Author results

2JBJ
  • Download 2jbj
  • View 2jbj
Molmil generated image of 2jbj
MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH 2-PMPA (2-PHOSPHONOMETHYL-PENTANEDIOIC ACID)
Descriptor:GLUTAMATE CARBOXYPEPTIDASE 2, ZINC ION, CALCIUM ION, ...
Authors:Mesters, J.R., Henning, K., Hilgenfeld, R.
Deposit date:2006-12-07
Release date:2006-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63, 2007
2JBK
  • Download 2jbk
  • View 2jbk
Molmil generated image of 2jbk
MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH QUISQUALIC ACID (QUISQUALATE, ALPHA-AMINO-3,5-DIOXO-1,2,4- OXADIAZOLIDINE-2-PROPANOIC ACID)
Descriptor:GLUTAMATE CARBOXYPEPTIDASE 2, ZINC ION, CALCIUM ION, ...
Authors:Mesters, J.R., Henning, K., Hilgenfeld, R.
Deposit date:2006-12-07
Release date:2006-12-18
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.
Acta Crystallogr.,Sect.D, 63, 2007
2C6C
  • Download 2c6c
  • View 2c6c
Molmil generated image of 2c6c
MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH GPI-18431 (S)-2-(4-IODOBENZYLPHOSPHONOMETHYL)-PENTANEDIOIC ACID
Descriptor:GLUTAMATE CARBOXYPEPTIDASE II, ZINC ION, CALCIUM ION, ...
Authors:Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.
Deposit date:2005-11-09
Release date:2006-02-15
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Glutamate Carboxypeptidase II, a Drug Target in Neuronal Damage and Prostate Cancer.
Embo J., 25, 2006
2C6G
  • Download 2c6g
  • View 2c6g
Molmil generated image of 2c6g
MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) WITH BOUND GLUTAMATE
Descriptor:GLUTAMATE CARBOXYPEPTIDASE II, GLUTAMIC ACID, ZINC ION, ...
Authors:Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.
Deposit date:2005-11-09
Release date:2006-02-15
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
EMBO J., 25, 2006
2C6P
  • Download 2c6p
  • View 2c6p
Molmil generated image of 2c6p
MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) IN COMPLEX WITH PHOSPHATE ANION
Descriptor:GLUTAMATE CARBOXYPEPTIDASE II, ZINC ION, CALCIUM ION, ...
Authors:Mesters, J.R., Barinka, C., Li, W., Tsukamoto, T., Majer, P., Slusher, B.S., Konvalinka, J., Hilgenfeld, R.
Deposit date:2005-11-11
Release date:2006-02-15
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of Glutamate Carboxypeptidase II, a Drug Target in Neuronal Damage and Prostate Cancer.
Embo J., 25, 2006
2CIJ
  • Download 2cij
  • View 2cij
Molmil generated image of 2cij
MEMBRANE-BOUND GLUTAMATE CARBOXYPEPTIDASE II (GCPII) WITH BOUND METHIONINE
Descriptor:GLUTAMATE CARBOXYPEPTIDASE II, METHIONINE, ZINC ION, ...
Authors:Barinka, C., Plechanovova, A., Rulisek, L., Mlcochova, P., Majer, P., Slusher, B.S., Hilgenfeld, R., Mesters, J.R., Konvalinka, J.
Deposit date:2006-03-21
Release date:2007-03-27
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Glutamate Carboxypeptidase II
Handbook of Metalloproteins, 4, 2011
2R96
  • Download 2r96
  • View 2r96
Molmil generated image of 2r96
CRYSTAL STRUCTURE OF E. COLI WRBA IN COMPLEX WITH FMN
Descriptor:Flavoprotein WrbA, FLAVIN MONONUCLEOTIDE, 1,2-ETHANEDIOL
Authors:Kuta Smatanova, I., Wolfova, J., Brynda, J., Mesters, J.R., Grandori, R., Carey, J.
Deposit date:2007-09-12
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural organization of WrbA in apo- and holoprotein crystals.
Biochim.Biophys.Acta, 1794, 2009
2R97
  • Download 2r97
  • View 2r97
Molmil generated image of 2r97
CRYSTAL STRUCTURE OF E. COLI WRBA IN COMPLEX WITH FMN
Descriptor:Flavoprotein WrbA, FLAVIN MONONUCLEOTIDE
Authors:Kuta Smatanova, I., Wolfova, J., Brynda, J., Mesters, J.R., Grandori, R., Carey, J.
Deposit date:2007-09-12
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural organization of WrbA in apo- and holoprotein crystals.
Biochim.Biophys.Acta, 1794, 2009
2XCI
  • Download 2xci
  • View 2xci
Molmil generated image of 2xci
MEMBRANE-EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS, SUBSTRATE-FREE FORM
Descriptor:3-DEOXY-D-MANNO-2-OCTULOSONIC ACID TRANSFERASE, TETRAETHYLENE GLYCOL, GLYCEROL, ...
