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3KAY
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CRYSTAL STRUCTURE OF ABSCISIC ACID RECEPTOR PYL1
Descriptor:Putative uncharacterized protein At5g46790
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Xu, H.E.
Deposit date:2009-10-19
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
3KAZ
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CRYSTAL STRUCTURE OF ABSCISIC ACID RECEPTOR PYL2
Descriptor:Putative uncharacterized protein At2g26040, 1,3-BUTANEDIOL
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Xu, H.E.
Deposit date:2009-10-19
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
3KB0
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CRYSTAL STRUCTURE OF ABSCISIC ACID-BOUND PYL2
Descriptor:Putative uncharacterized protein At2g26040, (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Xu, H.E.
Deposit date:2009-10-19
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
3KB3
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CRYSTAL STRUCTURE OF ABSCISIC ACID-BOUND PYL2 IN COMPLEX WITH HAB1
Descriptor:Putative uncharacterized protein At2g26040, Protein phosphatase 2C 16, (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ...
Authors:Zhou, X.E., Melcher, K., Soon, F.-F., Ng, L.-M., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Xu, H.E.
Deposit date:2009-10-20
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors
Nature, 462, 2009
3NMH
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CRYSTAL STRUCTURE OF THE ABSCISIC RECEPTOR PYL2 IN COMPLEX WITH PYRABACTIN
Descriptor:Abscisic acid receptor PYL2, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Yong, E.-L., Xu, H.E.
Deposit date:2010-06-22
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and mechanism of ABA receptor antagonism.
Nat.Struct.Mol.Biol., 17, 2010
3NMN
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CRYSTAL STRUCTURE OF PYRABACTIN-BOUND ABSCISIC ACID RECEPTOR PYL1 IN COMPLEX WITH TYPE 2C PROTEIN PHOSPHATASE ABI1
Descriptor:Abscisic acid receptor PYL1, Protein phosphatase 2C 56, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, ...
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Yong, E.-L., Xu, H.E.
Deposit date:2010-06-22
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Identification and mechanism of ABA receptor antagonism.
Nat.Struct.Mol.Biol., 17, 2010
3NMP
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CRYSTAL STRUCTURE OF THE ABSCISIC RECEPTOR PYL2 MUTANT A93F IN COMPLEX WITH PYRABACTIN
Descriptor:Abscisic acid receptor PYL2, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Yong, E.-L., Xu, H.E.
Deposit date:2010-06-22
Release date:2010-08-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification and mechanism of ABA receptor antagonism.
Nat.Struct.Mol.Biol., 17, 2010
3NMT
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CRYSTAL STRUCTURE OF PYRABACTIN BOUND ABSCISIC ACID RECEPTOR PYL2 MUTANT A93F IN COMPLEX WITH TYPE 2C PROTEIN PHOSPHATASE HAB1
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 16, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, ...
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Yong, E.-L., Xu, H.E.
Deposit date:2010-06-22
Release date:2010-08-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Identification and mechanism of ABA receptor antagonism.
Nat.Struct.Mol.Biol., 17, 2010
3NMV
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CRYSTAL STRUCTURE OF PYRABACTIN-BOUND ABSCISIC ACID RECEPTOR PYL2 MUTANT A93F IN COMPLEX WITH TYPE 2C PROTEIN PHOSPHATASE ABI2
Descriptor:Abscisic acid receptor PYL2, Protein phosphatase 2C 77, 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, ...
Authors:Zhou, X.E., Melcher, K., Ng, L.-M., Soon, F.-F., Xu, Y., Suino-Powell, K.M., Kovach, A., Li, J., Yong, E.-L., Xu, H.E.
Deposit date:2010-06-22
Release date:2010-08-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification and mechanism of ABA receptor antagonism.
Nat.Struct.Mol.Biol., 17, 2010
5J9K
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) IN COMPLEX WITH RICE D53 REPRESSOR EAR PEPTIDE MOTIF
Descriptor:Protein TPR1, rice D53 peptide 794-808, ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-10
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
5JA5
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) L111A AND L130A MUTANT IN COMPLEX WITH RICE D53 REPRESSOR EAR PEPTIDE MOTIF
Descriptor:Protein TPR1, The rice D53 peptide (a.a. 794-808), ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-12
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
5JGC
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) L111A, L130A, L179A AND I195A MUTANT
Descriptor:Protein TPR1, ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-20
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
5JHP
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL TOPLESS DOMAIN (1-209) L179A AND I195A MUTANT IN COMPLEX WITH RICE D53 REPRESSOR EAR PEPTIDE MOTIF
Descriptor:Protein TPR1, The rice D53 EAR peptide (794-808)
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-04-21
Release date:2017-07-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.
Sci Adv, 3, 2017
4ZWJ
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO ARRESTIN BY FEMTOSECOND X-RAY LASER
Descriptor:Chimera protein of human Rhodopsin, mouse S-arrestin, and T4 Endolysin
Authors:Kang, Y., Zhou, X.E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T.A., Yefanov, O., Han, G.W., Xu, Q., de Waal, P.W., Ke, J., Tan, M.H.E., Zhang, C., Moeller, A., West, G.M., Pascal, B., Eps, N.V., Caro, L.N., Vishnivetskiy, S.A., Lee, R.J., Suino-Powell, K.M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G.J., Messerschmidt, M., Gati, C., Zatsepin, N.A., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohann, I., Fromme, R., Jiang, Y., Tan, M., Yang, H., Li, J., Wang, M., Zheng, Z., Li, D., Howe, N., Zhao, Y., Standfuss, J., Diederichs, K., Dong, Y., Potter, C.S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H.N., Spence, J.C.H., Fromme, P., Weierstall, U., Ernst, O.P., Katritch, V., Gurevich, V.V., Griffin, P.R., Hubbell, W.L., Stevens, R.C., Cherezov, V., Melcher, K., Xu, H.E., GPCR Network (GPCR)
Deposit date:2015-05-19
Release date:2015-07-29
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (3.302 Å)
Cite:Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.
