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5GM8
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ, SINEFUNGIN
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5GMB
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5GMC
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
Descriptor:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
Authors:Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2016-07-13
Release date:2016-10-26
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5WYQ
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W., McBee, M.E., Maenpuen, S., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M., Chaiyen, P.
Deposit date:2017-01-15
Release date:2017-12-20
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 2019
5WYR
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, SINEFUNGIN
Authors:Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W.H., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2017-01-15
Release date:2017-12-20
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 2019
6JKI
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, SINEFUNGIN, GLYCEROL, ...
Authors:Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W.H., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
Deposit date:2019-03-01
Release date:2019-07-03
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 25, 2019
5ZHI
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APO CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:tRNA (guanine-N(1)-)-methyltransferase
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHJ
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH S-ADENOSYL HOMOCYSTEINE (SAH)
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHK
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-[(4-{[cyclohexyl(ethyl)amino]methyl}phenyl)methyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHL
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHM
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(diethylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide, S-ADENOSYLMETHIONINE
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-06
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHN
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2018-03-13
Release date:2019-03-27
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
6JOE
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, ~{N}-[[4-[(4-azanylpiperidin-1-yl)methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2,3-d]pyrimidine-5-carboxamide, PHOSPHATE ION, ...
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2019-03-20
Release date:2019-09-04
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
6JOF
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, ~{N}-[[4-[(4-azanylpiperidin-1-yl)methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2,3-d]pyrimidine-5-carboxamide
Authors:Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
Deposit date:2019-03-20
Release date:2019-09-04
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019