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2W2D
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CRYSTAL STRUCTURE OF A CATALYTICALLY ACTIVE, NON-TOXIC ENDOPEPTIDASE DERIVATIVE OF CLOSTRIDIUM BOTULINUM TOXIN A
Descriptor:BOTULINUM NEUROTOXIN A LIGHT CHAIN, BOTULINUM NEUROTOXIN A HEAVY CHAIN, SULFATE ION, ...
Authors:Masuyer, G., Thiyagarajan, N., James, P.L., Marks, P.M.H., Chaddock, J.A., Acharya, K.R.
Deposit date:2008-10-29
Release date:2009-03-24
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal Structure of a Catalytically Active, Non-Toxic Endopeptidase Derivative of Clostridium Botulinum Toxin A.
Biochem.Biophys.Res.Commun., 381, 2009
2XHL
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STRUCTURE OF A FUNCTIONAL DERIVATIVE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE B
Descriptor:BOTULINUM NEUROTOXIN B LIGHT CHAIN, BOTULINUM NEUROTOXIN B HEAVY CHAIN, ZINC ION
Authors:Masuyer, G., Beard, M., Cadd, V.A., Chaddock, J.A., Acharya, K.R.
Deposit date:2010-06-18
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Activity of a Functional Derivative of Clostridium Botulinum Neurotoxin B.
J.Struct.Biol., 174, 2011
3ZUQ
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CRYSTAL STRUCTURE OF AN ENGINEERED BOTULINUM NEUROTOXIN TYPE B - DERIVATIVE, LC-B-GS-HN-B
Descriptor:BOTULINUM NEUROTOXIN TYPE B, ZINC ION
Authors:Masuyer, G., Stancombe, P., Chaddock, J.A., Acharya, K.R.
Deposit date:2011-07-19
Release date:2011-12-07
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives
Acta Crystallogr.,Sect.F, 67, 2011
3ZUR
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CRYSTAL STRUCTURE OF AN ENGINEERED BOTULINUM NEUROTOXIN TYPE A- SNARE23 DERIVATIVE, LC0-A-SNAP25-HN-A
Descriptor:BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN, SULFATE ION
Authors:Masuyer, G., Stancombe, P., Chaddock, J.A., Acharya, K.R.
Deposit date:2011-07-19
Release date:2011-12-07
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives
Acta Crystallogr.,Sect.F, 67, 2011
3ZUS
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CRYSTAL STRUCTURE OF AN ENGINEERED BOTULINUM NEUROTOXIN TYPE A- SNARE23 DERIVATIVE, LC-A-SNAP23-HN-A
Descriptor:BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN 23, ZINC ION
Authors:Masuyer, G., Stancombe, P., Chaddock, J.A., Acharya, K.R.
Deposit date:2011-07-19
Release date:2011-12-07
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives
Acta Crystallogr.,Sect.F, 67, 2011
3ZXE
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH A GALACTOSE- BENZYLPHOSPHATE INHIBITOR
Descriptor:GALECTIN-7, METHYL 2-O-[(S)-(BENZYLOXY)(HYDROXY)PHOSPHORYL]-3-DEOXY-3-{[(4-METHYLPHENYL)CARBONYL]AMINO}-1-THIO-BETA-D-GALACTOPYRANOSIDE
Authors:Masuyer, G., Oberg, C.T., Leffler, H., Nilsson, U.J., Acharya, K.R.
Deposit date:2011-08-10
Release date:2011-11-30
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Inhibition Mechanism of Human Galectin-7 by a Novel Galactose-Benzylphosphate Inhibitor.
FEBS J., 279, 2012
3ZXF
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HIGH RESOLUTION STRUCTURE OF HUMAN GALECTIN-7
Descriptor:GALECTIN-7, ACETATE ION
Authors:Masuyer, G., Oberg, C.T., Leffler, H., Nilsson, U.J., Acharya, K.R.
Deposit date:2011-08-10
Release date:2011-11-30
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Inhibition Mechanism of Human Galectin-7 by a Novel Galactose-Benzylphosphate Inhibitor.
FEBS J., 279, 2012
4APH
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HUMAN ANGIOTENSIN-CONVERTING ENZYME IN COMPLEX WITH ANGIOTENSIN-II
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, ANGIOTENSIN-2, CHLORIDE ION, ...
Authors:Masuyer, G., Schwager, S.L.U., Sturrock, E.D., Isaac, R.E., Acharya, K.R.
Deposit date:2012-04-03
Release date:2012-10-17
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Molecular Recognition and Regulation of Human Angiotensin-I Converting Enzyme (Ace) Activity by Natural Inhibitory Peptides.
