Author results

4P8Z
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SPECIATION OF A GROUP I INTRON INTO A LARIAT CAPPING RIBOZYME
Descriptor:Didymium iridis partial IGS, 18S rRNA gene, I-DirI gene and partial ITS1
Authors:Meyer, M., Nielsen, H., Olieric, V., Roblin, P., Johansen, S.D., Westhof, E., Masquida, B.
Deposit date:2014-04-01
Release date:2014-05-28
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:Speciation of a group I intron into a lariat capping ribozyme.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P95
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SPECIATION OF A GROUP I INTRON INTO A LARIAT CAPPING RIBOZYME (CIRCULARLY PERMUTATED RIBOZYME)
Descriptor:RNA (192-MER), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ...
Authors:Meyer, M., Nielsen, H., Olieric, V., Roblin, P., Johansen, S.D., Westhof, E., Masquida, B.
Deposit date:2014-04-02
Release date:2014-05-28
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Speciation of a group I intron into a lariat capping ribozyme.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P9R
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SPECIATION OF A GROUP I INTRON INTO A LARIAT CAPPING RIBOZYME (HEAVY ATOM DERIVATIVE)
Descriptor:RNA (189-MER), IRIDIUM HEXAMMINE ION, MAGNESIUM ION
Authors:Meyer, M., Nielsen, H., Olieric, V., Roblin, P., Johansen, S.D., Westhof, E., Masquida, B.
Deposit date:2014-04-04
Release date:2014-05-28
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Speciation of a group I intron into a lariat capping ribozyme.
Proc.Natl.Acad.Sci.USA, 111, 2014
6GYV
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LARIAT-CAPPING RIBOZYME (CIRCULAR PERMUTATION FORM)
Descriptor:Lariat-capping ribozyme, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ...
Authors:Masquida, B., Meyer, M., Nielsen, H., Olieric, V., Roblin, P., Johansen, S.D., Westhof, E.
Deposit date:2018-07-02
Release date:2018-08-22
Method:X-RAY DIFFRACTION (2.500036 Å), SOLUTION SCATTERING
Cite:Speciation of a group I intron into a lariat capping ribozyme.
Proc. Natl. Acad. Sci. U.S.A., 111, 2014
1L5Y
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CRYSTAL STRUCTURE OF MG2+ / BEF3-BOUND RECEIVER DOMAIN OF SINORHIZOBIUM MELILOTI DCTD
Descriptor:C4-DICARBOXYLATE TRANSPORT TRANSCRIPTIONAL REGULATORY PROTEIN DCTD, MAGNESIUM ION, SULFATE ION, ...
Authors:Park, S., Meyer, M., Jones, A.D., Yennawar, H.P., Yennawar, N.H., Nixon, B.T.
Deposit date:2002-03-08
Release date:2002-10-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Two-component signaling in the AAA + ATPase DctD: binding Mg2+ and BeF3- selects between alternate dimeric states of the receiver domain
FASEB J., 16, 2002
1L5Z
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CRYSTAL STRUCTURE OF THE E121K SUBSTITUTION OF THE RECEIVER DOMAIN OF SINORHIZOBIUM MELILOTI DCTD
Descriptor:C4-DICARBOXYLATE TRANSPORT TRANSCRIPTIONAL REGULATORY PROTEIN DCTD, SULFATE ION, GLYCEROL
Authors:Park, S., Meyer, M., Jones, A.D., Yennawar, H.P., Yennawar, N.H., Nixon, B.T.
Deposit date:2002-03-08
Release date:2002-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two-component signaling in the AAA + ATPase DctD: binding Mg2+ and BeF3- selects between alternate dimeric states of the receiver domain
FASEB J., 16, 2002
6G7Z
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LARIAT-CAPPING RIBOZYME WITH A SHORTENED DP2 STEM LOOP
Descriptor:Lariat-capping ribozyme, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Masquida, B., Meyer, M., Olieric, V.
