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6GRR
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BU of 6grr by Molmil
Crystal structure of Escherichia coli amine oxidase mutant I342F/E573Q
Descriptor: Amine oxidase, CALCIUM ION, COPPER (II) ION, ...
Authors:Gaule, T.G, Smith, M.A, Tych, K.M, Pirrat, P, Trinh, C.H, Pearson, A.R, Knowles, P.F, McPherson, M.J.
Deposit date:2018-06-12
Release date:2018-09-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli.
Biochemistry, 57, 2018
6QOZ
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BU of 6qoz by Molmil
CryoEM reconstruction of Cowpea Mosaic Virus (CPMV) bound to an Affimer reagent
Descriptor: Affimer binding protein, Cowpea mosaic virus large subunit, RNA2 polyprotein
Authors:Hesketh, E.L, Tiede, C, Adamson, H, Adams, T.L, Byrne, M.J, Meshcheriakova, Y, Lomonossoff, G.P, Kruse, I, McPherson, M.J, Tomlinson, D.C, Ranson, N.A.
Deposit date:2019-02-13
Release date:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Affimer reagents as tools in diagnosing plant virus diseases.
Sci Rep, 9, 2019
5ML9
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BU of 5ml9 by Molmil
Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Affimer F4 with specificity for Fc gamma receptor IIIa, CHLORIDE ION, ...
Authors:Robinson, J.I, Tomlinson, D.C, Baxter, E.W, Owen, R.L, Thomsen, M, Win, S.J, Nettleship, J.E, Tiede, C, Foster, R.J, Waterhouse, M.P, Harris, S.A, Owens, R.J, Fishwick, C.W.G, Goldman, A, McPherson, M.J, Morgan, A.W.
Deposit date:2016-12-06
Release date:2017-12-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5MN2
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BU of 5mn2 by Molmil
Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Affimer G3, DI(HYDROXYETHYL)ETHER, ...
Authors:Robinson, J.I, Owen, R.L, Tomlinson, D.C, Baxter, E.W, Nettleship, J.E, Waterhouse, M.P, Harris, S.A, Owens, R.J, McPherson, M.J, Morgan, A.W, Tiede, C, Goldman, A, Thomsen, M.
Deposit date:2016-12-12
Release date:2017-12-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2EIB
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BU of 2eib by Molmil
Crystal Structure of Galactose Oxidase, W290H mutant
Descriptor: ACETATE ION, COPPER (II) ION, Galactose oxidase, ...
Authors:Phillips, S.E, McPherson, M.J, Knowles, P.F, Wilmot, C.
Deposit date:2007-03-12
Release date:2007-04-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Stacking Tryptophan of Galactose Oxidase: A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis
Biochemistry, 46, 2007
1D6U
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BU of 1d6u by Molmil
CRYSTAL STRUCTURE OF E. COLI AMINE OXIDASE ANAEROBICALLY REDUCED WITH BETA-PHENYLETHYLAMINE
Descriptor: 2-PHENYLETHYLAMINE, CALCIUM ION, COPPER (II) ION, ...
Authors:Wilmot, C.M, Hajdu, J, McPherson, M.J, Knowles, P.F, Phillips, S.E.V.
Deposit date:1999-10-15
Release date:2000-02-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Visualization of dioxygen bound to copper during enzyme catalysis.
Science, 286, 1999
1D6Z
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BU of 1d6z by Molmil
CRYSTAL STRUCTURE OF THE AEROBICALLY FREEZE TRAPPED RATE-DETERMINING CATALYTIC INTERMEDIATE OF E. COLI COPPER-CONTAINING AMINE OXIDASE.
Descriptor: 2-PHENYLETHYLAMINE, CALCIUM ION, COPPER (II) ION, ...
Authors:Wilmot, C.M, Hajdu, J, McPherson, M.J, Knowles, P.F, Phillips, S.E.V.
Deposit date:1999-10-16
Release date:2000-02-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Visualization of dioxygen bound to copper during enzyme catalysis.
Science, 286, 1999
1D6Y
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BU of 1d6y by Molmil
CRYSTAL STRUCTURE OF E. COLI COPPER-CONTAINING AMINE OXIDASE ANAEROBICALLY REDUCED WITH BETA-PHENYLETHYLAMINE AND COMPLEXED WITH NITRIC OXIDE.
