Author results

6NCU
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INTERLEUKIN-37 RESIDUES 53-206- DIMER
Descriptor:Interleukin-37
Authors:Eisenmesser, E.Z.
Deposit date:2018-12-12
Release date:2019-03-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Interleukin-37 monomer is the active form for reducing innate immunity.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6ED3
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MTB CLPB IN COMPLEX WITH AMPPNP
Descriptor:Chaperone protein ClpB
Authors:Yu, H.J., Li, H.L.
Deposit date:2018-08-08
Release date:2018-09-26
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DJV
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MTB CLPB IN COMPLEX WITH ATPGAMMAS AND CASEIN, CONFORMER 2
Descriptor:Chaperone protein ClpB, casein polyAlanine model, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Yu, H.J., Li, H.L.
Deposit date:2018-05-26
Release date:2018-09-26
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DJU
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MTB CLPB IN COMPLEX WITH ATPGAMMAS AND CASEIN, CONFORMER 1
Descriptor:Chaperone protein ClpB, casein polyAlanine model, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Yu, H.J., Li, H.L.
Deposit date:2018-05-26
Release date:2018-09-26
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:ATP hydrolysis-coupled peptide translocation mechanism ofMycobacterium tuberculosisClpB.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CMO
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RHODOPSIN-GI COMPLEX
Descriptor:chimera protein of Soluble cytochrome b562 and Rhodopsin, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kang, Y., Kuybeda, O., de Waal, P.W., Mukherjee, S., Van Eps, N., Dutka, P., Zhou, X.E., Bartesaghi, A., Erramilli, S., Morizumi, T., Gu, X., Yin, Y., Liu, P., Jiang, Y., Meng, X., Zhao, G., Melcher, K., Earnst, O.P., Kossiakoff, A.A., Subramaniam, S., Xu, H.E.
Deposit date:2018-03-05
Release date:2018-06-20
Last modified:2019-04-17
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
6CB7
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CRYSTAL STRUCTURE OF VACCINIA VIRUS A6 N-TERMINUS (SPACE GROUP C2)
Descriptor:Protein A6, NICKEL (II) ION
Authors:Han, Y., Zhang, B., Deng, J.
Deposit date:2018-02-02
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CB6
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CRYSTAL STRUCTURE OF VACCINIA VIRUS A6 N-TERMINUS (SPACE GROUP C2)
Descriptor:Protein A6
Authors:Han, Y., Zhang, B., Deng, J.
Deposit date:2018-02-02
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BR9
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STRUCTURE OF A6 REVEALS A NOVEL LIPID TRANSPORTER
Descriptor:Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE
Authors:Deng, J., Peng, S., Pathak, P.
Deposit date:2017-11-30
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BR8
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STRUCTURE OF A6 REVEALS A NOVEL LIPID TRANSPORTER
Descriptor:Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE
Authors:Deng, J., Peng, S., Pathak, P.
Deposit date:2017-11-30
Release date:2018-06-20
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6B9J
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STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV138
Descriptor:IMV membrane protein, Fab vv138 Heavy chain, Fab vv138 Light chain, ...
Authors:Zajonc, D.M.
Deposit date:2017-10-10
Release date:2017-11-22
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
6ATZ
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HLA-DRB1*1402 IN COMPLEX WITH CITRULLINATED FIBRINOGEN PEPTIDE
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen, ...
Authors:Ting, Y.T., Scally, S.W., Rossjohn, J.
Deposit date:2017-08-29
Release date:2017-09-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.
Ann. Rheum. Dis., 76, 2017
6ATI
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HLA-DRB1*1402 IN COMPLEX WITH VIMENTIN-64CIT59-71
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen, ...
Authors:Scally, S.W., Ting, Y.T., Rossjohn, J.
Deposit date:2017-08-29
Release date:2017-09-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.
Ann. Rheum. Dis., 76, 2017
6ATF
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HLA-DRB1*1402 IN COMPLEX WITH VIMENTIN59-71
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, MHC class II antigen, ...
Authors:Scally, S.W., Ting, Y.T., Rossjohn, J.
Deposit date:2017-08-29
Release date:2017-09-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.
Ann. Rheum. Dis., 76, 2017
5YGI
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CRYSTAL STRUCTURE OF HUMAN FPPS IN COMPLEX WITH AN INHIBITOR THZ93
Descriptor:Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Li, X.