Deposit date:2018-04-06
Release date:2018-12-05
Method:X-RAY DIFFRACTION (3.33595 Å)
Cite:Lariat-capping ribozyme with a shortened DP2 stem loop
To Be Published
3G8I
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ALEGLITAZAR, A NEW, POTENT, AND BALANCED PPAR ALPHA/GAMMA AGONIST FOR THE TREATMENT OF TYPE II DIABETES
Descriptor:Peroxisome proliferator-activated receptor alpha, Nuclear receptor coactivator 1, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid
Authors:Benz, J., Bernardeau, A., Binggeli, A., Blum, D., Boehringer, M., Grether, U., Hilpert, H., Kuhn, B., Maerki, H.P., Meyer, M., Puentener, K., Raab, S., Ruf, A., Schlatter, D., Gsell, B., Stihle, M., Mohr, P.
Deposit date:2009-02-12
Release date:2009-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg.Med.Chem.Lett., 19, 2009
3G9E
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ALEGLITAAR. A NEW. POTENT, AND BALANCED DUAL PPARA/G AGONIST FOR THE TREATMENT OF TYPE II DIABETES
Descriptor:Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, (2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid
Authors:Ruf, A., Benz, J., Bernardeau, A., Binggeli, A., Blum, D., Boehringer, M., Grether, U., Hilpert, H., Kuhn, B., Maerki, H.P., Meyer, M., Puenterner, K., Raab, S., Schlatter, D., Gsell, B., Stihle, M., Mohr, P.
Deposit date:2009-02-13
Release date:2009-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.
Bioorg.Med.Chem.Lett., 19, 2009
5MEI
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CRYSTAL STRUCTURE OF AGELASTATIN A BOUND TO THE 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:McClary, B., Zinshteyn, B., Meyer, M., Jouanneau, M., Pellegrino, S., Yusupova, G., Schuller, A., Reyes, J.C.P., Lu, J., Luo, C., Dang, Y., Romo, D., Yusupov, M., Green, R., Liu, J.O.
Deposit date:2016-11-15
Release date:2017-06-28
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Cell Chem Biol, 24, 2017
2FVJ
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A NOVEL ANTI-ADIPOGENIC PARTIAL AGONIST OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA (PPARG) RECRUITS PPARG-COACTIVATOR-1 ALPHA (PGC1A) BUT POTENTIATES INSULIN SIGNALING IN VITRO
Descriptor:Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-4-{[4-(2-METHOXYPHENYL)PIPERIDIN-1-YL]METHYL}ISOQUINOLINE, ...
Authors:Benz, J., Burgermeister, E., Flament, A., Schnoebelen, A., Stihle, M., Gsell, B., Rufer, A., Ruf, A., Kuhn, B., Maerki, H.P., Mizrahi, J., Sebokova, E., Niesor, E., Meyer, M.
Deposit date:2006-01-31
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro
Mol.Endocrinol., 20, 2006
5ON6
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CRYSTAL STRUCTURE OF HAEMANTHAMINE BOUND TO THE 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Meyer, M., Yusupova, G., Yusupov, M.
Deposit date:2017-08-03
Release date:2018-02-28
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3.100002 Å)
Cite:The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.
Structure, 26, 2018
5TBW
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CRYSTAL STRUCTURE OF CHLOROLISSOCLIMIDE BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Konst, Z.A., Szklarski, A.R., Pellegrino, S., Michalak, S.E., Meyer, M., Zanette, C., Cencic, R., Nam, S., Horne, D.A., Pelletier, J., Mobley, D.L., Yusupova, G., Yusupov, M., Vanderwal, C.D.
Deposit date:2016-09-13
Release date:2017-07-26
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9, 2017
2GTK
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STRUCTURE-BASED DESIGN OF INDOLE PROPIONIC ACIDS AS NOVEL PPARAG CO-AGONISTS
Descriptor:Peroxisome proliferator-activated receptor gamma, Decamer from Nuclear receptor coactivator 1, (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID
Authors:Kuhn, B., Hilpert, H., Benz, J., Binggeli, A., Grether, U., Humm, R., Maerki, H.-P., Meyer, M., Mohr, P.
Deposit date:2006-04-28
Release date:2006-09-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists
Bioorg.Med.Chem.Lett., 16, 2006
4AQY
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STRUCTURE OF RIBOSOME-APRAMYCIN COMPLEXES
Descriptor:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Matt, T., Ng, C.L., Lang, K., Sha, S.H., Akbergenov, R., Shcherbakov, D., Meyer, M., Duscha, S., Xie, J., Dubbaka, S.R., Perez-Fernandez, D., Vasella, A., Ramakrishnan, V., Schacht, J., Bottger, E.C.
