Determinants for Improved Thermal Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module.
J.Mol.Biol., 404, 2010
2XZD
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CASPASE-3 IN COMPLEX WITH AN INHIBITORY DARPIN-3.4
Descriptor:CASPASE-3, DARPIN-3.4, (4R)-2-METHYLPENTANE-2,4-DIOL, ...
Authors:Barandun, J., Schroeder, T., Mittl, P., Grutter, M.G.
Deposit date:2010-11-24
Release date:2011-12-14
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21, 2013
2Y0B
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CASPASE-3 IN COMPLEX WITH AN INHIBITORY DARPIN-3.4_S76R
Descriptor:CASPASE-3 SUBUNIT P17, CASPASE-3, DARPIN-3.4_S76R, ...
Authors:Barandun, J., Schroeder, T., Mittl, P., Grutter, M.G.
Deposit date:2010-12-01
Release date:2011-12-21
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific Inhibition of Caspase-3 by a Competitive Darpin: Molecular Mimicry between Native and Designed Inhibitors.
Structure, 21, 2013
1HIA
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KALLIKREIN COMPLEXED WITH HIRUSTASIN
Descriptor:KALLIKREIN, HIRUSTASIN
Authors:Mittl, P., Di Marco, S., Gruetter, M.
Deposit date:1996-12-12
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A new structural class of serine protease inhibitors revealed by the structure of the hirustasin-kallikrein complex.
Structure, 5, 1997
5OD1
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STRUCTURE OF THE ENGINEERED METALLOESTERASE MID1SC10 COMPLEXED WITH A PHOSPHONATE TRANSITION STATE ANALOGUE
Descriptor:MID1sc10, ZINC ION, [2-oxidanylidene-7-[oxidanyl-[(1~{S})-1-phenylethyl]phosphoryl]oxy-chromen-4-yl]methanesulfonic acid, ...
Authors:Mittl, P.R.E., Studer, S., Hansen, D.A., Hilvert, D.
Deposit date:2017-07-04
Release date:2018-12-12
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:engineered metalloenzyme
To Be Published
6HV2
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MMP-13 IN COMPLEX WITH THE PEPTIDE IMISF
Descriptor:Collagenase 3, ZINC ION, CALCIUM ION, ...
Authors:Mittl, P., Riedl, R., Hohl, D.
Deposit date:2018-10-10
Release date:2019-01-30
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.709 Å)
Cite:Drug Design Inspired by Nature: Crystallographic Detection of an Auto-Tailored Protease Inhibitor Template.
Angew.Chem.Int.Ed.Engl., 58, 2019
5MFB
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DESIGNED ARMADILLO REPEAT PROTEIN YIII(DQ)4CQI
Descriptor:YIII(Dq)4CqI
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFE
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DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII IN COMPLEX WITH (RR)4 PEPTIDE
Descriptor:YIIIM5AII, (RR)4, 1,2-ETHANEDIOL, ...
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFF
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DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII IN COMPLEX WITH PEPTIDE (RR)5
Descriptor:YIIIM5AII, (RR)5, 1,2-ETHANEDIOL
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFG
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DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII IN COMPLEX WITH PEPTIDE (RR)4
Descriptor:YIIIM5AII, (RR)4, CALCIUM ION
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFH
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DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII IN COMPLEX WITH PEPTIDE (RR)5
Descriptor:YIIIM5AII, (RR)5, CALCIUM ION
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFI
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DESIGNED ARMADILLO REPEAT PROTEIN YIII(DQ.V2)4CQI IN COMPLEX WITH PEPTIDE (KR)4
Descriptor:YIII(Dq.V2)4CqI, (KR)4
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFJ
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DESIGNED ARMADILLO REPEAT PROTEIN YIII(DQ.V2)4CQI IN COMPLEX WITH PEPTIDE (KR)5
Descriptor:YIII(Dq.V2)4CqI, (KR)5
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFK
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DESIGNED ARMADILLO REPEAT PROTEIN YIII(DQ.V1)4CPAF IN COMPLEX WITH PEPTIDE (KR)4
Descriptor:YIII(Dq.V1)4CPAF, (KR)4
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFL
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DESIGNED ARMADILLO REPEAT PROTEIN (KR)5_GS10_YIIIM6AII
Descriptor:(KR)5_GS10_YIIIM6AII, CALCIUM ION, MAGNESIUM ION, ...
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFM
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DESIGNED ARMADILLO REPEAT PROTEIN PEPTIDE FUSION YIIIM6AII_GS11_(KR)5
Descriptor:YIIIM6AII_GS11_(KR)5, Importin subunit alpha, CALCIUM ION, ...
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFN
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DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII
Descriptor:YIIIM5AII, CALCIUM ION, D-MALATE
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
5MFO
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DESIGNED ARMADILLO REPEAT PROTEIN YIIIM3AIII
Descriptor:YIIIM3AIII, CALCIUM ION, 1,2-ETHANEDIOL
Authors:Hansen, S., Ernst, P., Reichen, C., Ewald, C., Mittl, P., Plueckthun, A.
Deposit date:2016-11-18
Release date:2017-09-13
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Curvature of designed armadillo repeat proteins allows modular peptide binding.
J. Struct. Biol., 201, 2018
4PLR
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CRYSTAL STRUCTURES OF DESIGNED ARMADILLO REPEAT PROTEINS: IMPLICATIONS OF CONSTRUCT DESIGN AND CRYSTALLIZATION CONDITIONS ON OVERALL STRUCTURE.
Descriptor:Arm00008, CALCIUM ION
Authors:Reichen, C., Madhurantakam, C., Plueckthun, A., Mittl, P.
Deposit date:2014-05-19
Release date:2014-08-27
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of designed armadillo repeat proteins: Implications of construct design and crystallization conditions on overall structure.
Protein Sci., 23, 2014
4V3O
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DESIGNED ARMADILLO REPEAT PROTEIN WITH 5 INTERNAL REPEATS, 2ND GENERATION C-CAP AND 3RD GENERATION N-CAP.
Descriptor:YIII_M5_AII, CALCIUM ION, ACETATE ION
Authors:Reichen, C., Madhurantakam, C., Pluckthun, A., Mittl, P.
Deposit date:2014-10-20
Release date:2016-01-13
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects
Acta Crystallogr.,Sect.D, 72, 2016
4V3Q
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DESIGNED ARMADILLO REPEAT PROTEIN WITH 4 INTERNAL REPEATS, 2ND GENERATION C-CAP AND 3RD GENERATION N-CAP.
Descriptor:YIII_M4_AII, GLYCEROL, CALCIUM ION
Authors:Reichen, C., Madhurantakam, C., Pluckthun, A., Mittl, P.
Deposit date:2014-10-20
Release date:2016-01-13
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of designed armadillo-repeat proteins show propagation of inter-repeat interface effects.
Acta Crystallogr D Struct Biol, 72, 2016
4V3R
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DESIGNED ARMADILLO REPEAT PROTEIN WITH 5 INTERNAL REPEATS, 2ND GENERATION C-CAP AND 3RD GENERATION N-CAP.
Descriptor:YIII_M5_AII, MAGNESIUM ION
Authors:Reichen, C., Madhurantakam, C., Pluckthun, A., Mittl, P.
Deposit date:2014-10-20
Release date:2016-01-13
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of Designed Armadillo-Repeat Proteins Show Propagation of Inter-Repeat Interface Effects
Acta Crystallogr.,Sect.D, 72, 2016
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