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6H47
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BU of 6h47 by Molmil
Human KRAS in complex with darpin K19
Descriptor: GTPase KRas, SULFATE ION, darpin K19
Authors:Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H.
Deposit date:2018-07-20
Release date:2019-04-24
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun, 10, 2019
6H46
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BU of 6h46 by Molmil
Human KRAS in complex with darpin K13
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H.
Deposit date:2018-07-20
Release date:2019-04-24
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun, 10, 2019
5MLB
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BU of 5mlb by Molmil
Crystal structure of human RAS in complex with darpin K27
Descriptor: DARPin K27, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R.
Deposit date:2016-12-06
Release date:2017-12-20
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
5MLA
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BU of 5mla by Molmil
Crystal structure of human RAS in complex with darpin K55
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase KRas, MAGNESIUM ION, ...
Authors:Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R.
Deposit date:2016-12-06
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Inhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
5O2S
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BU of 5o2s by Molmil
Human KRAS in complex with darpin K27
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R.
Deposit date:2017-05-22
Release date:2017-07-26
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun, 8, 2017
5O2T
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BU of 5o2t by Molmil
Human KRAS in complex with darpin K27
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase KRas, MAGNESIUM ION, ...
Authors:Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R.
Deposit date:2017-05-22
Release date:2017-07-26
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun, 8, 2017
6XZ6
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BU of 6xz6 by Molmil
Structure of the trypanosome brucei factor H receptor bound to domain D5 of bovine factor H
Descriptor: Complement factor H, GARP domain-containing protein
Authors:Macleod, O.J.S, Carrington, M, Higgins, M.K.
Deposit date:2020-02-02
Release date:2020-03-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
Nat Commun, 11, 2020
6SOY
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BU of 6soy by Molmil
Trypanosoma brucei transferrin receptor in complex with human transferrin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, subunit of heterodimeric transferrin receptor, ...
Authors:Trevor, C, Carrington, M, Higgins, M.K.
Deposit date:2019-08-30
Release date:2019-11-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.
Nat Microbiol, 4, 2019
6SOZ
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BU of 6soz by Molmil
Glycosylated Trypanosoma brucei transferrin receptor in complex with human transferrin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ESAG6, ...
Authors:Trevor, C, Carrington, M, Higgins, M.K.
Deposit date:2019-08-30
Release date:2019-11-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.
Nat Microbiol, 4, 2019
5L6Y
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BU of 5l6y by Molmil
il13 in complex with tralokinumab
Descriptor: FORMIC ACID, Interleukin-13, tralokinumab FAb digest VH, ...
Authors:Breed, J.
Deposit date:2016-06-01
Release date:2016-12-21
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R alpha 1 and IL-13R alpha 2.
J. Mol. Biol., 429, 2017

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PDB entries from 2024-03-27

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