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5YJO
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CRYSTAL STRUCTURE OF SMYD3 IN COMPLEX WITH COVALENT INHIBITOR 4
Descriptor:Histone-lysine N-methyltransferase SMYD3, ZINC ION, propyl (3~{S})-4-[[(6~{R})-6-(aminomethyl)-5,6,7,8-tetrahydroacridin-3-yl]carbonyl]-3-methyl-piperazine-1-carboxylate, ...
Authors:Baburajendran, N., Anna E, J.
Deposit date:2017-10-11
Release date:2018-10-17
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.135 Å)
Cite:Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.
Acs Med.Chem.Lett., 10, 2019
6AFK
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
Descriptor:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYLMETHIONINE, N-{(3S)-1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl}-1H-indole-2-carboxamide
Authors:Zhong, W., Koay, A., Wong, Y.W., Sahili, A.E., Nah, Q., Kang, C., Poulsen, A., Chionh, Y.K., McBee, M., Matter, A., Hill, J., Lescar, J., Dedon, P.C.
Deposit date:2018-08-08
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of TrmD from Pseudomonas aeruginosa in complex with active-site inhibitor
To Be Published
6IJL
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CRYSTAL STRUCTURE OF SMYD3 IN COMPLEX WITH COVALENT INHIBITOR 5
Descriptor:Histone-lysine N-methyltransferase SMYD3, propyl (2~{R})-4-[2-[4-(1-azanylcyclopropyl)phenyl]quinolin-7-yl]carbonyl-2-methyl-piperazine-1-carboxylate, ZINC ION, ...
Authors:Baburajendran, N., Joy, J.
Deposit date:2018-10-10
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.
Acs Med.Chem.Lett., 10, 2019