Author results

3HEI
  • Download 3hei
  • View 3hei
Molmil generated image of 3hei
LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTAL STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THE EPHA2/EPHRIN-A1 COMPLEX
Descriptor:Ephrin type-A receptor 2, Ephrin-A1
Authors:Himanen, J.P., Goldgur, Y., Miao, H., Myshkin, E., Guo, H., Buck, M., Nguyen, M., Rajashankar, K.R., Wang, B., Nikolov, D.B.
Deposit date:2009-05-08
Release date:2009-06-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
3HPN
  • Download 3hpn
  • View 3hpn
Molmil generated image of 3hpn
LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTAL STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THE EPHA2/EPHRIN-A1 COMPLEX
Descriptor:Ephrin type-A receptor 2
Authors:Himanen, J.P., Goldgur, Y., Miao, H., Myshkin, E., Guo, H., Buck, M., Nguyen, M., Rajashankar, K.R., Wang, B., Nikolov, D.B.
Deposit date:2009-06-04
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
4OUL
  • Download 4oul
  • View 4oul
Molmil generated image of 4oul
CRYSTAL STRUCTURE OF HUMAN CAPRIN-2 C1Q DOMAIN
Descriptor:Caprin-2, CALCIUM ION, GLYCEROL
Authors:Song, X., Li, L.
Deposit date:2014-02-17
Release date:2014-10-29
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling
J.Biol.Chem., 289, 2014
4OUM
  • Download 4oum
  • View 4oum
Molmil generated image of 4oum
CRYSTAL STRUCTURE OF HUMAN CAPRIN-2 C1Q DOMAIN
Descriptor:Caprin-2, TETRAETHYLENE GLYCOL, CITRATE ANION, ...
Authors:Song, X., Li, L.
Deposit date:2014-02-18
Release date:2014-10-29
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling
J.Biol.Chem., 289, 2014
4OUS
  • Download 4ous
  • View 4ous
Molmil generated image of 4ous
CRYSTAL STRUCTURE OF ZEBRAFISH CAPRIN-2 C1Q DOMAIN
Descriptor:Caprin-2, CALCIUM ION
Authors:Song, X., Li, L.
Deposit date:2014-02-18
Release date:2014-10-29
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling
J.Biol.Chem., 289, 2014
6DE7
  • Download 6de7
  • View 6de7
Molmil generated image of 6de7
CRYSTAL STRUCTURE AT 4.3 A RESOLUTION OF GLYCOSYLATED HIV-1 CLADE A BG505 SOSIP.664 PREFUSION ENV TRIMER WITH INTERDOMAIN STABILIZATION 113C-429GCG IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODIES PGT122 AND 35O22
Descriptor:Envelope glycoprotein gp160, 35O22 heavy chain, 35O22 light chain, ...
Authors:Gorman, J., Kwong, P.D.
Deposit date:2018-05-11
Release date:2018-06-06
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (4.123 Å)
Cite:Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.
Cell Host Microbe, 23, 2018
4X5Y
  • Download 4x5y
  • View 4x5y
Molmil generated image of 4x5y
MENIN IN COMPLEX WITH MI-503
Descriptor:Menin, 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ...
Authors:Pollock, J., Borkin, D., Cierpicki, T., Grembecka, J.
Deposit date:2014-12-06
Release date:2015-04-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo.
Cancer Cell, 27, 2015
4X5Z
  • Download 4x5z
  • View 4x5z
Molmil generated image of 4x5z
MENIN IN COMPLEX WITH MI-136
Descriptor:Menin, SULFATE ION, 5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, ...
Authors:Pollock, J., Borkin, D., Cierpicki, T., Grembecka, J.
Deposit date:2014-12-06
Release date:2015-04-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo.
Cancer Cell, 27, 2015
5VNA
  • Download 5vna
  • View 5vna
Molmil generated image of 5vna
CRYSTAL STRUCTURE OF HUMAN YEATS DOMAIN
Descriptor:YEATS domain-containing protein 4, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Cho, H.J., Cierpicki, T.
Deposit date:2017-04-29
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
ACS Chem. Biol., 13, 2018
5VNB
  • Download 5vnb
  • View 5vnb
Molmil generated image of 5vnb
YEATS IN COMPLEX WITH HISTONE H3
Descriptor:YEATS domain-containing protein 4, H3K23acK27ac peptide, 1,2-ETHANEDIOL, ...
Authors:Cho, H.J., Cierpicki, T.
Deposit date:2017-04-29
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
ACS Chem. Biol., 13, 2018
2MTN
  • Download 2mtn
  • View 2mtn
Molmil generated image of 2mtn
SOLUTION STRUCTURE OF MLL-IBD COMPLEX
Descriptor:Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein fusion
Authors:Cierpicki, T., Pollock, J., Murai, M.
Deposit date:2014-08-23
Release date:2014-12-03
Last modified:2015-04-22
Method:SOLUTION NMR
Cite:The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.
Blood, 124, 2014
5DB0
  • Download 5db0
  • View 5db0
Molmil generated image of 5db0
MENIN IN COMPLEX WITH MI-352
Descriptor:Menin, TETRAETHYLENE GLYCOL, SULFATE ION, ...
Authors:Pollock, J., Dmitry, B., Cierpicki, T., Grembecka, J.