Sci.Rep., 2, 2012
4APJ
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HUMAN ANGIOTENSIN-CONVERTING ENZYME IN COMPLEX WITH BPPB
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, BRADYKININ-POTENTIATING PEPTIDE B, CHLORIDE ION, ...
Authors:Masuyer, G., Schwager, S.L.U., Sturrock, E.D., Isaac, R.E., Acharya, K.R.
Deposit date:2012-04-03
Release date:2012-10-17
Last modified:2012-10-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Recognition and Regulation of Human Angiotensin-I Converting Enzyme (Ace) Activity by Natural Inhibitory Peptides.
Sci.Rep., 2, 2012
4CA5
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HUMAN ANGIOTENSIN CONVERTING ENZYME IN COMPLEX WITH A PHOSPHINIC TRIPEPTIDE FI
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, ZINC ION, CHLORIDE ION, ...
Authors:Masuyer, G., Akif, M., Czarny, B., Beau, F., Schwager, S.L.U., Sturrock, E.D., Isaac, R.E., Dive, V., Acharya, K.R.
Deposit date:2013-10-07
Release date:2013-12-11
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of Highly Specific Phosphinic Tripeptide Enantiomers in Complex with the Angiotensin-I Converting Enzyme.
FEBS J., 281, 2014
4CA6
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HUMAN ANGIOTENSIN CONVERTING ENZYME N-DOMAIN IN COMPLEX WITH A PHOSPHINIC TRIPEPTIDE FI
Descriptor:ANGIOTENSIN-CONVERTING ENZYME N-DOMAIN, ZINC ION, CHLORIDE ION, ...
Authors:Masuyer, G., Akif, M., Czarny, B., Beau, F., Schwager, S.L.U., Sturrock, E.D., Isaac, R.E., Dive, V., Acharya, K.R.
Deposit date:2013-10-07
Release date:2013-12-11
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme.
FEBS J., 281, 2014
4CA7
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DROSOPHILA ANGIOTENSIN CONVERTING ENZYME (ANCE) IN COMPLEX WITH A PHOSPHINIC TRIPEPTIDE FI
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, ZINC ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Masuyer, G., Akif, M., Czarny, B., Beau, F., Schwager, S.L.U., Sturrock, E.D., Isaac, R.E., Dive, V., Acharya, K.R.
Deposit date:2013-10-07
Release date:2013-12-11
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structures of Highly Specific Phosphinic Tripeptide Enantiomers in Complex with the Angiotensin-I Converting Enzyme.
FEBS J., 281, 2014
4CA8
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DROSOPHILA ANGIOTENSIN CONVERTING ENZYME (ANCE) IN COMPLEX WITH A PHOSPHINIC TRIPEPTIDE FII
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, [(2S)-2-({3-[HYDROXYL(2-PHENYL-(1R)-1-{[(BENZYLOXY)[(2S)-2-({3-[HYDROXYL(2-PHENYL-(1R)-1-CARBONYL]-AMINO}ETHYL)PHOSPHINYL]-2-[(3-PHENYLISOXAZOL-5-YL)METHYL]-1-OXO-PROPYL}AMINO)-3-(4-HYDROXY-PHENYL), SULFATE ION, ...
Authors:Masuyer, G., Akif, M., Czarny, B., Beau, F., Schwager, S.L.U., Sturrock, E.D., Isaac, R.E., Dive, V., Acharya, K.R.
Deposit date:2013-10-07
Release date:2013-12-11
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal Structures of Highly Specific Phosphinic Tripeptide Enantiomers in Complex with the Angiotensin-I Converting Enzyme.
FEBS J., 281, 2014
4UFA
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CRYSTAL STRUCTURE OF THE ANGIOTENSIN-1 CONVERTING ENZYME N-DOMAIN IN COMPLEX WITH AC-SD
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, ZINC ION, CHLORIDE ION, ...
Authors:Masuyer, G., Douglas, R.G., Sturrock, E.D., Acharya, K.R.
Deposit date:2015-03-16
Release date:2015-10-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Ac-Sdkp Hydrolysis by Angiotensin-I Converting Enzyme
Sci.Rep., 5, 2015
4UFB
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CRYSTAL STRUCTURE OF THE ANGIOTENSIN-1 CONVERTING ENZYME N-DOMAIN IN COMPLEX WITH LYS-PRO
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, LYSINE, PROLINE, ...
Authors:Masuyer, G., Douglas, R.G., Sturrock, E.D., Acharya, K.R.
Deposit date:2015-03-16
Release date:2015-10-07
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Ac-Sdkp Hydrolysis by Angiotensin-I Converting Enzyme
Sci.Rep., 5, 2015
5BQM
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CRYSTAL STRUCTURE OF SXN101959, A CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE D DERIVATIVE AND TARGETED SECRETION INHIBITOR
Descriptor:Botulinum neurotoxin type D, Somatoliberin,Botulinum neurotoxin type D, ZINC ION
Authors:Masuyer, G., Davies, J.R., Moore, K., Chaddock, J.A., Acharya, K.R.
