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2B0K
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CRYSTAL STRUCTURE OF THE DB921-D(CGCGAATTCGCG)2 COMPLEX.
Descriptor:5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3', MAGNESIUM ION, 2-(4'-AMIDINOBIPHENYL-4-YL)-1H-BENZIMIDAZOLE-5-AMIDINE
Authors:Miao, Y., Lee, M.P., Parkinson, G.N., Batista-Parra, A., Ismail, M.A., Neidle, S., Boykin, D.W., Wilson, W.D.
Deposit date:2005-09-14
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Out-of-Shape DNA Minor Groove Binders: Induced Fit Interactions of Heterocyclic Dications with the DNA Minor Groove.
Biochemistry, 44, 2005
5DX9
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STRUCTURE OF TREHALOSE-6-PHOSPHATE PHOSPHATASE FROM CRYPTOCOCCUS NEOFORMANS
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION, Trehalose-6-phosphate, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXF
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE PHOSPHATASE N-TERMINAL DOMAIN
Descriptor:trehalose-6-phosphate phosphatase
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.563 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXI
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STRUCTURE OF C. ALBICANS TREHALOSE-6-PHOSPHATE PHOSPHATASE C-TERMINAL DOMAIN
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXL
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 1
Descriptor:trehalose-6-phosphate phosphatase
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.573 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXN
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 2
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DXO
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE PHOSPHATASE CRYSTAL FORM 3
Descriptor:trehalose-6-phosphate phosphatase, MAGNESIUM ION
Authors:Miao, Y., Brennan, R.G.
Deposit date:2015-09-23
Release date:2016-06-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HUS
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE SYNTHASE REGULATORY PROTEIN C-TERMINAL DOMAIN
Descriptor:trehalose synthase regulatory protein
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Structure of Candida albicans trehalose synthase regulatory protein C-terminal domain
To Be Published
5HUT
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP-GLUCOSE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE-GLUCOSE, SULFATE ION
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HUU
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP AND GLUCOSE-6-PHOSPHATE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE, ALPHA-D-GLUCOSE-6-PHOSPHATE
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HUV
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE E341R/E346R IN COMPLEX WITH UDP-GLUCOSE
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-27
Release date:2017-05-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structure of Candida albicans trehalose-6-phosphate synthase E341R/E346R in complex with UDP-glucose
To Be Published
5HVL
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STRUCTURE OF CANDIDA ALBICANS TREHALOSE-6-PHOSPHATE SYNTHASE IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase [UDP-forming], URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL, ...
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HVM
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE SYNTHASE A IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.815 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
5HVO
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STRUCTURE OF ASPERGILLUS FUMIGATUS TREHALOSE-6-PHOSPHATE SYNTHASE B IN COMPLEX WITH UDP AND VALIDOXYLAMINE A
Descriptor:Alpha,alpha-trehalose-phosphate synthase (UDP-forming), URIDINE-5'-DIPHOSPHATE, (1S,2S,3R,6S)-4-(HYDROXYMETHYL)-6-{[(1S,2S,3S,4R,5R)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL]AMINO}CYCLOHEX-4-ENE-1,2,3-TRIOL
Authors:Miao, Y., Brennan, R.G.
Deposit date:2016-01-28
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.467 Å)
Cite:Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.
MBio, 8, 2017
3N6M
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CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH GTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6N
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CRYSTAL STRUCTURE OF EV71 RDRP IN COMPLEX WITH BR-UTP
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION, 5-bromouridine 5'-(tetrahydrogen triphosphate)
Authors:Wu, Y., Lou, Z.Y., Miao, Y., Yu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3N6L
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THE CRYSTAL STRUCUTRE OF RNA-DEPENDENT RNA POLYMERASE OF EV71 VIRUS
Descriptor:RNA-dependent RNA polymerase, NICKEL (II) ION
Authors:Wu, Y., Rao, Z.H.
Deposit date:2010-05-26
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China.
Protein Cell, 1, 2010
3TKY
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MONOLIGNOL O-METHYLTRANSFERASE (MOMT)
Descriptor:(Iso)eugenol O-methyltransferase, 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenol, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Bhuiya, M.W., Liu, C.J.
Deposit date:2011-08-29
Release date:2012-08-29
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:An engineered monolignol 4-o-methyltransferase depresses lignin biosynthesis and confers novel metabolic capability in Arabidopsis.
Plant Cell, 24, 2012
5CLN
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CRYSTAL STRUCTURE OF A 4-OXALOCROTONATE TAUTOMERASE MUTANT AT 2.7 ANGSTROM
Descriptor:2-hydroxymuconate tautomerase
Authors:Thunnissen, A.M.W.H., Poddar, H.
Deposit date:2015-07-16
Release date:2016-03-09
Last modified:2016-03-16
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases.
Nat Commun, 7, 2016
5CLO
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CRYSTAL STRUCTURE OF A 4-OXALOCROTONATE TAUTOMERASE MUTANT IN COMPLEX WITH NITROSTYRENE AT 2.3 ANGSTROM
Descriptor:2-hydroxymuconate tautomerase, trans beta nitrostyrene
Authors:Thunnissen, A.M.W.H., Poddar, H.
Deposit date:2015-07-16
Release date:2016-03-09
Last modified:2016-03-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases.
Nat Commun, 7, 2016