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3ZM5
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CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
Descriptor:UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE, 2,4-bis(chloranyl)-N-[3-cyano-6-[(4-hydroxyphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-5-morpholin-4-ylsulfonyl-benzamide
Authors:Hrast, M., Turk, S., Sosic, I., Knez, D., Randall, C.P., Barreteau, H., Contreras-Martel, C., Dessen, A., ONeill, A.J., Mengin-Lecreulx, D., Blanot, D., Gobec, S.
Deposit date:2013-02-05
Release date:2013-07-03
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Structure-Activity Relationships of New Cyanothiophene Inhibitors of the Essential Peptidoglycan Biosynthesis Enzyme Murf.
Eur.J.Med.Chem., 66C, 2013
3ZM6
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CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
Descriptor:UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE, N-(6-(4-(2h-tetrazol-5-yl)benzyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide
Authors:Hrast, M., Turk, S., Sosic, I., Knez, D., Randall, C.P., Barreteau, H., Contreras-Martel, C., Dessen, A., ONeill, A.J., Mengin-Lecreulx, D., Blanot, D., Gobec, S.
Deposit date:2013-02-05
Release date:2013-07-03
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure-Activity Relationships of New Cyanothiophene Inhibitors of the Essential Peptidoglycan Biosynthesis Enzyme Murf.
Eur.J.Med.Chem., 66C, 2013
2XGL
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THE X-RAY STRUCTURE OF THE ESCHERICHIA COLI COLICIN M IMMUNITY PROTEIN DEMONSTRATES THE PRESENCE OF A DISULPHIDE BRIDGE, WHICH IS FUNCTIONALLY ESSENTIAL
Descriptor:COLICIN-M IMMUNITY PROTEIN, CADMIUM ION, CHLORIDE ION, ...
Authors:Gerard, F., Brooks, M.A., Barreteau, H., Touze, T., Graille, M., Bouhss, A., Blanot, D., Tilbeurgh, H.v., Mengin-Lecreulx, D.
Deposit date:2010-06-07
Release date:2010-11-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-Ray Structure and Site-Directed Mutagenesis Analysis of the Escherichia Coli Colicin M Immunity Protein.
J.Bacteriol., 193, 2011
4C12
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X-RAY CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS MURE WITH UDP-MURNAC- ALA-GLU-LYS AND ADP
Descriptor:UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE, GLYCEROL, Uridine 5'Diphospho N-acetyl muramoyl-L-Alanyl-D-Glutamyl-L-Lysine, ...
Authors:Fulop, V., Roper, D.I., Ruane, K.M., Barreteau, H., Boniface, A., Dementin, S., Blanot, D., Mengin-Lecreulx, D., Gobec, S., Dessen, A., Dowson, C.G., Lloyd, A.J.
Deposit date:2013-08-09
Release date:2013-10-02
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Specificity Determinants for Lysine Incorporation in Staphylococcus Aureus Peptidoglycan as Revealed by the Structure of a Mure Enzyme Ternary Complex.
J.Biol.Chem., 288, 2013
4C13
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X-RAY CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS MURE WITH UDP-MURNAC- ALA-GLU-LYS
Descriptor:UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--L-LYSINE LIGASE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Ruane, K.M., Roper, D.I., Fulop, V., Barreteau, H., Boniface, A., Dementin, S., Blanot, D., Mengin-Lecreulx, D., Gobec, S., Dessen, A., Dowson, C.G., Lloyd, A.J.
Deposit date:2013-08-09
Release date:2013-10-02
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Specificity Determinants for Lysine Incorporation in Staphylococcus Aureus Peptidoglycan as Revealed by the Structure of a Mure Enzyme Ternary Complex.
J.Biol.Chem., 288, 2013
4G75
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STRUCTURE OF PAEM, A COLICIN M-LIKE BACTERIOCIN PRODUCED BY PSEUDOMONAS AERUGINOSA
Descriptor:phosphodiesterase, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Touze, T., Graille, M., Mengin-Lecreulx, D.
Deposit date:2012-07-20
Release date:2012-09-12
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional and Structural Characterization of PaeM, a Colicin M-like Bacteriocin Produced by Pseudomonas aeruginosa.
J.Biol.Chem., 287, 2012
4G76
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STRUCTURE OF PAEM, A COLICIN M-LIKE BACTERIOCIN PRODUCED BY PSEUDOMONAS AERUGINOSA
Descriptor:Phosphodiesterase
Authors:Touze, T., Graille, M., Mengin-Lecreulx, D.
Deposit date:2012-07-20
Release date:2012-09-12
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.385 Å)
Cite:Functional and Structural Characterization of PaeM, a Colicin M-like Bacteriocin Produced by Pseudomonas aeruginosa.
