Author results

1AB4
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59KDA FRAGMENT OF GYRASE A FROM E. COLI
Descriptor:GYRASE A
Authors:Cabral, J.H.M., Maxwell, A., Liddington, R.C.
Deposit date:1997-02-03
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the breakage-reunion domain of DNA gyrase.
Nature, 388, 1997
2Y3P
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF GYRA WITH THE ANTIBIOTIC SIMOCYCLINONE D8
Descriptor:DNA GYRASE SUBUNIT A, MAGNESIUM ION, SIMOCYCLINONE D8
Authors:Edwards, M.J., Flatman, R.H., Mitchenall, L.A., Stevenson, C.E.M., Le, T.B.K., Clarke, T.A., McKay, A.R., Fiedler, H.-P., Buttner, M.J., Lawson, D.M., Maxwell, A.
Deposit date:2010-12-22
Release date:2010-12-29
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase.
Science, 326, 2009
2BM4
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THE STRUCTURE OF MFPA (RV3361C, C2 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT- HANDED QUADRILATERAL BETA-HELIX.
Descriptor:PENTAPEPTIDE REPEAT FAMILY PROTEIN
Authors:Hegde, S.S., Vetting, M.W., Roderick, S.L., Mitchenall, L.A., Maxwell, A., Takiff, H.E., Blanchard, J.S.
Deposit date:2005-03-09
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA
Science, 308, 2005
2BM5
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THE STRUCTURE OF MFPA (RV3361C, P21 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT- HANDED QUADRILATERAL BETA-HELIX.
Descriptor:PENTAPEPTIDE REPEAT FAMILY PROTEIN, SULFATE ION
Authors:Hegde, S.S., Vetting, M.W., Roderick, S.L., Mitchenall, L.A., Maxwell, A., Takiff, H.E., Blanchard, J.S.
Deposit date:2005-03-09
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA
Science, 308, 2005
2BM6
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THE STRUCTURE OF MFPA (RV3361C, C2221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT- HANDED QUADRILATERAL BETA-HELIX.
Descriptor:PENTAPEPTIDE REPEAT FAMILY PROTEIN, CESIUM ION
Authors:Hegde, S.S., Vetting, M.W., Roderick, S.L., Mitchenall, L.A., Maxwell, A., Takiff, H.E., Blanchard, J.S.
Deposit date:2005-03-09
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA
Science, 308, 2005
2BM7
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THE STRUCTURE OF MFPA (RV3361C, P3221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT- HANDED QUADRILATERAL BETA-HELIX.
Descriptor:PENTAPEPTIDE REPEAT FAMILY PROTEIN
Authors:Hegde, S.S., Vetting, M.W., Roderick, S.L., Mitchenall, L.A., Maxwell, A., Takiff, H.E., Blanchard, J.S.
Deposit date:2005-03-09
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Fluroquinolone Resistance Protein from Mycobacterium Tuberculosis that Mimics DNA
Science, 308, 2005
2Y2Z
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LIGAND-FREE FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y30
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SIMOCYCLINONE D8 BOUND FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE D8, CHLORIDE ION
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
2Y31
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SIMOCYCLINONE C4 BOUND FORM OF TETR-LIKE REPRESSOR SIMR
Descriptor:PUTATIVE REPRESSOR SIMREG2, SIMOCYCLINONE C4, PENTAETHYLENE GLYCOL, ...
Authors:Le, T.B.K., Stevenson, C.E.M., Fiedler, H.-P., Maxwell, A., Lawson, D.M., Buttner, M.J.
Deposit date:2010-12-17
Release date:2011-03-09
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression.
J.Mol.Biol., 408, 2011
4CKK
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APO STRUCTURE OF 55 KDA N-TERMINAL DOMAIN OF E. COLI DNA GYRASE A SUBUNIT
Descriptor:DNA GYRASE SUBUNIT A
Authors:Hearnshaw, S.J., Edwards, M.J., Stevenson, C.E.M., Lawson, D.M., Maxwell, A.
Deposit date:2014-01-07
Release date:2014-03-12
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight Into the Mechanism of Inhibition.