Deposit date:2015-05-29
Release date:2015-08-19
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors.
Sci Rep, 5, 2015
5BQN
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CRYSTAL STRUCTURE OF THE LHN FRAGMENT OF BOTULINUM NEUROTOXIN TYPE D, MUTANT H233Y E230Q
Descriptor:Botulinum neurotoxin type D,Botulinum neurotoxin type D, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Masuyer, G., Davies, J.R., Moore, K., Chaddock, J.A., Acharya, K.R.
Deposit date:2015-05-29
Release date:2015-08-19
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors.
Sci Rep, 5, 2015
5L43
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STRUCTURE OF K26-DCP
Descriptor:K-26 dipeptidyl carboxypeptidase, ZINC ION, MAGNESIUM ION, ...
Authors:Masuyer, G., Acharya, K.R., Kramer, G.J., Bachmann, B.O.
Deposit date:2016-05-24
Release date:2016-10-26
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor.
FEBS J., 283, 2016
5L44
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STRUCTURE OF K-26-DCP IN COMPLEX WITH THE K-26 TRIPEPTIDE
Descriptor:K-26 dipeptidyl carboxypeptidase, ZINC ION, MAGNESIUM ION, ...
Authors:Masuyer, G., Acharya, K.R., Kramer, G.J., Bachmann, B.O.
Deposit date:2016-05-24
Release date:2016-10-26
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor.
FEBS J., 283, 2016
5N0B
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CRYSTAL STRUCTURE OF THE TETANUS NEUROTOXIN IN COMPLEX WITH GD1A
Descriptor:Tetanus toxin, ZINC ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Masuyer, G., Conrad, J., Stenmark, P.
Deposit date:2017-02-02
Release date:2017-06-21
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the tetanus toxin reveals pH-mediated domain dynamics.
EMBO Rep., 18, 2017
5N0C
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CRYSTAL STRUCTURE OF THE TETANUS NEUROTOXIN IN COMPLEX WITH GM1A
Descriptor:Tetanus toxin, BETA-D-GLUCOSE, BETA-D-GALACTOSE, ...
Authors:Masuyer, G., Conrad, J., Stenmark, P.
Deposit date:2017-02-02
Release date:2017-06-21
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the tetanus toxin reveals pH-mediated domain dynamics.
EMBO Rep., 18, 2017
6F47
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF BOTULINUM NEUROTOXIN X
Descriptor:Catalytic domain of botulinum neurotoxin X, ZINC ION
Authors:Masuyer, G., Henriksson, L., Kosenina, S., Zhang, S., Barkho, S., Shen, Y., Dong, M., Stenmark, P.
Deposit date:2017-11-29
Release date:2018-03-14
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.
Sci Rep, 8, 2018
6F4E
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CRYSTAL STRUCTURE OF THE ZINC-FREE CATALYTIC DOMAIN OF BOTULINUM NEUROTOXIN X
Descriptor:Catalytic domain of botulinum neurotoxin X, DI(HYDROXYETHYL)ETHER
Authors:Masuyer, G., Henriksson, L., Kosenina, S., Zhang, S., Barkho, S., Shen, Y., Dong, M., Stenmark, P.
Deposit date:2017-11-29
Release date:2018-03-14
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.
Sci Rep, 8, 2018
4C2N
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CRYSTAL STRUCTURE OF HUMAN TESTIS ANGIOTENSIN-I CONVERTING ENZYME MUTANT E403R
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, ZINC ION, CHLORIDE ION, ...
Authors:Masuyer, G., Yates, C.J., Schwager, S.L.U., Mohd, A., Sturrock, E.D., Acharya, K.R.
Deposit date:2013-08-19
Release date:2013-12-11
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Molecular and Thermodynamic Mechanisms of the Chloride Dependent Human Angiotensin-I Converting Enzyme (Ace)
J.Biol.Chem., 289, 2014
4C2O
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CRYSTAL STRUCTURE OF HUMAN TESTIS ANGIOTENSIN-I CONVERTING ENZYME MUTANT D465T
Descriptor:ANGIOTENSIN-CONVERTING ENZYME, SULFATE ION, CHLORIDE ION, ...
Authors:Masuyer, G., Yates, C.J., Schwager, S.L.U., Mohd, A., Sturrock, E.D., Acharya, K.R.
Deposit date:2013-08-19
Release date:2013-12-11
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular and Thermodynamic Mechanisms of the Chloride Dependent Human Angiotensin-I Converting Enzyme (Ace)
J.Biol.Chem., 289, 2014
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