Descriptor: 2-PHENYLETHYLAMINE, CALCIUM ION, COPPER (II) ION, ...
Authors:Wilmot, C.M, Hajdu, J, McPherson, M.J, Knowles, P.F, Phillips, S.E.V.
Deposit date:1999-10-16
Release date:2000-02-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Visualization of dioxygen bound to copper during enzyme catalysis.
Science, 286, 1999
6YR8
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BU of 6yr8 by Molmil
Affimer K6 - KRAS protein complex
Descriptor: Affimer K6, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2020-04-19
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
6YXW
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BU of 6yxw by Molmil
Affimer K3 - KRAS protein complex
Descriptor: Affimer K3, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2020-05-04
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
5ZZ1
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BU of 5zz1 by Molmil
Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum
Descriptor: 3-AMINO-1,2,4-TRIAZOLE, CALCIUM ION, CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, ...
Authors:Yuzugullu Karakus, Y, Trinh, C.H, Pearson, A.R, Ogel, Z.B, McPherson, M.J.
Deposit date:2018-05-29
Release date:2019-05-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase.
Acta Crystallogr D Struct Biol, 74, 2018
2EID
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BU of 2eid by Molmil
Galactose Oxidase W290G mutant
Descriptor: COPPER (II) ION, Galactose oxidase, SODIUM ION
Authors:Phillips, S.E, McPherson, M.J, Knowles, P.F, Akyumani, N, Firbank, S.J, Tamber, S.
Deposit date:2007-03-12
Release date:2007-04-24
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Stacking Tryptophan of Galactose Oxidase: A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis
Biochemistry, 46, 2007
2EIE
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BU of 2eie by Molmil
Crystal Structure of Galactose Oxidase complexed with Azide
Descriptor: AZIDE ION, COPPER (II) ION, Galactose oxidase
Authors:Phillips, S.E, McPherson, M.J, Knowles, P.F, Akyumani, N, Firbank, S.J, Tamber, S.
Deposit date:2007-03-12
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Stacking Tryptophan of Galactose Oxidase: A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis
Biochemistry, 46, 2007
2EIC
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BU of 2eic by Molmil
Crystal Structure of Galactose Oxidase mutant W290F
Descriptor: COPPER (I) ION, Galactose oxidase, SODIUM ION
Authors:Akyumani, N, Tamber, S, Firbank, S.J, Knowles, P.F, Phillips, S.E, McPherson, M.J.
Deposit date:2007-03-12
Release date:2007-04-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Stacking Tryptophan of Galactose Oxidase: A Second-Coordination Sphere Residue that Has Profound Effects on Tyrosyl Radical Behavior and Enzyme Catalysis
Biochemistry, 46, 2007
1T2X
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BU of 1t2x by Molmil
Glactose oxidase C383S mutant identified by directed evolution
Descriptor: ACETATE ION, COPPER (II) ION, Galactose Oxidase, ...
Authors:Wilkinson, D, Akumanyi, N, Hurtado-Guerrero, R, Dawkes, H, Knowles, P.F, Phillips, S.E.V, McPherson, M.J.
Deposit date:2004-04-23
Release date:2004-05-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic studies of a series of mutants of galactose oxidase identified by directed evolution.
Protein Eng.Des.Sel., 17, 2004
2JKX
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BU of 2jkx by Molmil
Galactose oxidase. MatGO. Copper free, expressed in Pichia Pastoris.
Descriptor: ACETATE ION, CALCIUM ION, GALACTOSE OXIDASE
Authors:Deacon, S.E, Mahmoud, K, Spooner, R.K, Firbank, S.J, Knowles, P.F, Phillips, S.E.V, McPherson, M.J.
Deposit date:2008-09-01
Release date:2008-09-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Enhanced Fructose Oxidase Activity in a Galactose Oxidase Variant
Chembiochem, 5, 2004
2VZ3
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BU of 2vz3 by Molmil
bleached galactose oxidase
Descriptor: ACETATE ION, COPPER (II) ION, GALACTOSE OXIDASE
Authors:Rogers, M.S, Hurtado-Guerrero, R, Firbank, S.J, Halcrow, M.A, Dooley, D.M, Phillips, S.E.V, Knowles, P.F, McPherson, M.J.
