Author results

3R0J
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STRUCTURE OF PHOP FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:POSSIBLE TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE REGULATOR PHOP, SULFATE ION, R-1,2-PROPANEDIOL
Authors:Menon, S., Wang, S.
Deposit date:2011-03-08
Release date:2011-07-13
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Response Regulator PhoP from Mycobacterium tuberculosis Reveals a Dimer through the Receiver Domain.
Biochemistry, 50, 2011
1DB3
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E.COLI GDP-MANNOSE 4,6-DEHYDRATASE
Descriptor:GDP-MANNOSE 4,6-DEHYDRATASE
Authors:Somoza, J.R., Menon, S., Somers, W.S., Sullivan, F.X.
Deposit date:1999-11-02
Release date:1999-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose.
Structure Fold.Des., 8, 2000
1R42
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NATIVE HUMAN ANGIOTENSIN CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE (ACE2)
Descriptor:angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Towler, P., Staker, B., Prasad, S.G., Menon, S., Ryan, D., Tang, J., Parsons, T., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., Pantoliano, M.W.
Deposit date:2003-10-07
Release date:2004-02-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279, 2004
1R4L
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INHIBITOR BOUND HUMAN ANGIOTENSIN CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE (ACE2)
Descriptor:angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Towler, P., Staker, B., Prasad, S.G., Menon, S., Ryan, D., Tang, J., Parsons, T., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., Pantoliano, M.W.
Deposit date:2003-10-07
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279, 2004
2WBT
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THE STRUCTURE OF A DOUBLE C2H2 ZINC FINGER PROTEIN FROM A HYPERTHERMOPHILIC ARCHAEAL VIRUS IN THE ABSENCE OF DNA
Descriptor:B-129, ZINC ION
Authors:Eilers, B.J., Menon, S., Windham, A.B., Kraft, P., Dlakic, M., Young, M.J., Lawrence, C.M.
Deposit date:2009-03-03
Release date:2010-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of a Double C2H2 Zinc Finger Protein from a Hyperthermophilic Archaeal Virus in the Absence of DNA
To be Published
4AAI
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THERMOSTABLE PROTEIN FROM HYPERTHERMOPHILIC VIRUS SSV-RH
Descriptor:ORF E73
Authors:Schlenker, C., Goel, A., Tripet, B.P., Menon, S., Lawrence, C.M., Copie, V.
Deposit date:2011-12-02
Release date:2012-01-11
Last modified:2016-11-30
Method:SOLUTION NMR
Cite:Structural Studies of E73 from a Hyperthermophilic Archaeal Virus Identify the "Rh3" Domain, an Elaborated Ribbon-Helix- Helix Motif Involved in DNA Recognition.
Biochemistry, 51, 2012
4PH4
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THE CRYSTAL STRUCTURE OF HUMAN VPS34 IN COMPLEX WITH PIK-III
Descriptor:Phosphatidylinositol 3-kinase catalytic subunit type 3, GLYCEROL, 4'-(cyclopropylmethyl)-N~2~-(pyridin-4-yl)-4,5'-bipyrimidine-2,2'-diamine
Authors:Knapp, M.S., Elling, R.A.
Deposit date:2014-05-04
Release date:2014-10-29
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nat.Cell Biol., 16, 2014
5TR4
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STRUCTURE OF UBIQUITIN ACTIVATING ENZYME (UBA1) IN COMPLEX WITH UBIQUITIN AND TAK-243
Descriptor:Ubiquitin-activating enzyme E1 1, Ubiquitin, [(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate
Authors:Sintchak, M.D.
Deposit date:2016-10-25
Release date:2017-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification and Characterization of a Small Molecule Inhibitor of the Ubiquitin Activating Enzyme (TAK-243)
To be published
5YO2
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THE CRYSTAL STRUCTURE OF RV2747 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACETYL COA AND L-ARGININE
Descriptor:Amino-acid acetyltransferase, ARGININE, ACETYL COENZYME *A
Authors:Singh, E., Tiruttani Subhramanyam, U.K., Pal, R.K., Srinivasan, A., Gourinath, S., Das, U.
Deposit date:2017-10-26
Release date:2018-11-07
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.997 Å)
Cite:Structural insights into the substrate binding mechanism of novel ArgA from Mycobacterium tuberculosis
Int. J. Biol. Macromol., 125, 2019
6ADD
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THE CRYSTAL STRUCTURE OF RV2747 FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH COA AND NLQ
Descriptor:Amino-acid acetyltransferase, COENZYME A, N~2~-ACETYL-L-GLUTAMINE
Authors:Das, U., Singh, E., Pal, R.K., Tiruttani Subhramanyam, U.K., Gourinath, S., Srinivasan, A.
Deposit date:2018-07-31
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structural insights into the substrate binding mechanism of novel ArgA from Mycobacterium tuberculosis
Int. J. Biol. Macromol., 125, 2019
3Q96
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B-RAF KINASE DOMAIN IN COMPLEX WITH A TETRAHYDRONAPHTHALENE INHIBITOR
Descriptor:Serine/threonine-protein kinase B-raf, (2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide
Authors:Sintchak, M.D., Aertgeerts, K., Yano, J.
Deposit date:2011-01-07
Release date:2011-03-23
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors.
J.Med.Chem., 54, 2011
3CUE
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CRYSTAL STRUCTURE OF A TRAPP SUBASSEMBLY ACTIVATING THE RAB YPT1P
Descriptor:Transport protein particle 23 kDa subunit, Transport protein particle 31 kDa subunit, Transport protein particle 18 kDa subunit, ...
Authors:Cai, Y., Reinisch, K.M.
Deposit date:2008-04-16
Release date:2008-07-08
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes.
Cell(Cambridge,Mass.), 133, 2008
1VLK
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STRUCTURE OF VIRAL INTERLEUKIN-10
Descriptor:VIRAL INTERLEUKIN-10
Authors:Zdanov, A., Schalk-Hihi, C., Wlodawer, A.
Deposit date:1997-02-14
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10.
J.Mol.Biol., 268, 1997
2CO5
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F93 FROM STIV, A WINGED-HELIX DNA-BINDING PROTEIN
Descriptor:VIRAL PROTEIN F93
Authors:Larson, E.T., Reiter, D., Lawrence, C.M.
Deposit date:2006-05-25
Release date:2006-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Winged-Helix Protein from Sulfolobus Turreted Icosahedral Virus Points Toward Stabilizing Disulfide Bonds in the Intracellular Proteins of a Hyperthermophilic Virus.
Virology, 368, 2007