Author results

1FNE
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HISTOCOMPATIBILITY ANTIGEN
Descriptor:PROTEIN (MHC CLASS II I-EK, ALPHA CHAIN), BETA CHAIN), ...
Authors:Miley, M.J., Nelson, C.A., Fremont, D.H.
Deposit date:2000-08-21
Release date:2001-03-07
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional consequences of altering a peptide MHC anchor residue.
J.Immunol., 166, 2001
1FNG
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HISTOCOMPATIBILITY ANTIGEN
Descriptor:PROTEIN (MHC CLASS II I-EK, ALPHA CHAIN), BETA CHAIN), ...
Authors:Miley, M.J., Nelson, C.A., Fremont, D.H.
Deposit date:2000-08-21
Release date:2001-03-07
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional consequences of altering a peptide MHC anchor residue.
J.Immunol., 166, 2001
1PQZ
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MURINE CYTOMEGALOVIRUS IMMUNOMODULATORY PROTEIN M144
Descriptor:MCMV M144, Beta-2-microglobulin
Authors:Miley, M.J., Fremont, D.H., Midwest Center for Structural Genomics (MCSG)
Deposit date:2003-06-19
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:MURINE CYTOMEGALOVIRUS IMMUNOMODULATORY PROTEIN M144
To be Published
1RJY
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MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND HERPES SIMPLEX VIRUS GLYCOPROTEIN B PEPTIDE
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Miley, M.J., Messaoudi, I., Nikolich-Zugich, J., Fremont, D.H.
Deposit date:2003-11-20
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
1RJZ
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MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND HERPIES SIMPLEX VIRUS MUTANT GLYCOPROTEIN B PEPTIDE
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Miley, M.J., Messaoudi, I., Nikolich-Zugich, J., Fremont, D.H.
Deposit date:2003-11-20
Release date:2004-12-14
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
1RK0
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MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND HERPES SIMPLEX VIRUS GLYCOPROTEIN B PEPTIDE
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Miley, M.J., Messaoudi, I., Nikolich-Zugich, J., Fremont, D.H.
Deposit date:2003-11-20
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
1RK1
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MHC CLASS I NATURAL H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND HERPES SIMPLEX VIRUS MUTANT GLYCOPROTEIN B PEPTIDE
Descriptor:H-2 class I histocompatibility antigen, K-B alpha chain, Beta-2-microglobulin, ...
Authors:Miley, M.J., Messaoudi, I., Nikolich-Zugich, J., Fremont, D.H.
Deposit date:2003-11-20
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
J.Exp.Med., 200, 2004
2O6L
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CRYSTAL STRUCTURE OF THE UDP-GLUCURONIC ACID BINDING DOMAIN OF THE HUMAN DRUG METABOLIZING UDP-GLUCURONOSYLTRANSFERASE 2B7
Descriptor:UDP-glucuronosyltransferase 2B7
Authors:Miley, M.J., Redinbo, M.R.
Deposit date:2006-12-07
Release date:2007-05-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Cofactor-Binding Domain of the Human Phase II Drug-Metabolism Enzyme UDP-Glucuronosyltransferase 2B7.
J.Mol.Biol., 369, 2007
3ONW
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STRUCTURE OF A G-ALPHA-I1 MUTANT WITH ENHANCED AFFINITY FOR THE RGS14 GOLOCO MOTIF.
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Kimple, A.J., Sammond, D.W., Miley, M.J., Machius, M., Kuhlman, B., Willard, F.S., Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
3QE0
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A GALPHA-I1 P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-19
Release date:2012-01-25
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3QI2
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A GALPHA P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE: G42R BOUND TO RGS14 GOLOCO
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-26
Release date:2012-02-01
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3TCP
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC569
Descriptor:Tyrosine-protein kinase Mer, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CHLORIDE ION, ...
Authors:Liu, J., Yang, C., Simpson, C., DeRyckere, D., Van Deusen, A., Miley, M., Kireev, D.B., Norris-Drouin, J., Sather, S., Hunter, D., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2011-08-09
Release date:2012-06-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett, 3, 2012
3ZY7
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CRYSTAL STRUCTURE OF COMPUTATIONALLY REDESIGNED GAMMA-ADAPTIN APPENDAGE DOMAIN FORMING A SYMMETRIC HOMODIMER
Descriptor:AP-1 COMPLEX SUBUNIT GAMMA-1, ISOPROPYL ALCOHOL, DI(HYDROXYETHYL)ETHER
Authors:Stranges, P.B., Machius, M., Miley, M.J., Tripathy, A., Kuhlman, B.
