Author results

2JBJ
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH 2-PMPA (2-PHOSPHONOMETHYL-PENTANEDIOIC ACID)
分子名称:GLUTAMATE CARBOXYPEPTIDASE 2, ZINC ION, CALCIUM ION, ...
著者Mesters, J.R., Henning, K., Hilgenfeld, R.
登録日2006-12-07
公開日2006-12-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63, 2007
2JBK
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH QUISQUALIC ACID (QUISQUALATE, ALPHA-AMINO-3,5-DIOXO-1,2,4- OXADIAZOLIDINE-2-PROPANOIC ACID)
分子名称:GLUTAMATE CARBOXYPEPTIDASE 2, ZINC ION, CALCIUM ION, ...
著者Mesters, J.R., Henning, K., Hilgenfeld, R.
登録日2006-12-07
公開日2006-12-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63, 2007
2C6C
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH GPI-18431 (S)-2-(4-IODOBENZYLPHOSPHONOMETHYL)-PENTANEDIOIC ACID
分子名称:GLUTAMATE CARBOXYPEPTIDASE II, ZINC ION, CALCIUM ION, ...
著者Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.
登録日2005-11-09
公開日2006-02-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of Glutamate Carboxypeptidase II, a Drug Target in Neuronal Damage and Prostate Cancer.
Embo J., 25, 2006
2C6G
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) WITH BOUND GLUTAMATE
分子名称:GLUTAMATE CARBOXYPEPTIDASE II, GLUTAMIC ACID, ZINC ION, ...
著者Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.
登録日2005-11-09
公開日2006-02-15
最終更新日2019-07-10
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
EMBO J., 25, 2006
2C6P
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH PHOSPHATE ANION
分子名称:GLUTAMATE CARBOXYPEPTIDASE II, ZINC ION, CALCIUM ION, ...
著者Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.
登録日2005-11-11
公開日2006-02-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Structure of Glutamate Carboxypeptidase II, a Drug Target in Neuronal Damage and Prostate Cancer.
Embo J., 25, 2006
2CIJ
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MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) WITH BOUND METHIONINE
分子名称:GLUTAMATE CARBOXYPEPTIDASE II, METHIONINE, ZINC ION, ...
著者Barinka, C., Plechanovova, A., Rulisek, L., Mlcochova, P., Majer, P., Slusher, B.S., Hilgenfeld, R., Mesters, J.R., Konvalinka, J.
登録日2006-03-21
公開日2007-03-27
最終更新日2014-06-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Glutamate Carboxypeptidase II
Handbook of Metalloproteins, 4, 2011
2R96
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CRYSTAL STRUCTURE OF E. COLI WRBA IN COMPLEX WITH FMN
分子名称:Flavoprotein WrbA, FLAVIN MONONUCLEOTIDE, 1,2-ETHANEDIOL
著者Kuta Smatanova, I., Wolfova, J., Brynda, J., Mesters, J.R., Grandori, R., Carey, J.
登録日2007-09-12
公開日2008-09-23
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural organization of WrbA in apo- and holoprotein crystals.
Biochim.Biophys.Acta, 1794, 2009
2R97
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CRYSTAL STRUCTURE OF E. COLI WRBA IN COMPLEX WITH FMN
分子名称:Flavoprotein WrbA, FLAVIN MONONUCLEOTIDE
著者Kuta Smatanova, I., Wolfova, J., Brynda, J., Mesters, J.R., Grandori, R., Carey, J.
登録日2007-09-12
公開日2008-09-23
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural organization of WrbA in apo- and holoprotein crystals.
Biochim.Biophys.Acta, 1794, 2009
2XCI
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MEMBRANE-EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS, SUBSTRATE-FREE FORM
分子名称:3-DEOXY-D-MANNO-2-OCTULOSONIC ACID TRANSFERASE, TETRAETHYLENE GLYCOL, GLYCEROL, ...
著者Schmidt, H., Hansen, G., Hilgenfeld, R., Mamat, U., Mesters, J.R.
