Author results

3C9R
  • Download 3c9r
  • View 3c9r
Molmil generated image of 3c9r
AATHIL COMPLEXED WITH ATP
Descriptor:Thiamine monophosphate kinase, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:McCulloch, K.M., Kinsland, C., Begley, T.P., Ealick, S.E.
Deposit date:2008-02-18
Release date:2008-03-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of thiamin monophosphate kinase in complex with substrates and products.
Biochemistry, 47, 2008
3C9S
  • Download 3c9s
  • View 3c9s
Molmil generated image of 3c9s
AATHIL COMPLEXED WITH AMPPCP
Descriptor:Thiamine monophosphate kinase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:McCulloch, K.M., Kinsland, C., Begley, T.P., Ealick, S.E.
Deposit date:2008-02-18
Release date:2008-03-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural studies of thiamin monophosphate kinase in complex with substrates and products.
Biochemistry, 47, 2008
3C9T
  • Download 3c9t
  • View 3c9t
Molmil generated image of 3c9t
AATHIL COMPLEXED WITH AMPPCP AND TMP
Descriptor:Thiamine monophosphate kinase, MAGNESIUM ION, THIAMIN PHOSPHATE, ...
Authors:McCulloch, K.M., Kinsland, C., Begley, T.P., Ealick, S.E.
Deposit date:2008-02-18
Release date:2008-03-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural studies of thiamin monophosphate kinase in complex with substrates and products.
Biochemistry, 47, 2008
3C9U
  • Download 3c9u
  • View 3c9u
Molmil generated image of 3c9u
AATHIL COMPLEXED WITH ADP AND TPP
Descriptor:Thiamine monophosphate kinase, MAGNESIUM ION, THIAMINE DIPHOSPHATE, ...
Authors:McCulloch, K.M., Kinsland, C., Begley, T.P., Ealick, S.E.
Deposit date:2008-02-18
Release date:2008-03-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural studies of thiamin monophosphate kinase in complex with substrates and products.
Biochemistry, 47, 2008
3GMB
  • Download 3gmb
  • View 3gmb
Molmil generated image of 3gmb
CRYSTAL STRUCTURE OF 2-METHYL-3-HYDROXYPYRIDINE-5-CARBOXYLIC ACID OXYGENASE
Descriptor:2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:McCulloch, K.M., Mukherjee, T., Begley, T.P., Ealick, S.E.
Deposit date:2009-03-13
Release date:2009-04-14
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications.
Biochemistry, 48, 2009
3GMC
  • Download 3gmc
  • View 3gmc
Molmil generated image of 3gmc
CRYSTAL STRUCTURE OF 2-METHYL-3-HYDROXYPYRIDINE-5-CARBOXYLIC ACID OXYGENASE WITH SUBSTRATE BOUND
Descriptor:2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 5-hydroxy-6-methylpyridine-3-carboxylic acid
Authors:McCulloch, K.M., Mukherjee, T., Begley, T.P., Ealick, S.E.
Deposit date:2009-03-13
Release date:2009-04-14
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications.
Biochemistry, 48, 2009
3KXP
  • Download 3kxp
  • View 3kxp
Molmil generated image of 3kxp
CRYSTAL STRUCTURE OF E-2-(ACETAMIDOMETHYLENE)SUCCINATE HYDROLASE
Descriptor:Alpha-(N-acetylaminomethylene)succinic acid hydrolase, CHLORIDE ION
Authors:McCulloch, K.M., Mukherjee, T., Begley, T.P., Ealick, S.E.
Deposit date:2009-12-03
Release date:2010-02-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structure determination and characterization of the vitamin B(6) degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase.
Biochemistry, 49, 2010
3O15
  • Download 3o15
  • View 3o15
Molmil generated image of 3o15
CRYSTAL STRUCTURE OF BACILLUS SUBTILIS THIAMIN PHOSPHATE SYNTHASE COMPLEXED WITH A CARBOXYLATED THIAZOLE PHOSPHATE
Descriptor:Thiamine-phosphate pyrophosphorylase, 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, 2-TRIFLUOROMETHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, ...
Authors:McCulloch, K.M., Hanes, J.W., Abdelwahed, S., Mahanta, N., Hazra, A., Ishida, K., Begley, T.P., Ealick, S.E.
