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6EHT
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MODULATION OF PCNA SLIDING SURFACE BY P15PAF SUGGESTS A SUPPRESSIVE MECHANISM FOR CISPLATIN-INDUCED DNA LESION BYPASS BY POL ETA HOLOENZYME
Descriptor:Proliferating cell nuclear antigen, PCNA-associated factor, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), ...
Authors:De March, M., Barrera-Vilarmau, S., Mentegari, E., Merino, N., Bressan, E., Maga, G., Crehuet, R., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2017-09-15
Release date:2018-08-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
6GIS
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STRUCTURAL BASIS OF HUMAN CLAMP SLIDING ON DNA
Descriptor:Proliferating cell nuclear antigen, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3')
Authors:De March, M., Merino, N., Barrera-Vilarmau, S., Crehuet, R., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2018-05-15
Release date:2018-05-30
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structural basis of human PCNA sliding on DNA.
Nat Commun, 8, 2017
2XE0
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:I-CREI V2V3 VARIANT, 24MER DNA, ACETATE ION, ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Redondo, P., Villate, M., Merino, N., Marenchino, M., D'Abramo, M., Gervasio, F.L., Grizot, S., Daboussi, F., Smith, J., Chion-Sotine, I., Paques, F., Duchateau, P., Alibes, A., Stricher, F., Serrano, L., Blanco, F.J., Montoya, G.
Deposit date:2010-05-10
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
Nucleic Acids Res., 39, 2011
4D2G
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH P15 PEPTIDE
Descriptor:PROLIFERATING CELL NUCLEAR ANTIGEN, P15
Authors:DeBiasio, A., Ibanez, A., Mortuza, G., Molina, R., Cordeiro, T.N., Castillo, F., Villate, M., Merino, N., Lelli, M., Diercks, T., Luque, I., Bernardo, P., Montoya, G., Blanco, F.J.
Deposit date:2014-05-09
Release date:2015-03-18
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of P15(Paf)-PCNA Complex and Implications for Clamp Sliding During DNA Replication and Repair.
Nat.Commun., 6, 2015
5A0M
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THE CRYSTAL STRUCTURE OF I-SCEI IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MN
Descriptor:INTRON-ENCODED ENDONUCLEASE I-SCEI, 5'-D(*CP*AP*CP*GP*CP*TP*AP*GP*GP*GP*AP*TP*AP*AP)-3', 5'-D(*GP*GP*TP*AP*TP*TP*AP*CP*CP*CP*TP*GP*TP*TP *AP*TP)-3', ...
Authors:Prieto, J., Redondo, P., Merino, N., Villate, M., Blanco, F.J., Molina, R.
Deposit date:2015-04-21
Release date:2016-05-04
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the I-Scei Nuclease Complexed with its DsDNA Target and Three Catalytic Metal Ions.
Acta Crystallogr.,Sect.F, 72, 2016
5A72
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH ITS TARGET (SRO1.3) IN THE PRESENCE OF 2 MM CA
Descriptor:DNA ENDONUCLEASE I-CVUI, 24MER DNA, 5'-D(*DTP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP *DCP*GP*AP*CP*GP*TP*TP*CP*TP*GP*A)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-02
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A74
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH ITS TARGET (SRO1.3) IN THE PRESENCE OF 2 MM MN
Descriptor:DNA ENDONUCLEASE I-CVUI, 14MER DNA, 5'-D(*TP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-02
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A77
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA CLEAVED
Descriptor:DNA ENDONUCLEASE I-CVUI, 14MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*DCP)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
5A78
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CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA NOT CLEAVED
Descriptor:DNA ENDONUCLEASE I-CVUI, 24MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP *CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', ...
Authors:Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G.
Deposit date:2015-07-03
Release date:2015-09-23
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
6G52
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CRYSTAL STRUCTURE OF THE CNMP BINDING DOMAIN OF THE MAGNESIUM TRANSPORTER CNNM4
Descriptor:Metal transporter CNNM4
Authors:Gimenez, P., Oyenarte, I., Hardy, S., Zubillaga, M., Merino, N., Blanco, F.J., Siliqi, D., Tremblay, M., Muller, D., Martinez-Cruz, L.A.