J.Mol.Biol., 426, 2014
4CKL
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STRUCTURE OF 55 KDA N-TERMINAL DOMAIN OF E. COLI DNA GYRASE A SUBUNIT WITH SIMOCYCLINONE D8 BOUND
Descriptor:DNA GYRASE SUBUNIT A, SIMOCYCLINONE D8
Authors:Hearnshaw, S.J., Edwards, M.J., Stevenson, C.E.M., Lawson, D.M., Maxwell, A.
Deposit date:2014-01-07
Release date:2014-03-12
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight Into the Mechanism of Inhibition.
J.Mol.Biol., 426, 2014
4WUB
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N-TERMINAL 43 KDA FRAGMENT OF THE E. COLI DNA GYRASE B SUBUNIT GROWN FROM 100 MM KCL CONDITION
Descriptor:DNA gyrase subunit B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Hearnshaw, S.J., Chung, T.T., Stevenson, C.E.M., Maxwell, A., Lawson, D.M.
Deposit date:2014-10-31
Release date:2015-04-08
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The role of monovalent cations in the ATPase reaction of DNA gyrase
Acta Crystallogr.,Sect.D, 71, 2015
4WUC
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N-TERMINAL 43 KDA FRAGMENT OF THE E. COLI DNA GYRASE B SUBUNIT GROWN FROM 100 MM NACL CONDITION
Descriptor:DNA gyrase subunit B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Hearnshaw, S.J., Chung, T.T., Stevenson, C.E.M., Maxwell, A., Lawson, D.M.
Deposit date:2014-10-31
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The role of monovalent cations in the ATPase reaction of DNA gyrase
Acta Crystallogr.,Sect.D, 71, 2015
4WUD
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N-TERMINAL 43 KDA FRAGMENT OF THE E. COLI DNA GYRASE B SUBUNIT GROWN FROM NO SALT CONDITION
Descriptor:DNA gyrase subunit B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Hearnshaw, S.J., Chung, T.T., Stevenson, C.E.M., Maxwell, A., Lawson, D.M.
Deposit date:2014-10-31
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The role of monovalent cations in the ATPase reaction of DNA gyrase
Acta Crystallogr.,Sect.D, 71, 2015
4XTJ
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N-TERMINAL 43 KDA FRAGMENT OF THE E. COLI DNA GYRASE B SUBUNIT GROWN FROM 100 MM KCL PLUS 100 MM NACL CONDITION
Descriptor:DNA gyrase subunit B, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Hearnshaw, S.J., Chung, T.T., Stevenson, C.E.M., Maxwell, A., Lawson, D.M.
Deposit date:2015-01-23
Release date:2015-04-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:The role of monovalent cations in the ATPase reaction of DNA gyrase
Acta Crystallogr.,Sect.D, 71, 2015
5NJ5
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E. COLI MICROCIN-PROCESSING METALLOPROTEASE TLDD/E WITH PHOSPHATE BOUND
Descriptor:Metalloprotease TldD, Metalloprotease PmbA, ZINC ION, ...
Authors:Ghilarov, D., Serebryakova, M., Stevenson, C.E.M., Hearnshaw, S.J., Volkov, D., Maxwell, A., Lawson, D.M., Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJ9
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E. COLI MICROCIN-PROCESSING METALLOPROTEASE TLDD/E WITH DRVY ANGIOTENSIN FRAGMENT BOUND
Descriptor:Metalloprotease TldD, Metalloprotease PmbA, ASP-ARG-VAL-TYR, ...
Authors:Ghilarov, D., Serebryakova, M., Stevenson, C.E.M., Hearnshaw, S.J., Volkov, D., Maxwell, A., Lawson, D.M., Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJA
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E. COLI MICROCIN-PROCESSING METALLOPROTEASE TLDD/E WITH ANGIOTENSIN ANALOGUE BOUND
Descriptor:Metalloprotease TldD, Metalloprotease PmbA, HIS-PRO-PHE, ...
Authors:Ghilarov, D., Serebryakova, M., Stevenson, C.E.M., Hearnshaw, S.J., Volkov, D., Maxwell, A., Lawson, D.M., Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJB
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E. COLI MICROCIN-PROCESSING METALLOPROTEASE TLDD/E WITH ACTINONIN BOUND
Descriptor:Metalloprotease TldD, Metalloprotease PmbA, ZINC ION, ...