Authors:Schmidt, H., Hansen, G., Hilgenfeld, R., Mamat, U., Mesters, J.R.
Deposit date:2010-04-26
Release date:2011-05-11
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
2XCU
  • Download 2xcu
  • View 2xcu
Molmil generated image of 2xcu
MEMBRANE-EMBEDDED MONOFUNCTIONAL GLYCOSYLTRANSFERASE WAAA OF AQUIFEX AEOLICUS, COMPLEX WITH CMP
Descriptor:3-DEOXY-D-MANNO-2-OCTULOSONIC ACID TRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE, PENTAETHYLENE GLYCOL, ...
Authors:Schmidt, H., Hansen, G., Hilgenfeld, R., Mamat, U., Mesters, J.R.
Deposit date:2010-04-26
Release date:2011-05-11
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Proc.Natl.Acad.Sci.USA, 109, 2012
1HA3
  • Download 1ha3
  • View 1ha3
Molmil generated image of 1ha3
ELONGATION FACTOR TU IN COMPLEX WITH AURODOX
Descriptor:ELONGATION FACTOR TU, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vogeley, L., Palm, G.J., Mesters, J.R., Hilgenfeld, R.
Deposit date:2001-03-26
Release date:2001-05-15
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational Change of Elongation Factor TU Induced by Antibiotic Binding: Crystal Structure of the Complex between EF-TU:Gdp and Aurodox
J.Biol.Chem., 276, 2001
1EXM
  • Download 1exm
  • View 1exm
Molmil generated image of 1exm
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS ELONGATION FACTOR TU (EF-TU) IN COMPLEX WITH THE GTP ANALOGUE GPPNHP.
Descriptor:ELONGATION FACTOR TU (EF-TU), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Hogg, T., Mesters, J.R., Hilgenfeld, R.
Deposit date:2000-05-03
Release date:2000-06-07
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into the GTPase Mechanism of EF-Tu from Structural Studies
The Ribosome: Structure, Function, Antibiotics, and Cellular Interactions, 28, 2000
1IZH
  • Download 1izh
  • View 1izh
Molmil generated image of 1izh
INHIBITOR OF HIV PROTEASE WITH UNUSUAL BINDING MODE POTENTLY INHIBITING MULTI-RESISTANT PROTEASE MUTANTS
Descriptor:proteinase, {(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER
Authors:Weber, J., Mesters, J.R., Lepsik, M., Prejdova, J., Svec, M., Sponarova, J., Mlcochova, P., Skalicka, K., Strisovsky, K., Uhlikova, T., Soucek, M., Machala, L., Stankova, M., Vondrasek, J., Klimkait, T., Kraeusslich, H.-G., Hilgenfeld, R., Konvalinka, J.
Deposit date:2002-10-02
Release date:2002-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains
J.MOL.BIOL., 324, 2002
1IZI
  • Download 1izi
  • View 1izi
Molmil generated image of 1izi
INHIBITOR OF HIV PROTEASE WITH UNUSUAL BINDING MODE POTENTLY INHIBITING MULTI-RESISTANT PROTEASE MUTANTS
Descriptor:proteinase, CHLORIDE ION, {(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER
Authors:Weber, J., Mesters, J.R., Lepsik, M., Prejdova, J., Svec, M., Sponarova, J., Mlcochova, P., Skalicka, K., Strisovsky, K., Uhlikova, T., Soucek, M., Machala, L., Stankova, M., Vondrasek, J., Klimkait, T., Kraeusslich, H.-G., Hilgenfeld, R., Konvalinka, J.
Deposit date:2002-10-02
Release date:2002-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains
J.MOL.BIOL., 324, 2002
1LVO
  • Download 1lvo
  • View 1lvo
Molmil generated image of 1lvo
STRUCTURE OF CORONAVIRUS MAIN PROTEINASE REVEALS COMBINATION OF A CHYMOTRYPSIN FOLD WITH AN EXTRA ALPHA-HELICAL DOMAIN
Descriptor:Replicase, hydrolase domain, SULFATE ION, ...
Authors:Anand, K., Palm, G.J., Mesters, J.R., Siddell, S.G., Ziebuhr, J., Hilgenfeld, R.
Deposit date:2002-05-29
Release date:2002-07-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain.
EMBO J., 21, 2002
1P9S
  • Download 1p9s
  • View 1p9s
Molmil generated image of 1p9s
CORONAVIRUS MAIN PROTEINASE (3CLPRO) STRUCTURE: BASIS FOR DESIGN OF ANTI-SARS DRUGS
Descriptor:Replicase polyprotein 1ab, 1,4-DIETHYLENE DIOXIDE
Authors:Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R.
Deposit date:2003-05-12
Release date:2003-05-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs
Science, 300, 2003
1P9U
  • Download 1p9u
  • View 1p9u
Molmil generated image of 1p9u
CORONAVIRUS MAIN PROTEINASE (3CLPRO) STRUCTURE: BASIS FOR DESIGN OF ANTI-SARS DRUGS
Descriptor:putative coronavirus nsp2 (3CL-PRO), PHQ-VNSTLQ-CHLOROMETHYLKETONE INHIBITOR, SULFATE ION, ...