Deposit date:2008-07-29
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Cross-Link Formation of the Cysteine 228-Tyrosine 272 Catalytic Cofactor of Galactose Oxidase Does not Require Dioxygen.
Biochemistry, 47, 2008
2W0Q
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BU of 2w0q by Molmil
E. coli copper amine oxidase in complex with Xenon
Descriptor: CALCIUM ION, COPPER (II) ION, COPPER AMINE OXIDASE, ...
Authors:Pirrat, P, Smith, M.A, Pearson, A.R, McPherson, M.J, Phillips, S.E.V.
Deposit date:2008-08-20
Release date:2008-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structure of a Xenon Derivative of Escherichia Coli Copper Amine Oxidase: Confirmation of the Proposed Oxygen-Entry Pathway.
Acta Crystallogr.,Sect.F, 64, 2008
2VZ1
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BU of 2vz1 by Molmil
Premat-galactose oxidase
Descriptor: ACETATE ION, CALCIUM ION, GALACTOSE OXIDASE
Authors:Rogers, M.S, Hurtado-Guerrero, R, Firbank, S.J, Halcrow, M.A, Dooley, D.M, Phillips, S.E.V, Knowles, P.F, McPherson, M.J.
Deposit date:2008-07-29
Release date:2008-09-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Cross-Link Formation of the Cysteine 228-Tyrosine 272 Catalytic Cofactor of Galactose Oxidase Does not Require Dioxygen.
Biochemistry, 47, 2008
2WOH
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BU of 2woh by Molmil
Strontium soaked E. coli copper amine oxidase
Descriptor: CALCIUM ION, COPPER (II) ION, PRIMARY AMINE OXIDASE, ...
Authors:Smith, M.A, Pirrat, P, Pearson, A.R, Knowles, P.F, Phillips, S.E.V, McPherson, M.J.
Deposit date:2009-07-23
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Exploring the Roles of the Metal Ions in Escherichia Coli Copper Amine Oxidase.
Biochemistry, 49, 2010
2WO0
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BU of 2wo0 by Molmil
EDTA treated E. coli copper amine oxidase
Descriptor: COPPER (II) ION, PRIMARY AMINE OXIDASE, SODIUM ION
Authors:Smith, M.A, Pirrat, P, Pearson, A.R, Knowles, P.F, Phillips, S.E.V, McPherson, M.J.
Deposit date:2009-07-21
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Exploring the Roles of the Metal Ions in Escherichia Coli Copper Amine Oxidase.
Biochemistry, 49, 2010
2WOF
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BU of 2wof by Molmil
EDTA treated E. coli copper amine oxidase
Descriptor: COPPER (II) ION, PRIMARY AMINE OXIDASE, SODIUM ION
Authors:Smith, M.A, Pirrat, P, Pearson, A.R, Knowles, P.F, Phillips, S.E.V, McPherson, M.J.
Deposit date:2009-07-23
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Exploring the Roles of the Metal Ions in Escherichia Coli Copper Amine Oxidase.
Biochemistry, 49, 2010
2XUT
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BU of 2xut by Molmil
Crystal structure of a proton dependent oligopeptide (POT) family transporter.
Descriptor: PROTON/PEPTIDE SYMPORTER FAMILY PROTEIN
Authors:Newstead, S, Drew, D, Cameron, A.D, Postis, V.L, Xia, X, Fowler, P.W, Ingram, J.C, Carpenter, E.P, Sansom, M.S.P, McPherson, M.J, Baldwin, S.A, Iwata, S.
Deposit date:2010-10-21
Release date:2010-12-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Crystal Structure of a Prokaryotic Homologue of the Mammalian Oligopeptide-Proton Symporters, Pept1 and Pept2.
Embo J., 30, 2011
5EQL
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BU of 5eql by Molmil
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Descriptor: SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 2
Authors:Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A.
Deposit date:2015-11-13
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10, 2017
5ELJ
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BU of 5elj by Molmil
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Descriptor: SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 1
Authors:Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A.
Deposit date:2015-11-04
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10, 2017

 

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