Deposit date:2010-07-20
Release date:2011-07-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure and Kinetic Characterization of Bacillus subtilis Thiamin Phosphate Synthase with a Carboxylated Thiazole Phosphate
to be published
3O16
  • Download 3o16
  • View 3o16
Molmil generated image of 3o16
CRYSTAL STRUCTURE OF BACILLUS SUBTILIS THIAMIN PHOSPHATE SYNTHASE K159A
Descriptor:Thiamine-phosphate pyrophosphorylase
Authors:McCulloch, K.M., Hanes, J.W., Abdelwahed, S., Mahanta, N., Hazra, A., Ishida, K., Begley, T.P., Ealick, S.E.
Deposit date:2010-07-20
Release date:2011-07-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure and Kinetic Characterization of Bacillus subtilis Thiamin Phosphate Synthase with a Carboxylated Thiazole Phosphate
to be published
3O63
  • Download 3o63
  • View 3o63
Molmil generated image of 3o63
CRYSTAL STRUCTURE OF THIAMIN PHOSPHATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable thiamine-phosphate pyrophosphorylase, PHOSPHATE ION
Authors:McCulloch, K.M., Ramamoorthy, D., Ishida, K., Guida, W.C., Begley, T.P., Ealick, S.E.
Deposit date:2010-07-28
Release date:2011-07-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure and Identification of Potential Inhibitor Compounds for Mycobacterium tuberculosis Thiamin Phosphate Synthase
to be published
4XAA
  • Download 4xaa
  • View 4xaa
Molmil generated image of 4xaa
CRYSTAL STRUCTURE OF AVIO1 FROM STREPTOMYCES VIRIDOCHROMOGENES TUE57
Descriptor:Putative oxygenase, NICKEL (II) ION
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-13
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XAB
  • Download 4xab
  • View 4xab
Molmil generated image of 4xab
CRYSTAL STRUCTURE OF EVDO2 FROM MICROMONOSPORA CARBONACEA VAR. AURANTIACA
Descriptor:EvdO2, NICKEL (II) ION, IMIDAZOLE
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-13
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XAC
  • Download 4xac
  • View 4xac
Molmil generated image of 4xac
CRYSTAL STRUCTURE OF EVDO2 FROM MICROMONOSPORA CARBONACEA VAR. AURANTIACA COMPLEXED WITH 2-OXOGLUTARATE
Descriptor:EvdO2, NICKEL (II) ION, IMIDAZOLE, ...
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-13
Release date:2015-08-05
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XBZ
  • Download 4xbz
  • View 4xbz
Molmil generated image of 4xbz
CRYSTAL STRUCTURE OF EVDO1 FROM MICROMONOSPORA CARBONACEA VAR. AURANTIACA
Descriptor:EvdO1, NICKEL (II) ION, GLYCEROL
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-17
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XC9
  • Download 4xc9
  • View 4xc9
Molmil generated image of 4xc9
CRYSTAL STRUCTURE OF APO HYGX FROM STREPTOMYCES HYGROSCOPICUS
Descriptor:oxidase/hydroxylase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-17
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XCA
  • Download 4xca
  • View 4xca
Molmil generated image of 4xca
CRYSTAL STRUCTURE OF HYGX FROM STREPTOMYCES HYGROSCOPICUS WITH NICKEL AND 2-OXOGLUTARATE BOUND
Descriptor:oxidase/hydroxylase, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-17
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XCB
  • Download 4xcb
  • View 4xcb
Molmil generated image of 4xcb
CRYSTAL STRUCTURE OF HYGX FROM STREPTOMYCES HYGROSCOPICUS WITH NICKEL, 2-OXOGLUTARATE, AND HYGROMYCIN B BOUND
Descriptor:oxidase/hydroxylase, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2014-12-17
Release date:2015-08-05
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZPI
  • Download 4zpi
  • View 4zpi
Molmil generated image of 4zpi
CRYSTAL STRUCTURE OF HYGX FROM STREPTOMYCES HYGROSCOPICUS WITH IRON BOUND
Descriptor:Putative oxidase/hydroxylase, FE (II) ION, SUCCINIC ACID
Authors:McCulloch, K.M., McCranie, E.K., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M.