Authors:Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R.
Deposit date:2003-05-12
Release date:2003-05-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs
Science, 300, 2003
2BX3
  • Download 2bx3
  • View 2bx3
Molmil generated image of 2bx3
CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (P43212)
Descriptor:MAIN PROTEINASE
Authors:Verschueren, K.H.G., Mesters, J.R., Hilgenfeld, R.
Deposit date:2005-07-22
Release date:2005-09-26
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ph-Dependent Conformational Flexibility of the Sars-Cov Main Proteinase (M(Pro)) Dimer: Molecular Dynamics Simulations and Multiple X-Ray Structure Analyses.
J.Mol.Biol., 354, 2005
2BX4
  • Download 2bx4
  • View 2bx4
Molmil generated image of 2bx4
CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (P21212)
Descriptor:3C-LIKE PROTEINASE
Authors:Verschueren, K.H.G., Mesters, J.R., Bigalke, J., Hilgenfeld, R.
Deposit date:2005-07-22
Release date:2005-09-26
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Ph-Dependent Conformational Flexibility of the Sars-Cov Main Proteinase (M(Pro)) Dimer: Molecular Dynamics Simulations and Multiple X-Ray Structure Analyses.
J.Mol.Biol., 354, 2005
2D6B
  • Download 2d6b
  • View 2d6b
Molmil generated image of 2d6b
NOVEL BROMATE SPECIES TRAPPED WITHIN A PROTEIN CRYSTAL
Descriptor:lysozyme C, CHLORIDE ION, SODIUM ION, ...
Authors:Ondracek, J., Mesters, J.R.
Deposit date:2005-11-10
Release date:2005-11-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:An ensemble of crystallographic models enables the description of novel bromate-oxoanion species trapped within a protein crystal
Acta Crystallogr.,Sect.D, 62, 2006
2J97
  • Download 2j97
  • View 2j97
Molmil generated image of 2j97
HUMAN CORONAVIRUS 229E NON STRUCTURAL PROTEIN 9 (NSP9)
Descriptor:REPLICASE POLYPROTEIN 1AB, (4S)-2-METHYL-2,4-PENTANEDIOL, SULFATE ION
Authors:Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.
Deposit date:2006-11-03
Release date:2007-11-27
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Variable Oligomerization Modes in Coronavirus Non-Structural Protein 9.
J.Mol.Biol., 383, 2008
2J98
  • Download 2j98
  • View 2j98
Molmil generated image of 2j98
HUMAN CORONAVIRUS 229E NON STRUCTURAL PROTEIN 9 CYS69ALA MUTANT (NSP9)
Descriptor:REPLICASE POLYPROTEIN 1AB, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Ponnusamy, R., Mesters, J.R., Moll, R., Hilgenfeld, R.
Deposit date:2006-11-03
Release date:2007-11-27
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Variable Oligomerization Modes in Coronavirus Non-Structural Protein 9.
J.Mol.Biol., 383, 2008
2RG1
  • Download 2rg1
  • View 2rg1
Molmil generated image of 2rg1
CRYSTAL STRUCTURE OF E. COLI WRBA APOPROTEIN
Descriptor:Flavoprotein WrbA, CHLORIDE ION
Authors:Kuta Smatanova, I., Wolfova, J., Brynda, J., Lapkouski, M., Mesters, J.R., Grandori, R., Carey, J.
Deposit date:2007-10-02
Release date:2008-10-14
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural organization of WrbA in apo- and holoprotein crystals.
Biochim.Biophys.Acta, 1794, 2009
2V6N
  • Download 2v6n
  • View 2v6n
Molmil generated image of 2v6n
CRYSTAL STRUCTURES OF THE SARS-CORONAVIRUS MAIN PROTEINASE INACTIVATED BY BENZOTRIAZOLE COMPOUNDS
Descriptor:REPLICASE POLYPROTEIN 1AB, 4-(DIMETHYLAMINO)BENZOIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Verschueren, K.H.G., Pumpor, K., Anemueller, S., Mesters, J.R., Hilgenfeld, R.
Deposit date:2007-07-19
Release date:2008-07-01
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:A Structural View of the Inactivation of the Sars Coronavirus Main Proteinase by Benzotriazole Esters.
Chem.Biol., 15, 2008
2VB0
  • Download 2vb0
  • View 2vb0
Molmil generated image of 2vb0
CRYSTAL STRUCTURE OF COXSACKIEVIRUS B3 PROTEINASE 3C
Descriptor:POLYPROTEIN 3BCD, CHLORIDE ION
Authors:Anand, K., Mesters, J.R., Goerlach, R., Zell, R., Hilgenfeld, R.
Deposit date:2007-09-05
Release date:2008-10-28
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Coxsackie Virus B3 Proteinase 3C
To be Published
<123>