Authors:Ghilarov, D., Serebryakova, M., Stevenson, C.E.M., Hearnshaw, S.J., Volkov, D., Maxwell, A., Lawson, D.M., Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJC
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E. COLI MICROCIN-PROCESSING METALLOPROTEASE TLDD/E (TLDD E263A MUTANT) WITH HEXAPEPTIDE BOUND
Descriptor:Metalloprotease TldD, Metalloprotease PmbA, VAL-LEU-GLU-ASP-ARG-ILE, ...
Authors:Ghilarov, D., Serebryakova, M., Stevenson, C.E.M., Hearnshaw, S.J., Volkov, D., Maxwell, A., Lawson, D.M., Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJF
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E. COLI MICROCIN-PROCESSING METALLOPROTEASE TLDD/E (TLDD H262A MUTANT) WITH PENTAPEPTIDE BOUND
Descriptor:Metalloprotease TldD, Metalloprotease PmbA, ALA-ALA-ALA-ALA-ALA, ...
Authors:Ghilarov, D., Serebryakova, M., Stevenson, C.E.M., Hearnshaw, S.J., Volkov, D., Maxwell, A., Lawson, D.M., Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
6F86
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CRYSTAL STRUCTURE OF E. COLI GYRASEB 24KDA IN COMPLEX WITH 4-(4-BROMO-1H-PYRAZOL-1-YL)-6-[(ETHYLCARBAMOYL)AMINO]-N-(PYRIDIN-3-YL)PYRIDINE-3-CARBOXAMIDE
Descriptor:DNA gyrase subunit B, 4-(4-bromanylpyrazol-1-yl)-6-(ethylcarbamoylamino)-~{N}-pyridin-3-yl-pyridine-3-carboxamide
Authors:Narramore, S.K., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Fishwick, C.W.G.
Deposit date:2017-12-12
Release date:2019-06-26
Last modified:2019-08-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
6F8J
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CRYSTAL STRUCTURE OF E. COLI GYRASEB 24KDA IN COMPLEX WITH 6-[(ETHYLCARBAMOYL)AMINO]-4-(1H-PYRAZOL-1-YL)-N-(PYRIDIN-3-YL)PYRIDINE-3-CARBOXAMIDE
Descriptor:DNA gyrase subunit B, 6-(ethylcarbamoylamino)-4-pyrazol-1-yl-~{N}-pyridin-3-yl-pyridine-3-carboxamide
Authors:Narramore, S.K., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Fishwick, C.W.G.
Deposit date:2017-12-13
Release date:2019-06-26
Last modified:2019-08-07
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
6F94
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CRYSTAL STRUCTURE OF E. COLI GYRASEB 24KDA IN COMPLEX WITH 6-[(ETHYLCARBAMOYL)AMINO]-4-[(3-METHYPHENYL)AMINO]-N-(3-METHYPHENYL)PYRIDINE-3-CARBOXAMIDE
Descriptor:DNA gyrase subunit B, 6-(ethylcarbamoylamino)-~{N}-(3-methylphenyl)-4-[(3-methylphenyl)amino]pyridine-3-carboxamide
Authors:Narramore, S.K., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Fishwick, C.W.G.
Deposit date:2017-12-14
Release date:2019-06-26
Last modified:2019-08-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
6F96
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CRYSTAL STRUCTURE OF E. COLI GYRASEB 24KDA IN COMPLEX WITH 6-[(ETHYLCARBAMOYL)AMINO]-4-[(4-METHOXYPHENYL)AMINO]-N-(PYRIDIN-3-YL)PYRIDINE-3-CARBOXAMIDE
Descriptor:DNA gyrase subunit B, 6-(ethylcarbamoylamino)-4-[(4-methoxyphenyl)amino]-~{N}-pyridin-3-yl-pyridine-3-carboxamide
Authors:Narramore, S.K., Stevenson, C.E.M., Lawson, D.M., Maxwell, A., Fishwick, C.W.G.
Deposit date:2017-12-14
Release date:2019-01-30
Last modified:2019-08-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase.
Bioorg.Med.Chem., 27, 2019
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