Deposit date:2015-05-07
Release date:2015-08-05
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.504 Å)
Cite:Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
6B3I
  • Download 6b3i
  • View 6b3i
Molmil generated image of 6b3i
ANNEXIN A13A
Descriptor:Annexin, 1,2-ETHANEDIOL
Authors:McCulloch, K.M., Iverson, T.M.
Deposit date:2017-09-21
Release date:2018-10-10
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding.
J. Biol. Chem., 294, 2019
2Z7B
  • Download 2z7b
  • View 2z7b
Molmil generated image of 2z7b
CRYSTAL STRUCTURE OF MESORHIZOBIUM LOTI 3-HYDROXY-2-METHYLPYRIDINE-4,5-DICARBOXYLATE DECARBOXYLASE
Descriptor:Mlr6791 protein, MANGANESE (II) ION
Authors:McCulloch, K.M., Mukherjee, T., Ealick, S.E., Begley, T.P.
Deposit date:2007-08-17
Release date:2007-11-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Gene Identification and Structural Characterization of the Pyridoxal 5'-Phosphate Degradative Protein 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate Decarboxylase from Mesorhizobium loti MAFF303099
Biochemistry, 46, 2007
5T38
  • Download 5t38
  • View 5t38
Molmil generated image of 5t38
CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF EVDMO1 WITH SAH BOUND
Descriptor:EvdMO1, S-ADENOSYL-L-HOMOCYSTEINE
Authors:McCulloch, K.M., Berndt, S., Yamakawa, I., Chen, Q., Loukachevitch, L.V., Starbird, C., Perry, N.A., Iverson, T.M.
Deposit date:2016-08-25
Release date:2017-09-06
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.1502 Å)
Cite:The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains.
Biochemistry, 57, 2018
5T39
  • Download 5t39
  • View 5t39
Molmil generated image of 5t39
CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF EVDMO1 IN THE PRESENCE OF SAH AND D-FUCOSE
Descriptor:EvdMO1, S-ADENOSYL-L-HOMOCYSTEINE
Authors:McCulloch, K.M., Starbird, C.A., Chen, Q., Perry, N.A., Berndt, S., Yamakawa, I., Loukachevitch, L.V., Iverson, T.M.
Deposit date:2016-08-25
Release date:2017-09-06
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.1004 Å)
Cite:The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains.
Biochemistry, 57, 2018
6EC3
  • Download 6ec3
  • View 6ec3
Molmil generated image of 6ec3
CRYSTAL STRUCTURE OF EVDMO1
Descriptor:Methyltransferase domain-containing protein, NICKEL (II) ION, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:McCulloch, K.M., Iverson, T.M., Starbird, C.A., Perry, N.A., Chen, Q., Berndt, S., Yamakawa, I., Loukachevitch, L.V.
Deposit date:2018-08-07
Release date:2018-12-26
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains.
Biochemistry, 57, 2018
5EQ2
  • Download 5eq2
  • View 5eq2
Molmil generated image of 5eq2
CRYSTAL STRUCTURE OF THE SRPA ADHESIN FROM STREPTOCOCCUS SANGUINIS
Descriptor:Platelet-binding glycoprotein, CALCIUM ION, ACETATE ION
Authors:Loukachevitch, L.V., McCulloch, K.M., Vann, K.R., Wawrzak, Z., Anderson, S., Iverson, T.M.
Deposit date:2015-11-12
Release date:2016-01-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.
J.Biol.Chem., 291, 2016
5EQ3
  • Download 5eq3
  • View 5eq3
Molmil generated image of 5eq3
CRYSTAL STRUCTURE OF THE SRPA ADHESIN FROM STREPTOCOCCUS SANGUINIS WITH A SIALYL GALACTOSE DISACCHARIDE BOUND
Descriptor:Platelet-binding glycoprotein, 3,5-dideoxy-5-[(hydroxyacetyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid, METHYL-BETA-GALACTOSE, ...
Authors:Loukachevitch, L.V., McCulloch, K.M., Vann, K.R., Wawrzak, Z., Anderson, S., Iverson, T.M.
Deposit date:2015-11-12
Release date:2016-01-27
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin.
J.Biol.Chem., 291, 2016
<12>