Deposit date:2012-04-20
Release date:2012-07-18
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Dissociation of Antibacterial Activity and Aminoglycoside Ototoxicity in the 4-Monosubstituted 2-Deoxystreptamine Apramycin.
Proc.Natl.Acad.Sci.USA, 109, 2012
4B3M
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 1
Descriptor:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
Deposit date:2012-07-25
Release date:2013-08-07
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3R
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 30
Descriptor:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
Deposit date:2012-07-26
Release date:2013-08-07
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3S
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 37
Descriptor:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
Deposit date:2012-07-26
Release date:2013-08-07
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
4B3T
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CRYSTAL STRUCTURE OF THE 30S RIBOSOME IN COMPLEX WITH COMPOUND 39
Descriptor:16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Ng, C.L., Lang, K., Shcherbakov, D., Matt, T., Perez-Fernandez, D., Patak, R., Meyer, M., Duscha, S., Akbergenov, R., Boukari, H., Freihofer, P., Kudyba, I., Reddy, M.S.K., Nandurikar, R.S., Ramakrishnan, V., Vasella, A., Bottger, E.C.
Deposit date:2012-07-26
Release date:2013-08-07
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:4'-O-Substitutions Determine Selectivity of Aminoglycoside Antibiotics
Nat.Commun., 5, 2014
6HHQ
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CRYSTAL STRUCTURE OF COMPOUND C45 BOUND TO THE YEAST 80S RIBOSOME
Descriptor:25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Pellegrino, S., Vanderwal, C.D., Yusupov, M.
Deposit date:2018-08-28
Release date:2019-02-20
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.
Nucleic Acids Res., 47, 2019
3FEI
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DESIGN AND BIOLOGICAL EVALUATION OF NOVEL, BALANCED DUAL PPARA/G AGONISTS
Descriptor:Peroxisome proliferator-activated receptor alpha, Peptide motif 5 of Nuclear receptor coactivator 1, (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid
Authors:Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M., Schlatter, D.
Deposit date:2008-11-30
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
Chemmedchem, 4, 2009
3FEJ
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DESIGN AND BIOLOGICAL EVALUATION OF NOVEL, BALANCED DUAL PPARA/G AGONISTS
Descriptor:Peroxisome proliferator-activated receptor gamma, peptide motif 3 of Nuclear receptor coactivator 1, (2S)-3-(4-{[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methoxy}-2-methylphenyl)-2-ethoxypropanoic acid
Authors:Benz, J., Grether, U., Gsell, B., Binggeli, A., Hilpert, H., Kuhn, B., Maerki, H.P., Mohr, P., Ruf, A., Stihle, M.
Deposit date:2008-11-30
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
Chemmedchem, 4, 2009
1UYA
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THE SOLUTION STRUCTURE OF THE A-FORM OF UROGUANYLIN-16 NMR, 10 STRUCTURES
Descriptor:UROGUANYLIN-16, ISOMER A
Authors:Marx, U.C., Adermann, K., Forssmann, W.-G., Roesch, P.
Deposit date:1997-09-11
Release date:1998-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers.
J.Pept.Res., 52, 1998
1UYB
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THE SOLUTION STRUCTURE OF THE B-FORM OF UROGUANYLIN-16 NMR, 10 STRUCTURES
Descriptor:UROGUANYLIN-16, ISOMER B
Authors:Marx, U.C., Adermann, K., Forssmann, W.-G., Roesch, P.
Deposit date:1997-09-11
Release date:1998-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers.
J.Pept.Res., 52, 1998
1ZWB
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STRUCTURE OF HUMAN PARATHYROID HORMONE FRAGMENT 2-37, NMR, 10 STRUCTURES
Descriptor:PARATHYROID HORMONE
Authors:Roesch, P., Marx, U.C.
Deposit date:1996-06-17
Release date:1997-03-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-activity relation of NH2-terminal human parathyroid hormone fragments.
J.Biol.Chem., 273, 1998
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