Author results

3SLS
  • Download 3sls
  • View 3sls
Molmil generated image of 3sls
CRYSTAL STRUCTURE OF HUMAN MEK-1 KINASE IN COMPLEX WITH UCB1353770 AND AMPPNP
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Meier, C., Ceska, T.A.
Deposit date:2011-06-25
Release date:2012-02-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting.
J.Struct.Biol., 177, 2012
2CME
  • Download 2cme
  • View 2cme
Molmil generated image of 2cme
THE CRYSTAL STRUCTURE OF SARS CORONAVIRUS ORF-9B PROTEIN
Descriptor:HYPOTHETICAL PROTEIN 5, DECANE
Authors:Meier, C., Aricescu, A.R., Assenberg, R., Aplin, R.T., Gilbert, R.J.C., Grimes, J.M., Stuart, D.I.
Deposit date:2006-05-06
Release date:2006-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of Orf-9B, a Lipid Binding Protein from the Sars Coronavirus.
Structure, 14, 2006
2JCB
  • Download 2jcb
  • View 2jcb
Molmil generated image of 2jcb
THE CRYSTAL STRUCTURE OF 5-FORMYL-TETRAHYDROFOLATE CYCLOLIGASE FROM BACILLUS ANTHRACIS (BA4489)
Descriptor:5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE FAMILY PROTEIN, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, ...
Authors:Meier, C., Carter, L.G., Winter, G., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2006-12-21
Release date:2007-02-20
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of 5-Formyltetrahydrofolate Cyclo-Ligase from Bacillus Anthracis (Ba4489).
Acta Crystallogr.,Sect.F, 63, 2007
2JJX
  • Download 2jjx
  • View 2jjx
Molmil generated image of 2jjx
THE CRYSTAL STRUCTURE OF UMP KINASE FROM BACILLUS ANTHRACIS (BA1797)
Descriptor:URIDYLATE KINASE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Meier, C., Carter, L.G., Mancini, E.J., Owens, R.J., Stuart, D.I., Esnouf, R.M., Oxford Protein Production Facility (OPPF), Structural Proteomics in Europe (SPINE)
Deposit date:2008-04-23
Release date:2008-07-29
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:The Crystal Structure of Ump Kinase from Bacillus Anthracis (Ba1797) Reveals an Allosteric Nucleotide-Binding Site.
J.Mol.Biol., 381, 2008
3F66
  • Download 3f66
  • View 3f66
Molmil generated image of 3f66
HUMAN C-MET KINASE IN COMPLEX WITH QUINOXALINE INHIBITOR
Descriptor:Hepatocyte growth factor receptor, 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol, GAMMA-BUTYROLACTONE, ...
Authors:Meier, C., Ceska, T.
Deposit date:2008-11-05
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
Bioorg.Med.Chem.Lett., 19, 2009
1NMX
  • Download 1nmx
  • View 1nmx
Molmil generated image of 1nmx
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH FLTMP AND ADP
Descriptor:similar to THYMIDYLATE KINASE (DTMP KINASE), MAGNESIUM ION, 3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMY
  • Download 1nmy
  • View 1nmy
Molmil generated image of 1nmy
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH FLTMP AND APPNHP
Descriptor:similar to THYMIDYLATE KINASE (DTMP KINASE), MAGNESIUM ION, 3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMZ
  • Download 1nmz
  • View 1nmz
Molmil generated image of 1nmz
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH NH2TMP AND APPNHP
Descriptor:similar to THYMIDYLATE KINASE (DTMP KINASE), MAGNESIUM ION, 3'-DEOXY-3'-AMINOTHYMIDINE MONOPHOSPHATE, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN0
  • Download 1nn0
  • View 1nn0
Molmil generated image of 1nn0
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH DDTMP AND ADP
Descriptor:Thymidylate kinase, MAGNESIUM ION, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN1
  • Download 1nn1
  • View 1nn1
Molmil generated image of 1nn1
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH DDTMP AND APPNHP
Descriptor:similar to THYMIDYLATE KINASE (DTMP KINASE), MAGNESIUM ION, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN3
  • Download 1nn3
  • View 1nn3
Molmil generated image of 1nn3
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH D4TMP + ADP
Descriptor:similar to THYMIDYLATE KINASE (DTMP KINASE), MAGNESIUM ION, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN5
  • Download 1nn5
  • View 1nn5
Molmil generated image of 1nn5
CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE KINASE WITH D4TMP + APPNHP
Descriptor:Similar to deoxythymidylate kinase (thymidylate kinase), MAGNESIUM ION, 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ...