Deposit date:2018-03-28
Release date:2019-04-10
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.691 Å)
Cite:CRYSTAL STRUCTURE OF THE CNMP BINDING DOMAIN OF THE MAGNESIUM TRANSPORTER CNNM4
To Be Published
6GWS
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH THREE P15 PEPTIDES
Descriptor:Proliferating cell nuclear antigen, PCNA-associated factor
Authors:De March, M., Merino, N., Gonzalez-Magana, A., Romano-Moreno, M., Onesti, S., Blanco, F.J., De Biasio, A.
Deposit date:2018-06-25
Release date:2018-08-22
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
3MX9
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:Protein scV3V2(G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*GP*CP*TP*GP*AP*GP*GP*TP*AP*CP*CP*TP*GP*AP*GP*AP*AP*CP*AP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MXA
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:scV3V2(G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(P*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
3MXB
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MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
Descriptor:V3(E8K), V2(K7E-G19S), DNA (5'-D(*TP*TP*GP*TP*TP*CP*TP*CP*AP*GP*GP*TP*AP*CP*CP*TP*CP*AP*GP*CP*CP*AP*GP*A)-3'), ...
Authors:Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Montoya, G.
Deposit date:2010-05-07
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus.
Nucleic Acids Res., 39, 2011
5ME8
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5
Descriptor:Inhibitor of growth protein 5, (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL
Authors:Roversi, P., Blanco, F.J., Rojas, A.L., Buitrago, J.A.R.
Deposit date:2016-11-14
Release date:2018-03-14
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
J.Mol.Biol., 431, 2019
5MTO
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N-TERMINAL DOMAIN OF THE HUMAN TUMOR SUPPRESSOR ING5 C19S MUTANT
Descriptor:Inhibitor of growth protein 5, SODIUM ION, SULFATE ION
Authors:Ormaza, G., Buitrago, J.A.R., Roversi, P., Rojas, A.L., Blanco, F.J.
Deposit date:2017-01-10
Release date:2018-02-28
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Tumor Suppressor ING5 Is a Dimeric, Bivalent Recognition Molecule of the Histone H3K4me3 Mark.
J.Mol.Biol., 431, 2019
6FB0
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF CALCIUM
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*GP*AP*GP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB1
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF MAGNESIUM
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (3.024 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB2
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) IN THE PRESENCE OF MANGANESE
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB5
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) AT 5NNN REGION IN THE PRESENCE OF MAGNESIUM
Descriptor:I-CreI monomer A, I-CreI monomer B, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB6
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CRYSTAL STRUCTURE OF A TAILORED I-CREI HOMING ENDONUCLEASE PROTEIN (3115 VARIANT) IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA (HAEMOGLOBIN BETA SUBUNIT GENE) AT 5NNN REGION IN THE PRESENCE OF MANGANESE
Descriptor:I-CreI monomer A, I-CreI monomer B, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*C)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB7
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MANGANESE
Descriptor:DNA endonuclease I-CreI, DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.689 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB8
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA AT 5NNN REGION IN THE PRESENCE OF MAGNESIUM
Descriptor:DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP*GP*CP*AP*GP*TP*TP*TP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), DNA endonuclease I-CreI, ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6FB9
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CRYSTAL STRUCTURE OF THE I-CREI HOMING ENDONUCLEASE D75N VARIANT IN COMPLEX WITH AN ALTERED VERSION OF ITS TARGET DNA AT 5NNN REGION IN THE PRESENCE OF MANGANESE
Descriptor:DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*C)-3'), DNA endonuclease I-CreI, ...
Authors:Molina, R., Prieto, J.
Deposit date:2017-12-18
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Understanding the indirect DNA read-out specificity of I-CreI Meganuclease.
Sci Rep, 8, 2018
6HVO
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CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH THREE PEPTIDES OF P12 SUBUNIT OF HUMAN POLYMERASE DELTA
Descriptor:Proliferating cell nuclear antigen, DNA polymerase delta subunit 4, SULFATE ION
Authors:Gonzalez-Magana, A., Romano-Moreno, M., Rojas, A.L., Blanco, F.J., De Biasio, A.
Deposit date:2018-10-11
Release date:2019-01-23
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA).
J.Biol.Chem., 294, 2019
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