Author results

3FL5
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PROTEIN KINASE CK2 IN COMPLEX WITH THE INHIBITOR QUINALIZARIN
Descriptor:Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER, 1,2,5,8-tetrahydroxyanthracene-9,10-dione
Authors:Mazzorana, M., Franchin, C., Battistutta, R.
Deposit date:2008-12-18
Release date:2009-08-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2
Biochem.J., 421, 2009
4A7C
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CRYSTAL STRUCTURE OF PIM1 KINASE WITH ETP46546
Descriptor:PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, N-(piperidin-4-ylmethyl)-3-[3-(trifluoromethyloxy)phenyl]-[1,2,3]triazolo[4,5-b]pyridin-5-amine, IMIDAZOLE, ...
Authors:Mazzorana, M., Montoya, G.
Deposit date:2011-11-12
Release date:2012-02-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Hit to Lead Evaluation of 1,2,3-Triazolo[4,5-B]Pyridines as Pim Kinase Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
6FSW
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STRUCTURE OF ARCHAEOGLOBUS FULGIDUS SBDS PROTEIN AT 1.9 ANGSTROM
Descriptor:Ribosome maturation protein SDO1-like protein, DI(HYDROXYETHYL)ETHER
Authors:Mazzorana, M., Foadi, J., Siliqi, D., Sanchez-Puig, N.
Deposit date:2018-02-20
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational flexibility of proteins involved in ribosome biogenesis: investigations via Small Angle X-ray Scattering (SAXS)
Crystals, 8, 2018
3PWD
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CRYSTAL STRUCTURE OF MAIZE CK2 IN COMPLEX WITH NBC (Z1)
Descriptor:Casein kinase II subunit alpha, 8-hydroxy-4-methyl-9-nitro-2H-benzo[g]chromen-2-one
Authors:Battistutta, R., Mazzorana, M.
Deposit date:2010-12-08
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A
Cell.Mol.Life Sci., 69, 2012
1ZOE
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CRYSTAL STRUCTURE OF PROTEIN KINASE CK2 IN COMPLEX WITH TBB-DERIVATIVES INHIBITORS
Descriptor:Protein kinase CK2, alpha Subunit, CHLORIDE ION, ...
Authors:Battistutta, R., Mazzorana, M., Sarno, S., Kazimierczuk, Z., Zanotti, G., Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
1ZOG
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CRYSTAL STRUCTURE OF PROTEIN KINASE CK2 IN COMPLEX WITH TBB-DERIVATIVES
Descriptor:PROTEIN KINASE CK2, alpha SUBUNIT, 4,5,6,7-TETRABROMO-2-(METHYLSULFANYL)-1H-BENZIMIDAZOLE
Authors:Battistutta, R., Mazzorana, M., Sarno, S., Kazimierczuk, Z., Zanotti, G., Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
1ZOH
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CRYSTAL STRUCTURE OF PROTEIN KINASE CK2 IN COMPLEX WITH TBB-DERIVATIVES INHIBITORS
Descriptor:PROTEIN KINASE CK2, ALPHA SUBUNIT, SODIUM ION, ...
Authors:Battistutta, R., Mazzorana, M., Sarno, S., Kazimierczuk, Z., Zanotti, G., Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
4DGM
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CRYSTAL STRUCTURE OF MAIZE CK2 IN COMPLEX WITH THE INHIBITOR APIGENIN
Descriptor:Casein kinase II subunit alpha, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Lolli, G., Mazzorana, M., Battistutta, R.
Deposit date:2012-01-26
Release date:2012-08-01
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Biochemistry, 51, 2012
4DGN
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CRYSTAL STRUCTURE OF MAIZE CK2 IN COMPLEX WITH THE INHIBITOR LUTEOLIN
Descriptor:Casein kinase II subunit alpha, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
Authors:Lolli, G., Mazzorana, M., Battistutta, R.
Deposit date:2012-01-26
Release date:2012-08-01
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Biochemistry, 51, 2012
6QS5
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CRYSTAL STRUCTURE OF MAIZE CK2 IN COMPLEX WITH TYRPHOSTIN AG99
Descriptor:Casein kinase II subunit alpha, (~{E})-3-[3,4-bis(oxidanyl)phenyl]-2-cyano-prop-2-enamide
Authors:Lolli, G., Mazzorana, M., Battistutta, R.
Deposit date:2019-02-20
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.961 Å)
Cite:Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Biochemistry, 51, 2012
3KXG
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CRYSTAL STRUCTURE OF Z. MAYS CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR 3,4,5,6,7-PENTABROMO-1H-INDAZOLE (K64)
Descriptor:Casein kinase II subunit alpha, 3,4,5,6,7-pentabromo-1H-indazole
Authors:Papinutto, E., Franchin, C., Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3KXM
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CRYSTAL STRUCTURE OF Z. MAYS CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR K74
Descriptor:Casein kinase II subunit alpha, N-methyl-2-[(4,5,6,7-tetrabromo-1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetamide
Authors:Papinutto, E., Franchin, C., Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
2OXD
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PROTEIN KINASE CK2 IN COMPLEX WITH TETRABROMOBENZOIMIDAZOLE K17, K22 AND K32 INHIBITORS
Descriptor:Casein kinase II subunit alpha, 4,5,6,7-TETRABROMO-1H,3H-BENZIMIDAZOL-2-ONE
Authors:Battistutta, R., Zanotti, G., Cendron, L.
Deposit date:2007-02-20
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules.