登録日2010-04-26
公開日2011-05-11
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
2XCU
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MEMBRANE-EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS, COMPLEX WITH CMP
分子名称:3-DEOXY-D-MANNO-2-OCTULOSONIC ACID TRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE, PENTAETHYLENE GLYCOL, ...
著者Schmidt, H., Hansen, G., Hilgenfeld, R., Mamat, U., Mesters, J.R.
登録日2010-04-26
公開日2011-05-11
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
1HA3
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ELONGATION FACTOR TU IN COMPLEX WITH AURODOX
分子名称:ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Vogeley, L., Palm, G.J., Mesters, J.R., Hilgenfeld, R.
登録日2001-03-26
公開日2001-05-15
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Conformational Change of Elongation Factor TU Induced by Antibiotic Binding: Crystal Structure of the Complex between EF-TU:Gdp and Aurodox
J.Biol.Chem., 276, 2001
1EXM
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS ELONGATION FACTOR TU (EF-TU) IN COMPLEX WITH THE GTP ANALOGUE GPPNHP.
分子名称:ELONGATION FACTOR TU (EF-TU), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Hogg, T., Mesters, J.R., Hilgenfeld, R.
登録日2000-05-03
公開日2000-06-07
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Insights into the GTPase Mechanism of EF-Tu from Structural Studies
The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, 28, 2000
1IZH
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INHIBITOR OF HIV PROTEASE WITH UNUSUAL BINDING MODE POTENTLY INHIBITING MULTI-RESISTANT PROTEASE MUTANTS
分子名称:proteinase, {(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER
著者Weber, J., Mesters, J.R., Lepsik, M., Prejdova, J., Svec, M., Sponarova, J., Mlcochova, P., Skalicka, K., Strisovsky, K., Uhlikova, T., Soucek, M., Machala, L., Stankova, M., Vondrasek, J., Klimkait, T., Kraeusslich, H.-G., Hilgenfeld, R., Konvalinka, J.
登録日2002-10-02
公開日2002-12-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains
J.MOL.BIOL., 324, 2002
1IZI
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INHIBITOR OF HIV PROTEASE WITH UNUSUAL BINDING MODE POTENTLY INHIBITING MULTI-RESISTANT PROTEASE MUTANTS
分子名称:proteinase, CHLORIDE ION, {(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER
著者Weber, J., Mesters, J.R., Lepsik, M., Prejdova, J., Svec, M., Sponarova, J., Mlcochova, P., Skalicka, K., Strisovsky, K., Uhlikova, T., Soucek, M., Machala, L., Stankova, M., Vondrasek, J., Klimkait, T., Kraeusslich, H.-G., Hilgenfeld, R., Konvalinka, J.
登録日2002-10-02
公開日2002-12-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains
J.MOL.BIOL., 324, 2002
1LVO
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STRUCTURE OF CORONAVIRUS MAIN PROTEINASE REVEALS COMBINATION OF A CHYMOTRYPSIN FOLD WITH AN EXTRA ALPHA-HELICAL DOMAIN
分子名称:Replicase, hydrolase domain, SULFATE ION, ...
著者Anand, K., Palm, G.J., Mesters, J.R., Siddell, S.G., Ziebuhr, J., Hilgenfeld, R.
登録日2002-05-29
公開日2002-07-17
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.
EMBO J., 21, 2002
1P9S
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CORONAVIRUS MAIN PROTEINASE (3CLPRO) STRUCTURE: BASIS FOR DESIGN OF ANTI-SARS DRUGS
分子名称:Replicase polyprotein 1ab, 1,4-DIETHYLENE DIOXIDE
著者Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R.
登録日2003-05-12
公開日2003-05-20
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs
Science, 300, 2003
1P9U
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CORONAVIRUS MAIN PROTEINASE (3CLPRO) STRUCTURE: BASIS FOR DESIGN OF ANTI-SARS DRUGS
分子名称:putative coronavirus nsp2 (3CL-PRO), PHQ-VNSTLQ-CHLOROMETHYLKETONE INHIBITOR, SULFATE ION, ...