J.Biol.Chem., 287, 2012
1FWY
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CRYSTAL STRUCTURE OF N-ACETYLGLUCOSAMINE 1-PHOSPHATE URIDYLTRANSFERASE BOUND TO UDP-GLCNAC
Descriptor:UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE, SULFATE ION, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ...
Authors:Brown, K., Pompeo, F., Dixon, S., Mengin-Lecreulx, D., Cambillau, C., Bourne, Y.
Deposit date:2000-09-25
Release date:2000-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamily.
EMBO J., 18, 1999
1FXJ
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CRYSTAL STRUCTURE OF N-ACETYLGLUCOSAMINE 1-PHOSPHATE URIDYLTRANSFERASE
Descriptor:UDP-N-ACETYLGLUCOSAMINE PYROPHOSPHORYLASE, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Brown, K., Pompeo, F., Dixon, S., Mengin-Lecreulx, D., Cambillau, C., Bourne, Y.
Deposit date:2000-09-26
Release date:2000-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of the bifunctional N-acetylglucosamine 1-phosphate uridyltransferase from Escherichia coli: a paradigm for the related pyrophosphorylase superfamily.
EMBO J., 18, 1999
1I12
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CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE GNA1 COMPLEXED WITH ACCOA
Descriptor:GLUCOSAMINE-PHOSPHATE N-ACETYLTRANSFERASE, ACETYL COENZYME *A, IMIDAZOLE
Authors:Peneff, C., Mengin-Lecreulx, D., Bourne, Y.
Deposit date:2001-01-30
Release date:2001-05-16
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase.
J.Biol.Chem., 276, 2001
1I1D
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CRYSTAL STRUCTURE OF YEAST GNA1 BOUND TO COA AND GLNAC-6P
Descriptor:GLUCOSAMINE-PHOSPHATE N-ACETYLTRANSFERASE, N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE, COENZYME A, ...
Authors:Peneff, C., Mengin-Lecreulx, D., Bourne, Y.
Deposit date:2001-02-01
Release date:2001-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase.
J.Biol.Chem., 276, 2001
1I21
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CRYSTAL STRUCTURE OF YEAST GNA1
Descriptor:GLUCOSAMINE-PHOSPHATE N-ACETYLTRANSFERASE
Authors:Peneff, C., Mengin-Lecreulx, D., Bourne, Y.
Deposit date:2001-02-05
Release date:2001-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structures of Apo and complexed Saccharomyces cerevisiae GNA1 shed light on the catalytic mechanism of an amino-sugar N-acetyltransferase.
J.Biol.Chem., 276, 2001
1S2J
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CRYSTAL STRUCTURE OF THE DROSOPHILA PATTERN-RECOGNITION RECEPTOR PGRP-SA
Descriptor:Peptidoglycan recognition protein SA CG11709-PA, PHOSPHATE ION
Authors:Chang, C.-I., Pili-Floury, S., Chelliah, Y., Lemaitre, B., Mengin-Lecreulx, D., Deisenhofer, J.
Deposit date:2004-01-08
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual l,d-carboxypeptidase activity.
PLOS BIOL., 2, 2004
1Z6I
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CRYSTAL STRUCTURE OF THE ECTODOMAIN OF DROSOPHILA TRANSMEMBRANE RECEPTOR PGRP-LCA
Descriptor:Peptidoglycan-recognition protein-LC, N-ACETYL-D-GLUCOSAMINE, SULFATE ION
Authors:Chang, C.-I., Ihara, K., Chelliah, Y., Mengin-Lecreulx, D., Wakatsuki, S., Deisenhofer, J.
Deposit date:2005-03-22
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition
Proc.Natl.Acad.Sci.Usa, 102, 2005
4AXV
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BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF THE MPAA AMIDASE AS PART OF A CONSERVED SCAVENGING PATHWAY FOR PEPTIDOGLYCAN DERIVED PEPTIDES IN GAMMA-PROTEOBACTERIA
Descriptor:MPAA, ZINC ION, 1,2-ETHANEDIOL
Authors:Maqbool, A., Herve, M., Mengin-Lecreulx, D., Dodson, E., Wilkinson, A.J., Thomas, G.H.
Deposit date:2012-06-14
Release date:2012-09-26
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Mpaa is a Murein-Tripeptide-Specific Zinc Carboxypeptidase that Functions as Part of a Catabolic Pathway for Peptidoglycan Derived Peptides in Gamma-Proteobacteria.
Biochem.J., 448, 2012
5JKI
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CRYSTAL STRUCTURE OF THE FIRST TRANSMEMBRANE PAP2 TYPE PHOSPHATIDYLGLYCEROLPHOSPHATE PHOSPHATASE FROM BACILLUS SUBTILIS
Descriptor:Putative lipid phosphate phosphatase YodM, TUNGSTATE(VI)ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:El Ghachi, M., Howe, N., Lampion, A., Delbrassine, F., Vogeley, L., Caffrey, M., Sauvage, E., Auger, R., Guiseppe, A., Roure, S., Perlier, S., Mengin-lecreulx, D., Foglino, M., Touze, T.