Chembiochem, 8, 2007
2OXX
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PROTEIN KINASE CK2 IN COMPLEX WITH TETRABROMOBENZOIMIDAZOLE DERIVATIVES K17, K22 AND K32
Descriptor:Casein kinase II subunit alpha, 4,5,6,7-TETRABROMO-1H,3H-BENZIMIDAZOL-2-THIONE
Authors:Battistutta, R., Zanotti, G., Cendron, L.
Deposit date:2007-02-21
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules.
Chembiochem, 8, 2007
2OXY
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PROTEIN KINASE CK2 IN COMPLEX WITH TETRABROMOBENZOIMIDAZOLE DERIVATIVES K17, K22 AND K32
Descriptor:Casein kinase II subunit alpha, 4,5,6,7-TETRABROMO-BENZIMIDAZOLE
Authors:Battistutta, R., Zanotti, G., Cendron, L.
Deposit date:2007-02-21
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.812 Å)
Cite:The ATP-Binding Site of Protein Kinase CK2 Holds a Positive Electrostatic Area and Conserved Water Molecules.
Chembiochem, 8, 2007
2QC6
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PROTEIN KINASE CK2 IN COMPLEX WITH DBC
Descriptor:Casein kinase II subunit alpha, 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE
Authors:Battistutta, R.
Deposit date:2007-06-19
Release date:2008-02-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Coumarin as attractive casein kinase 2 (CK2) inhibitor scaffold: an integrate approach to elucidate the putative binding motif and explain structure-activity relationships.
J.Med.Chem., 51, 2008
3PZH
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CRYSTAL STRUCTURE OF MAIZE CK2 ALPHA IN COMPLEX WITH EMODIN AT 1.92 A RESOLUTION
Descriptor:Casein kinase II subunit alpha, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, ACETATE ION, ...
Authors:Battistutta, R., Mazzorana, M.
Deposit date:2010-12-14
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.919 Å)
Cite:Structural and functional analysis of the flexible regions of the catalytic alpha-subunit of protein kinase CK2
to be published
4ZB0
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A DEHYDRATED FORM OF GLUCOSE ISOMERASE COLLECTED AT ROOM TEMPERATURE.
Descriptor:Xylose isomerase, MANGANESE (II) ION, ALPHA-D-GLUCOSE, ...
Authors:Sandy, J.
Deposit date:2015-04-14
Release date:2016-03-23
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A generic protocol for protein crystal dehydration using the HC1b humidity controller.
Acta Crystallogr D Struct Biol, 72, 2016
4ZB2
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A NATIVE FORM OF GLUCOSE ISOMERASE COLLECTED AT ROOM TEMPERATURE.
Descriptor:Xylose isomerase, MANGANESE (II) ION, ALPHA-D-GLUCOSE, ...
Authors:Sandy, J.
Deposit date:2015-04-14
Release date:2016-03-23
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A generic protocol for protein crystal dehydration using the HC1b humidity controller.
Acta Crystallogr D Struct Biol, 72, 2016
4ZB5
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A FORM OF GLUCOSE ISOMERASE COLLECTED AT 100K.
Descriptor:Xylose isomerase, MANGANESE (II) ION, ALPHA-D-GLUCOSE
Authors:Sandy, J.
Deposit date:2015-04-14
Release date:2016-03-23
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A generic protocol for protein crystal dehydration using the HC1b humidity controller.
Acta Crystallogr D Struct Biol, 72, 2016
4ZBC
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A DEHYDRATED FORM OF GLUCOSE ISOMERASE COLLECTED AT 100K.
Descriptor:Xylose isomerase, MANGANESE (II) ION, ALPHA-D-GLUCOSE, ...
Authors:Sandy, J.
Deposit date:2015-04-14
Release date:2016-03-23
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A generic protocol for protein crystal dehydration using the HC1b humidity controller.
Acta Crystallogr D Struct Biol, 72, 2016
3PE1
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR CX-4945
Descriptor:Casein kinase II subunit alpha, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, SULFATE ION
Authors:Battistutta, R., Papinutto, E., Lolli, G., Pierre, F., Haddach, M., Ryckman, D.M.
Deposit date:2010-10-25
Release date:2011-09-07
Last modified:2012-01-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry, 50, 2011
3PE2
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 IN COMPLEX WITH THE INHIBITOR CX-5011
Descriptor:Casein kinase II subunit alpha, 5-[(3-ethynylphenyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid, SULFATE ION
Authors:Battistutta, R., Papinutto, E., Lolli, G., Pierre, F., Haddach, M., Ryckman, D.M.
Deposit date:2010-10-25
Release date:2011-09-07
Last modified:2012-01-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry, 50, 2011
3R0T
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR CX-5279
Descriptor:Casein kinase II subunit alpha, 3-(cyclopropylamino)-5-{[3-(trifluoromethyl)phenyl]amino}pyrimido[4,5-c]quinoline-8-carboxylic acid, SULFATE ION, ...
Authors:Battistutta, R., Papinutto, E., Lolli, G., Pierre, F., Haddach, M., Ryckman, D.M.
Deposit date:2011-03-09
Release date:2011-12-07
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Biochemistry, 50, 2011
3KXH
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CRYSTAL STRUCTURE OF Z. MAYS CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE INHIBITOR (2-DYMETHYLAMMINO-4,5,6,7-TETRABROMOBENZOIMIDAZOL-1YL-ACETIC ACID (K66)
Descriptor:Casein kinase II subunit alpha, [4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazol-1-yl]acetic acid, DI(HYDROXYETHYL)ETHER
Authors:Papinutto, E., Franchin, C., Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
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