Authors:Ostermann, N., Segura-Pena, D., Meier, C., Veit, T., Monnerjahn, M., Konrad, M., Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
2J23
  • Download 2j23
  • View 2j23
Molmil generated image of 2j23
CROSS-REACTIVITY AND CRYSTAL STRUCTURE OF MALASSEZIA SYMPODIALIS THIOREDOXIN (MALA S 13), A MEMBER OF A NEW PAN-ALLERGEN FAMILY
Descriptor:THIOREDOXIN
Authors:Limacher, A., Glaser, A.G., Meier, C., Scapozza, L., Crameri, R.
Deposit date:2006-08-16
Release date:2006-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Cross-Reactivity and 1.4-A Crystal Structure of Malassezia Sympodialis Thioredoxin (Mala S 13), a Member of a New Pan-Allergen Family.
J.Immunol., 178, 2007
2WD1
  • Download 2wd1
  • View 2wd1
Molmil generated image of 2wd1
HUMAN C-MET KINASE IN COMPLEX WITH AZAINDOLE INHIBITOR
Descriptor:HEPATOCYTE GROWTH FACTOR RECEPTOR, 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE, GAMMA-BUTYROLACTONE
Authors:Porter, J., Lumb, S., Franklin, R.J., Gascon-Simorte, J.M., Calmiano, M., Le Riche, K., Lallemand, B., Keyaerts, J., Edwards, H., Maloney, A., Delgado, J., King, L., Foley, A., Lecomte, F., Reuberson, J., Meier, C., Batchelor, M.
Deposit date:2009-03-19
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 4-Azaindoles as Novel Inhibitors of C- met Kinase.
Bioorg.Med.Chem.Lett., 19, 2009
4BLO
  • Download 4blo
  • View 4blo
Molmil generated image of 4blo
P4 PROTEIN FROM BACTERIOPHAGE PHI6 IN COMPLEX WITH ADP
Descriptor:PACKAGING ENZYME P4, CALCIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:El Omari, K., Meier, C., Kainov, D., Sutton, G., Grimes, J.M., Poranen, M.M., Bamford, D.H., Tuma, R., Stuart, D.I., Mancini, E.J.
Deposit date:2013-05-04
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution.
Nucleic Acids Res., 41, 2013
4BLP
  • Download 4blp
  • View 4blp
Molmil generated image of 4blp
P4 PROTEIN FROM BACTERIOPHAGE PHI13
Descriptor:PACKAGING ENZYME P4, CITRATE ANION, GLYCEROL
Authors:El Omari, K., Meier, C., Kainov, D., Sutton, G., Grimes, J.M., Poranen, M.M., Bamford, D.H., Tuma, R., Stuart, D.I., Mancini, E.J.
Deposit date:2013-05-04
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution.
Nucleic Acids Res., 41, 2013
4BLQ
  • Download 4blq
  • View 4blq
Molmil generated image of 4blq
P4 PROTEIN FROM BACTERIOPHAGE PHI8
Descriptor:P4
Authors:El Omari, K., Meier, C., Kainov, D., Sutton, G., Grimes, J.M., Poranen, M.M., Bamford, D.H., Tuma, R., Stuart, D.I., Mancini, E.J.
Deposit date:2013-05-04
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution.
Nucleic Acids Res., 41, 2013
4BLR
  • Download 4blr
  • View 4blr
Molmil generated image of 4blr
P4 PROTEIN FROM BACTERIOPHAGE PHI12 IN COMPLEX WITH UTP
Descriptor:NTPASE P4, URIDINE 5'-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:El Omari, K., Meier, C., Kainov, D., Sutton, G., Grimes, J.M., Poranen, M.M., Bamford, D.H., Tuma, R., Stuart, D.I., Mancini, E.J.
Deposit date:2013-05-04
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution.