著者Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R.
登録日2003-05-12
公開日2003-05-20
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs
Science, 300, 2003
2BX3
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (P43212)
分子名称:MAIN PROTEINASE
著者Verschueren, K.H.G., Mesters, J.R., Hilgenfeld, R.
登録日2005-07-22
公開日2005-09-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Ph-Dependent Conformational Flexibility of the Sars-Cov Main Proteinase (M(Pro)) Dimer: Molecular Dynamics Simulations and Multiple X-Ray Structure Analyses.
J.Mol.Biol., 354, 2005
2BX4
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (P21212)
分子名称:3C-LIKE PROTEINASE
著者Verschueren, K.H.G., Mesters, J.R., Bigalke, J., Hilgenfeld, R.
登録日2005-07-22
公開日2005-09-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Ph-Dependent Conformational Flexibility of the Sars-Cov Main Proteinase (M(Pro)) Dimer: Molecular Dynamics Simulations and Multiple X-Ray Structure Analyses.
J.Mol.Biol., 354, 2005
2D6B
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NOVEL BROMATE SPECIES TRAPPED WITHIN A PROTEIN CRYSTAL
分子名称:lysozyme C, CHLORIDE ION, SODIUM ION, ...
著者Ondracek, J., Mesters, J.R.
登録日2005-11-10
公開日2005-11-29
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献An ensemble of crystallographic models enables the description of novel bromate-oxoanion species trapped within a protein crystal
Acta Crystallogr.,Sect.D, 62, 2006
2J97
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HUMAN CORONAVIRUS 229E NON STRUCTURAL PROTEIN 9 (NSP9)
分子名称:REPLICASE POLYPROTEIN 1AB, (4S)-2-METHYL-2,4-PENTANEDIOL, SULFATE ION
著者Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.
登録日2006-11-03
公開日2007-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Variable Oligomerization Modes in Coronavirus Non-Structural Protein 9.
J.Mol.Biol., 383, 2008
2J98
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HUMAN CORONAVIRUS 229E NON STRUCTURAL PROTEIN 9 CYS69ALA MUTANT (NSP9)
分子名称:REPLICASE POLYPROTEIN 1AB, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
著者Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.
登録日2006-11-03
公開日2007-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Variable Oligomerization Modes in Coronavirus Non-Structural Protein 9.
J.Mol.Biol., 383, 2008
2RG1
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CRYSTAL STRUCTURE OF E. COLI WRBA APOPROTEIN
分子名称:Flavoprotein WrbA, CHLORIDE ION
著者Kuta Smatanova, I., Wolfova, J., Brynda, J., Lapkouski, M., Mesters, J.R., Grandori, R., Carey, J.
登録日2007-10-02
公開日2008-10-14
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural organization of WrbA in apo- and holoprotein crystals.
Biochim.Biophys.Acta, 1794, 2009
2V6N
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CRYSTAL STRUCTURES OF THE SARS-CORONAVIRUS MAIN PROTEINASE INACTIVATED BY BENZOTRIAZOLE COMPOUNDS
分子名称:REPLICASE POLYPROTEIN 1AB, 4-(DIMETHYLAMINO)BENZOIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Verschueren, K.H.G., Pumpor, K., Anemueller, S., Mesters, J.R., Hilgenfeld, R.
登録日2007-07-19
公開日2008-07-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献A Structural View of the Inactivation of the Sars Coronavirus Main Proteinase by Benzotriazole Esters.
Chem.Biol., 15, 2008
2VB0
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CRYSTAL STRUCTURE OF COXSACKIEVIRUS B3 PROTEINASE 3C
分子名称:POLYPROTEIN 3BCD, CHLORIDE ION
著者Anand, K., Mesters, J.R., Goerlach, R., Zell, R., Hilgenfeld, R.
登録日2007-09-05
公開日2008-10-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Coxsackie Virus B3 Proteinase 3C
To be Published
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