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2Z9T
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BU of 2z9t by Molmil
Crystal structure of the human beta-2 microglobulin mutant W60G
Descriptor: Beta-2-microglobulin
Authors:Ricagno, S, Bolognesi, M, Bellotti, V, Corazza, A, Rennella, E, Gural, D, Mimmi, M.C, Betto, E, Pucillo, C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M.
Deposit date:2007-09-26
Release date:2008-04-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties
J.Mol.Biol., 378, 2008
2VB5
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BU of 2vb5 by Molmil
Solution structure of W60G mutant of human beta2-microglobulin
Descriptor: BETA-2-MICROGLOBULIN
Authors:Esposito, G, Corazza, A, Rennella, E, Gumral, D, Mimmi, M.C, Fogolari, F, Viglino, P, Raimondi, S, Giorgetti, S, Bolognesi, B, Merlini, G, Stoppini, M, Bellotti, V.
Deposit date:2007-09-06
Release date:2007-09-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Controlling Roles of Trp60 and Trp95 in Beta2-Microglobulin Function, Folding and Amyloid Aggregation Properties.
J.Mol.Biol., 378, 2008
8P89
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BU of 8p89 by Molmil
X-ray structure of cardiotoxic light chain H3 in complex to neutralizing nanobody B5
Descriptor: CHLORIDE ION, Light chain H3, Nanobody B5
Authors:Broggini, L, Ricagno, S.
Deposit date:2023-05-31
Release date:2024-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.187 Å)
Cite:Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation.
J.Mol.Biol., 435, 2023
8P88
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BU of 8p88 by Molmil
X-ray structure of cardiotoxic light chain H3 in complex to neutralizing nanobody C4
Descriptor: CHLORIDE ION, Light Chain H3, Nanobody C4, ...
Authors:Broggini, L, Ricagno, S.
Deposit date:2023-05-31
Release date:2024-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.022 Å)
Cite:Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation.
J.Mol.Biol., 435, 2023
6GRZ
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BU of 6grz by Molmil
Crystal structure of the light chain dimer mH6
Descriptor: GLYCEROL, mH6
Authors:Maritan, M, Ricagno, S, Ambrosetti, A, Oberti, L.
Deposit date:2018-06-13
Release date:2019-06-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains
J.Mol.Biol., 2020
8CPE
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BU of 8cpe by Molmil
CryoEM structure of AL55 amyloid fibrils extracted from the kidney of an AL amyloidosis patient.
Descriptor: Immunoglobulin lambda light chain
Authors:Puri, S, Schulte, T, Chaves-Sanjuan, A, Ricagno, S.
Deposit date:2023-03-02
Release date:2023-08-16
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The Cryo-EM STRUCTURE of Renal Amyloid Fibril Suggests Structurally Homogeneous Multiorgan Aggregation in AL Amyloidosis.
J.Mol.Biol., 435, 2023
7ZH7
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BU of 7zh7 by Molmil
Cryo-EM structure of ex vivo AA amyloid from renal tissue of a short hair cat deceased in a shelter
Descriptor: Serum amyloid A protein
Authors:Schulte, T, Chaves-Sanjuan, A, Ricagno, S.
Deposit date:2022-04-05
Release date:2022-11-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter.
Nat Commun, 13, 2022
6HUD
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BU of 6hud by Molmil
Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient.
Descriptor: Monoclonal immunoglobulin light chains (LC)
Authors:Paissoni, C, Camilloni, C.
Deposit date:2018-10-06
Release date:2019-03-27
Last modified:2019-04-03
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient.
Nat Commun, 10, 2019
1JNJ
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BU of 1jnj by Molmil
NMR solution structure of the human beta2-microglobulin
Descriptor: beta2-microglobulin
Authors:Verdone, G, Corazza, A, Viglino, P, Pettirossi, F, Giorgetti, S, Mangione, P, Andreola, A, Stoppini, M, Bellotti, V, Esposito, G.
Deposit date:2001-07-24
Release date:2002-02-27
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The solution structure of human beta2-microglobulin reveals the prodromes of its amyloid transition.
Protein Sci., 11, 2002
6MG4
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BU of 6mg4 by Molmil
Structure of full-length human lambda-6A light chain JTO
Descriptor: JTO light chain
Authors:Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
Deposit date:2018-09-12
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
6MG5
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BU of 6mg5 by Molmil
Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1
Descriptor: 7-(diethylamino)-4-methyl-2H-1-benzopyran-2-one, Light chain JTO, PHOSPHATE ION
Authors:Morgan, G.J, Yan, N.L, Mortenson, D.E, Stanfield, R.L, Wilson, I.A, Kelly, J.W.
Deposit date:2018-09-12
Release date:2019-04-10
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Proc.Natl.Acad.Sci.USA, 116, 2019
5M6A
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BU of 5m6a by Molmil
Crystal structure of cardiotoxic Bence-Jones light chain dimer H9
Descriptor: Bence-Jones light chain, GLYCEROL, PHOSPHATE ION
Authors:Oberti, L, Rognoni, P, Bacarizo, J, Bolognesi, M, Ricagno, S.
Deposit date:2016-10-24
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Sci Rep, 7, 2017
5M76
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BU of 5m76 by Molmil
Crystal structure of cardiotoxic Bence-Jones light chain dimer H10
Descriptor: BROMIDE ION, light chain dimer
Authors:Oberti, L, Rognoni, P, Bacarizo, J, Bolognesi, M, Ricagno, S.
Deposit date:2016-10-26
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Sci Rep, 7, 2017
5M6I
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BU of 5m6i by Molmil
Crystal structure of non-cardiotoxic Bence-Jones light chain dimer M8
Descriptor: SODIUM ION, light chain dimer
Authors:Oberti, L, Rognoni, P, Russo, R, Bacarizo, J, Bolognesi, M, Ricagno, S.
Deposit date:2016-10-25
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Sci Rep, 7, 2017
5MUH
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BU of 5muh by Molmil
Crystal structure of an amyloidogenic light chain dimer H7
Descriptor: light chain dimer
Authors:Oberti, L, Rognoni, P, Russo, R, Maritan, M, Bacarizo, J, Bolognesi, M, Ricagno, S.
Deposit date:2017-01-13
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Sci Rep, 7, 2017
5MVG
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BU of 5mvg by Molmil
Crystal structure of non-amyloidogenic light chain dimer M7
Descriptor: GLYCEROL, light chain dimer
Authors:Oberti, L, Rognoni, P, Bacarizo, J, Bolognesi, M, Ricagno, S.
Deposit date:2017-01-16
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Sci Rep, 7, 2017
5MTL
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BU of 5mtl by Molmil
Crystal structure of an amyloidogenic light chain
Descriptor: light chain dimer,IGL@ protein,IGL@ protein
Authors:Oberti, L, Rognoni, P, Russo, R, Bacarizo, J, Bolognesi, M, Ricagno, S.
Deposit date:2017-01-10
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Sci Rep, 7, 2017
5MUD
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BU of 5mud by Molmil
Crystal structure of an amyloidogenic light chain dimer H6
Descriptor: light chain dimer,IGL@ protein
Authors:Oberti, L, Bacarizo, J, Maritan, M, Rognoni, P, Bolognesi, M, Ricagno, S.
Deposit date:2017-01-13
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Sci Rep, 7, 2017

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