Deposit date:2011-08-17
Release date:2011-12-28
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Computational Design of a Symmetric Homodimer Using Beta-Strand Assembly.
Proc.Natl.Acad.Sci.USA, 108, 2011
3U3B
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CRYSTAL STRUCTURE OF COMPUTATIONALLY REDESIGNED FOUR-HELIX BUNDLE
Descriptor:computationally designed four-helix bundle protein
Authors:Murphy, G.S., Machius, M.
Deposit date:2011-10-05
Release date:2012-06-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core.
Structure, 20, 2012
3V1A
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-APO1
Descriptor:Computational design, MID1-apo1
Authors:Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
Deposit date:2011-12-09
Release date:2012-01-11
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1B
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-APO2
Descriptor:Computational design, MID1-apo2, GLYCEROL
Authors:Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
Deposit date:2011-12-09
Release date:2012-01-11
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1C
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-ZINC
Descriptor:Computational design, MID1-zinc, ZINC ION, ...
Authors:Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
Deposit date:2011-12-09
Release date:2012-01-11
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.129 Å)
Cite:Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1D
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-COBALT
Descriptor:Computational design, MID1-cobalt, COBALT (II) ION, ...
Authors:Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
Deposit date:2011-12-09
Release date:2012-01-11
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.239 Å)
Cite:Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1E
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-ZINC H12E MUTANT
Descriptor:Computational design, MID1-zinc H12E mutant, ZINC ION
Authors:Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
Deposit date:2011-12-09
Release date:2012-01-11
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.073 Å)
Cite:Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
3V1F
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED MID1-ZINC H35E MUTANT
Descriptor:Computational design, MID1-zinc H35E mutant, ZINC ION, ...
Authors:Der, B.S., Machius, M., Miley, M.J., Kuhlman, B.
Deposit date:2011-12-09
Release date:2012-01-11
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.151 Å)
Cite:Metal-mediated affinity and orientation specificity in a computationally designed protein homodimer.
J.Am.Chem.Soc., 134, 2012
4M3Q
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1917
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Zhang, W., Zhang, D., Stashko, M.A., DeRyckere, D., Hunter, D., Kireev, D.B., Miley, M., Cummings, C., Lee, M., Norris-Drouin, J., Stewart, W.M., Sather, S., Zhou, Y., Kirkpatrick, G., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-06
Release date:2013-11-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.718 Å)
Cite:Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors.
J.Med.Chem., 56, 2013
4MH7
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1896
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Zhang, W., McIver, A., Stashko, M.A., Deryckere, D., Branchford, B.R., Hunter, D., Kireev, D.B., Miley, M.J., Norris-Drouin, J., Stewart, W.M., Lee, M., Sather, S., Zhou, Y., DiPaola, J.A., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-29
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
4MHA
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTO-ONCOGENE TYROSINE-PROTEIN KINASE MER IN COMPLEX WITH INHIBITOR UNC1817
Descriptor:Tyrosine-protein kinase Mer, CHLORIDE ION, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, ...
Authors:Zhang, W., Mciver, A., Stashko, M.A., Deryckere, D., Branchford, B.R., Hunter, D., Kireev, D.B., Miley, D.B.M., Norris-Drouin, J., Stewart, W.M., Lee, M., Sather, S., Zhou, Y., Dipaola, J.A., Machius, M., Janzen, W.P., Earp, H.S., Graham, D.K., Frye, S., Wang, X.
Deposit date:2013-08-29
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
J.Med.Chem., 56, 2013
5C7I
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MOUSE SPERM GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE: APO ENZYME
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Authors:Danshina, P., Betts, L., O'Brien, D.
Deposit date:2015-06-24
Release date:2016-03-09
Last modified:2016-06-15
Method:X-RAY DIFFRACTION (2.0098 Å)
Cite:Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22, 2016
5C7L
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STRUCTURE OF HUMAN TESTIS-SPECIFIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE APO FORM
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Authors:Betts, L., Machius, M., Danshina, P., O'Brien, D.
Deposit date:2015-06-24
Release date:2016-03-09
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.862 Å)
Cite:Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme.
Mol. Hum. Reprod., 22, 2016
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