Nucleic Acids Res., 41, 2013
4BLS
  • Download 4bls
  • View 4bls
Molmil generated image of 4bls
P4 PROTEIN FROM BACTERIOPHAGE PHI12 Q278A MUTANT IN COMPLEX WITH AMPCPP
Descriptor:NTPASE P4, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
Authors:El Omari, K., Meier, C., Kainov, D., Sutton, G., Grimes, J.M., Poranen, M.M., Bamford, D.H., Tuma, R., Stuart, D.I., Mancini, E.J.
Deposit date:2013-05-04
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution.
Nucleic Acids Res., 41, 2013
4BLT
  • Download 4blt
  • View 4blt
Molmil generated image of 4blt
P4 PROTEIN FROM BACTERIOPHAGE PHI12 S292A MUTANT IN COMPLEX WITH AMPCPP
Descriptor:NTPASE P4, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
Authors:El Omari, K., Meier, C., Kainov, D., Sutton, G., Grimes, J.M., Poranen, M.M., Bamford, D.H., Tuma, R., Stuart, D.I., Mancini, E.J.
Deposit date:2013-05-04
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution.
Nucleic Acids Res., 41, 2013
4BWY
  • Download 4bwy
  • View 4bwy
Molmil generated image of 4bwy
P4 PROTEIN FROM BACTERIOPHAGE PHI8 (R32)
Descriptor:P4
Authors:El Omari, K., Meier, C., Kainov, D., Sutton, G., Grimes, J.M., Poranen, M.M., Bamford, D.H., Tuma, R., Stuart, D.I., Mancini, E.J.
Deposit date:2013-07-05
Release date:2013-08-21
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Tracking in Atomic Detail the Functional Specializations in Viral Reca Helicases that Occur During Evolution.
Nucleic Acids Res., 41, 2013
4CNI
  • Download 4cni
  • View 4cni
Molmil generated image of 4cni
CRYSTAL STRUCTURE OF THE FAB PORTION OF OLOKIZUMAB IN COMPLEX WITH IL- 6
Descriptor:OLOKIZUMAB HEAVY CHAIN, FAB PORTION, OLOKIZUMAB LIGHT CHAIN, ...
Authors:Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A., Popplewell, A., Adams, R., Baker, T., Rapecki, S., Marshall, D., Neale, H., Lawson, A.
Deposit date:2014-01-22
Release date:2014-04-30
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.
Mabs, 6, 2014
6FGB
  • Download 6fgb
  • View 6fgb
Molmil generated image of 6fgb
HUMAN FCRN EXTRA-CELLULAR DOMAIN COMPLEXED WITH FAB FRAGMENT OF ROZANOLIXIZUMAB
Descriptor:IgG receptor FcRn large subunit p51, Beta-2-microglobulin, 1519.g57- Light chain, ...
Authors:Sarkar, K., Ceska, T., Meier, C.
Deposit date:2018-01-10
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration.
MAbs, 10, 2018
5FUC
  • Download 5fuc
  • View 5fuc
Molmil generated image of 5fuc
BIOPHYSICAL AND CELLULAR CHARACTERISATION OF A JUNCTIONAL EPITOPE ANTIBODY THAT LOCKS IL-6 AND GP80 TOGETHER IN A STABLE COMPLEX: IMPLICATIONS FOR NEW THERAPEUTIC STRATEGIES
Descriptor:INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-6 RECEPTOR, ...
Authors:Adams, R., Griffin, R., Doyle, C., Ettorre, A.
Deposit date:2016-01-25
Release date:2017-01-25
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Sci Rep, 7, 2017
5MUV
  • Download 5muv
  • View 5muv
Molmil generated image of 5muv
ATOMIC STRUCTURE FITTED INTO A LOCALIZED RECONSTRUCTION OF BACTERIOPHAGE PHI6 PACKAGING HEXAMER P4
Descriptor:Packaging enzyme P4, CALCIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Sun, Z., El Omari, K., Sun, X., Ilca, S., Kotecha, A., Stuart, D.I., Poranen, M.M., Huiskonen, J.T.
Deposit date:2017-01-14
Release date:2017-03-22
Last modified:2019-04-24
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:Double-stranded RNA virus outer shell assembly by bona fide domain-swapping.
Nat Commun, 8, 2017
<12>