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2B0K
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CRYSTAL STRUCTURE OF THE DB921-D(CGCGAATTCGCG)2 COMPLEX.
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, 2-(4'-AMIDINOBIPHENYL-4-YL)-1H-BENZIMIDAZOLE-5-AMIDINE
Authors:Miao, Y., Lee, M.P., Parkinson, G.N., Batista-Parra, A., Ismail, M.A., Neidle, S., Boykin, D.W., Wilson, W.D.
Deposit date:2005-09-14
Release date:2005-11-22
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Out-of-Shape DNA Minor Groove Binders: Induced Fit Interactions of Heterocyclic Dications with the DNA Minor Groove.
Biochemistry, 44, 2005
5DX9
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STRUCTURE OF TREHALOSE-6-PHOSPHATE PHOSPHATASE FROM CRYPTOCOCCUS NEOFORMANS
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION, Trehalose-6-phosphate, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXF
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE PHOSPHATASE N-TERMINAL DOMAIN
Descriptor:trehalose-6-phosphate phosphatase
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.563 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXI
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STRUCTURE OF C. ALBICANS TREHALOSE-6-PHOSPHATE PHOSPHATASE C-TERMINAL DOMAIN
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXL
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 1
Descriptor:trehalose-6-phosphate phosphatase
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.573 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXN
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 2
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXO
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 3
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HUS
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE SYNTHASE REGULATORY PROTEIN C-TERMINAL DOMAIN
Descriptor:trehalose synthase regulatory protein
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Structure of Candida albicans trehalose synthase regulatory protein C-terminal domain
To Be Published
5HUT
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP-GLUCOSE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE-GLUCOSE, SULFATE ION, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HUU
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP AND GLUCOSE-6-PHOSPHATE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE, ALPHA-D-GLUCOSE-6-PHOSPHATE
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HUV
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE E341R/E346R IN COMPLEX WITH UDP-GLUCOSE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose
To Be Published
5HVL
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HVM
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE SYNTHASE A IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.815 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HVO
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE SYNTHASE B IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.467 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
6NDZ
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DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ8
Descriptor:Frizzled-8, Designed repeat binding protein, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-14
Release date:2019-05-15
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.264 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE1
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DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ4
Descriptor:Frizzled-4, Pfs, NACHT and Ankyrin domain protein, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-15
Release date:2019-05-15
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3.011 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE2
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DESIGNED REPEAT PROTEIN IN COMPLEX WITH FZ7
Descriptor:Designed repeat protein binder, Frizzled-7, ACETATE ION, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-15
Release date:2019-05-15
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.299 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
6NE4
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DESIGNED REPEAT PROTEIN SPECIFICALLY IN COMPLEX WITH FZ7CRD
Descriptor:Designed repeat binding protein, Frizzled-7, SULFATE ION, ...
Authors:Miao, Y., Jude, K.M., Garcia, K.C.
Deposit date:2018-12-16
Release date:2019-05-15
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.648 Å)
Cite:Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
3N6M
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CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH GTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6N
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CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH BR-UTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, 5-bromouridine 5'-(tetrahydrogen triphosphate)
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
6ABR
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ACTIN INTERACTING PROTEIN 5 (AIP5, WILD TYPE)
Descriptor:Actin binding protein
Authors:Sun, J., Xie, Y., Toh, J.D.W., Hong, W., MIao, Y., Gao, Y.G.
Deposit date:2018-07-23
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization.
Nat Commun, 10, 2019
6ABS
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ACTIN INTERACTING PROTEIN 5 (AIP5, MUTANT)
Descriptor:Actin binding protein, TRIETHYLENE GLYCOL, PENTAETHYLENE GLYCOL
Authors:Sun, J., Ying, X., Toh, J., Hong, W., Miao, Y., Gao, Y.G.
Deposit date:2018-07-23
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization.
Nat Commun, 10, 2019
3N6L
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THE CRYSTAL STRUCUTRE OF RNA-DEPENDENT RNA POLYMERASE OF EV71 VIRUS
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION
Authors:Wu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
6IQI
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA PROFILIN 2
Descriptor:Profilin-2
Authors:Qiao, Z., Gao, Y.
Deposit date:2018-11-08
Release date:2019-11-06
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and computational examination of theArabidopsisprofilin-Poly-P complex reveals mechanistic details in profilin-regulated actin assembly.
J.Biol.Chem., 294, 2019
6IQJ
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA PROFILIN 2 COMPLEX WITH FORMIN1
Descriptor:Profilin-2, Formin-like protein 1
Authors:Qiao, Z., Gao, Y.
Deposit date:2018-11-08
Release date:2019-11-06
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.922 Å)
Cite:Structural and computational examination of theArabidopsisprofilin-Poly-P complex reveals mechanistic details in profilin-regulated actin assembly.
J.Biol.Chem., 294, 2019
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