Deposit date:2015-08-20
Release date:2016-03-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
J.Med.Chem., 59, 2016
5DB1
  • Download 5db1
  • View 5db1
Molmil generated image of 5db1
MENIN IN COMPLEX WITH MI-336
Descriptor:Menin, 6-methoxy-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indole-2-carbonitrile, DIMETHYL SULFOXIDE, ...
Authors:Pollock, J., Dmitry, B., Cierpicki, T., Grembecka, J.
Deposit date:2015-08-20
Release date:2016-03-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
J.Med.Chem., 59, 2016
5DB2
  • Download 5db2
  • View 5db2
Molmil generated image of 5db2
MENIN IN COMPLEX WITH MI-389
Descriptor:Menin, 2-{2-cyano-5-[(4-{[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino}piperidin-1-yl)methyl]-1H-indol-1-yl}acetamide, DIMETHYL SULFOXIDE, ...
Authors:Pollock, J., Dmitry, B., Cierpicki, T., Grembecka, J.
Deposit date:2015-08-20
Release date:2016-03-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
J.Med.Chem., 59, 2016
5DB3
  • Download 5db3
  • View 5db3
Molmil generated image of 5db3
MENIN IN COMPLEX WITH MI-574
Descriptor:Menin, DIMETHYL SULFOXIDE, TETRAETHYLENE GLYCOL, ...
Authors:Pollock, J., Borkin, D., Cierpicki, T., Grembecka, J.
Deposit date:2015-08-20
Release date:2016-03-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
J.Med.Chem., 59, 2016
5U1F
  • Download 5u1f
  • View 5u1f
Molmil generated image of 5u1f
INITIAL CONTACT OF HIV-1 ENV WITH CD4: CRYO-EM STRUCTURE OF BG505 DS-SOSIP TRIMER IN COMPLEX WITH CD4 AND ANTIBODY PGT145
Descriptor:BG505 DS-SOSIP gp120, BG505 SOSIP gp41, PGT145 heavy chain, ...
Authors:Acharya, P., Kwong, P.D., Potter, C.S., Carragher, B.
Deposit date:2016-11-28
Release date:2017-02-22
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
Nat. Struct. Mol. Biol., 24, 2017
5YEY
  • Download 5yey
  • View 5yey
Molmil generated image of 5yey
THE STRUCTURE OF A CHAIR-TYPE G-QUADRUPLEX OF THE HUMAN TELOMERIC VARIANT IN K+ SOLUTION
Descriptor:DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3')
Authors:Liu, C., Zhou, B., Kuryavyi, V.V., Zhu, G.
Deposit date:2017-09-20
Release date:2018-09-26
Last modified:2019-04-10
Method:SOLUTION NMR
Cite:A chair-type G-quadruplex structure formed by a human telomeric variant DNA in K+solution.
Chem Sci, 10, 2019
6JKN
  • Download 6jkn
  • View 6jkn
Molmil generated image of 6jkn
CRYSTAL STRUCTURE OF G-QUADRUPLEX FORMED BY BROMO-SUBSTITUTED HUMAN TELOMERIC DNA
Descriptor:DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*(BGM)P*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*(BGM)P*G)-3'), POTASSIUM ION
Authors:Geng, Y., Cai, Q., Liu, C., Zhu, G.
Deposit date:2019-03-01
Release date:2019-04-03
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:The crystal structure of an antiparallel chair-type G-quadruplex formed by Bromo-substituted human telomeric DNA.
Nucleic Acids Res., 2019
6NM6
  • Download 6nm6
  • View 6nm6
Molmil generated image of 6nm6
CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO N6 FR3-03 SCFV IN COMPLEX WITH CRYSTALLIZATION CHAPERONES 3H109L FAB AND 35O22 SCFV AT 3.2 ANGSTROM
Descriptor:Envelope glycoprotein gp41, 35O22 scFv heavy chain, 35O22 scFv light chain, ...
Authors:Lai, Y.-T., Kwong, P.D.
Deposit date:2019-01-10
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.739 Å)
Cite:Improvement of antibody functionality by structure-guided paratope engraftment.
Nat Commun, 10, 2019
6NNF
  • Download 6nnf
  • View 6nnf
Molmil generated image of 6nnf
CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO VRC01 FR3-03 SCFV IN COMPLEX WITH CRYSTALLIZATION CHAPERONES 3H109L FAB AND 35O22 SCFV AT 3.5 ANGSTROM
Descriptor:Envelope glycoprotein gp41, 35O22 scFv heavy chain, 35O22 scFv light chain, ...
Authors:Lai, Y.-T., Kwong, P.D.
Deposit date:2019-01-14
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.762 Å)
Cite:Improvement of antibody functionality by structure-guided paratope engraftment.
Nat Commun, 10, 2019
6NNJ
  • Download 6nnj
  • View 6nnj
Molmil generated image of 6nnj
CRYSTAL STRUCTURE OF HIV-1 BG505 SOSIP.664 PREFUSION ENV TRIMER BOUND TO CH31 SCFV IN COMPLEX WITH CRYSTALLIZATION CHAPERONES 3H109L FAB AND 35O22 SCFV AT 3.1 ANGSTROM
Descriptor:Envelope glycoprotein gp41, 35O22 scFv heavy chain, 35O22 scFv light chain, ...
Authors:Lai, Y.-T., Kwong, P.D.
Deposit date:2019-01-15
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Improvement of antibody functionality by structure-guided paratope engraftment.
Nat Commun, 10, 2019