Deposit date:2016-04-26
Release date:2017-02-22
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis.
Cell. Mol. Life Sci., 74, 2017
4QDN
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CRYSTAL STRUCTURE OF THE ENDO-BETA-N-ACETYLGLUCOSAMINIDASE FROM THERMOTOGA MARITIMA
Descriptor:Flagellar protein FlgJ [peptidoglycan hydrolase], PHOSPHATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Lipski, A., Nurizzo, D., Bourne, Y., Vincent, F.
Deposit date:2014-05-14
Release date:2014-11-12
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and biochemical characterization of the beta-N-acetylglucosaminidase from Thermotoga maritima: Toward rationalization of mechanistic knowledge in the GH73 family.
Glycobiology, 25, 2015
2F2L
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CRYSTAL STRUCTURE OF TRACHEAL CYTOTOXIN (TCT) BOUND TO THE ECTODOMAIN COMPLEX OF PEPTIDOGLYCAN RECOGNITION PROTEINS LCA (PGRP-LCA) AND LCX (PGRP-LCX)
Descriptor:Peptidoglycan-recognition protein-LC isoform LCa, Peptidoglycan recognition protein-LC isoform LCx, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Chang, C.I., Deisenhofer, J.
Deposit date:2005-11-17
Release date:2006-04-04
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of tracheal cytotoxin in complex with a heterodimeric pattern-recognition receptor.
Science, 311, 2006
3G23
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CRYSTAL STRUCTURE OF A LD-CARBOXYPEPTIDASE A (SARO_1426) FROM NOVOSPHINGOBIUM AROMATICIVORANS DSM AT 1.89 A RESOLUTION
Descriptor:LD-carboxypeptidase A, SULFATE ION, GLYCEROL, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2009-01-30
Release date:2009-02-10
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling.
J.Bacteriol., 195, 2013
3HN7
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CRYSTAL STRUCTURE OF A MUREIN PEPTIDE LIGASE MPL (PSYC_0032) FROM PSYCHROBACTER ARCTICUS 273-4 AT 1.65 A RESOLUTION
Descriptor:UDP-N-acetylmuramate-L-alanine ligase
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2009-05-29
Release date:2009-06-16
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and function of the first full-length murein Peptide ligase (mpl) cell wall recycling protein.
Plos One, 6, 2011
4H4J
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CRYSTAL STRUCTURE OF A N-ACETYLMURAMOYL-L-ALANINE AMIDASE (BACUNI_02947) FROM BACTEROIDES UNIFORMIS ATCC 8492 AT 1.15 A RESOLUTION
Descriptor:hypothetical protein
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2012-09-17
Release date:2012-10-17
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family.
Structure, 22, 2014
4Q5K
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CRYSTAL STRUCTURE OF A N-ACETYLMURAMOYL-L-ALANINE AMIDASE (BACUNI_02947) FROM BACTEROIDES UNIFORMIS ATCC 8492 AT 1.30 A RESOLUTION
Descriptor:Uncharacterized protein, (2R)-2-[[(1R,2S,3R,4R,5R)-4-acetamido-2-[(2S,3R,4R,5S,6R)-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-6,8-dioxabicyclo[3.2.1]octan-3-yl]oxy]propanoic acid, SODIUM ION
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2014-04-17
Release date:2014-05-21
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family.
Structure, 22, 2014
4Q68
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CRYSTAL STRUCTURE OF A N-ACETYLMURAMOYL-L-ALANINE AMIDASE (BACUNI_02947) FROM BACTEROIDES UNIFORMIS ATCC 8492 AT 1.07 A RESOLUTION
Descriptor:Uncharacterized protein, N-ACETYL-D-GLUCOSAMINE, SODIUM ION
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2014-04-21
Release date:2014-05-07
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family.
Structure, 22, 2014
6GYW
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CRYSTAL STRUCTURE OF DACA FROM STAPHYLOCOCCUS AUREUS
Descriptor:Diadenylate cyclase
Authors:Tosi, T., Freemont, P.S., Grundling, A.
Deposit date:2018-07-02
Release date:2019-01-23
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM.
PLoS Pathog., 15, 2019
6GYX
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CRYSTAL STRUCTURE OF DACA FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH APCPP
Descriptor:Diadenylate cyclase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MANGANESE (II) ION
Authors:Tosi, T., Freemont, P.S., Grundling, A.
Deposit date:2018-07-02
Release date:2019-01-23
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM.
PLoS Pathog., 15, 2019
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