Nature, 523, 2015
4P6W
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CRYSTAL STRUCTURE OF MOMETASONE FUROATE-BOUND GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, MOMETASONE FUROATE
Authors:He, Y., Zhou, X.E., Tolbert, W.D., Powell, K., Melcher, K., Xu, H.E.
Deposit date:2014-03-25
Release date:2014-04-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Structures and mechanism for the design of highly potent glucocorticoids.
Cell Res., 24, 2014
4P6X
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CRYSTAL STRUCTURE OF CORTISOL-BOUND GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2, (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
Authors:He, Y., Zhou, X.E., Tolbert, W.D., Powell, K., Melcher, K., Xu, H.E.
Deposit date:2014-03-25
Release date:2014-04-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures and mechanism for the design of highly potent glucocorticoids.
Cell Res., 24, 2014
5TO5
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STRUCTURE OF THE TPR OLIGOMERIZATION DOMAIN
Descriptor:Nucleoprotein TPR
Authors:Pal, K., Xu, Q., Zhou, X.E., Melcher, K., Xu, H.E.
Deposit date:2016-10-16
Release date:2017-10-18
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
5TO6
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STRUCTURE OF THE TPR OLIGOMERIZATION DOMAIN
Descriptor:Nucleoprotein TPR
Authors:Pal, K., Bandyopadhyay, A., Xu, Q., Zhou, X.E., Melcher, K., Xu, H.E.
Deposit date:2016-10-16
Release date:2017-10-18
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
5TO7
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STRUCTURE OF THE TPR OLIGOMERIZATION DOMAIN
Descriptor:Nucleoprotein TPR
Authors:Pal, K., Xu, Q., Zhou, X.E., Melcher, K., Xu, H.E.
Deposit date:2016-10-16
Release date:2017-10-18
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
5TVB
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STRUCTURE OF THE TPR OLIGOMERIZATION DOMAIN
Descriptor:Nucleoprotein TPR
Authors:Pal, K., Xu, Q., Zhou, X.E., Melcher, K., Xu, H.E.
Deposit date:2016-11-08
Release date:2017-09-20
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases.
Structure, 25, 2017
5TWO
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PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A NOVEL SELECTIVELY PPAR GAMMA-MODULATING LIGAND VSP-51
Descriptor:Peroxisome proliferator-activated receptor gamma, PRO-SER-LEU-LEU-LYS-LYS-LEU-LEU-LEU-ALA-PRO, N-benzyl-1-[(4-chloro-3-fluorophenyl)methyl]-1H-indole-5-carboxamide
Authors:Yi, W., Shi, J., Zhao, G., Zhou, X.E., Suino-Powell, K., Melcher, K., Xu, H.E.
Deposit date:2016-11-14
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.927 Å)
Cite:Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro.
Sci Rep, 7, 2017
5W0P
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO VISUAL ARRESTIN DETERMINED BY X-RAY FREE ELECTRON LASER
Descriptor:Endolysin,Rhodopsin,S-arrestin, N-ACETYL-D-GLUCOSAMINE
Authors:Zhou, X.E., He, Y., de Waal, P.W., Gao, X., Kang, Y., Van Eps, N., Yin, Y., Pal, K., Goswami, D., White, T.A., Barty, A., Latorraca, N.R., Chapman, H.N., Hubbell, W.L., Dror, R.O., Stevens, R.C., Cherezov, V., Gurevich, V.V., Griffin, P.R., Ernst, O.P., Melcher, K., Xu, H.E.
Deposit date:2017-05-31
Release date:2017-08-09
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (3.013 Å)
Cite:Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
Cell, 170, 2017
5IZQ
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CRYSTAL STRUCTURE OF HUMAN FOLATE RECEPTOR ALPHA IN COMPLEX WITH NOVEL ANTIFOLATE AGF183
Descriptor:Folate receptor alpha, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid
Authors:Ke, J., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2016-03-25
Release date:2016-08-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
5T0F
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CRYSTAL STRUCTURE OF THE MYC3 N-TERMINAL DOMAIN [44-242] IN COMPLEX WITH JAZ10 CMID DOMAIN [16-58] FROM ARABIDOPSIS
Descriptor:Transcription factor MYC3, Protein TIFY 9
Authors:Ke, J., Zhang, F., Brunzelle, J.S., He, S.Y., Xu, H.E., Melcher, K.
Deposit date:2016-08-16
Release date:2017-01-25
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into alternative splicing-mediated desensitization of jasmonate signaling.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5T0Q
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CRYSTAL STRUCTURE OF THE MYC3 N-TERMINAL DOMAIN [44-242] IN COMPLEX WITH JAZ10 JAS DOMAIN [166-192] FROM ARABIDOPSIS
Descriptor:Transcription factor MYC3, Protein TIFY 9
Authors:Ke, J., Zhang, F., Brunzelle, J.S., He, S.Y., Xu, H.E., Melcher, K.
Deposit date:2016-08-16
Release date:2017-01-25
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural insights into alternative splicing-mediated desensitization of jasmonate signaling.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017