Deposit date:2017-09-23
Release date:2018-09-26
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.177 Å)
Cite:The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell, 175, 2018
5USL
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STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV304
Descriptor:IMV membrane protein, Fab vv304 Heavy chain, Fab vv304 Light chain
Authors:Zajonc, D.M.
Deposit date:2017-02-13
Release date:2017-09-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
5USH
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STRUCTURE OF VACCINIA VIRUS D8 PROTEIN BOUND TO HUMAN FAB VV66
Descriptor:IMV membrane protein, Fab vv66 heavy chain, Fab vv66 light chain
Authors:Zajonc, D.M.
Deposit date:2017-02-13
Release date:2017-09-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.
J. Biol. Chem., 293, 2018
5JLJ
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CRYSTAL STRUCTURE OF KPT8602 IN COMPLEX WITH CRM1-RAN-RANBP1
Descriptor:GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ...
Authors:Fung, H.Y., Chook, Y.M.
Deposit date:2016-04-27
Release date:2016-06-29
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Leukemia, 30, 2016
5IMX
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ANAPLASTIC LYMPHOMA KINASE (ALK) CATALYTIC DOMAIN COMPLEXED WITH NOVEL INHIBITOR 3-SULFONYLPYRAZOL-4-AMINO PYRIMIDINE
Descriptor:ALK tyrosine kinase receptor, 5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine
Authors:Wang, C., Zhang, P., Dong, J.
Deposit date:2016-03-07
Release date:2016-05-04
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5GQH
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CRYO-EM STRUCTURE OF PAECAS3-ACRF3 COMPLEX
Descriptor:CRISPR-associated nuclease/helicase Cas3 subtype I-F/YPEST, anti-CRISPR protein 3
Authors:Zhang, X., Ma, J., Wang, Y., Wang, J.
Deposit date:2016-08-07
Release date:2016-09-21
Last modified:2016-10-19
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses
Cell Res., 26, 2016
5GNF
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CRYSTAL STRUCTURE OF ANTI-CRISPR PROTEIN ACRF3
Descriptor:Uncharacterized protein AcrF3, CALCIUM ION
Authors:Wang, J., Wang, Y.
Deposit date:2016-07-20
Release date:2016-09-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses
Cell Res., 26, 2016
5EOR
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STRUCTURE OF THE MURINE ANTIBODY FAB 8E3 BOUND TO THE VACCINIA VIRUS A27 PEPTIDE 101-110
Descriptor:anti vaccinia virus A27 antibody 8E3 heavy chain, anti vaccinia virus A27 antibody 8E3 light chain, Protein A27, ...
Authors:Matho, M.H., Zajonc, D.M.
Deposit date:2015-11-10
Release date:2016-03-02
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox.
J.Virol., 90, 2016
5EOQ
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STRUCTURE OF THE MURINE FAB 1G6 BOUND TO THE VACCINIA VIRUS A27 PEPTIDE 31-40
Descriptor:Anti vaccinia virus A27 antibody Fab 1G6 heavy chain, Anti vaccinia virus A27 antibody Fab 1G6 light chain, Protein A27
Authors:Matho, M.H., Zajonc, D.M.
Deposit date:2015-11-10
Release date:2016-03-02
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Linear Epitopes in Vaccinia Virus A27 Are Targets of Protective Antibodies Induced by Vaccination against Smallpox.
J.Virol., 90, 2016
5CZ3
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CRYSTAL STRUCTURE OF MYXOMA VIRUS M64
Descriptor:M64R, BETA-MERCAPTOETHANOL
Authors:Krumm, B.E., Meng, X., Li, Y., Xiang, Y., Deng, J.
Deposit date:2015-07-31
Release date:2015-11-18
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
5CYW
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CRYSTAL STRUCTURE OF VACCINIA VIRUS C7
Descriptor:Interferon antagonist C7, GLYCEROL
Authors:Krumm, B.E., Meng, X., Li, Y., Xiang, Y., Deng, J.
Deposit date:2015-07-30
Release date:2015-11-18
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZO5
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PDE10 COMPLEXED WITH 4-ISOPROPOXY-2-(2-(3-(4-METHOXYPHENYL)-4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)ETHYL)ISOINDOLINE-1,3-DIONE
Descriptor:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ...
Authors:Yan, Y.
Deposit date:2015-05-06
Release date:2015-08-12
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of [(11)C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
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